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Conserved domains on  [gi|312284070|ref|NP_060166|]
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DNA helicase MCM9 isoform 1 [Homo sapiens]

Protein Classification

ATP-binding protein; minichromosome maintenance protein MCM; minichromosome maintenance protein MCM; minichromosome maintenance protein; ATP-binding protein; minichromosome maintenance protein MCM; minichromosome maintenance protein MCM; minichromosome maintenance protein; minichromosome maintenance protein MCM; ATP-binding protein; minichromosome maintenance protein MCM; minichromosome maintenance protein MCM; minichromosome maintenance protein; ATP-binding protein; minichromosome maintenance protein MCM; minichromosome maintenance protein MCM; minichromosome maintenance protein; minichromosome maintenance protein MCM; minichromosome maintenance protein; minichromosome maintenance protein MCM( domain architecture ID 13599676)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication

EC:  3.6.4.12
Gene Ontology:  GO:0032508|GO:0003677|GO:0005524
PubMed:  15007098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 305-603 0e+00

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


:

Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 611.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760     1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760    81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  465 PQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQ 544
Cdd:cd17760   161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKGEPSKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 312284070  545 VLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17760   241 ILLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 super family cl34204
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 2-605 8.84e-155

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1241:

Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 477.75  E-value: 8.84e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241     2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241    70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241   141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241   202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT 386
Cdd:COG1241   277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLT 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  387 VTAVKD---SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:COG1241   357 AAAVRDdfgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyGR 436

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN--KGYPSKSEKLWSMEKMKTYfclI--------- 531
Cdd:COG1241   437 FDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVhrAGELLEQEIEEETEEVKPE---Idpdllrkyi 513

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  532 ----RNLQPTLSDVGNQVLLRYY-QMQRQSDCRNAART-TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQ 605
Cdd:COG1241   514 ayarRNVFPVLTEEAKDLIEDFYvDMRKKGEDEDSPVPiTARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLK 593
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 751-1113 1.12e-06

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  751 HQSEPKNTVVVSPHPKTSGENMASKISNSTSQG----KEKSEPGQRSKVDIGLLPSPGETGVPWRADNVesNKKKRLALD 826
Cdd:PTZ00449  507 HDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKEsdepKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTL--SKKPEFPKD 584

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  827 SEaavSADKPDSVLTHHVPRNLQKLCKERAQKLcRNSTRVPAQCTVPSHPQStpvhsPDRmldSPKRKRPKSLAQVEEPA 906
Cdd:PTZ00449  585 PK---HPKDPEEPKKPKRPRSAQRPTRPKSPKL-PELLDIPKSPKRPESPKS-----PKR---PPPPQRPSSPERPEGPK 652

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  907 IenVKPPGSPVAKLAKFTFKQKSKLIHSFEDHShvspGATKIAVHSPKISQRRTRRDAALPVKRPGKLTSTPGNQISSQP 986
Cdd:PTZ00449  653 I--IKSPKPPKSPKPPFDPKFKEKFYDDYLDAA----AKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP 726

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  987 QgeTKEVSQQPP-----EKHGPREKVMCAPEKRIIQPELElgNETGCAHLTCEGDKKEEVSgsnksgkvhactlarlanf 1061
Cdd:PTZ00449  727 R--DEEFPFEPIgdpdaEQPDDIEFFTPPEEERTFFHETP--ADTPLPDILAEEFKEEDIH------------------- 783

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 312284070 1062 cftppSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKL 1113
Cdd:PTZ00449  784 -----AETGEPDEAMKRPDSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTDL 830
 
Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 305-603 0e+00

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 611.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760     1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760    81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  465 PQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQ 544
Cdd:cd17760   161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKGEPSKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 312284070  545 VLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17760   241 ILLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 2-605 8.84e-155

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 477.75  E-value: 8.84e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241     2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241    70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241   141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241   202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT 386
Cdd:COG1241   277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLT 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  387 VTAVKD---SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:COG1241   357 AAAVRDdfgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyGR 436

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN--KGYPSKSEKLWSMEKMKTYfclI--------- 531
Cdd:COG1241   437 FDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVhrAGELLEQEIEEETEEVKPE---Idpdllrkyi 513

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  532 ----RNLQPTLSDVGNQVLLRYY-QMQRQSDCRNAART-TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQ 605
Cdd:COG1241   514 ayarRNVFPVLTEEAKDLIEDFYvDMRKKGEDEDSPVPiTARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLK 593
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
9-605 2.07e-145

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 452.84  E-value: 2.07e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    9 VGQVFESYVSEYHKNDILLILKERDED--AHYP--VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsaltILQSL 84
Cdd:NF040949    1 LGEKFKEFIRTFRDSFGNEKYKERIFEmiAMRKrsLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALK-----EIVEE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   85 SQPEAVSMKQNLHARISGLPvcpELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADFEQYY 164
Cdd:NF040949   76 EDPEYAEEVAKFHVRFRNLP---RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  165 TFC-RPSSCPSLEScdSSKFTCLSGLSssptRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:NF040949  153 EIVePPTVCPVCGK--PGSFRLLQEKS----KFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGI 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  244 V-MQRWKPFQQDVRCEVEIVLKANYIqvnnEQSSGIIMDEEVQKEFEDFWEYYKSDPFAgRNVILASLCPQVFGMYLVKL 322
Cdd:NF040949  227 LrIKPDSSLKKGSRPIFKNYIEANHI----EVSQKELEEVEITEEDEEKILELAKDPWI-REKIIASIAPSIYGHWEIKE 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  323 AVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEA 400
Cdd:NF040949  302 AIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDklTGEYYLEA 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  401 GALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPL 479
Cdd:NF040949  382 GALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKfGRYDPNRSVAENIDLPPTI 461

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  480 LSRFDLILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY-QMQRQSD 557
Cdd:NF040949  462 LSRFDLIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEIDPDLLKKYIAYARkYVRPKLTEEAKKLIEDFYvEMRKSSK 541

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 312284070  558 CRNAART----TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQ 605
Cdd:NF040949  542 SSEDPDSpipiTARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLMLAFLE 593
MCM smart00350
minichromosome maintenance proteins;
116-603 1.35e-138

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 428.99  E-value: 1.35e-138
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 194
Cdd:smart00350    9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    195 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 269
Cdd:smart00350   81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    270 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSDPFAgrNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGE 345
Cdd:smart00350  159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGD 236

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHD 423
Cdd:smart00350  237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEFDKMDDSD 316

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    424 RTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIIS 502
Cdd:smart00350  317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPiGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    503 SFILENKGY-----PSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY----QMQRQSDCRNAARTTIRLLESL 572
Cdd:smart00350  397 KHVVDLHRYshpeeDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYvdlrKEDSQTESRSSIPITVRQLESI 476

                           490       500       510
                    ....*....|....*....|....*....|.
gi 312284070    573 IRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:smart00350  477 IRLSEAHAKMRLSDVVEEADVEEAIRLLRES 507
MCM pfam00493
MCM P-loop domain;
304-508 1.68e-98

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 311.39  E-value: 1.68e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   304 NVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:pfam00493   16 DKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 460
Cdd:pfam00493   96 GLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIf 175

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 312284070   461 GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN 508
Cdd:pfam00493  176 GRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDL 223
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 140-603 2.06e-59

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 221.41  E-value: 2.06e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  140 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 216
Cdd:PTZ00111  279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  217 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 280
Cdd:PTZ00111  346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  281 DEEVQKEFEdfweyYKSDPFAGRnVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRV---------RGESHLLLV 351
Cdd:PTZ00111  425 DLQVYKILE-----LSRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLC 498

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  352 GDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIH 428
Cdd:PTZ00111  499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLY 578

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  429 EAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILE 507
Cdd:PTZ00111  579 EVMEQQTVTIAKAGIVATLKAETAILASCNPiNSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK 658

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  508 NKGYPS---------------------------KSEKLWSMEKMKTY--FCLIrNLQPTLSDVGNQVLLRYYQMQRQSD- 557
Cdd:PTZ00111  659 DFLLPHmtgsgndedtydrsntmhvedeslrseKDYNKNDLDMLRMYikFSKL-HCFPKLSDEAKKVITREYVKMRQGNf 737

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  558 ---------------------CRNAART---TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:PTZ00111  738 qtsnldelehaqedddddlyyQSSGTRMiyvSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 116-243 1.37e-24

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 99.86  E-value: 1.37e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSS 191
Cdd:pfam17207    6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVH 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 312284070   192 SPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:pfam17207   70 EKSKFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 751-1113 1.12e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  751 HQSEPKNTVVVSPHPKTSGENMASKISNSTSQG----KEKSEPGQRSKVDIGLLPSPGETGVPWRADNVesNKKKRLALD 826
Cdd:PTZ00449  507 HDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKEsdepKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTL--SKKPEFPKD 584

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  827 SEaavSADKPDSVLTHHVPRNLQKLCKERAQKLcRNSTRVPAQCTVPSHPQStpvhsPDRmldSPKRKRPKSLAQVEEPA 906
Cdd:PTZ00449  585 PK---HPKDPEEPKKPKRPRSAQRPTRPKSPKL-PELLDIPKSPKRPESPKS-----PKR---PPPPQRPSSPERPEGPK 652

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  907 IenVKPPGSPVAKLAKFTFKQKSKLIHSFEDHShvspGATKIAVHSPKISQRRTRRDAALPVKRPGKLTSTPGNQISSQP 986
Cdd:PTZ00449  653 I--IKSPKPPKSPKPPFDPKFKEKFYDDYLDAA----AKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP 726

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  987 QgeTKEVSQQPP-----EKHGPREKVMCAPEKRIIQPELElgNETGCAHLTCEGDKKEEVSgsnksgkvhactlarlanf 1061
Cdd:PTZ00449  727 R--DEEFPFEPIgdpdaEQPDDIEFFTPPEEERTFFHETP--ADTPLPDILAEEFKEEDIH------------------- 783

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 312284070 1062 cftppSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKL 1113
Cdd:PTZ00449  784 -----AETGEPDEAMKRPDSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTDL 830
 
Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 305-603 0e+00

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 611.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760     1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760    81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  465 PQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQ 544
Cdd:cd17760   161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKGEPSKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 312284070  545 VLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17760   241 ILLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 2-605 8.84e-155

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 477.75  E-value: 8.84e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241     2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241    70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241   141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241   202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT 386
Cdd:COG1241   277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLT 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  387 VTAVKD---SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:COG1241   357 AAAVRDdfgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyGR 436

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN--KGYPSKSEKLWSMEKMKTYfclI--------- 531
Cdd:COG1241   437 FDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVhrAGELLEQEIEEETEEVKPE---Idpdllrkyi 513

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  532 ----RNLQPTLSDVGNQVLLRYY-QMQRQSDCRNAART-TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQ 605
Cdd:COG1241   514 ayarRNVFPVLTEEAKDLIEDFYvDMRKKGEDEDSPVPiTARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLK 593
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
9-605 2.07e-145

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 452.84  E-value: 2.07e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    9 VGQVFESYVSEYHKNDILLILKERDED--AHYP--VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsaltILQSL 84
Cdd:NF040949    1 LGEKFKEFIRTFRDSFGNEKYKERIFEmiAMRKrsLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALK-----EIVEE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   85 SQPEAVSMKQNLHARISGLPvcpELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADFEQYY 164
Cdd:NF040949   76 EDPEYAEEVAKFHVRFRNLP---RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  165 TFC-RPSSCPSLEScdSSKFTCLSGLSssptRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:NF040949  153 EIVePPTVCPVCGK--PGSFRLLQEKS----KFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGI 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  244 V-MQRWKPFQQDVRCEVEIVLKANYIqvnnEQSSGIIMDEEVQKEFEDFWEYYKSDPFAgRNVILASLCPQVFGMYLVKL 322
Cdd:NF040949  227 LrIKPDSSLKKGSRPIFKNYIEANHI----EVSQKELEEVEITEEDEEKILELAKDPWI-REKIIASIAPSIYGHWEIKE 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  323 AVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEA 400
Cdd:NF040949  302 AIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDklTGEYYLEA 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  401 GALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPL 479
Cdd:NF040949  382 GALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKfGRYDPNRSVAENIDLPPTI 461

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  480 LSRFDLILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY-QMQRQSD 557
Cdd:NF040949  462 LSRFDLIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEIDPDLLKKYIAYARkYVRPKLTEEAKKLIEDFYvEMRKSSK 541

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 312284070  558 CRNAART----TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQ 605
Cdd:NF040949  542 SSEDPDSpipiTARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLMLAFLE 593
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 306-603 4.01e-139

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 422.52  E-value: 4.01e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17706     2 LADSIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  386 TVTAVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQ- 462
Cdd:cd17706    82 TAAVVRDSetGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGGr 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFIL--------ENKGYPSKSEKLWSMEKMKTYFCLIRNL 534
Cdd:cd17706   162 YNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIdlhrgsdpEEQVKPEEDGIPIDIELLRKYILYARQI 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  535 QPTLSDVGNQVLLRYYQMQRQSDCRN-AARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17706   242 HPKISEEAREKLVRWYVELRKESERRsTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVRHS 311
MCM smart00350
minichromosome maintenance proteins;
116-603 1.35e-138

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 428.99  E-value: 1.35e-138
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 194
Cdd:smart00350    9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    195 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 269
Cdd:smart00350   81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    270 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSDPFAgrNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGE 345
Cdd:smart00350  159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGD 236

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHD 423
Cdd:smart00350  237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEFDKMDDSD 316

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    424 RTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIIS 502
Cdd:smart00350  317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPiGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    503 SFILENKGY-----PSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY----QMQRQSDCRNAARTTIRLLESL 572
Cdd:smart00350  397 KHVVDLHRYshpeeDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYvdlrKEDSQTESRSSIPITVRQLESI 476

                           490       500       510
                    ....*....|....*....|....*....|.
gi 312284070    573 IRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:smart00350  477 IRLSEAHAKMRLSDVVEEADVEEAIRLLRES 507
MCM pfam00493
MCM P-loop domain;
304-508 1.68e-98

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 311.39  E-value: 1.68e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   304 NVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:pfam00493   16 DKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 460
Cdd:pfam00493   96 GLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIf 175

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 312284070   461 GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN 508
Cdd:pfam00493  176 GRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDL 223
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 306-603 3.31e-98

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 313.92  E-value: 3.31e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17757     2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQ 462
Cdd:cd17757    82 TAAVVRDeeTGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPvGGR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKGYPSKS-EKLWSMEKMKTYFCLIRNLQPTLSDV 541
Cdd:cd17757   162 YDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAiEPPFTAEQLKRYIAYARTFKPKLTKE 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312284070  542 GNQVLLRYYQMQRQSDC----RNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17757   242 AKDELVEQYKELRQDDAsgstRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 306-603 6.57e-98

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 313.23  E-value: 6.57e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17761     3 IISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:cd17761    83 TAAVVRDegTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKfGR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILE--NKGYPSKSEKLWSMEKMKTYFCLIR-NLQPTLS 539
Cdd:cd17761   163 FDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDthSGGEMREIKPEIDPDLLRKYIAYARkNVRPVLT 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312284070  540 DVGNQVLLRYYQMQRQS--DCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17761   243 EEAKQLIKDFYVEMRKSgqETPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIMLNC 308
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 306-603 9.11e-91

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 294.74  E-value: 9.11e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17753     2 IINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:cd17753    82 TASVRKDpvTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIgGR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN--KGYPSKSEKLWSMEK----------------- 523
Cdd:cd17753   162 YNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGShvRSHPENDEDREGEEEknqrqrpketkvepipq 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  524 --MKTYFCLIR-NLQPTLSDVGNQVLLRYY-QMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSV 599
Cdd:cd17753   242 elLRKYIHYAReKVRPKLNQMDMDKVSRVYaDLRKESMATGSLPITVRHLESIIRISEAHAKMHLREYVSEEDVDMAIRV 321


                  ....
gi 312284070  600 MESS 603
Cdd:cd17753   322 MLDS 325
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 308-603 1.20e-88

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 288.15  E-value: 1.20e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  308 ASLCPQVFGMYLVKLAVAMVLAGGIQRTdATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTV 387
Cdd:cd17758     4 ASIAPEIYGHEDVKKALLLLLVGGVDKR-GDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGLTA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  388 TAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYD 464
Cdd:cd17758    83 AVMKDpvTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAyGRYN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  465 PQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFIL----ENKGYPSKSEKLwSMEKMKTYFCLIRNLQPTLS- 539
Cdd:cd17758   163 PRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTyvhqHNKQPDSDFEPL-DPKLLRAYIALAKRKRPTVPp 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312284070  540 DVGNQVLLRYYQMQRQSDCRN-AARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17758   242 ALADYIVQAYVEMRQEAKRSKdFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 306-603 4.73e-87

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 283.94  E-value: 4.73e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  306 ILA-SLCPQVFGMYLVKLAVAMVLAGGIQRTDAT-GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:cd17755     1 RLArSIAPSIYELEDVKKGILLQLFGGTRKDFTKtGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKG 461
Cdd:cd17755    81 GLTAYVTRDpdTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  462 -QYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFI----LENKGYPSKSEkLWSMEKMKTYFCLIR-NLQ 535
Cdd:cd17755   161 sRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLvslyLEDTPEHIQDE-VLDVEVLTDYISYAReHIH 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  536 PTLSDVGNQVLLRYYQMQRQ--SDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17755   240 PKLSEEAAQELVQAYVDMRKmgSDARKRITATPRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIREA 309
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 305-593 9.52e-81

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 266.94  E-value: 9.52e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17756     1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  385 LTVTAVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-G 461
Cdd:cd17756    81 LTASVMRDPstREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVfG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  462 QYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILE------NKGYPSKSEKLWSMEKMKTYFCLIR-NL 534
Cdd:cd17756   161 RYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINihasarKASQSQENEGEIPISKLKRYIAYCRaKC 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 312284070  535 QPTLSDVGNQVLLRYY--------QMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDA 593
Cdd:cd17756   241 APRLSEEAAEKLSNHYvtirkdvrQNELESDNRSSIPITVRQLEAIIRISESLAKMELSPIATEKHV 307
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 309-600 1.60e-80

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 265.48  E-value: 1.60e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  309 SLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT-- 386
Cdd:cd17754     5 SLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGLTaa 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  387 VTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDP 465
Cdd:cd17754    85 VTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPvYGRYDV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  466 QESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKGYpskseklwsMEKMKTYFCLIRNL-QPTLSDVGNQ 544
Cdd:cd17754   165 YKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY---------IKFLRKYIHYAKERiKPKLTQEAAE 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312284070  545 VLLRYYQMQRQSDC--RNAART---TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVM 600
Cdd:cd17754   236 YIAEEYADLRNDDNtkTDKARTspiTARTLETLIRLATAHAKARLSKTVDKVDAEVALNLL 296
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 306-603 1.13e-77

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 257.46  E-value: 1.13e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRT--DATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:cd17759     2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKYadDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSL-KEHdrTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK 460
Cdd:cd17759    82 GLTVTLTKDgrSGDFALEAGALVLGDQGICGIDEFDKMgSQH--QALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  461 -GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSfilenkgypskseklwSMEKMKTYFCLIR-NLQPTL 538
Cdd:cd17759   160 gGHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSE----------------HHQLLRKYISYARqYVNPVL 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312284070  539 SDVGNQVLLRYY-QMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:cd17759   224 SKDASEALQEFYlELRKQNQLADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 140-603 2.06e-59

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 221.41  E-value: 2.06e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  140 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 216
Cdd:PTZ00111  279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  217 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 280
Cdd:PTZ00111  346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  281 DEEVQKEFEdfweyYKSDPFAGRnVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRV---------RGESHLLLV 351
Cdd:PTZ00111  425 DLQVYKILE-----LSRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLC 498

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  352 GDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIH 428
Cdd:PTZ00111  499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLY 578

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  429 EAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILE 507
Cdd:PTZ00111  579 EVMEQQTVTIAKAGIVATLKAETAILASCNPiNSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK 658

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  508 NKGYPS---------------------------KSEKLWSMEKMKTY--FCLIrNLQPTLSDVGNQVLLRYYQMQRQSD- 557
Cdd:PTZ00111  659 DFLLPHmtgsgndedtydrsntmhvedeslrseKDYNKNDLDMLRMYikFSKL-HCFPKLSDEAKKVITREYVKMRQGNf 737

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  558 ---------------------CRNAART---TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 603
Cdd:PTZ00111  738 qtsnldelehaqedddddlyyQSSGTRMiyvSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 116-243 1.37e-24

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 99.86  E-value: 1.37e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSS 191
Cdd:pfam17207    6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVH 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 312284070   192 SPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:pfam17207   70 EKSKFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 532-604 1.25e-15

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 72.96  E-value: 1.25e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312284070   532 RNLQPTLSDVGNQVLLRYY-QM-QRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSM 604
Cdd:pfam17855   12 EKIKPKLSEEAREKLVDAYvELrKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIRLLKESL 86
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 347-483 2.15e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 53.84  E-value: 2.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   347 HLLLVGDPGTGKSQFLK-YAAKITPRSVLTTGIgstSAGLTVTAVKdsGEWNLEAGALVLADAGL---------CCIDEF 416
Cdd:pfam07728    1 GVLLVGPPGTGKTELAErLAAALSNRPVFYVQL---TRDTTEEDLF--GRRNIDPGGASWVDGPLvraaregeiAVLDEI 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312284070   417 NSLKEHDRTSIHEAMEQQTISVAKAG-LVCKLNTRTTILAATNPkgqydPQESVSVniaLGSPLLSRF 483
Cdd:pfam07728   76 NRANPDVLNSLLSLLDERRLLLPDGGeLVKAAPDGFRLIATMNP-----LDRGLNE---LSPALRSRF 135
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 751-1113 1.12e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  751 HQSEPKNTVVVSPHPKTSGENMASKISNSTSQG----KEKSEPGQRSKVDIGLLPSPGETGVPWRADNVesNKKKRLALD 826
Cdd:PTZ00449  507 HDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKEsdepKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTL--SKKPEFPKD 584

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  827 SEaavSADKPDSVLTHHVPRNLQKLCKERAQKLcRNSTRVPAQCTVPSHPQStpvhsPDRmldSPKRKRPKSLAQVEEPA 906
Cdd:PTZ00449  585 PK---HPKDPEEPKKPKRPRSAQRPTRPKSPKL-PELLDIPKSPKRPESPKS-----PKR---PPPPQRPSSPERPEGPK 652

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  907 IenVKPPGSPVAKLAKFTFKQKSKLIHSFEDHShvspGATKIAVHSPKISQRRTRRDAALPVKRPGKLTSTPGNQISSQP 986
Cdd:PTZ00449  653 I--IKSPKPPKSPKPPFDPKFKEKFYDDYLDAA----AKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP 726

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  987 QgeTKEVSQQPP-----EKHGPREKVMCAPEKRIIQPELElgNETGCAHLTCEGDKKEEVSgsnksgkvhactlarlanf 1061
Cdd:PTZ00449  727 R--DEEFPFEPIgdpdaEQPDDIEFFTPPEEERTFFHETP--ADTPLPDILAEEFKEEDIH------------------- 783

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 312284070 1062 cftppSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKL 1113
Cdd:PTZ00449  784 -----AETGEPDEAMKRPDSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTDL 830
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 346-489 1.96e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 45.99  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070  346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTgIGSTSAGLTVTAVKDS--GEWNLEAGALVLADAGLCC--IDEFNSLKE 421
Cdd:cd00009    20 KNLLLYGPPGTGKTTLARAIANELFRPGAPF-LYLNASDLLEGLVVAElfGHFLVRLLFELAEKAKPGVlfIDEIDSLSR 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312284070  422 HDRTSIHEAMEQQTISVakaglvcKLNTRTTILAATNPKGQYDPQEsvsvnialgsPLLSRFDLILVL 489
Cdd:cd00009    99 GAQNALLRVLETLNDLR-------IDRENVRVIGATNRPLLGDLDR----------ALYDRLDIRIVI 149
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 347-491 6.98e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.20  E-value: 6.98e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070    347 HLLLVGDPGTGKSQFLKYAAKITPR---SVLTTGIGSTSAGLTVTAVKDSGEWNLEAG------ALVLADA-----GLCC 412
Cdd:smart00382    4 VILIVGPPGSGKTTLARALARELGPpggGVIYIDGEDILEEVLDQLLLIIVGGKKASGsgelrlRLALALArklkpDVLI 83

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312284070    413 IDEFNSLKEHDRtsiheAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPqesvsvnialgSPLLSRFDLILVLLD 491
Cdd:smart00382   84 LDEITSLLDAEQ-----EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGP-----------ALLRRRFDRRIVLLL 146
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 348-487 8.60e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 37.57  E-value: 8.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312284070   348 LLLVGDPGTGKSQFLKYAAKITPRSVLTT---GIGSTSAGLTVTAVKDsgewnleagALVLADAGLCC---IDEFNSL-K 420
Cdd:pfam00004    1 LLLYGPPGTGKTTLAKAVAKELGAPFIEIsgsELVSKYVGESEKRLRE---------LFEAAKKLAPCvifIDEIDALaG 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 312284070   421 EHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPqesvsvnialgsPLLSRFDLIL 487
Cdd:pfam00004   72 SRGSGGDSESRRVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDP------------ALLGRFDRII 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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