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Conserved domains on  [gi|170784861|ref|NP_060664|]
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protein-cysteine N-palmitoyltransferase HHAT isoform 1 [Homo sapiens]

Protein Classification

MBOAT family protein( domain architecture ID 10503555)

membrane-bound O-acyltransferase (MBOAT) family protein catalyzes the transfer of an acyl group from acyl-CoA to an alcohol substrate to form the corresponding alcohol ester

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
150-442 8.30e-56

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


:

Pssm-ID: 427117  Cd Length: 334  Bit Score: 189.19  E-value: 8.30e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  150 QGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFS----LELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEF 225
Cdd:pfam03062  26 QLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRpvslSFRKLASAAALSQDPSLLEYLGYVFFYPGLLVGPIFSYSDY 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  226 IKQMQQQEHDSLKASLCVLALGLGRL--------LCWWWLAELMAHLMYMHAIYSSIPLLE-TVSCWTLGGLALAQVLFF 296
Cdd:pfam03062 106 MSFPRDPLFRWLYYVKRNLAPALGALflgltyliLIQYLLSHLPDKDFSKFKFLSYAFLLRfSVIMRILLGLLWLFLLIF 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  297 Y-------VKYLVLFGVPALLmrLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGgsQHGLLGTLFSTA 369
Cdd:pfam03062 186 DflgwlfaEGEDILFGLGFNG--WDRVAPENIYRCWENAVSFSEFWRAWNIPVHKWLKRYVYKPLG--KKGKLNKFLATL 261
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 170784861  370 MTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQARRRFHAALASCSTSMLILS 442
Cdd:pfam03062 262 ATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRLSFLKTDRRRPNLSNVIFWLGAFLGPSLALLLSLS 334
 
Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
150-442 8.30e-56

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 189.19  E-value: 8.30e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  150 QGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFS----LELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEF 225
Cdd:pfam03062  26 QLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRpvslSFRKLASAAALSQDPSLLEYLGYVFFYPGLLVGPIFSYSDY 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  226 IKQMQQQEHDSLKASLCVLALGLGRL--------LCWWWLAELMAHLMYMHAIYSSIPLLE-TVSCWTLGGLALAQVLFF 296
Cdd:pfam03062 106 MSFPRDPLFRWLYYVKRNLAPALGALflgltyliLIQYLLSHLPDKDFSKFKFLSYAFLLRfSVIMRILLGLLWLFLLIF 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  297 Y-------VKYLVLFGVPALLmrLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGgsQHGLLGTLFSTA 369
Cdd:pfam03062 186 DflgwlfaEGEDILFGLGFNG--WDRVAPENIYRCWENAVSFSEFWRAWNIPVHKWLKRYVYKPLG--KKGKLNKFLATL 261
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 170784861  370 MTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQARRRFHAALASCSTSMLILS 442
Cdd:pfam03062 262 ATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRLSFLKTDRRRPNLSNVIFWLGAFLGPSLALLLSLS 334
DltB COG1696
D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane ...
179-420 3.02e-04

D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441302 [Multi-domain]  Cd Length: 472  Bit Score: 43.28  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861 179 YYT----SFSLELCWQQLPAAstsYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKAslcvLALGLgRLLCW 254
Cdd:COG1696  127 FYTfqaiSYLVDVYRGKIKPE---RNFLDYALFVSFFPQLVAGPIVRAKDLLPQLRKRRTFDYEN----FARGL-RLFLL 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861 255 -----WWLAELMAhlMYMHAIYSSIPLLETVSCWtLGGLALAQVLFF----YVkYLVLfGVpALLMRLDgltppaLPR-- 323
Cdd:COG1696  199 glfkkVVIADNLA--PYVDPVFDNPESLSGLEAW-LGALAYTLQIYFdfsgYS-DMAI-GL-ALLFGFR------LPEnf 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861 324 ---CVSTmfSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHG-GYDYLwCWAALNWLGVTVE 399
Cdd:COG1696  267 nspYFAR--SITEFWRRWHISLSTWLRDYLYIPLGGNRKGKLRTYLNLFITMLLGGLWHGaGWTFV-IWGALHGLYLVLE 343
                        250       260
                 ....*....|....*....|.
gi 170784861 400 NGVRRLVETPCIQDSLARYFS 420
Cdd:COG1696  344 RLWRKLRLKLPRLSRLGRLLG 364
 
Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
150-442 8.30e-56

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 189.19  E-value: 8.30e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  150 QGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFS----LELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEF 225
Cdd:pfam03062  26 QLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRpvslSFRKLASAAALSQDPSLLEYLGYVFFYPGLLVGPIFSYSDY 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  226 IKQMQQQEHDSLKASLCVLALGLGRL--------LCWWWLAELMAHLMYMHAIYSSIPLLE-TVSCWTLGGLALAQVLFF 296
Cdd:pfam03062 106 MSFPRDPLFRWLYYVKRNLAPALGALflgltyliLIQYLLSHLPDKDFSKFKFLSYAFLLRfSVIMRILLGLLWLFLLIF 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861  297 Y-------VKYLVLFGVPALLmrLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGgsQHGLLGTLFSTA 369
Cdd:pfam03062 186 DflgwlfaEGEDILFGLGFNG--WDRVAPENIYRCWENAVSFSEFWRAWNIPVHKWLKRYVYKPLG--KKGKLNKFLATL 261
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 170784861  370 MTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQARRRFHAALASCSTSMLILS 442
Cdd:pfam03062 262 ATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRLSFLKTDRRRPNLSNVIFWLGAFLGPSLALLLSLS 334
DltB COG1696
D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane ...
179-420 3.02e-04

D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441302 [Multi-domain]  Cd Length: 472  Bit Score: 43.28  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861 179 YYT----SFSLELCWQQLPAAstsYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKAslcvLALGLgRLLCW 254
Cdd:COG1696  127 FYTfqaiSYLVDVYRGKIKPE---RNFLDYALFVSFFPQLVAGPIVRAKDLLPQLRKRRTFDYEN----FARGL-RLFLL 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861 255 -----WWLAELMAhlMYMHAIYSSIPLLETVSCWtLGGLALAQVLFF----YVkYLVLfGVpALLMRLDgltppaLPR-- 323
Cdd:COG1696  199 glfkkVVIADNLA--PYVDPVFDNPESLSGLEAW-LGALAYTLQIYFdfsgYS-DMAI-GL-ALLFGFR------LPEnf 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170784861 324 ---CVSTmfSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHG-GYDYLwCWAALNWLGVTVE 399
Cdd:COG1696  267 nspYFAR--SITEFWRRWHISLSTWLRDYLYIPLGGNRKGKLRTYLNLFITMLLGGLWHGaGWTFV-IWGALHGLYLVLE 343
                        250       260
                 ....*....|....*....|.
gi 170784861 400 NGVRRLVETPCIQDSLARYFS 420
Cdd:COG1696  344 RLWRKLRLKLPRLSRLGRLLG 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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