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Conserved domains on  [gi|8923040|ref|NP_060102|]
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CDKN2A-interacting protein isoform 1 [Homo sapiens]

Protein Classification

XTBD domain-containing protein( domain architecture ID 10571605)

XTBD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XTBD pfam11952
XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an ...
 19-124 8.82e-30

XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1.


:

Pssm-ID: 463409  Cd Length: 85  Bit Score: 111.99  E-value: 8.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923040     19 VEALRCDGETDKHWRHRRDFLLRNAGDLapaggaasastdeaadaesgtrnrQLQQLISFSMAWANHVFLGCRYPQKVMD 98
Cdd:pfam11952   1 VEAYRGEWESDEHWELRREFIERHKDDF------------------------PEDRLLSLAQVFANMEFLGCRYPQEVME 56

                          90       100
                  ....*....|....*....|....*....
gi 8923040     99 KILSMAEGI--KVTDAPTYT-TRDELVAK 124
Cdd:pfam11952  57 KVAELAEGIaaEVREAPKFKlTRTFVSAS 85
 
Name Accession Description Interval E-value
XTBD pfam11952
XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an ...
 19-124 8.82e-30

XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1.


Pssm-ID: 463409  Cd Length: 85  Bit Score: 111.99  E-value: 8.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923040     19 VEALRCDGETDKHWRHRRDFLLRNAGDLapaggaasastdeaadaesgtrnrQLQQLISFSMAWANHVFLGCRYPQKVMD 98
Cdd:pfam11952   1 VEAYRGEWESDEHWELRREFIERHKDDF------------------------PEDRLLSLAQVFANMEFLGCRYPQEVME 56

                          90       100
                  ....*....|....*....|....*....
gi 8923040     99 KILSMAEGI--KVTDAPTYT-TRDELVAK 124
Cdd:pfam11952  57 KVAELAEGIaaEVREAPKFKlTRTFVSAS 85
 
Name Accession Description Interval E-value
XTBD pfam11952
XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an ...
 19-124 8.82e-30

XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1.


Pssm-ID: 463409  Cd Length: 85  Bit Score: 111.99  E-value: 8.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923040     19 VEALRCDGETDKHWRHRRDFLLRNAGDLapaggaasastdeaadaesgtrnrQLQQLISFSMAWANHVFLGCRYPQKVMD 98
Cdd:pfam11952   1 VEAYRGEWESDEHWELRREFIERHKDDF------------------------PEDRLLSLAQVFANMEFLGCRYPQEVME 56

                          90       100
                  ....*....|....*....|....*....
gi 8923040     99 KILSMAEGI--KVTDAPTYT-TRDELVAK 124
Cdd:pfam11952  57 KVAELAEGIaaEVREAPKFKlTRTFVSAS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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