NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24308169|ref|NP_060009|]
View 

dynein axonemal heavy chain 3 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1391-1717 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


:

Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 688.06  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1391 YGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKG 1470
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1471 LAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFR 1550
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1551 TVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLL 1630
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1631 RALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVG 1710
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 24308169   1711 DPMGGKT 1717
Cdd:pfam12774  321 PTGSGKT 327
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
859-1262 2.82e-160

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


:

Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 502.56  E-value: 2.82e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169    859 LQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDvpapRRLAENVKIKIDKFK 938
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRD----WDVAEELKKKIDDFK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169    939 QYIPILSISCNPGMKDRHWQQISEIVGYEIKP-TETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVN 1017
Cdd:pfam08393   77 KSLPLIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKT 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1018 VTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIF 1097
Cdd:pfam08393  157 MEFELVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIF 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1098 SSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFL 1177
Cdd:pfam08393  237 SSEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFL 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1178 SNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKiyPANAKGMVEKWLQQVEQMMLAS 1257
Cdd:pfam08393  317 SNDELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEITGMISKEGEVVPFSKP--PVEAKGNVEEWLNELEEEMRET 394

                   ....*
gi 24308169   1258 MREVI 1262
Cdd:pfam08393  395 LRDLL 399
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
3811-4112 1.99e-147

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


:

Pssm-ID: 465677  Cd Length: 301  Bit Score: 460.93  E-value: 1.99e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3811 NQETNQLFEGVLLTLPR---QSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLT 3887
Cdd:pfam18199    1 TNETNELLSTLLSLQPRsdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPVGYEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3888 KVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWI-DKGPPVVFWI 3966
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3967 SGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENN--PEDGAYIKGLFLEGARWDRKTMQIGESLPKILYD 4044
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTepPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24308169   4045 PLPIIWLKPGESAMF-LHQDIYVCPVYKTSARrgtlsttgHSTNYVLSIELPTDMPQKHWINRGVASLC 4112
Cdd:pfam18199  241 PLPVIHLKPVESDKKkLDENTYECPVYKTSER--------HSTNFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2404-2664 9.36e-127

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


:

Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 399.68  E-value: 9.36e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2404 MSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVA 2483
Cdd:pfam12780    1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2484 TKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGekVEVTPLSMYNFFIERVINKISFS 2563
Cdd:pfam12780   81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQN--IEDSREAVYNYFVKRCRNNLHIV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2564 LAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKL 2643
Cdd:pfam12780  159 LCMSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPEELKSNVVKVFVYVHSSVEDMSKKFYEEL 238
                          250       260
                   ....*....|....*....|.
gi 24308169   2644 RRHNYVTPTSYLELILTFKTL 2664
Cdd:pfam12780  239 KRKNYVTPKSYLELLRLYKNL 259
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3052-3273 9.31e-113

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


:

Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 357.91  E-value: 9.31e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3052 RAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIG 3131
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3132 EELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAA 3211
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308169   3212 KEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEI 3273
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
DYN1 super family cl34955
Dynein, heavy chain [Cytoskeleton];
1062-3743 2.96e-107

Dynein, heavy chain [Cytoskeleton];


The actual alignment was detected with superfamily member COG5245:

Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 387.42  E-value: 2.96e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1062 IEAECRKW----------EEKLIRIQDNLDAWLKCQAT-------WLYLEPIF-SSEDIIAQMPEEGRKFGIVDSYWKSL 1123
Cdd:COG5245  582 IDDEIREWcssvlsddflEERAVRVERGADGARRLRASsgspvlrRLDEYLMMmSLEDLMPLIPHAVHRKMSLVSGVRGI 661
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1124 MSQAVKDNRILVAADQPrMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFflSNDELLEILSETKDPLRVQPHLKKCF 1203
Cdd:COG5245  662 YKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERAS--EVEELMDRVRELENRVYSYRFFVKKI 738
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1204 EGIAKLEFTDNLeIVGMISSEKETVPFIQKIyPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAY-VKVPRNHWVLQwp 1282
Cdd:COG5245  739 AKEEMKTVFSSR-IQKKEPFSLDSEAYVGFF-RLYEKSIVIRGINRSMGRVLSQYLESVQEALEIEdGSFFVSRHRVR-- 814
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1283 gqvVICVSSIFWTQevsqaLAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDL 1362
Cdd:COG5245  815 ---DGGLEKGRGCD-----AWENCFDPPLSEYFRILEKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCL 886
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1363 NDFQWISQLRYYWVAKDVQVQIITTEAL-YGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGApegpAGTGKTETTKD 1441
Cdd:COG5245  887 EVLGSVSISELPQGLYKRFIKVRSSYRSaEMFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGM 962
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1442 LAKALAKqcvvfnCSDGLDYKAmgKFFKGLAQAGAWAcFDEFNRIEVEVLSVVA-QQILSIQQAIIRKLKTFIFEGTELS 1520
Cdd:COG5245  963 LVAGKGR------IYDGTEPRS--RIEAGPICEEERG-TEESALLDEISRTILVdEYLNSDEFRMLEELNSAVVEHGLKS 1033
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1521 lnPTCAVFITMNPgyagRAELPDNLKALFRTVAMMVPdYALIGEISlysmgfldsRSLAQKIVATYRLCSEQLSSQHHYD 1600
Cdd:COG5245 1034 --PSTPVEMIINE----RNIVLEIGRRALDMFLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELM 1097
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1601 YgmRAVKSVLTAAGNLKLKYPEENESVLLLRALldvnlakflaqdvPLFQGII---SDLFPGVVLPkpdyevfLKVLNDN 1677
Cdd:COG5245 1098 F--YPMFKSLKAKHRMLEEKTEYLNKILSITGL-------------PLISDTLrerIDTLDAEWDS-------FCRISES 1155
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1678 IKKMKLQPVPWF-IGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGdlHAAnqmeefaVEYKIINPKAITMgQL 1756
Cdd:COG5245 1156 LKKYESQQVSGLdVAQFVSFLRSVDTGAFHAEYFRVFLCKIKHYTDACDYLW--HVK-------SPYVKKKYFDADM-EL 1225
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1757 YGCFDQVSHEWMDGVLANAfreqasslsddRKWIIFDGpvdaiWIENMNTVLDDNKKLCLMSGEiiqmnskMSLIFEPAD 1836
Cdd:COG5245 1226 RQFFLMFNREDMEARLADS-----------KMEYEVER-----YVEKTKAEVSSLKLELSSVGE-------GQVVVSNLG 1282
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1837 leqASPATVSRCGMIY----------MEPHQLG--WKPLkDSYMDTLpsSLTKEHKELVNDMFMWLVQPCLefgrlhcKF 1904
Cdd:COG5245 1283 ---SIGDKVGRCLVEYdsisrlstkgVFLDELGdtKRYL-DECLDFF--SCFEEVQKEIDELSMVFCADAL-------RF 1349
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1905 VVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGlSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFdvffrNLIM 1984
Cdd:COG5245 1350 SADLYHIVKERRFSGVLAGSDASESLGGKSIELAAIL-EHKDLIVEMKRGINDVLKLRIFGDKCRESTPRF-----YLIS 1423
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1985 GMDDNHPRPksvkltkNNIFPERGSIYDFYfIKQASGHWETWTQYITKEEEKVPAGakvsELIIPTMETARQSFFLKTYL 2064
Cdd:COG5245 1424 DGDLIKDLN-------ERSDYEEMLIMMFN-ISAVITNNGSIAGFELRGERVMLRK----EVVIPTSDTGFVDSFSNEAL 1491
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2065 DHEIPMLFVGPTGTGKSAITNNFLLHlpKNTYLPNCINFSARTSANQtqdiIMSKLDR-----RRKG---LFGPPIGKKA 2136
Cdd:COG5245 1492 NTLRSYIYCGPPGSGKEMLMCPSLRS--ELITEVKYFNFSTCTMTPS----KLSVLEReteyyPNTGvvrLYPKPVVKDL 1565
                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2137 VVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGG-GRNDITGRFTRHLNIIsinaF 2215
Cdd:COG5245 1566 VLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTDeGRVKYYERFIRKPVFV----F 1641
                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2216 EDDILTKIFSSIVDWHFGKGFDVM--FLRYGKMLVQATKTIYRDAVENFlPTPSKSHYVFNLRDFSRVIQGVLLCPHTHL 2293
Cdd:COG5245 1642 CCYPELASLRNIYEAVLMGSYLCFdeFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRI 1720
                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2294 -QDVEKCIRLWIHEVYRVFYDRLIDkedrqvffnmVKEttSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESd 2372
Cdd:COG5245 1721 dTPDVSLIIDWYCEAIREKIDRLVQ----------QKE--SSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFGM- 1787
                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2373 qkiydEITDLKQLTVVMEHYLEEFNNiSKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNA 2452
Cdd:COG5245 1788 -----ACLLKKDLAVFVEEVRKIFGS-SHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNP 1861
                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2453 YELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQT 2532
Cdd:COG5245 1862 RNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRF 1941
                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2533 AARTQGEKVEvTPLSMYNFFIERVI-NKISFSLAMSPIGDAFRNRLRmFPSLINCCTIDWFQSWPTDALELVANKfLEDV 2611
Cdd:COG5245 1942 VFESTSLEKD-TEATLTRVFLVYMEeNLPVVFSACCSQDTSVLAGIR-SPALKNRCFIDFKKLWDTEEMSQYANS-VETL 2018
                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2612 ELDDNIRVEVVSMCKYFQES-----------VKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYL 2680
Cdd:COG5245 2019 SRDGGRVFFINGELGVGKGAlisevfgddavVIEGRGFEISMIEGSLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLV 2098
                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2681 TGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDL 2760
Cdd:COG5245 2099 EGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFK 2178
                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2761 AEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKperkpdpsgsgkmIEDYWGVSKKILGDlKFL 2840
Cdd:COG5245 2179 SSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGFE-------------AKIWFGEQQSLRRD-DFI 2244
                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2841 ESLKTYDKD-NIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRE------------- 2906
Cdd:COG5245 2245 RIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREeekridgeaflve 2324
                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2907 -RLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNddfEEMNTKKKDLEENIEicsqklvraekLISGLGGEKDRWTEAA 2985
Cdd:COG5245 2325 dRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKI---ADMDTVHKDVLRSIF-----------VSEILINEDSEWGGVF 2390
                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2986 RQLGIRYTNLTGDVLLSSGTVAYLGafTVDYRvqCQNQWLAECKDKVIPGFSDFS------LSHTLGDPIKIRAWQIAGl 3059
Cdd:COG5245 2391 SEVPKLMVELDGDGHPSSCLHPYIG--TLGFL--CRAIEFGMSFIRISKEFRDKEirrrqfITEGVQKIEDFKEEACST- 2465
                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3060 pvDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENiGEELDASIE 3139
Cdd:COG5245 2466 --DYGLENSRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGD-AEALDEEIG 2542
                       2170      2180      2190      2200      2210      2220      2230      2240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3140 PiLLKATFKQQGVEY-MRLGENIIEYSRDFKLYITTRLRNPHyLPEVAVK-VCLLNFMITPLGLQDQLLGIVAAKEKPEL 3217
Cdd:COG5245 2543 R-LIKEEFKSNLSEVkVMINPPEIVRSTVEAVFWLSEGRSGD-MGSIEWKqLIQVMFVSKVLGCETEIPDALEKLVSGPL 2620
                       2250      2260      2270      2280      2290      2300      2310      2320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3218 EEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPV 3297
Cdd:COG5245 2621 FVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNAS 2700
                       2330      2340      2350      2360      2370      2380      2390      2400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3298 AVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLthSTKSEELNlRIKYIIDHFTLSIYNNvcrslfekDKLLFSLLL 3377
Cdd:COG5245 2701 VKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWR--RMKSKYLC-AIRYMLMSSEWILDHE--------DRSGFIHRL 2769
                       2410      2420      2430      2440      2450      2460      2470      2480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3378 tigiMKQKKEITEEVWYFLLtggiaLDNPYpnpaPQWLSEKAwaeivrasalpkLHGLMEHLEQNLGEWKLIYDSawphE 3457
Cdd:COG5245 2770 ----DVSFLLRTKRFVSTLL-----EDKNY----RQVLSSCS------------LYGNDVISHSCDRFDRDVYRA----L 2820
                       2490      2500      2510      2520      2530      2540      2550      2560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3458 EQLPGSWKFSqgLEKMVILRClRPDKMVPAVRE----FIAEHMGKLYieapTFdLQGSYNDSSCCAPLIFVLSPSADpma 3533
Cdd:COG5245 2821 KHQMDNRTHS--TILTSNSKT-NPYKEYTYNDSwaeaFEVEDSGDLY----KF-EEGLLELIVGHAPLIYAHKKSLE--- 2889
                       2570      2580      2590      2600      2610      2620      2630      2640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3534 gLLKFADDLGmggtRTQTISLGQGQgpiaakmINNAIKDGTWVVLQNCHLAASWMPT-LEKICEEVIVPESTNARFRLWL 3612
Cdd:COG5245 2890 -NERNVDRLG----SKENEVYAVLN-------SLFSRKEKSWFEVYNISLSFGWFKRyVEDVVYPIKASRVCGKVKNMWT 2957
                       2650      2660      2670      2680      2690      2700      2710      2720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3613 TSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPisdpvfFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGW 3692
Cdd:COG5245 2958 SMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDR------YPFDYTLVIACDDAFYLSWEHAAVASVISAGPKEN 3031
                       2730      2740      2750      2760      2770
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24308169 3693 NIPYEFNESDLRISMWQIQ--MFLNDYKEVPFDALTYLTGECNYGGRVTDDKD 3743
Cdd:COG5245 3032 NEEIYFGDKDFEFKTHLLKniLFLNHLNARKWGNNRDLIFTIVYGKKHSLMED 3084
 
Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1391-1717 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 688.06  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1391 YGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKG 1470
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1471 LAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFR 1550
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1551 TVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLL 1630
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1631 RALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVG 1710
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 24308169   1711 DPMGGKT 1717
Cdd:pfam12774  321 PTGSGKT 327
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
859-1262 2.82e-160

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 502.56  E-value: 2.82e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169    859 LQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDvpapRRLAENVKIKIDKFK 938
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRD----WDVAEELKKKIDDFK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169    939 QYIPILSISCNPGMKDRHWQQISEIVGYEIKP-TETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVN 1017
Cdd:pfam08393   77 KSLPLIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKT 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1018 VTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIF 1097
Cdd:pfam08393  157 MEFELVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIF 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1098 SSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFL 1177
Cdd:pfam08393  237 SSEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFL 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1178 SNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKiyPANAKGMVEKWLQQVEQMMLAS 1257
Cdd:pfam08393  317 SNDELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEITGMISKEGEVVPFSKP--PVEAKGNVEEWLNELEEEMRET 394

                   ....*
gi 24308169   1258 MREVI 1262
Cdd:pfam08393  395 LRDLL 399
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
3811-4112 1.99e-147

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 460.93  E-value: 1.99e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3811 NQETNQLFEGVLLTLPR---QSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLT 3887
Cdd:pfam18199    1 TNETNELLSTLLSLQPRsdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPVGYEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3888 KVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWI-DKGPPVVFWI 3966
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3967 SGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENN--PEDGAYIKGLFLEGARWDRKTMQIGESLPKILYD 4044
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTepPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24308169   4045 PLPIIWLKPGESAMF-LHQDIYVCPVYKTSARrgtlsttgHSTNYVLSIELPTDMPQKHWINRGVASLC 4112
Cdd:pfam18199  241 PLPVIHLKPVESDKKkLDENTYECPVYKTSER--------HSTNFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2404-2664 9.36e-127

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 399.68  E-value: 9.36e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2404 MSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVA 2483
Cdd:pfam12780    1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2484 TKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGekVEVTPLSMYNFFIERVINKISFS 2563
Cdd:pfam12780   81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQN--IEDSREAVYNYFVKRCRNNLHIV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2564 LAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKL 2643
Cdd:pfam12780  159 LCMSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPEELKSNVVKVFVYVHSSVEDMSKKFYEEL 238
                          250       260
                   ....*....|....*....|.
gi 24308169   2644 RRHNYVTPTSYLELILTFKTL 2664
Cdd:pfam12780  239 KRKNYVTPKSYLELLRLYKNL 259
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3052-3273 9.31e-113

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 357.91  E-value: 9.31e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3052 RAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIG 3131
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3132 EELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAA 3211
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308169   3212 KEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEI 3273
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1062-3743 2.96e-107

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 387.42  E-value: 2.96e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1062 IEAECRKW----------EEKLIRIQDNLDAWLKCQAT-------WLYLEPIF-SSEDIIAQMPEEGRKFGIVDSYWKSL 1123
Cdd:COG5245  582 IDDEIREWcssvlsddflEERAVRVERGADGARRLRASsgspvlrRLDEYLMMmSLEDLMPLIPHAVHRKMSLVSGVRGI 661
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1124 MSQAVKDNRILVAADQPrMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFflSNDELLEILSETKDPLRVQPHLKKCF 1203
Cdd:COG5245  662 YKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERAS--EVEELMDRVRELENRVYSYRFFVKKI 738
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1204 EGIAKLEFTDNLeIVGMISSEKETVPFIQKIyPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAY-VKVPRNHWVLQwp 1282
Cdd:COG5245  739 AKEEMKTVFSSR-IQKKEPFSLDSEAYVGFF-RLYEKSIVIRGINRSMGRVLSQYLESVQEALEIEdGSFFVSRHRVR-- 814
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1283 gqvVICVSSIFWTQevsqaLAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDL 1362
Cdd:COG5245  815 ---DGGLEKGRGCD-----AWENCFDPPLSEYFRILEKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCL 886
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1363 NDFQWISQLRYYWVAKDVQVQIITTEAL-YGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGApegpAGTGKTETTKD 1441
Cdd:COG5245  887 EVLGSVSISELPQGLYKRFIKVRSSYRSaEMFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGM 962
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1442 LAKALAKqcvvfnCSDGLDYKAmgKFFKGLAQAGAWAcFDEFNRIEVEVLSVVA-QQILSIQQAIIRKLKTFIFEGTELS 1520
Cdd:COG5245  963 LVAGKGR------IYDGTEPRS--RIEAGPICEEERG-TEESALLDEISRTILVdEYLNSDEFRMLEELNSAVVEHGLKS 1033
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1521 lnPTCAVFITMNPgyagRAELPDNLKALFRTVAMMVPdYALIGEISlysmgfldsRSLAQKIVATYRLCSEQLSSQHHYD 1600
Cdd:COG5245 1034 --PSTPVEMIINE----RNIVLEIGRRALDMFLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELM 1097
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1601 YgmRAVKSVLTAAGNLKLKYPEENESVLLLRALldvnlakflaqdvPLFQGII---SDLFPGVVLPkpdyevfLKVLNDN 1677
Cdd:COG5245 1098 F--YPMFKSLKAKHRMLEEKTEYLNKILSITGL-------------PLISDTLrerIDTLDAEWDS-------FCRISES 1155
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1678 IKKMKLQPVPWF-IGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGdlHAAnqmeefaVEYKIINPKAITMgQL 1756
Cdd:COG5245 1156 LKKYESQQVSGLdVAQFVSFLRSVDTGAFHAEYFRVFLCKIKHYTDACDYLW--HVK-------SPYVKKKYFDADM-EL 1225
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1757 YGCFDQVSHEWMDGVLANAfreqasslsddRKWIIFDGpvdaiWIENMNTVLDDNKKLCLMSGEiiqmnskMSLIFEPAD 1836
Cdd:COG5245 1226 RQFFLMFNREDMEARLADS-----------KMEYEVER-----YVEKTKAEVSSLKLELSSVGE-------GQVVVSNLG 1282
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1837 leqASPATVSRCGMIY----------MEPHQLG--WKPLkDSYMDTLpsSLTKEHKELVNDMFMWLVQPCLefgrlhcKF 1904
Cdd:COG5245 1283 ---SIGDKVGRCLVEYdsisrlstkgVFLDELGdtKRYL-DECLDFF--SCFEEVQKEIDELSMVFCADAL-------RF 1349
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1905 VVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGlSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFdvffrNLIM 1984
Cdd:COG5245 1350 SADLYHIVKERRFSGVLAGSDASESLGGKSIELAAIL-EHKDLIVEMKRGINDVLKLRIFGDKCRESTPRF-----YLIS 1423
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1985 GMDDNHPRPksvkltkNNIFPERGSIYDFYfIKQASGHWETWTQYITKEEEKVPAGakvsELIIPTMETARQSFFLKTYL 2064
Cdd:COG5245 1424 DGDLIKDLN-------ERSDYEEMLIMMFN-ISAVITNNGSIAGFELRGERVMLRK----EVVIPTSDTGFVDSFSNEAL 1491
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2065 DHEIPMLFVGPTGTGKSAITNNFLLHlpKNTYLPNCINFSARTSANQtqdiIMSKLDR-----RRKG---LFGPPIGKKA 2136
Cdd:COG5245 1492 NTLRSYIYCGPPGSGKEMLMCPSLRS--ELITEVKYFNFSTCTMTPS----KLSVLEReteyyPNTGvvrLYPKPVVKDL 1565
                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2137 VVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGG-GRNDITGRFTRHLNIIsinaF 2215
Cdd:COG5245 1566 VLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTDeGRVKYYERFIRKPVFV----F 1641
                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2216 EDDILTKIFSSIVDWHFGKGFDVM--FLRYGKMLVQATKTIYRDAVENFlPTPSKSHYVFNLRDFSRVIQGVLLCPHTHL 2293
Cdd:COG5245 1642 CCYPELASLRNIYEAVLMGSYLCFdeFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRI 1720
                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2294 -QDVEKCIRLWIHEVYRVFYDRLIDkedrqvffnmVKEttSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESd 2372
Cdd:COG5245 1721 dTPDVSLIIDWYCEAIREKIDRLVQ----------QKE--SSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFGM- 1787
                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2373 qkiydEITDLKQLTVVMEHYLEEFNNiSKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNA 2452
Cdd:COG5245 1788 -----ACLLKKDLAVFVEEVRKIFGS-SHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNP 1861
                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2453 YELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQT 2532
Cdd:COG5245 1862 RNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRF 1941
                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2533 AARTQGEKVEvTPLSMYNFFIERVI-NKISFSLAMSPIGDAFRNRLRmFPSLINCCTIDWFQSWPTDALELVANKfLEDV 2611
Cdd:COG5245 1942 VFESTSLEKD-TEATLTRVFLVYMEeNLPVVFSACCSQDTSVLAGIR-SPALKNRCFIDFKKLWDTEEMSQYANS-VETL 2018
                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2612 ELDDNIRVEVVSMCKYFQES-----------VKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYL 2680
Cdd:COG5245 2019 SRDGGRVFFINGELGVGKGAlisevfgddavVIEGRGFEISMIEGSLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLV 2098
                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2681 TGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDL 2760
Cdd:COG5245 2099 EGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFK 2178
                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2761 AEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKperkpdpsgsgkmIEDYWGVSKKILGDlKFL 2840
Cdd:COG5245 2179 SSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGFE-------------AKIWFGEQQSLRRD-DFI 2244
                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2841 ESLKTYDKD-NIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRE------------- 2906
Cdd:COG5245 2245 RIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREeekridgeaflve 2324
                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2907 -RLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNddfEEMNTKKKDLEENIEicsqklvraekLISGLGGEKDRWTEAA 2985
Cdd:COG5245 2325 dRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKI---ADMDTVHKDVLRSIF-----------VSEILINEDSEWGGVF 2390
                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2986 RQLGIRYTNLTGDVLLSSGTVAYLGafTVDYRvqCQNQWLAECKDKVIPGFSDFS------LSHTLGDPIKIRAWQIAGl 3059
Cdd:COG5245 2391 SEVPKLMVELDGDGHPSSCLHPYIG--TLGFL--CRAIEFGMSFIRISKEFRDKEirrrqfITEGVQKIEDFKEEACST- 2465
                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3060 pvDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENiGEELDASIE 3139
Cdd:COG5245 2466 --DYGLENSRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGD-AEALDEEIG 2542
                       2170      2180      2190      2200      2210      2220      2230      2240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3140 PiLLKATFKQQGVEY-MRLGENIIEYSRDFKLYITTRLRNPHyLPEVAVK-VCLLNFMITPLGLQDQLLGIVAAKEKPEL 3217
Cdd:COG5245 2543 R-LIKEEFKSNLSEVkVMINPPEIVRSTVEAVFWLSEGRSGD-MGSIEWKqLIQVMFVSKVLGCETEIPDALEKLVSGPL 2620
                       2250      2260      2270      2280      2290      2300      2310      2320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3218 EEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPV 3297
Cdd:COG5245 2621 FVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNAS 2700
                       2330      2340      2350      2360      2370      2380      2390      2400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3298 AVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLthSTKSEELNlRIKYIIDHFTLSIYNNvcrslfekDKLLFSLLL 3377
Cdd:COG5245 2701 VKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWR--RMKSKYLC-AIRYMLMSSEWILDHE--------DRSGFIHRL 2769
                       2410      2420      2430      2440      2450      2460      2470      2480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3378 tigiMKQKKEITEEVWYFLLtggiaLDNPYpnpaPQWLSEKAwaeivrasalpkLHGLMEHLEQNLGEWKLIYDSawphE 3457
Cdd:COG5245 2770 ----DVSFLLRTKRFVSTLL-----EDKNY----RQVLSSCS------------LYGNDVISHSCDRFDRDVYRA----L 2820
                       2490      2500      2510      2520      2530      2540      2550      2560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3458 EQLPGSWKFSqgLEKMVILRClRPDKMVPAVRE----FIAEHMGKLYieapTFdLQGSYNDSSCCAPLIFVLSPSADpma 3533
Cdd:COG5245 2821 KHQMDNRTHS--TILTSNSKT-NPYKEYTYNDSwaeaFEVEDSGDLY----KF-EEGLLELIVGHAPLIYAHKKSLE--- 2889
                       2570      2580      2590      2600      2610      2620      2630      2640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3534 gLLKFADDLGmggtRTQTISLGQGQgpiaakmINNAIKDGTWVVLQNCHLAASWMPT-LEKICEEVIVPESTNARFRLWL 3612
Cdd:COG5245 2890 -NERNVDRLG----SKENEVYAVLN-------SLFSRKEKSWFEVYNISLSFGWFKRyVEDVVYPIKASRVCGKVKNMWT 2957
                       2650      2660      2670      2680      2690      2700      2710      2720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3613 TSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPisdpvfFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGW 3692
Cdd:COG5245 2958 SMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDR------YPFDYTLVIACDDAFYLSWEHAAVASVISAGPKEN 3031
                       2730      2740      2750      2760      2770
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24308169 3693 NIPYEFNESDLRISMWQIQ--MFLNDYKEVPFDALTYLTGECNYGGRVTDDKD 3743
Cdd:COG5245 3032 NEEIYFGDKDFEFKTHLLKniLFLNHLNARKWGNNRDLIFTIVYGKKHSLMED 3084
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2038-2215 1.76e-104

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 332.43  E-value: 1.76e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2038 PAGAKVSELIIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIM 2117
Cdd:pfam12775    2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEKYLPLFINFSAQTTSNQTQDIIE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2118 SKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRN 2197
Cdd:pfam12775   82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGRN 161
                          170
                   ....*....|....*...
gi 24308169   2198 DITGRFTRHLNIISINAF 2215
Cdd:pfam12775  162 DITPRLLRHFNVFNITFP 179
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
2069-2209 6.83e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 40.21  E-value: 6.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2069 PMLFVGPTGTGKSAITNNFLLHLPKNTYlpNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAK 2148
Cdd:cd00009   21 NLLLYGPPGTGKTTLARAIANELFRPGA--PFLYLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPGVLFIDEIDSLSR 98
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24308169 2149 evyGAQPpiELLRQwidhgywFDKKDTTRLDIVDM--LLVTAMGPPGGGRNDITGRFTRHLNI 2209
Cdd:cd00009   99 ---GAQN--ALLRV-------LETLNDLRIDRENVrvIGATNRPLLGDLDRALYDRLDIRIVI 149
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
2886-2981 9.09e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 9.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2886 KWVRAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLV 2965
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312
                           90
                   ....*....|....*.
gi 24308169   2966 RAEKLISGLGGEKDRW 2981
Cdd:TIGR02168  313 NLERQLEELEAQLEEL 328
 
Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1391-1717 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 688.06  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1391 YGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKG 1470
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1471 LAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFR 1550
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1551 TVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLL 1630
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1631 RALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVG 1710
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 24308169   1711 DPMGGKT 1717
Cdd:pfam12774  321 PTGSGKT 327
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
859-1262 2.82e-160

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 502.56  E-value: 2.82e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169    859 LQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDvpapRRLAENVKIKIDKFK 938
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRD----WDVAEELKKKIDDFK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169    939 QYIPILSISCNPGMKDRHWQQISEIVGYEIKP-TETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVN 1017
Cdd:pfam08393   77 KSLPLIEDLRNPALRERHWKQLSEILGFDFDPlSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKT 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1018 VTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIF 1097
Cdd:pfam08393  157 MEFELVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIF 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1098 SSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFL 1177
Cdd:pfam08393  237 SSEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFL 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1178 SNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKiyPANAKGMVEKWLQQVEQMMLAS 1257
Cdd:pfam08393  317 SNDELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEITGMISKEGEVVPFSKP--PVEAKGNVEEWLNELEEEMRET 394

                   ....*
gi 24308169   1258 MREVI 1262
Cdd:pfam08393  395 LRDLL 399
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
3811-4112 1.99e-147

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 460.93  E-value: 1.99e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3811 NQETNQLFEGVLLTLPR---QSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLT 3887
Cdd:pfam18199    1 TNETNELLSTLLSLQPRsdsGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPVGYEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3888 KVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWI-DKGPPVVFWI 3966
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLdDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3967 SGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENN--PEDGAYIKGLFLEGARWDRKTMQIGESLPKILYD 4044
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSPEEVTepPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24308169   4045 PLPIIWLKPGESAMF-LHQDIYVCPVYKTSARrgtlsttgHSTNYVLSIELPTDMPQKHWINRGVASLC 4112
Cdd:pfam18199  241 PLPVIHLKPVESDKKkLDENTYECPVYKTSER--------HSTNFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2404-2664 9.36e-127

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 399.68  E-value: 9.36e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2404 MSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVA 2483
Cdd:pfam12780    1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2484 TKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGekVEVTPLSMYNFFIERVINKISFS 2563
Cdd:pfam12780   81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQN--IEDSREAVYNYFVKRCRNNLHIV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2564 LAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKL 2643
Cdd:pfam12780  159 LCMSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPEELKSNVVKVFVYVHSSVEDMSKKFYEEL 238
                          250       260
                   ....*....|....*....|.
gi 24308169   2644 RRHNYVTPTSYLELILTFKTL 2664
Cdd:pfam12780  239 KRKNYVTPKSYLELLRLYKNL 259
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3052-3273 9.31e-113

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 357.91  E-value: 9.31e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3052 RAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIG 3131
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3132 EELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAA 3211
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308169   3212 KEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEI 3273
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1062-3743 2.96e-107

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 387.42  E-value: 2.96e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1062 IEAECRKW----------EEKLIRIQDNLDAWLKCQAT-------WLYLEPIF-SSEDIIAQMPEEGRKFGIVDSYWKSL 1123
Cdd:COG5245  582 IDDEIREWcssvlsddflEERAVRVERGADGARRLRASsgspvlrRLDEYLMMmSLEDLMPLIPHAVHRKMSLVSGVRGI 661
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1124 MSQAVKDNRILVAADQPrMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFflSNDELLEILSETKDPLRVQPHLKKCF 1203
Cdd:COG5245  662 YKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRWREVERAS--EVEELMDRVRELENRVYSYRFFVKKI 738
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1204 EGIAKLEFTDNLeIVGMISSEKETVPFIQKIyPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAY-VKVPRNHWVLQwp 1282
Cdd:COG5245  739 AKEEMKTVFSSR-IQKKEPFSLDSEAYVGFF-RLYEKSIVIRGINRSMGRVLSQYLESVQEALEIEdGSFFVSRHRVR-- 814
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1283 gqvVICVSSIFWTQevsqaLAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDL 1362
Cdd:COG5245  815 ---DGGLEKGRGCD-----AWENCFDPPLSEYFRILEKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCL 886
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1363 NDFQWISQLRYYWVAKDVQVQIITTEAL-YGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGApegpAGTGKTETTKD 1441
Cdd:COG5245  887 EVLGSVSISELPQGLYKRFIKVRSSYRSaEMFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGM 962
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1442 LAKALAKqcvvfnCSDGLDYKAmgKFFKGLAQAGAWAcFDEFNRIEVEVLSVVA-QQILSIQQAIIRKLKTFIFEGTELS 1520
Cdd:COG5245  963 LVAGKGR------IYDGTEPRS--RIEAGPICEEERG-TEESALLDEISRTILVdEYLNSDEFRMLEELNSAVVEHGLKS 1033
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1521 lnPTCAVFITMNPgyagRAELPDNLKALFRTVAMMVPdYALIGEISlysmgfldsRSLAQKIVATYRLCSEQLSSQHHYD 1600
Cdd:COG5245 1034 --PSTPVEMIINE----RNIVLEIGRRALDMFLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELM 1097
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1601 YgmRAVKSVLTAAGNLKLKYPEENESVLLLRALldvnlakflaqdvPLFQGII---SDLFPGVVLPkpdyevfLKVLNDN 1677
Cdd:COG5245 1098 F--YPMFKSLKAKHRMLEEKTEYLNKILSITGL-------------PLISDTLrerIDTLDAEWDS-------FCRISES 1155
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1678 IKKMKLQPVPWF-IGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGdlHAAnqmeefaVEYKIINPKAITMgQL 1756
Cdd:COG5245 1156 LKKYESQQVSGLdVAQFVSFLRSVDTGAFHAEYFRVFLCKIKHYTDACDYLW--HVK-------SPYVKKKYFDADM-EL 1225
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1757 YGCFDQVSHEWMDGVLANAfreqasslsddRKWIIFDGpvdaiWIENMNTVLDDNKKLCLMSGEiiqmnskMSLIFEPAD 1836
Cdd:COG5245 1226 RQFFLMFNREDMEARLADS-----------KMEYEVER-----YVEKTKAEVSSLKLELSSVGE-------GQVVVSNLG 1282
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1837 leqASPATVSRCGMIY----------MEPHQLG--WKPLkDSYMDTLpsSLTKEHKELVNDMFMWLVQPCLefgrlhcKF 1904
Cdd:COG5245 1283 ---SIGDKVGRCLVEYdsisrlstkgVFLDELGdtKRYL-DECLDFF--SCFEEVQKEIDELSMVFCADAL-------RF 1349
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1905 VVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGlSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFdvffrNLIM 1984
Cdd:COG5245 1350 SADLYHIVKERRFSGVLAGSDASESLGGKSIELAAIL-EHKDLIVEMKRGINDVLKLRIFGDKCRESTPRF-----YLIS 1423
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 1985 GMDDNHPRPksvkltkNNIFPERGSIYDFYfIKQASGHWETWTQYITKEEEKVPAGakvsELIIPTMETARQSFFLKTYL 2064
Cdd:COG5245 1424 DGDLIKDLN-------ERSDYEEMLIMMFN-ISAVITNNGSIAGFELRGERVMLRK----EVVIPTSDTGFVDSFSNEAL 1491
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2065 DHEIPMLFVGPTGTGKSAITNNFLLHlpKNTYLPNCINFSARTSANQtqdiIMSKLDR-----RRKG---LFGPPIGKKA 2136
Cdd:COG5245 1492 NTLRSYIYCGPPGSGKEMLMCPSLRS--ELITEVKYFNFSTCTMTPS----KLSVLEReteyyPNTGvvrLYPKPVVKDL 1565
                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2137 VVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGG-GRNDITGRFTRHLNIIsinaF 2215
Cdd:COG5245 1566 VLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTDeGRVKYYERFIRKPVFV----F 1641
                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2216 EDDILTKIFSSIVDWHFGKGFDVM--FLRYGKMLVQATKTIYRDAVENFlPTPSKSHYVFNLRDFSRVIQGVLLCPHTHL 2293
Cdd:COG5245 1642 CCYPELASLRNIYEAVLMGSYLCFdeFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRI 1720
                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2294 -QDVEKCIRLWIHEVYRVFYDRLIDkedrqvffnmVKEttSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESd 2372
Cdd:COG5245 1721 dTPDVSLIIDWYCEAIREKIDRLVQ----------QKE--SSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFGM- 1787
                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2373 qkiydEITDLKQLTVVMEHYLEEFNNiSKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNA 2452
Cdd:COG5245 1788 -----ACLLKKDLAVFVEEVRKIFGS-SHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNP 1861
                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2453 YELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQT 2532
Cdd:COG5245 1862 RNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRF 1941
                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2533 AARTQGEKVEvTPLSMYNFFIERVI-NKISFSLAMSPIGDAFRNRLRmFPSLINCCTIDWFQSWPTDALELVANKfLEDV 2611
Cdd:COG5245 1942 VFESTSLEKD-TEATLTRVFLVYMEeNLPVVFSACCSQDTSVLAGIR-SPALKNRCFIDFKKLWDTEEMSQYANS-VETL 2018
                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2612 ELDDNIRVEVVSMCKYFQES-----------VKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYL 2680
Cdd:COG5245 2019 SRDGGRVFFINGELGVGKGAlisevfgddavVIEGRGFEISMIEGSLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLV 2098
                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2681 TGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDL 2760
Cdd:COG5245 2099 EGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFK 2178
                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2761 AEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKperkpdpsgsgkmIEDYWGVSKKILGDlKFL 2840
Cdd:COG5245 2179 SSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGFE-------------AKIWFGEQQSLRRD-DFI 2244
                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2841 ESLKTYDKD-NIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRE------------- 2906
Cdd:COG5245 2245 RIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREeekridgeaflve 2324
                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2907 -RLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNddfEEMNTKKKDLEENIEicsqklvraekLISGLGGEKDRWTEAA 2985
Cdd:COG5245 2325 dRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKI---ADMDTVHKDVLRSIF-----------VSEILINEDSEWGGVF 2390
                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2986 RQLGIRYTNLTGDVLLSSGTVAYLGafTVDYRvqCQNQWLAECKDKVIPGFSDFS------LSHTLGDPIKIRAWQIAGl 3059
Cdd:COG5245 2391 SEVPKLMVELDGDGHPSSCLHPYIG--TLGFL--CRAIEFGMSFIRISKEFRDKEirrrqfITEGVQKIEDFKEEACST- 2465
                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3060 pvDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENiGEELDASIE 3139
Cdd:COG5245 2466 --DYGLENSRIRKDLQDLTAVLNDPSSKIVTSQRQMYDEKKAILGSFREMEFAFGLSQARREGSDKIIGD-AEALDEEIG 2542
                       2170      2180      2190      2200      2210      2220      2230      2240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3140 PiLLKATFKQQGVEY-MRLGENIIEYSRDFKLYITTRLRNPHyLPEVAVK-VCLLNFMITPLGLQDQLLGIVAAKEKPEL 3217
Cdd:COG5245 2543 R-LIKEEFKSNLSEVkVMINPPEIVRSTVEAVFWLSEGRSGD-MGSIEWKqLIQVMFVSKVLGCETEIPDALEKLVSGPL 2620
                       2250      2260      2270      2280      2290      2300      2310      2320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3218 EEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPV 3297
Cdd:COG5245 2621 FVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNAS 2700
                       2330      2340      2350      2360      2370      2380      2390      2400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3298 AVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLthSTKSEELNlRIKYIIDHFTLSIYNNvcrslfekDKLLFSLLL 3377
Cdd:COG5245 2701 VKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWR--RMKSKYLC-AIRYMLMSSEWILDHE--------DRSGFIHRL 2769
                       2410      2420      2430      2440      2450      2460      2470      2480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3378 tigiMKQKKEITEEVWYFLLtggiaLDNPYpnpaPQWLSEKAwaeivrasalpkLHGLMEHLEQNLGEWKLIYDSawphE 3457
Cdd:COG5245 2770 ----DVSFLLRTKRFVSTLL-----EDKNY----RQVLSSCS------------LYGNDVISHSCDRFDRDVYRA----L 2820
                       2490      2500      2510      2520      2530      2540      2550      2560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3458 EQLPGSWKFSqgLEKMVILRClRPDKMVPAVRE----FIAEHMGKLYieapTFdLQGSYNDSSCCAPLIFVLSPSADpma 3533
Cdd:COG5245 2821 KHQMDNRTHS--TILTSNSKT-NPYKEYTYNDSwaeaFEVEDSGDLY----KF-EEGLLELIVGHAPLIYAHKKSLE--- 2889
                       2570      2580      2590      2600      2610      2620      2630      2640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3534 gLLKFADDLGmggtRTQTISLGQGQgpiaakmINNAIKDGTWVVLQNCHLAASWMPT-LEKICEEVIVPESTNARFRLWL 3612
Cdd:COG5245 2890 -NERNVDRLG----SKENEVYAVLN-------SLFSRKEKSWFEVYNISLSFGWFKRyVEDVVYPIKASRVCGKVKNMWT 2957
                       2650      2660      2670      2680      2690      2700      2710      2720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 3613 TSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPisdpvfFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGW 3692
Cdd:COG5245 2958 SMVDADMLPIQLLIAIDSFVSSTYPETGCGYADLVEIDR------YPFDYTLVIACDDAFYLSWEHAAVASVISAGPKEN 3031
                       2730      2740      2750      2760      2770
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24308169 3693 NIPYEFNESDLRISMWQIQ--MFLNDYKEVPFDALTYLTGECNYGGRVTDDKD 3743
Cdd:COG5245 3032 NEEIYFGDKDFEFKTHLLKniLFLNHLNARKWGNNRDLIFTIVYGKKHSLMED 3084
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2038-2215 1.76e-104

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 332.43  E-value: 1.76e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2038 PAGAKVSELIIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIM 2117
Cdd:pfam12775    2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEKYLPLFINFSAQTTSNQTQDIIE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2118 SKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRN 2197
Cdd:pfam12775   82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGRN 161
                          170
                   ....*....|....*...
gi 24308169   2198 DITGRFTRHLNIISINAF 2215
Cdd:pfam12775  162 DITPRLLRHFNVFNITFP 179
AAA_lid_11 pfam18198
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ...
3667-3805 3.94e-75

Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.


Pssm-ID: 465676  Cd Length: 139  Bit Score: 246.60  E-value: 3.94e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3667 WQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLNDYKE-VPFDALTYLTGECNYGGRVTDDKDRR 3745
Cdd:pfam18198    1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEYDEkIPWDALRYLIGEINYGGRVTDDWDRR 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3746 LLLSLLSMFYCKEIEEDYYSLAPGdTYYIPPHGSYQSYIDYLRNLPITAHPEVFGLHENA 3805
Cdd:pfam18198   81 LLNTYLEEFFNPEVLEEDFKFSPS-LYYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
Dynein_heavy pfam03028
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
3516-3632 8.81e-64

Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.


Pssm-ID: 460782  Cd Length: 115  Bit Score: 213.08  E-value: 8.81e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   3516 SCCAPLIFVLSPSADPMAGLLKFADDLGMGGtRTQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKIC 3595
Cdd:pfam03028    1 SPTTPLIFILSPGSDPTADLEKLAKKLGFGG-KLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEKIL 79
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 24308169   3596 EEvIVPESTNARFRLWLTSYPSEKFPVSILQNGIKMT 3632
Cdd:pfam03028   80 EE-LPEETLHPDFRLWLTSEPSPKFPISILQNSIKIT 115
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
2678-3017 5.24e-47

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 174.11  E-value: 5.24e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2678 RYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLvqADEKEANVAAaIAQGIKNE-- 2755
Cdd:pfam12777    2 RLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAI--ADEEEQKVAV-IMKEVKEKqk 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2756 -CEGDLAEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMkgMKPerkpdpsgSGKMIED-YWGVSKKI 2833
Cdd:pfam12777   79 aCEEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMIL--MAP--------GGKIPKDkSWKAAKIM 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2834 LGDLK-FLESLKTYDKDNIPPLTMKRIRErFINHPEFQPAVIKNVSSACEGLCKW----VRAMEVY-DrvakvVAPKRER 2907
Cdd:pfam12777  149 MAKVDgFLDSLIKFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWciniVRFYEVFcD-----VAPKRQA 222
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2908 LREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQ 2987
Cdd:pfam12777  223 LEEANADLAAAQEKLAAIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVEN 302
                          330       340       350
                   ....*....|....*....|....*....|
gi 24308169   2988 LGIRYTNLTGDVLLSSGTVAYLGAFTVDYR 3017
Cdd:pfam12777  303 FKQQERTLCGDILLISAFISYLGFFTKKYR 332
Dynein_AAA_lid pfam17852
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ...
1884-2028 3.60e-35

Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.


Pssm-ID: 465532 [Multi-domain]  Cd Length: 126  Bit Score: 132.02  E-value: 3.60e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1884 NDMFMWLVQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAveeeeMELGEGLSSQQIFLWLQGLFLFSLVWTV 1963
Cdd:pfam17852    2 EPLFEWLVPPALEFVRKNCKEIVPTSDLNLVQSLCRLLESLLDEVLE-----YNGVHPLSPDKLKEYLEKLFLFALVWSI 76
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24308169   1964 AGTINADSRKKFDVFFRNLIMGMDdnhpRPKsvkltknnifPERGSIYDFYFIKQaSGHWETWTQ 2028
Cdd:pfam17852   77 GGTLDEDSRKKFDEFLRELFSGLD----LPP----------PEKGTVYDYFVDLE-KGEWVPWSD 126
AAA_lid_1 pfam17857
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
2247-2344 3.17e-15

AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.


Pssm-ID: 465535 [Multi-domain]  Cd Length: 100  Bit Score: 74.20  E-value: 3.17e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2247 LVQATKTIYRDAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYDRLIDKEDRQVFFN 2326
Cdd:pfam17857    1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80
                           90
                   ....*....|....*...
gi 24308169   2327 MVKETTSNCFKQTIEKVL 2344
Cdd:pfam17857   81 IQMASLKKFFDDIEDELE 98
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2069-2199 1.66e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 55.76  E-value: 1.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2069 PMLFVGPTGTGKSAITNNFLLHLPKNTYLPncINFSARTSANQTQDI--IMSKLDRRRKGLFGPPIGKKAVVFVDDLNMP 2146
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSNRPVFY--VQLTRDTTEEDLFGRrnIDPGGASWVDGPLVRAAREGEIAVLDEINRA 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 24308169   2147 AKEVYGAQ-PPIELLRQWIDHGYWFDKKDTTrldivDMLLVTAMGPPGGGRNDI 2199
Cdd:pfam07728   79 NPDVLNSLlSLLDERRLLLPDGGELVKAAPD-----GFRLIATMNPLDRGLNEL 127
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
1707-1848 3.26e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 46.52  E-value: 3.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1707 MIVGDPMGGKTSAYKVLAAALgdlhaanqmEEFAVEYkIINPKAITMGQLYGC--FDQVSHEWMDGVLANAFREqassls 1784
Cdd:pfam07728    3 LLVGPPGTGKTELAERLAAAL---------SNRPVFY-VQLTRDTTEEDLFGRrnIDPGGASWVDGPLVRAARE------ 66
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308169   1785 ddrKWIIFDGPVDAI---WIENMNTVLDDNKKLCLMSGEIIQM-NSKMSLIFE----PADLEQASPATVSRC 1848
Cdd:pfam07728   67 ---GEIAVLDEINRAnpdVLNSLLSLLDERRLLLPDGGELVKAaPDGFRLIATmnplDRGLNELSPALRSRF 135
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
1429-1549 1.33e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.59  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1429 GPAGTGKTETTKDLAKALAkQCVVF--NCSD---------GLDYKAMGKFFKGL-----AQAGAWACFDEFNRIEVEVLS 1492
Cdd:pfam07728    6 GPPGTGKTELAERLAAALS-NRPVFyvQLTRdtteedlfgRRNIDPGGASWVDGplvraAREGEIAVLDEINRANPDVLN 84
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   1493 VVaQQILSiqqaiirkLKTFIFE--GTELSLNPTCAVFI-TMNPGYAGRAELPDNLKALF 1549
Cdd:pfam07728   85 SL-LSLLD--------ERRLLLPdgGELVKAAPDGFRLIaTMNPLDRGLNELSPALRSRF 135
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
2889-2988 4.14e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.05  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2889 RAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAE 2968
Cdd:COG4372   35 KALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQ 114
                         90       100
                 ....*....|....*....|
gi 24308169 2969 KLISGLGGEKDRWTEAARQL 2988
Cdd:COG4372  115 EELEELQKERQDLEQQRKQL 134
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
2904-2979 5.76e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 5.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24308169 2904 KRERLREAEGKLAAQMQKLNQKRAELKlvvDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAEKLISGLGGEKD 2979
Cdd:COG1579   18 ELDRLEHRLKELPAELAELEDELAALE---ARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKE 90
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
2069-2209 6.83e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 40.21  E-value: 6.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169 2069 PMLFVGPTGTGKSAITNNFLLHLPKNTYlpNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAK 2148
Cdd:cd00009   21 NLLLYGPPGTGKTTLARAIANELFRPGA--PFLYLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPGVLFIDEIDSLSR 98
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24308169 2149 evyGAQPpiELLRQwidhgywFDKKDTTRLDIVDM--LLVTAMGPPGGGRNDITGRFTRHLNI 2209
Cdd:cd00009   99 ---GAQN--ALLRV-------LETLNDLRIDRENVrvIGATNRPLLGDLDRALYDRLDIRIVI 149
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
2886-2981 9.09e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 9.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308169   2886 KWVRAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLV 2965
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312
                           90
                   ....*....|....*.
gi 24308169   2966 RAEKLISGLGGEKDRW 2981
Cdd:TIGR02168  313 NLERQLEELEAQLEEL 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH