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large ribosomal subunit protein mL39 isoform 1 [Mus musculus]
threonine--tRNA ligase family protein( domain architecture ID 1000183)
threonine--tRNA ligase family protein such as threonine--tRNA ligase ThrRS, also termed cytoplasmic threonine--tRNA ligase, a class II aminoacyl-tRNA synthetase (aaRS) that plays an essential role in protein synthesis by catalyzing the aminoacylation of tRNA(Thr), generating aminoacyl-tRNA, and editing misacylation, and such as the large ribosomal subunit protein mL39.
List of domain hits
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Name | Accession | Description | Interval | E-value | |||||
PLN02908 super family | cl31949 | threonyl-tRNA synthetase |
27-270 | 9.94e-29 | |||||
threonyl-tRNA synthetase The actual alignment was detected with superfamily member PLN02908: Pssm-ID: 178496 [Multi-domain] Cd Length: 686 Bit Score: 116.79 E-value: 9.94e-29
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Name | Accession | Description | Interval | E-value | |||||
PLN02908 | PLN02908 | threonyl-tRNA synthetase |
27-270 | 9.94e-29 | |||||
threonyl-tRNA synthetase Pssm-ID: 178496 [Multi-domain] Cd Length: 686 Bit Score: 116.79 E-value: 9.94e-29
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TGS | cd01616 | TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; ... |
63-125 | 4.96e-24 | |||||
TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; This family includes eukaryotic and some bacterial threonyl-tRNA synthetases (ThrRSs), a distinct Obg family GTPases, and guanosine polyphosphate hydrolase (SpoT) and synthetase (RelA), which are involved in stringent response in bacteria, as well as uridine kinase (UDK) from Thermotogales. All family members contain a TGS domain named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs. It is a small domain with a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions. The functions of the TGS domain remains unclear, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, with a regulatory role. Pssm-ID: 340455 [Multi-domain] Cd Length: 61 Bit Score: 93.05 E-value: 4.96e-24
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ThrS | COG0441 | Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA ... |
99-272 | 3.43e-20 | |||||
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases Pssm-ID: 440210 [Multi-domain] Cd Length: 639 Bit Score: 91.25 E-value: 3.43e-20
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Name | Accession | Description | Interval | E-value | |||||
PLN02908 | PLN02908 | threonyl-tRNA synthetase |
27-270 | 9.94e-29 | |||||
threonyl-tRNA synthetase Pssm-ID: 178496 [Multi-domain] Cd Length: 686 Bit Score: 116.79 E-value: 9.94e-29
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TGS | cd01616 | TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; ... |
63-125 | 4.96e-24 | |||||
TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; This family includes eukaryotic and some bacterial threonyl-tRNA synthetases (ThrRSs), a distinct Obg family GTPases, and guanosine polyphosphate hydrolase (SpoT) and synthetase (RelA), which are involved in stringent response in bacteria, as well as uridine kinase (UDK) from Thermotogales. All family members contain a TGS domain named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs. It is a small domain with a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions. The functions of the TGS domain remains unclear, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, with a regulatory role. Pssm-ID: 340455 [Multi-domain] Cd Length: 61 Bit Score: 93.05 E-value: 4.96e-24
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ThrS | COG0441 | Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA ... |
99-272 | 3.43e-20 | |||||
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases Pssm-ID: 440210 [Multi-domain] Cd Length: 639 Bit Score: 91.25 E-value: 3.43e-20
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TGS_ThrRS | cd01667 | TGS (ThrRS, GTPase and SpoT) domain found in threonyl-tRNA synthetase (ThrRS) and similar ... |
73-131 | 1.67e-19 | |||||
TGS (ThrRS, GTPase and SpoT) domain found in threonyl-tRNA synthetase (ThrRS) and similar proteins; ThrRS, also termed cytoplasmic threonine--tRNA ligase, is a class II aminoacyl-tRNA synthetase (aaRS) that plays an essential role in protein synthesis by catalyzing the aminoacylation of tRNA(Thr), generating aminoacyl-tRNA, and editing misacylation. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs. TGS is a small domain with a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions. Pssm-ID: 340458 [Multi-domain] Cd Length: 65 Bit Score: 80.99 E-value: 1.67e-19
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PRK12444 | PRK12444 | threonyl-tRNA synthetase; Reviewed |
99-269 | 5.22e-10 | |||||
threonyl-tRNA synthetase; Reviewed Pssm-ID: 183530 [Multi-domain] Cd Length: 639 Bit Score: 60.53 E-value: 5.22e-10
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Ubiquitin_like_fold | cd00196 | Beta-grasp ubiquitin-like fold; Ubiquitin is a protein modifier that is involved in various ... |
64-124 | 1.75e-06 | |||||
Beta-grasp ubiquitin-like fold; Ubiquitin is a protein modifier that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes. The ubiquitination process comprises a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of ubiquitin and the epsilon-amino group of a substrate lysine. Ubiquitin-like proteins have similar ubiquitin beta-grasp fold and attach to other proteins in a ubiquitin-like manner but with biochemically distinct roles. Ubiquitin and ubiquitin-like proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some other ubiquitin-like domains have adaptor roles in ubiquitin-signaling by mediating protein-protein interaction. In addition to Ubiquitin-like (Ubl) domain, Ras-associating (RA) domain, F0/F1 sub-domain of FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, TGS (ThrRS, GTPase and SpoT) domain, Ras-binding domain (RBD), Ubiquitin regulatory domain X (UBX), Dublecortin-like domain, and RING finger- and WD40-associated ubiquitin-like (RAWUL) domain have beta-grasp ubiquitin-like folds, and are included in this superfamily. Pssm-ID: 340450 Cd Length: 68 Bit Score: 45.01 E-value: 1.75e-06
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Blast search parameters | ||||
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