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Conserved domains on  [gi|194306539|ref|NP_060513|]
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anoctamin-1 isoform a [Homo sapiens]

Protein Classification

anoctamin( domain architecture ID 11241320)

anoctamin (anion channel with 8 transmembrane domains) is a calcium-activated protein and may mediate the calcium-dependent exposure of phospholipids to the extracellular surface, a process called phospholipid scrambling

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
320-926 4.36e-132

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 403.12  E-value: 4.36e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  320 VRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATmdenipsmemcdqrhnitmcplcdktcsywkmssacatar 399
Cdd:pfam04547   1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLAT---------------------------------------- 40
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  400 ashLFDnPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEavkdhPRAEYEARVLEKSLKKEsrnkEKRRH 479
Cdd:pfam04547  41 ---LFD-PYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTTGFEEEEE-----PRPEFKGEKERINPVTG----EKEPY 107
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  480 IPEestnkwkqrvktamagvkltdkvkltWRDRFPAYLTNLVSIIFMIAVtfaIVLGVIIYrismaaalamnsspsvrsn 559
Cdd:pfam04547 108 YPP--------------------------WKRRLRRYLLSIPLVLLLIAL---LVLGVIIY------------------- 139
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  560 irvtvtataviinlvviilLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLlkfvnsytpifyvaffkgrfvgrpgdy 639
Cdd:pfam04547 140 -------------------LNFVYTKLAKKLTDWENHRTQSEYENSLILKVFL--------------------------- 173
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  640 vyifrsfrmeecapggclMELCIQLSIIMLGKQLIqNNLFEIGIPKMKKLIRYLKLKQ-------QSPPDHEECVKRKQR 712
Cdd:pfam04547 174 ------------------DRLRIQLAIIMVTKQII-NNITEVVLPYLKRKRRKKRKKKkkkeepsVSIKDEPEESEFLER 234
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  713 YEVDYNLEPFAGLtPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRG 792
Cdd:pfam04547 235 VEKEYELEPYDGL-DDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKLCTELRRPVPERADSIGPWLNILEF 313
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  793 IGKLAVIINAFVI-SFTSDFiprlvylymyskngtmhgfvnhtlssfnvsdfqngtapndpldlgyevqicrykdyrepp 871
Cdd:pfam04547 314 LSWLAVITNAALIyAFTSDQ------------------------------------------------------------ 333
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 194306539  872 wsenkydiskdFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKE 926
Cdd:pfam04547 334 -----------YWSLLALLLAFVIVFEHVVLLLKFLIAWLIPDVPEWVRKERKRE 377
Anoct_dimer pfam16178
dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be ...
54-317 5.60e-112

dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be the cytoplasmic domain of the calcium-activated chloride-channel, anoctamin, protein. It is responsible for creating the homodimeric architecture of the chloride-channel proteins.


:

Pssm-ID: 465044  Cd Length: 224  Bit Score: 344.54  E-value: 5.60e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539   54 YFRDGRRKVDYILVYHHKRPsgnrtlvrrvqhsdtpsgarsvkqdhplpgkgasldagsgepPMDYHEDDKRFRREEYEG 133
Cdd:pfam16178   1 YFRDGKRKIDYVLVYEEEKE------------------------------------------ESKREEEKKREKRETFEE 38
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  134 NLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHiNETRGLLKKINSVLQKI-TDPIQPKVaEH 212
Cdd:pfam16178  39 NLIEEGLELEREKEESDQGTHFVKIHAPWEVLCRYAEILKIKMPIKKKIE-KEESSIPGRLDNLSRKLlSKPFIPDV-ET 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  213 RPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTC-TKAKYSMGITSLLANGVYAAAYPLHDGDYN-- 289
Cdd:pfam16178 117 FPKEPDYFTAPFSRDKMYLFLIEDKDTFFTNATRSRIVYEILSRTRYgGRKKKEVGIKRLLNEGVYLAAYPLHDGPYKlp 196
                         250       260
                  ....*....|....*....|....*...
gi 194306539  290 GENVEFNDRKLLYEEWARYGVFYKYQPI 317
Cdd:pfam16178 197 KDPSELNERQLLYEEWARWGKWYKYQPL 224
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
320-926 4.36e-132

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 403.12  E-value: 4.36e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  320 VRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATmdenipsmemcdqrhnitmcplcdktcsywkmssacatar 399
Cdd:pfam04547   1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLAT---------------------------------------- 40
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  400 ashLFDnPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEavkdhPRAEYEARVLEKSLKKEsrnkEKRRH 479
Cdd:pfam04547  41 ---LFD-PYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTTGFEEEEE-----PRPEFKGEKERINPVTG----EKEPY 107
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  480 IPEestnkwkqrvktamagvkltdkvkltWRDRFPAYLTNLVSIIFMIAVtfaIVLGVIIYrismaaalamnsspsvrsn 559
Cdd:pfam04547 108 YPP--------------------------WKRRLRRYLLSIPLVLLLIAL---LVLGVIIY------------------- 139
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  560 irvtvtataviinlvviilLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLlkfvnsytpifyvaffkgrfvgrpgdy 639
Cdd:pfam04547 140 -------------------LNFVYTKLAKKLTDWENHRTQSEYENSLILKVFL--------------------------- 173
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  640 vyifrsfrmeecapggclMELCIQLSIIMLGKQLIqNNLFEIGIPKMKKLIRYLKLKQ-------QSPPDHEECVKRKQR 712
Cdd:pfam04547 174 ------------------DRLRIQLAIIMVTKQII-NNITEVVLPYLKRKRRKKRKKKkkkeepsVSIKDEPEESEFLER 234
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  713 YEVDYNLEPFAGLtPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRG 792
Cdd:pfam04547 235 VEKEYELEPYDGL-DDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKLCTELRRPVPERADSIGPWLNILEF 313
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  793 IGKLAVIINAFVI-SFTSDFiprlvylymyskngtmhgfvnhtlssfnvsdfqngtapndpldlgyevqicrykdyrepp 871
Cdd:pfam04547 314 LSWLAVITNAALIyAFTSDQ------------------------------------------------------------ 333
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 194306539  872 wsenkydiskdFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKE 926
Cdd:pfam04547 334 -----------YWSLLALLLAFVIVFEHVVLLLKFLIAWLIPDVPEWVRKERKRE 377
Anoct_dimer pfam16178
dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be ...
54-317 5.60e-112

dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be the cytoplasmic domain of the calcium-activated chloride-channel, anoctamin, protein. It is responsible for creating the homodimeric architecture of the chloride-channel proteins.


Pssm-ID: 465044  Cd Length: 224  Bit Score: 344.54  E-value: 5.60e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539   54 YFRDGRRKVDYILVYHHKRPsgnrtlvrrvqhsdtpsgarsvkqdhplpgkgasldagsgepPMDYHEDDKRFRREEYEG 133
Cdd:pfam16178   1 YFRDGKRKIDYVLVYEEEKE------------------------------------------ESKREEEKKREKRETFEE 38
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  134 NLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHiNETRGLLKKINSVLQKI-TDPIQPKVaEH 212
Cdd:pfam16178  39 NLIEEGLELEREKEESDQGTHFVKIHAPWEVLCRYAEILKIKMPIKKKIE-KEESSIPGRLDNLSRKLlSKPFIPDV-ET 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  213 RPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTC-TKAKYSMGITSLLANGVYAAAYPLHDGDYN-- 289
Cdd:pfam16178 117 FPKEPDYFTAPFSRDKMYLFLIEDKDTFFTNATRSRIVYEILSRTRYgGRKKKEVGIKRLLNEGVYLAAYPLHDGPYKlp 196
                         250       260
                  ....*....|....*....|....*...
gi 194306539  290 GENVEFNDRKLLYEEWARYGVFYKYQPI 317
Cdd:pfam16178 197 KDPSELNERQLLYEEWARWGKWYKYQPL 224
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
320-926 4.36e-132

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 403.12  E-value: 4.36e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  320 VRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATmdenipsmemcdqrhnitmcplcdktcsywkmssacatar 399
Cdd:pfam04547   1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLAT---------------------------------------- 40
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  400 ashLFDnPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEavkdhPRAEYEARVLEKSLKKEsrnkEKRRH 479
Cdd:pfam04547  41 ---LFD-PYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTTGFEEEEE-----PRPEFKGEKERINPVTG----EKEPY 107
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  480 IPEestnkwkqrvktamagvkltdkvkltWRDRFPAYLTNLVSIIFMIAVtfaIVLGVIIYrismaaalamnsspsvrsn 559
Cdd:pfam04547 108 YPP--------------------------WKRRLRRYLLSIPLVLLLIAL---LVLGVIIY------------------- 139
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  560 irvtvtataviinlvviilLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLlkfvnsytpifyvaffkgrfvgrpgdy 639
Cdd:pfam04547 140 -------------------LNFVYTKLAKKLTDWENHRTQSEYENSLILKVFL--------------------------- 173
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  640 vyifrsfrmeecapggclMELCIQLSIIMLGKQLIqNNLFEIGIPKMKKLIRYLKLKQ-------QSPPDHEECVKRKQR 712
Cdd:pfam04547 174 ------------------DRLRIQLAIIMVTKQII-NNITEVVLPYLKRKRRKKRKKKkkkeepsVSIKDEPEESEFLER 234
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  713 YEVDYNLEPFAGLtPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRG 792
Cdd:pfam04547 235 VEKEYELEPYDGL-DDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKLCTELRRPVPERADSIGPWLNILEF 313
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  793 IGKLAVIINAFVI-SFTSDFiprlvylymyskngtmhgfvnhtlssfnvsdfqngtapndpldlgyevqicrykdyrepp 871
Cdd:pfam04547 314 LSWLAVITNAALIyAFTSDQ------------------------------------------------------------ 333
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 194306539  872 wsenkydiskdFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKE 926
Cdd:pfam04547 334 -----------YWSLLALLLAFVIVFEHVVLLLKFLIAWLIPDVPEWVRKERKRE 377
Anoct_dimer pfam16178
dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be ...
54-317 5.60e-112

dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be the cytoplasmic domain of the calcium-activated chloride-channel, anoctamin, protein. It is responsible for creating the homodimeric architecture of the chloride-channel proteins.


Pssm-ID: 465044  Cd Length: 224  Bit Score: 344.54  E-value: 5.60e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539   54 YFRDGRRKVDYILVYHHKRPsgnrtlvrrvqhsdtpsgarsvkqdhplpgkgasldagsgepPMDYHEDDKRFRREEYEG 133
Cdd:pfam16178   1 YFRDGKRKIDYVLVYEEEKE------------------------------------------ESKREEEKKREKRETFEE 38
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  134 NLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHiNETRGLLKKINSVLQKI-TDPIQPKVaEH 212
Cdd:pfam16178  39 NLIEEGLELEREKEESDQGTHFVKIHAPWEVLCRYAEILKIKMPIKKKIE-KEESSIPGRLDNLSRKLlSKPFIPDV-ET 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306539  213 RPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTC-TKAKYSMGITSLLANGVYAAAYPLHDGDYN-- 289
Cdd:pfam16178 117 FPKEPDYFTAPFSRDKMYLFLIEDKDTFFTNATRSRIVYEILSRTRYgGRKKKEVGIKRLLNEGVYLAAYPLHDGPYKlp 196
                         250       260
                  ....*....|....*....|....*...
gi 194306539  290 GENVEFNDRKLLYEEWARYGVFYKYQPI 317
Cdd:pfam16178 197 KDPSELNERQLLYEEWARWGKWYKYQPL 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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