NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|9257257|ref|NP_059830|]
View 

WD repeat-containing protein 1 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11525814)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-389 6.79e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.32  E-value: 6.79e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   50 LADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGA 129
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  130 VFLWD--SGSSVGEITGHNKVINSVDIKQSRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATA 207
Cdd:cd00200  75 IRLWDleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  208 SADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVnsvvstfpmgstvldqqlgclw 287
Cdd:cd00200 154 SQDGTIKLWDLRTGKCVATLTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST---------------------- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  288 qkdhllsvslsgyinyldrnnpSKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQ 367
Cdd:cd00200 209 ----------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNS 263

                       330       340
                ....*....|....*....|...
gi 9257257  368 VSRMTVDESGQ-LISCSMDDTVR 389
Cdd:cd00200 264 VTSLAWSPDGKrLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
129-605 1.97e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.34  E-value: 1.97e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  129 AVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPfKFKFTIGDHSRFVNCVRFSPDGNRFATAS 208
Cdd:COG2319  19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  209 ADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvnsvvstfpmgstvldqqlgclwq 288
Cdd:COG2319  98 ADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA------------------------ 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  289 kdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQV 368
Cdd:COG2319 151 ---------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAV 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  369 SRMTVDESGQLI-SCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCigqivllkdqrkcfsidnpgye 447
Cdd:COG2319 208 RSVAFSPDGKLLaSGSADGTVR-----LWDLATG---------KLLRTLTGHSGSVRS---------------------- 251

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  448 pevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNV 527
Cdd:COG2319 252 ---VAFSPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRT 325

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9257257  528 FYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEWTIT 605
Cdd:COG2319 326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-389 6.79e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.32  E-value: 6.79e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   50 LADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGA 129
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  130 VFLWD--SGSSVGEITGHNKVINSVDIKQSRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATA 207
Cdd:cd00200  75 IRLWDleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  208 SADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVnsvvstfpmgstvldqqlgclw 287
Cdd:cd00200 154 SQDGTIKLWDLRTGKCVATLTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST---------------------- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  288 qkdhllsvslsgyinyldrnnpSKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQ 367
Cdd:cd00200 209 ----------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNS 263

                       330       340
                ....*....|....*....|...
gi 9257257  368 VSRMTVDESGQ-LISCSMDDTVR 389
Cdd:cd00200 264 VTSLAWSPDGKrLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
40-389 6.24e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 6.24e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   40 VILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR--TLTGHTGAVRSVAFSPDGKTLAS 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  120 VGEGrekfGAVFLWD--SGSSVGEITGHNKVINSVDIkqsRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319 138 GSAD----GTVRLWDlaTGKLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  196 RFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMG 275
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  276 StvlDQQLGCLWQKD--HLLSVSLSGYINYLDRNNPsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSET 353
Cdd:COG2319 288 S---GGVNSVAFSPDgkLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLAT 361

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 9257257  354 GENDSFAgKGHTNQVSRMTVDESGQ-LISCSMDDTVR 389
Cdd:COG2319 362 GELLRTL-TGHTGAVTSVAFSPDGRtLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
129-605 1.97e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.34  E-value: 1.97e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  129 AVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPfKFKFTIGDHSRFVNCVRFSPDGNRFATAS 208
Cdd:COG2319  19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  209 ADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvnsvvstfpmgstvldqqlgclwq 288
Cdd:COG2319  98 ADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA------------------------ 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  289 kdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQV 368
Cdd:COG2319 151 ---------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAV 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  369 SRMTVDESGQLI-SCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCigqivllkdqrkcfsidnpgye 447
Cdd:COG2319 208 RSVAFSPDGKLLaSGSADGTVR-----LWDLATG---------KLLRTLTGHSGSVRS---------------------- 251

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  448 pevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNV 527
Cdd:COG2319 252 ---VAFSPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRT 325

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9257257  528 FYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEWTIT 605
Cdd:COG2319 326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-602 5.54e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 5.54e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  312 PLHVIKGHSKSIQCLTVHKNGGksYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSR-MTVDESGQLISCSMDDTVRY 390
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  391 TSL----MLRDYSG--QGVVKLDVQPKC-VAVGpGGYAVVVCIGQIVLLKDQRKCFSIDNPGYepeVVAVHPGGDTVAIG 463
Cdd:cd00200  78 WDLetgeCVRTLTGhtSYVSSVAFSPDGrILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVN---SVAFSPDGTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  464 GVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPD 543
Cdd:cd00200 154 SQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  544 NEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEW 602
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLS-GHT-NSVTSLAWSpDGKRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 70-381 2.13e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 70.12  E-value: 2.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257    70 GFYIASGDVSGKLRIWD---TTQKEHLLKYEYQPFAG--KIKDIAWTEDSKRiAVVGEGREkfGAVFLWDSGSS--VGEI 142
Cdd:PLN00181 495 GEFFATAGVNKKIKIFEcesIIKDGRDIHYPVVELASrsKLSGICWNSYIKS-QVASSNFE--GVVQVWDVARSqlVTEM 571

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   143 TGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRfVNCVRFSPD-GNRFATASADGQIYIYDGKTG 221
Cdd:PLN00181 572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYYYDLRNP 650

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   222 E-KVCALGGskaHDGGIYAISWSpDSTHLLSASGDKTSKIWDvsvnsvvstfpmgstvldqqlgclwqkdhlLSVSLSGy 300
Cdd:PLN00181 651 KlPLCTMIG---HSKTVSYVRFV-DSSTLVSSSTDNTLKLWD------------------------------LSMSISG- 695

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   301 INyldrnnpSKPLHVIKGHS--KSIQCLTVhkngGKSYIYSGSHDGHI-NYWDSETGENDSFAGKgHTNQVSRMTVDESG 377
Cdd:PLN00181 696 IN-------ETPLHSFMGHTnvKNFVGLSV----SDGYIATGSETNEVfVYHKAFPMPVLSYKFK-TIDPVSGLEVDDAS 763


                 ....
gi 9257257   378 QLIS 381
Cdd:PLN00181 764 QFIS 767
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-217 2.11e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 9257257     178 PFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
179-217 1.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 9257257    179 FKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 526-559 1.79e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.79e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 9257257     526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
527-559 9.93e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 9.93e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 9257257    527 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 460-605 7.76e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 7.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   460 VAIGGVDGNVRLYSILGTTLKDEGKllEAKGPVTDVAYSH-DGAFLAVCDASKVVTVFSVADGYSENNVfyGHHAKIVCL 538
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMK--EHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI--KTKANICCV 623

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9257257   539 AWSPDN-EHFASGGMDMMVYVWTLSDPETRVKIQDAHRlHHVSSLAWLDEHTLVTTSHDASVKEWTIT 605
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHS-KTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-389 6.79e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.32  E-value: 6.79e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   50 LADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGA 129
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  130 VFLWD--SGSSVGEITGHNKVINSVDIKQSRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATA 207
Cdd:cd00200  75 IRLWDleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  208 SADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVnsvvstfpmgstvldqqlgclw 287
Cdd:cd00200 154 SQDGTIKLWDLRTGKCVATLTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST---------------------- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  288 qkdhllsvslsgyinyldrnnpSKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQ 367
Cdd:cd00200 209 ----------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNS 263

                       330       340
                ....*....|....*....|...
gi 9257257  368 VSRMTVDESGQ-LISCSMDDTVR 389
Cdd:cd00200 264 VTSLAWSPDGKrLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
40-389 6.24e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 6.24e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   40 VILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR--TLTGHTGAVRSVAFSPDGKTLAS 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  120 VGEGrekfGAVFLWD--SGSSVGEITGHNKVINSVDIkqsRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319 138 GSAD----GTVRLWDlaTGKLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  196 RFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMG 275
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  276 StvlDQQLGCLWQKD--HLLSVSLSGYINYLDRNNPsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSET 353
Cdd:COG2319 288 S---GGVNSVAFSPDgkLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLAT 361

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 9257257  354 GENDSFAgKGHTNQVSRMTVDESGQ-LISCSMDDTVR 389
Cdd:COG2319 362 GELLRTL-TGHTGAVTSVAFSPDGRtLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
129-605 1.97e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.34  E-value: 1.97e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  129 AVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPfKFKFTIGDHSRFVNCVRFSPDGNRFATAS 208
Cdd:COG2319  19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  209 ADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvnsvvstfpmgstvldqqlgclwq 288
Cdd:COG2319  98 ADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA------------------------ 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  289 kdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQV 368
Cdd:COG2319 151 ---------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAV 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  369 SRMTVDESGQLI-SCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCigqivllkdqrkcfsidnpgye 447
Cdd:COG2319 208 RSVAFSPDGKLLaSGSADGTVR-----LWDLATG---------KLLRTLTGHSGSVRS---------------------- 251

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  448 pevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNV 527
Cdd:COG2319 252 ---VAFSPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRT 325

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9257257  528 FYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEWTIT 605
Cdd:COG2319 326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
67-563 6.38e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 6.38e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   67 APSGFYIASGDVSGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAVVGEGREkfGAVFLWDSGSSVGEITGHN 146
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLL--LLLGLAAAVASLAASPDGARLAAGAGDLT--LLLLDAAAGALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  147 KVINSVDIKQSRPyRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCA 226
Cdd:COG2319  79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  227 LGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvnsvvstfpmgstvldqqlgclwqkdhllsvslSGyinyldr 306
Cdd:COG2319 158 LTG---HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA---------------------------------TG------- 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  307 nnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSRMTVDESGQ-LISCSMD 385
Cdd:COG2319 195 ----KLLRTLTGHTGAVRSVAFSPDG--KLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRlLASGSAD 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  386 DTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGV 465
Cdd:COG2319 268 GTVR-----LWDLATG---------ELLRTLTGHSGGVNS-------------------------VAFSPDGKLLASGSD 308

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  466 DGNVRLYSIlgttlkDEGKLLEA----KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWS 541
Cdd:COG2319 309 DGTVRLWDL------ATGKLLRTltghTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFS 381

                       490       500
                ....*....|....*....|..
gi 9257257  542 PDNEHFASGGMDMMVYVWTLSD 563
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-559 4.42e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.26  E-value: 4.42e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  182 KFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  262 DVSVNSVVSTFpmgstvldqqlgclwqkdhllsvslsgyinyldrnnpskplhviKGHSKSIQCLTVHKNGgkSYIYSGS 341
Cdd:cd00200  79 DLETGECVRTL--------------------------------------------TGHTSYVSSVAFSPDG--RILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  342 HDGHINYWDSETGENdSFAGKGHTNQVSRMTVDESGQLISCSMDDtvrytslmlrdysgqGVVKL-DV-QPKCVAVGPGG 419
Cdd:cd00200 113 RDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQD---------------GTIKLwDLrTGKCVATLTGH 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  420 YAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSILGTTLKdegKLLEAK-GPVTDVAYS 498
Cdd:cd00200 177 TGEVNS-------------------------VAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHeNGVNSVAFS 228

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9257257  499 HDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
40-264 9.11e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.37  E-value: 9.11e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   40 VILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLlkYEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLAS 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  120 VGEGrekfGAVFLWD--SGSSVGEITGHNKVINSVDI-KQSRpyRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVR 196
Cdd:COG2319 264 GSAD----GTVRLWDlaTGELLRTLTGHSGGVNSVAFsPDGK--LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9257257  197 FSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVS 264
Cdd:COG2319 338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-262 3.41e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 3.41e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   38 KCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRI 117
Cdd:cd00200  73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFV 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  118 AVVGEGrekfGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRpYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:cd00200 151 ASSSQD----GTIKLWDlrTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9257257  196 RFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-602 5.54e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 5.54e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  312 PLHVIKGHSKSIQCLTVHKNGGksYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSR-MTVDESGQLISCSMDDTVRY 390
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  391 TSL----MLRDYSG--QGVVKLDVQPKC-VAVGpGGYAVVVCIGQIVLLKDQRKCFSIDNPGYepeVVAVHPGGDTVAIG 463
Cdd:cd00200  78 WDLetgeCVRTLTGhtSYVSSVAFSPDGrILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVN---SVAFSPDGTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  464 GVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPD 543
Cdd:cd00200 154 SQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  544 NEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEW 602
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLS-GHT-NSVTSLAWSpDGKRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 70-381 2.13e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 70.12  E-value: 2.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257    70 GFYIASGDVSGKLRIWD---TTQKEHLLKYEYQPFAG--KIKDIAWTEDSKRiAVVGEGREkfGAVFLWDSGSS--VGEI 142
Cdd:PLN00181 495 GEFFATAGVNKKIKIFEcesIIKDGRDIHYPVVELASrsKLSGICWNSYIKS-QVASSNFE--GVVQVWDVARSqlVTEM 571

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   143 TGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRfVNCVRFSPD-GNRFATASADGQIYIYDGKTG 221
Cdd:PLN00181 572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSADHKVYYYDLRNP 650

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   222 E-KVCALGGskaHDGGIYAISWSpDSTHLLSASGDKTSKIWDvsvnsvvstfpmgstvldqqlgclwqkdhlLSVSLSGy 300
Cdd:PLN00181 651 KlPLCTMIG---HSKTVSYVRFV-DSSTLVSSSTDNTLKLWD------------------------------LSMSISG- 695

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   301 INyldrnnpSKPLHVIKGHS--KSIQCLTVhkngGKSYIYSGSHDGHI-NYWDSETGENDSFAGKgHTNQVSRMTVDESG 377
Cdd:PLN00181 696 IN-------ETPLHSFMGHTnvKNFVGLSV----SDGYIATGSETNEVfVYHKAFPMPVLSYKFK-TIDPVSGLEVDDAS 763


                 ....
gi 9257257   378 QLIS 381
Cdd:PLN00181 764 QFIS 767
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-217 2.11e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 9257257     178 PFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
179-217 1.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 9257257    179 FKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-262 1.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 9257257     231 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 526-559 1.79e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.79e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 9257257     526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-350 4.33e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.33e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 9257257     309 PSKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWD 350
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG--KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
231-262 6.20e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.20e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 9257257    231 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
527-559 9.93e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 9.93e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 9257257    527 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
310-350 1.48e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.48e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 9257257    310 SKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWD 350
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG--KLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 195-264 2.45e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 47.34  E-value: 2.45e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9257257   195 VRFSPDGNRFATAS-ADG--QIYIYDGKTGEKVCALggSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVS 264
Cdd:COG4946  348 PAWSPDGKSIAYFSdASGeyELYIAPADGSGEPKQL--TLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLA 418
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 187-395 2.40e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   187 DHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK--------VCALGGSKAHDGgiyaISW-SPDSTHLLSASGDKT 257
Cdd:PLN00181 481 NSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKdgrdihypVVELASRSKLSG----ICWnSYIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   258 SKIWDVSVNSVVstfpmgsTVLDQQLGCLWQKDH-------LLSVSLSGYINyLDRNNPSKPLHVIKGHSkSIQCLTVHK 330
Cdd:PLN00181 557 VQVWDVARSQLV-------TEMKEHEKRVWSIDYssadptlLASGSDDGSVK-LWSINQGVSIGTIKTKA-NICCVQFPS 627

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9257257   331 NGGKSYIYsGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLML 395
Cdd:PLN00181 628 ESGRSLAF-GSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSM 691
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 196-276 2.70e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.58  E-value: 2.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257  196 RFSPDGNRFATASADG---QIYIYDGKTGEkvcalggSKAHDGGIYAISWSPDSTHLL-SASGDKTSKIWDVSVNSVVST 271
Cdd:COG0823  81 SWSPDGKRLAFVSRSDgrfDIYVLDLDGGA-------PRRLTDGPGSPSWSPDGRRIVfSSDRGGRPDLYVVDLDGRKRR 153


                ....*
gi 9257257  272 FPMGS 276
Cdd:COG0823 154 LTPAS 158
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 205-277 3.79e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 3.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9257257    205 ATASADGQIYIYDGKtGEKVCALGGSKaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGST 277
Cdd:pfam12894  11 ALATEDGELLLHRLN-WQRVWTLSPDK-EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 182-246 5.08e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.10  E-value: 5.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9257257   182 KFTIGDHSRFVNcVRFSPDGNRFATASADGQIYIYDGKTGE--KVcalgGSKAHDGGIYAISWSPDS 246
Cdd:COG4946  382 QLTLGDLGRVFN-PVWSPDGKKIAFTDNRGRLWVVDLASGKvrKV----DTDGYGDGISDLAWSPDS 443
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-243 5.44e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 5.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 9257257    192 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALggsKAHDGGIYAISWS 243
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF---SAGSDLITCLGWG 89
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 133-263 6.15e-04

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 43.08  E-value: 6.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257    133 WDSGSSVGEIT-GHNKVINSVDIkqsrpYRLATGSDDNCAAFFEGPPFKfkftigDHSRFVNCVRFSPDGNRFATASADG 211
Cdd:pfam04762  29 FDTTSDSITFVlGPTESEGAIEV-----QQFMKDGQVSVLASFPAPLPV------GPDDKILSFQHLADSESLCFASASG 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 9257257    212 QI--YIYDGKTGEKVCALGGSKahDGGIYAISWSPDSTHLLSASGDKT----SKIWDV 263
Cdd:pfam04762  98 DIilVTYDPDPETTVVEIVGSI--DSGITAAAWSPDEELLALVTGEGTvllmTRDFEP 153
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 460-605 7.76e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 7.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   460 VAIGGVDGNVRLYSILGTTLKDEGKllEAKGPVTDVAYSH-DGAFLAVCDASKVVTVFSVADGYSENNVfyGHHAKIVCL 538
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMK--EHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI--KTKANICCV 623

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9257257   539 AWSPDN-EHFASGGMDMMVYVWTLSDPETRVKIQDAHRlHHVSSLAWLDEHTLVTTSHDASVKEWTIT 605
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHS-KTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 188-297 1.96e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257   188 HSRFVNCVRFSPDG-NRFATASADGQIYIYDGKTGEKVCALggsKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVN 266
Cdd:PTZ00421 124 HTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110
                 ....*....|....*....|....*....|.
gi 9257257   267 SVVSTFPMGSTVLDQQlgCLWQKDHLLSVSL 297
Cdd:PTZ00421 201 TIVSSVEAHASAKSQR--CLWAKRKDLIITL 229
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 168-264 4.78e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 38.79  E-value: 4.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9257257    168 DNCAAFFEgPPFKFKFTIGDHSRfvNCVRFSPDGNRFATA---SADGQIYIYDGKTGEKVCALGGSKAHDggiyaISWSP 244
Cdd:pfam08662  82 PAKVSFFD-LKGNVIHSFGEQPR--NTIFWSPFGRLVLLAgfgNLAGDIEFWDVVNKKKIATAEASNATL-----CEWSP 153

                          90       100
                  ....*....|....*....|....*.
gi 9257257    245 DSTHLLSASG------DKTSKIWDVS 264
Cdd:pfam08662 154 DGRYFLTATTaprlrvDNGFKIWHYN 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH