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Conserved domains on  [gi|120444908|ref|NP_059074|]
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protocadherin-12 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 13228088)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-348 3.21e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 3.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  251 LEIPEDTVPGTLLINLTATDPDQGPNGEVEFFFgkhVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPN 330
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 120444908  331 SIPGHCKVLIKVLDVNDN 348
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 5.74e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.64  E-value: 5.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  465 YEVSTWENNPPSLHLITLKAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRGQPQ 544
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 120444908  545 LASSISVWVSLLDANDN 561
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-456 1.90e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  363 VSEDLPRDSFIALVSANDLDSGNNGLVHCWL--NQELGHFRLKRTNGNtymLLTNATLDREQWPIYTLTVFAQDQGPQPL 440
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 120444908  441 SAEKELQIQVSDVNDN 456
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-240 1.69e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  139 EQELEISESASLHTRIPLDRALDQDTGPNSLYS---YSLSPSEHFALDVIVGpdetkhaELVVVKELDRELHSYFDLVLT 215
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 120444908  216 AYDNGNPPKSGISVVKVNVLDSNDN 240
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 617-693 4.43e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 4.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  617 LLLTIVARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFINvtnaSSL---IGSQWDLGIVVEDQGSPSLQTQVSLKV 693
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA----KPLdreEQSSYTLTVTATDGGGPPLSSTATVTI 90
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-111 1.06e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 59.08  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    32 VKFQVTEEVPSGTVIGKLSQELRVE----ERRGkagdaFQILQLPQALPVQMNSEDGLLSTSSRLDREKLCRQEDPCLVS 107
Cdd:pfam08266    2 IRYSVPEETERGSFVGNLAKDLGLEvgelAARG-----ARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLH 76


                   ....
gi 120444908   108 FDVL 111
Cdd:pfam08266   77 FQVL 80
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-348 3.21e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 3.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  251 LEIPEDTVPGTLLINLTATDPDQGPNGEVEFFFgkhVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPN 330
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 120444908  331 SIPGHCKVLIKVLDVNDN 348
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 5.74e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.64  E-value: 5.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  465 YEVSTWENNPPSLHLITLKAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRGQPQ 544
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 120444908  545 LASSISVWVSLLDANDN 561
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-456 1.90e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  363 VSEDLPRDSFIALVSANDLDSGNNGLVHCWL--NQELGHFRLKRTNGNtymLLTNATLDREQWPIYTLTVFAQDQGPQPL 440
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 120444908  441 SAEKELQIQVSDVNDN 456
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 483-563 1.56e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 1.56e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    483 KAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRGQPQLASSISVWVSLLDANDNA 562
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 120444908    563 P 563
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-350 8.10e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 8.10e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    267 TATDPDQGPNGEVEFFFgkhVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPNSIPGHCKVLIKVLDVN 346
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 120444908    347 DNAP 350
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-458 4.92e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 4.92e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    377 SANDLDSGNNGLVHCWLNQ--ELGHFRLKRTNGntyMLLTNATLDREQWPIYTLTVFAQDQGPQPLSAEKELQIQVSDVN 454
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 120444908    455 DNAP 458
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
252-343 9.35e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 9.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   252 EIPEDTVPGTLLINLTATDPDQGPNGEVEFFFgkhVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPNS 331
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 120444908   332 IPGHCKVLIKVL 343
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-240 1.69e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  139 EQELEISESASLHTRIPLDRALDQDTGPNSLYS---YSLSPSEHFALDVIVGpdetkhaELVVVKELDRELHSYFDLVLT 215
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 120444908  216 AYDNGNPPKSGISVVKVNVLDSNDN 240
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
465-556 3.28e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 3.28e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   465 YEVSTWENNPPSLHLITLKAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRGQPQ 544
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 120444908   545 LASSISVWVSLL 556
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-242 6.06e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 6.06e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    158 RALDQDTGPNSLYS---YSLSPSEHFALDVIVGpdetkhaELVVVKELDRELHSYFDLVLTAYDNGNPPKSGISVVKVNV 234
Cdd:smart00112    1 SATDADSGENGKVTysiLSGNDDGLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 120444908    235 LDSNDNSP 242
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
363-450 2.49e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 2.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   363 VSEDLPRDSFIALVSANDLDSGNNGLVHCWLNQ--ELGHFRLKRTNGntyMLLTNATLDREQWPIYTLTVFAQDQGPQPL 440
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 120444908   441 SAEKELQIQV 450
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 617-693 4.43e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 4.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  617 LLLTIVARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFINvtnaSSL---IGSQWDLGIVVEDQGSPSLQTQVSLKV 693
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA----KPLdreEQSSYTLTVTATDGGGPPLSSTATVTI 90
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-111 1.06e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 59.08  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    32 VKFQVTEEVPSGTVIGKLSQELRVE----ERRGkagdaFQILQLPQALPVQMNSEDGLLSTSSRLDREKLCRQEDPCLVS 107
Cdd:pfam08266    2 IRYSVPEETERGSFVGNLAKDLGLEvgelAARG-----ARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLH 76


                   ....
gi 120444908   108 FDVL 111
Cdd:pfam08266   77 FQVL 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 34-131 3.26e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   34 FQVTEEVPSGTVIGKLSqelrveerrgkAGDA---------FQILQLPQALPVQMNSEDGLLSTSSRLDREKLCRqedpc 104
Cdd:cd11304     4 VSVPENAPPGTVVLTVS-----------ATDPdsgengevtYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSS----- 67

                          90       100       110
                  ....*....|....*....|....*....|..
gi 120444908  105 lVSFDVLAT-----GASALIHVEIQVLDINDH 131
Cdd:cd11304    68 -YTLTVTATdgggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 622-693 4.04e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 4.04e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120444908    622 VARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFINvtnaSSL---IGSQWDLGIVVEDQGSPSLQTQVSLKV 693
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT----KPLdreEQPEYTLTVEATDGGGPPLSSTATVTI 71
Cadherin pfam00028
Cadherin domain;
143-235 1.84e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 1.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   143 EISESASLHTRIPLDRALDQDTGPNSL---YSYSLSPSEHFALDVIVGpdetkhaELVVVKELDRELHSYFDLVLTAYDN 219
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRifySILGGGPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 120444908   220 GNPPKSGISVVKVNVL 235
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
617-693 2.86e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 2.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   617 LLLTIVARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFInvtnASSL---IGSQWDLGIVVEDQGSPSLQTQVSLKV 693
Cdd:pfam00028   14 EVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIST----TKPLdreSIGEYELTVEATDSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-133 1.32e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 1.32e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 120444908     66 FQILQLPQALPVQMNSEDGLLSTSSRLDREKLCRqedpclVSFDVLAT-----GASALIHVEIQVLDINDHQP 133
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPE------YTLTVEATdgggpPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-348 3.21e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 3.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  251 LEIPEDTVPGTLLINLTATDPDQGPNGEVEFFFgkhVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPN 330
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 120444908  331 SIPGHCKVLIKVLDVNDN 348
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 5.74e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.64  E-value: 5.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  465 YEVSTWENNPPSLHLITLKAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRGQPQ 544
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 120444908  545 LASSISVWVSLLDANDN 561
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-456 1.90e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  363 VSEDLPRDSFIALVSANDLDSGNNGLVHCWL--NQELGHFRLKRTNGNtymLLTNATLDREQWPIYTLTVFAQDQGPQPL 440
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 120444908  441 SAEKELQIQVSDVNDN 456
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 483-563 1.56e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 1.56e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    483 KAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRGQPQLASSISVWVSLLDANDNA 562
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 120444908    563 P 563
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-350 8.10e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 8.10e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    267 TATDPDQGPNGEVEFFFgkhVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPNSIPGHCKVLIKVLDVN 346
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 120444908    347 DNAP 350
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-458 4.92e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 4.92e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    377 SANDLDSGNNGLVHCWLNQ--ELGHFRLKRTNGntyMLLTNATLDREQWPIYTLTVFAQDQGPQPLSAEKELQIQVSDVN 454
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 120444908    455 DNAP 458
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
252-343 9.35e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 9.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   252 EIPEDTVPGTLLINLTATDPDQGPNGEVEFFFgkhVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPNS 331
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 120444908   332 IPGHCKVLIKVL 343
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-240 1.69e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  139 EQELEISESASLHTRIPLDRALDQDTGPNSLYS---YSLSPSEHFALDVIVGpdetkhaELVVVKELDRELHSYFDLVLT 215
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 120444908  216 AYDNGNPPKSGISVVKVNVLDSNDN 240
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
465-556 3.28e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 3.28e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   465 YEVSTWENNPPSLHLITLKAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRGQPQ 544
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 120444908   545 LASSISVWVSLL 556
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-242 6.06e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 6.06e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    158 RALDQDTGPNSLYS---YSLSPSEHFALDVIVGpdetkhaELVVVKELDRELHSYFDLVLTAYDNGNPPKSGISVVKVNV 234
Cdd:smart00112    1 SATDADSGENGKVTysiLSGNDDGLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 120444908    235 LDSNDNSP 242
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
363-450 2.49e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 2.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   363 VSEDLPRDSFIALVSANDLDSGNNGLVHCWLNQ--ELGHFRLKRTNGntyMLLTNATLDREQWPIYTLTVFAQDQGPQPL 440
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 120444908   441 SAEKELQIQV 450
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 617-693 4.43e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 4.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908  617 LLLTIVARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFINvtnaSSL---IGSQWDLGIVVEDQGSPSLQTQVSLKV 693
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA----KPLdreEQSSYTLTVTATDGGGPPLSSTATVTI 90
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-111 1.06e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 59.08  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908    32 VKFQVTEEVPSGTVIGKLSQELRVE----ERRGkagdaFQILQLPQALPVQMNSEDGLLSTSSRLDREKLCRQEDPCLVS 107
Cdd:pfam08266    2 IRYSVPEETERGSFVGNLAKDLGLEvgelAARG-----ARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLH 76


                   ....
gi 120444908   108 FDVL 111
Cdd:pfam08266   77 FQVL 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 34-131 3.26e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   34 FQVTEEVPSGTVIGKLSqelrveerrgkAGDA---------FQILQLPQALPVQMNSEDGLLSTSSRLDREKLCRqedpc 104
Cdd:cd11304     4 VSVPENAPPGTVVLTVS-----------ATDPdsgengevtYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSS----- 67

                          90       100       110
                  ....*....|....*....|....*....|..
gi 120444908  105 lVSFDVLAT-----GASALIHVEIQVLDINDH 131
Cdd:cd11304    68 -YTLTVTATdgggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 622-693 4.04e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 4.04e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120444908    622 VARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFINvtnaSSL---IGSQWDLGIVVEDQGSPSLQTQVSLKV 693
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT----KPLdreEQPEYTLTVEATDGGGPPLSSTATVTI 71
Cadherin pfam00028
Cadherin domain;
143-235 1.84e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 1.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   143 EISESASLHTRIPLDRALDQDTGPNSL---YSYSLSPSEHFALDVIVGpdetkhaELVVVKELDRELHSYFDLVLTAYDN 219
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRifySILGGGPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 120444908   220 GNPPKSGISVVKVNVL 235
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
617-693 2.86e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 2.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120444908   617 LLLTIVARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFInvtnASSL---IGSQWDLGIVVEDQGSPSLQTQVSLKV 693
Cdd:pfam00028   14 EVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIST----TKPLdreSIGEYELTVEATDSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-133 1.32e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 1.32e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 120444908     66 FQILQLPQALPVQMNSEDGLLSTSSRLDREKLCRqedpclVSFDVLAT-----GASALIHVEIQVLDINDHQP 133
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPE------YTLTVEATdgggpPLSSTATVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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