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Conserved domains on  [gi|27881484|ref|NP_060060|]
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zinc finger CCCH domain-containing protein 7B [Homo sapiens]

Protein Classification

zinc finger CCCH domain-containing protein 7B( domain architecture ID 13518797)

zinc finger CCCH domain-containing protein 7B (ZC3H7B) may be a specific regulator of miRNA biogenesis and binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop

Gene Symbol:  ZC3H7B
Gene Ontology:  GO:0005515|GO:0035198|GO:0008270
PubMed:  22803940|11179890

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 18-162 6.67e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.24  E-value: 6.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484    18 QSTLPLKQEEYEAFLLKLVQnlfaEGNDLFREKDYKQALVQYmeglnvadyaasdqvalPRELLCK----LHVNRAACYF 93
Cdd:TIGR00990 113 SSVANLSEEERKKYAAKLKE----KGNKAYRNKDFNKAIKLY-----------------SKAIECKpdpvYYSNRAACHN 171

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484    94 TMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEA-YECSSRCSLALPHDESVTQLGQELAQK 162
Cdd:TIGR00990 172 ALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLTASCIIDGFRNEQSAQAVERLLKK 241
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
890-913 8.52e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


:

Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 37.56  E-value: 8.52e-04
                          10        20
                  ....*....|....*....|....
gi 27881484   890 RLCDRLQKGKACPDGDKCRCAHGQ 913
Cdd:pfam00642   4 ELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 844-867 6.75e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.84  E-value: 6.75e-03
                          10        20
                  ....*....|....*....|....
gi 27881484   844 CWLCGKNSNSKKQWQQHIQSEKHK 867
Cdd:pfam12171   4 CVLCDKYFKSENALQNHLKSKKHK 27
 
Name Accession Description Interval E-value
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 18-162 6.67e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.24  E-value: 6.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484    18 QSTLPLKQEEYEAFLLKLVQnlfaEGNDLFREKDYKQALVQYmeglnvadyaasdqvalPRELLCK----LHVNRAACYF 93
Cdd:TIGR00990 113 SSVANLSEEERKKYAAKLKE----KGNKAYRNKDFNKAIKLY-----------------SKAIECKpdpvYYSNRAACHN 171

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484    94 TMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEA-YECSSRCSLALPHDESVTQLGQELAQK 162
Cdd:TIGR00990 172 ALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLTASCIIDGFRNEQSAQAVERLLKK 241
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
9-138 1.81e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 1.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484   9 DIEKGLQFIQSTLPLKQEEYEAfllklvqnLFAEGNDLFREKDYKQALVQYMEGLNVA-DYAASdqvalprellcklHVN 87
Cdd:COG0457  23 RYEEAIEDYEKALELDPDDAEA--------LYNLGLAYLRLGRYEEALADYEQALELDpDDAEA-------------LNN 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 27881484  88 RAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYEC 138
Cdd:COG0457  82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEA 132
TPR_12 pfam13424
Tetratricopeptide repeat;
80-135 4.69e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 4.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27881484    80 LLCKLHVNRAACYFTMGLYEKALEDSEKAL-------GLDSESI-RALFRKARALNELGRHKEA 135
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALeiarrllGPDHPLTaTTLLNLGRLYLELGRYEEA 64
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
890-913 8.52e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 37.56  E-value: 8.52e-04
                          10        20
                  ....*....|....*....|....
gi 27881484   890 RLCDRLQKGKACPDGDKCRCAHGQ 913
Cdd:pfam00642   4 ELCRFFLRTGYCKYGDRCKFAHGQ 27
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 86-142 5.06e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 5.06e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27881484  86 VNRAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRC 142
Cdd:cd24142   4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRA 60
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 844-867 6.75e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.84  E-value: 6.75e-03
                          10        20
                  ....*....|....*....|....
gi 27881484   844 CWLCGKNSNSKKQWQQHIQSEKHK 867
Cdd:pfam12171   4 CVLCDKYFKSENALQNHLKSKKHK 27
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 82-114 7.26e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.11  E-value: 7.26e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27881484     82 CKLHVNRAACYFTMGLYEKALEDSEKALGLDSE 114
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
 
Name Accession Description Interval E-value
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 18-162 6.67e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.24  E-value: 6.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484    18 QSTLPLKQEEYEAFLLKLVQnlfaEGNDLFREKDYKQALVQYmeglnvadyaasdqvalPRELLCK----LHVNRAACYF 93
Cdd:TIGR00990 113 SSVANLSEEERKKYAAKLKE----KGNKAYRNKDFNKAIKLY-----------------SKAIECKpdpvYYSNRAACHN 171

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484    94 TMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEA-YECSSRCSLALPHDESVTQLGQELAQK 162
Cdd:TIGR00990 172 ALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLTASCIIDGFRNEQSAQAVERLLKK 241
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
9-138 1.81e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 1.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484   9 DIEKGLQFIQSTLPLKQEEYEAfllklvqnLFAEGNDLFREKDYKQALVQYMEGLNVA-DYAASdqvalprellcklHVN 87
Cdd:COG0457  23 RYEEAIEDYEKALELDPDDAEA--------LYNLGLAYLRLGRYEEALADYEQALELDpDDAEA-------------LNN 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 27881484  88 RAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYEC 138
Cdd:COG0457  82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEA 132
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
39-170 2.49e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.03  E-value: 2.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  39 LFAEGNDLFREKDYKQALVQYMEGLNVA-DYAasdqvalprellcKLHVNRAACYFTMGLYEKALEDSEKALGLDSESIR 117
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDpDDA-------------EALYNLGLAYLRLGRYEEALADYEQALELDPDDAE 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27881484 118 ALFRKARALNELGRHKEAYECSSRcSLAL-PHD-ESVTQLGqELAQKLGlRVRKA 170
Cdd:COG0457  78 ALNNLGLALQALGRYEEALEDYDK-ALELdPDDaEALYNLG-LALLELG-RYDEA 129
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-178 6.06e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 6.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  34 KLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAAsdqvalprellcKLHVNRAACYFTMGLYEKALEDSEKALGLDS 113
Cdd:COG0457  74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDA------------EALYNLGLALLELGRYDEAIEAYERALELDP 141

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27881484 114 ESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELE 178
Cdd:COG0457 142 DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 6-149 1.01e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.89  E-value: 1.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484   6 RKADIEKGLQFIQSTLPLKQEEYEAFLLKlvqnlfaeGNDLFREKDYKQALVQYMEGLNVAdyaasdqvalPRELLckLH 85
Cdd:COG4783  16 LAGDYDEAEALLEKALELDPDNPEAFALL--------GEILLQLGDLDEAIVLLHEALELD----------PDEPE--AR 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27881484  86 VNRAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHD 149
Cdd:COG4783  76 LNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
29-137 1.67e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 1.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  29 EAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNV-ADYAAsdqvalprellckLHVNRAACYFTMGLYEKALEDSEK 107
Cdd:COG4785  66 ALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELdPDLAE-------------AYNNRGLAYLLLGDYDAALEDFDR 132

                        90       100       110
                ....*....|....*....|....*....|
gi 27881484 108 ALGLDSESIRALFRKARALNELGRHKEAYE 137
Cdd:COG4785 133 ALELDPDYAYAYLNRGIALYYLGRYELAIA 162
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 39-188 5.76e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.54  E-value: 5.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  39 LFAEGNDLFREKDYKQALVQYMEGLNVA-DYAAsdqvalprellckLHVNRAACYFTMGLYEKALEDSEKALGLDSESIR 117
Cdd:COG3914 115 LFNLGNLLLALGRLEEALAALRRALALNpDFAE-------------AYLNLGEALRRLGRLEEAIAALRRALELDPDNAE 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484 118 ALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQL---------GQELAQKLGLRVRKAYKRPQELETFSLLSNGTA 188
Cdd:COG3914 182 ALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNllfalrqacDWEVYDRFEELLAALARGPSELSPFALLYLPDD 261
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 6-137 1.22e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.27  E-value: 1.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484   6 RKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASdqvalprellckLH 85
Cdd:COG5010  24 VEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPE------------LY 91

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 27881484  86 VNRAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYE 137
Cdd:COG5010  92 YNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 39-164 2.81e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.58  E-value: 2.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  39 LFAEGNDLFREKDYKQALVQYMEGLNVADYAASdqvalprellckLHVNRAACYFTMGLYEKALEDSEKALGLDSESIRA 118
Cdd:COG4783   7 LYALAQALLLAGDYDEAEALLEKALELDPDNPE------------AFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 27881484 119 LFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLG 164
Cdd:COG4783  75 RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALG 120
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 84-161 5.19e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 5.19e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27881484  84 LHVNRAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQ 161
Cdd:COG4235  53 ALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
21-137 2.25e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 2.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  21 LPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASD--QVALPRELLC----KLHVNRAACYFT 94
Cdd:COG4785   6 LALLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAAAlaAERIDRALALpdlaQLYYERGVAYDS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 27881484  95 MGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYE 137
Cdd:COG4785  86 LGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALE 128
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
91-137 2.90e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 2.90e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 27881484  91 CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYE 137
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA 47
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 23-164 3.32e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.73  E-value: 3.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  23 LKQEEY---EAFLLKLVQN-------LFAEGNDLFREKDYKQALVQYMEGLNVADYAAsdqvalprELLCKLhvnrAACY 92
Cdd:COG2956  87 LKAGLLdraEELLEKLLELdpddaeaLRLLAEIYEQEGDWEKAIEVLERLLKLGPENA--------HAYCEL----AELY 154

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27881484  93 FTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLG 164
Cdd:COG2956 155 LEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLG 226
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 10-173 6.29e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.96  E-value: 6.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  10 IEKGLQFiqstlpLKQEEYE---AFLLKLVQN-------LFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALpre 79
Cdd:COG2956  12 YFKGLNY------LLNGQPDkaiDLLEEALELdpetveaHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLEL--- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  80 llcklhvnrAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESV-TQLGQE 158
Cdd:COG2956  83 ---------AQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAyCELAEL 153

                       170
                ....*....|....*.
gi 27881484 159 -LAQKLGLRVRKAYKR 173
Cdd:COG2956 154 yLEQGDYDEAIEALEK 169
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
46-138 9.63e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 9.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  46 LFREKDYKQALVQYMEGLNVA-DYAASdqvalprellcklHVNRAACYFTMGLYEKALEdSEKALGLDSESIRALFRKAR 124
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDpDNADA-------------LNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAE 67

                        90
                ....*....|....
gi 27881484 125 ALNELGRHKEAYEC 138
Cdd:COG3063  68 LLLELGDYDEALAY 81
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 32-137 2.94e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 2.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  32 LLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYEKALEDSEKALGL 111
Cdd:COG5010   4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQL 83

                        90       100
                ....*....|....*....|....*.
gi 27881484 112 DSESIRALFRKARALNELGRHKEAYE 137
Cdd:COG5010  84 DPNNPELYYNLALLYSRSGDKDEAKE 109
TPR_12 pfam13424
Tetratricopeptide repeat;
80-135 4.69e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 4.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27881484    80 LLCKLHVNRAACYFTMGLYEKALEDSEKAL-------GLDSESI-RALFRKARALNELGRHKEA 135
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALeiarrllGPDHPLTaTTLLNLGRLYLELGRYEEA 64
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 45-137 5.61e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 43.44  E-value: 5.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  45 DLFREKDYKQALvQYMEGLnVADYAASDQVAlprellcKLHVNRAACYFTMGLYEKALEDSEKALGLDSESIR---ALFR 121
Cdd:COG1729   2 ALLKAGDYDEAI-AAFKAF-LKRYPNSPLAP-------DALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLK 72

                        90
                ....*....|....*.
gi 27881484 122 KARALNELGRHKEAYE 137
Cdd:COG1729  73 LGLSYLELGDYDKARA 88
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 43-175 9.87e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 9.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  43 GNDLFREKDYKQALVQYMEGLNVADYAAsdqvalprellcKLHVNRAACYFTMGLYEKALEDSEKALGLDSESIRALFRK 122
Cdd:COG2956 151 AELYLEQGDYDEAIEALEKALKLDPDCA------------RALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRL 218

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 27881484 123 ARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQ 175
Cdd:COG2956 219 AELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQ 271
TPR_1 pfam00515
Tetratricopeptide repeat;
83-112 3.20e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.94  E-value: 3.20e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 27881484    83 KLHVNRAACYFTMGLYEKALEDSEKALGLD 112
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELN 31
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 14-164 3.67e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.21  E-value: 3.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484  14 LQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYF 93
Cdd:COG3914  10 AALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQ 89

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27881484  94 TMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECsSRCSLALPHD--ESVTQLGQeLAQKLG 164
Cdd:COG3914  90 ALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAA-LRRALALNPDfaEAYLNLGE-ALRRLG 160
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 83-137 4.88e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.14  E-value: 4.88e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27881484  83 KLHVNRAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYE 137
Cdd:COG4235  18 EGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEE 72
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
890-913 8.52e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 37.56  E-value: 8.52e-04
                          10        20
                  ....*....|....*....|....
gi 27881484   890 RLCDRLQKGKACPDGDKCRCAHGQ 913
Cdd:pfam00642   4 ELCRFFLRTGYCKYGDRCKFAHGQ 27
DUF3856 pfam12968
Domain of Unknown Function (DUF3856); TPR-like protein. The 2hr2 structure belongs to the SCOP ...
 22-135 1.24e-03

Domain of Unknown Function (DUF3856); TPR-like protein. The 2hr2 structure belongs to the SCOP all alpha class, TPR-like superfamily, CT2138-like family. A DALI search gives hits with the putative peptidyl-prolyl isomerase 2fbn (Z=16), the SGTA protein (Z=16), the PLCR protein 2qfc (Z=16), a putative FK506-binding protein (PDB:1qz2-A; DALI Z-score 15.3; RMSD 2.9; 16% sequence identity within 132 superimposed residues), and with the tetratricopeptide repeats of the protein phosphatase 5 (PDB:2bug; DALI Z-score 15.1; RMSD 2.5; 19% sequence identity within 117 superimposed residues).


Pssm-ID: 463761 [Multi-domain]  Cd Length: 142  Bit Score: 40.23  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27881484    22 PLKQEEYEAFLLklvqnlfAEGNDLFREKDYKQALVQYMEGLNVA---------DYAASDQVAlprellcklHVNRAACY 92
Cdd:pfam12968   2 PLKQVGESYLAL-------SQGEKQLEAAAFEEAAESYRRAMEMSrtipteeafDYDGFDAFC---------HAGLSEAL 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 27881484    93 FTMGLYEKALEDSEKAL-------GLDSES----IRALFRKARALNELGRHKEA 135
Cdd:pfam12968  66 IGLGRYEEALHSAEKALryfnrrgELHQDEgklwIAAVFSKARALEGLGRKEEA 119
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 89-135 3.54e-03

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 37.23  E-value: 3.54e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 27881484    89 AACYFTMGLYEKALEDSEKAlGLDSESIRALFRKARALNELGRHKEA 135
Cdd:pfam12895  30 AQCLFLNGQYKRAYELLRKA-KLNGSSLGCRYLFAQCLLKLKKYDEA 75
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 86-142 5.06e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 5.06e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27881484  86 VNRAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRC 142
Cdd:cd24142   4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRA 60
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 844-867 6.75e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.84  E-value: 6.75e-03
                          10        20
                  ....*....|....*....|....
gi 27881484   844 CWLCGKNSNSKKQWQQHIQSEKHK 867
Cdd:pfam12171   4 CVLCDKYFKSENALQNHLKSKKHK 27
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 82-114 7.26e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.11  E-value: 7.26e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27881484     82 CKLHVNRAACYFTMGLYEKALEDSEKALGLDSE 114
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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