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Conserved domains on  [gi|153791244|ref|NP_060698|]
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vertnin [Homo sapiens]

Protein Classification

vertnin( domain architecture ID 17785140)

vertnin acts as a transcription factor that regulates development of thoracic vertebrae

Gene Ontology:  GO:0003677|GO:0006357
PubMed:  31884527|12704427|10664582|23827681
SCOP:  4004307

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
 74-241 7.12e-54

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


:

Pssm-ID: 438612  Cd Length: 137  Bit Score: 181.26  E-value: 7.12e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791244  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791244 154 EAIFDADVKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHVPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126

                        170
                 ....*....|.
gi 153791244 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
276-312 1.90e-04

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


:

Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 40.68  E-value: 1.90e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 153791244 276 REPGLSYSHLCERYSVTKSTFYRWRRQSQEHRQKVAA 312
Cdd:COG2963   21 LEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFP 57
 
Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
 74-241 7.12e-54

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


Pssm-ID: 438612  Cd Length: 137  Bit Score: 181.26  E-value: 7.12e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791244  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791244 154 EAIFDADVKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHVPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126

                        170
                 ....*....|.
gi 153791244 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
276-312 1.90e-04

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 40.68  E-value: 1.90e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 153791244 276 REPGLSYSHLCERYSVTKSTFYRWRRQSQEHRQKVAA 312
Cdd:COG2963   21 LEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFP 57
transpos_IS481 NF033577
IS481 family transposase; null
 271-305 7.72e-03

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 38.73  E-value: 7.72e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 153791244 271 LELLNR--EPGLSYSHLCERYSVTKSTFYRWRRQSQE 305
Cdd:NF033577   3 LELVRLvlEDGWSVREAARRFGISRKTVYKWLKRYRA 39
 
Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
 74-241 7.12e-54

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


Pssm-ID: 438612  Cd Length: 137  Bit Score: 181.26  E-value: 7.12e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791244  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791244 154 EAIFDADVKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHVPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126

                        170
                 ....*....|.
gi 153791244 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
OTU cd22744
OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved ...
 79-231 1.78e-09

OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation.


Pssm-ID: 438581 [Multi-domain]  Cd Length: 128  Bit Score: 56.29  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791244  79 CKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYLQGMidskvmlqavryslcseespemtsLPPATLEAIFD 158
Cdd:cd22744    5 VPGDGNCLFRALAHALYGDQESHRELRQEVVDYLRENPDLYEPAE------------------------LADEDDGEDFD 60

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153791244 159 ADVKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNlkirpYFNRVIRPRRCDHVPSTLHIMWAGQpltSHF 231
Cdd:cd22744   61 EYLQRMRKPGTWGGELELQALANALNVPIVVYSEDGG-----FLPVSVFGPGPGPSGRPIHLLYTGG---NHY 125
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
276-312 1.90e-04

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 40.68  E-value: 1.90e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 153791244 276 REPGLSYSHLCERYSVTKSTFYRWRRQSQEHRQKVAA 312
Cdd:COG2963   21 LEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFP 57
transpos_IS481 NF033577
IS481 family transposase; null
 271-305 7.72e-03

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 38.73  E-value: 7.72e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 153791244 271 LELLNR--EPGLSYSHLCERYSVTKSTFYRWRRQSQE 305
Cdd:NF033577   3 LELVRLvlEDGWSVREAARRFGISRKTVYKWLKRYRA 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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