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Conserved domains on  [gi|8922735|ref|NP_060725|]
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elongator complex protein 2 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11525814)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-416 4.20e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 4.20e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200   5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  133 AAADSAVRLWSKKGPEvmCLQTLnfgNGFALA-LCLSFLPNTdvPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIR 211
Cdd:cd00200  69 GSSDKTIRLWDLETGE--CVRTL---TGHTSYvSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVN 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  212 GVEWAAFGRdlFLASCSQDCLIRIWklyikstsletqDDDNIRLKentftienesvkiafavtleTVLAGHENWVNAVHW 291
Cdd:cd00200 140 SVAFSPDGT--FVASSSQDGTIKLW------------DLRTGKCV--------------------ATLTGHTGEVNSVAF 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  292 QPvfykDGvlqqpVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqn 371
Cdd:cd00200 186 SP----DG-----EKLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVW--- 246

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 8922735  372 tvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFA 416
Cdd:cd00200 247 --DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
274-696 9.05e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 9.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  274 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 353
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  354 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 433
Cdd:COG2319 133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  434 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 508
Cdd:COG2319 200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  509 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 583
Cdd:COG2319 249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  584 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 663
Cdd:COG2319 305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                       410       420       430
                ....*....|....*....|....*....|...
gi 8922735  664 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
Cdd:COG2319 371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
595-822 5.30e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  595 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 674
Cdd:COG2319  59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  675 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 753
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8922735  754 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 822
Cdd:COG2319 191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-416 4.20e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 4.20e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200   5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  133 AAADSAVRLWSKKGPEvmCLQTLnfgNGFALA-LCLSFLPNTdvPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIR 211
Cdd:cd00200  69 GSSDKTIRLWDLETGE--CVRTL---TGHTSYvSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVN 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  212 GVEWAAFGRdlFLASCSQDCLIRIWklyikstsletqDDDNIRLKentftienesvkiafavtleTVLAGHENWVNAVHW 291
Cdd:cd00200 140 SVAFSPDGT--FVASSSQDGTIKLW------------DLRTGKCV--------------------ATLTGHTGEVNSVAF 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  292 QPvfykDGvlqqpVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqn 371
Cdd:cd00200 186 SP----DG-----EKLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVW--- 246

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 8922735  372 tvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFA 416
Cdd:cd00200 247 --DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-414 1.94e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 1.94e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIEDNQLLK 99
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPdGKTLASGSADGTVRLWDLATGKLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  100 AvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALCLSflPNTDvpILA 179
Cdd:COG2319 157 T--LTGHSGAVTSV-AF----SPDG---KLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFS--PDGK--LLA 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  180 CGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQDddnirlkent 259
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGR--LLASGSADGTVRLW-------DLATGE---------- 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  260 ftienesvkiafavtLETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWAPDEESgvwleqvRVGEVGG 339
Cdd:COG2319 280 ---------------LLRTLTGHSGGVNSVAFSP----DG-----KLLASGSDDGTVRLWDLATGK-------LLRTLTG 328

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8922735  340 NTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRL 414
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
274-696 9.05e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 9.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  274 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 353
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  354 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 433
Cdd:COG2319 133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  434 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 508
Cdd:COG2319 200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  509 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 583
Cdd:COG2319 249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  584 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 663
Cdd:COG2319 305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                       410       420       430
                ....*....|....*....|....*....|...
gi 8922735  664 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
Cdd:COG2319 371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-818 2.42e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 2.42e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  559 EVQKLYGHGYEIFCVTCNSSKTLLASAckaakKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 638
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  639 SLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVLD 718
Cdd:cd00200 160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLR 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  719 V-GGAVTAVSVCPvlhpsQRYVVAVGLECGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqk 797
Cdd:cd00200 217 GhENGVNSVAFSP-----DGYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAWSP-DGKR--- 275

                       250       260
                ....*....|....*....|.
gi 8922735  798 eaegaewlhFASCGEDHTVKI 818
Cdd:cd00200 276 ---------LASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
595-822 5.30e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  595 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 674
Cdd:COG2319  59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  675 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 753
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8922735  754 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 822
Cdd:COG2319 191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 668-696 1.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.21e-05
                           10        20
                   ....*....|....*....|....*....
gi 8922735     668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
668-696 1.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.69e-05
                          10        20
                  ....*....|....*....|....*....
gi 8922735    668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-237 3.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 8922735     196 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 237
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
197-236 4.65e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 8922735    197 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 668-823 6.01e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 6.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 746
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8922735  747 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 823
Cdd:cd00200  73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-416 4.20e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 4.20e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200   5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  133 AAADSAVRLWSKKGPEvmCLQTLnfgNGFALA-LCLSFLPNTdvPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIR 211
Cdd:cd00200  69 GSSDKTIRLWDLETGE--CVRTL---TGHTSYvSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVN 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  212 GVEWAAFGRdlFLASCSQDCLIRIWklyikstsletqDDDNIRLKentftienesvkiafavtleTVLAGHENWVNAVHW 291
Cdd:cd00200 140 SVAFSPDGT--FVASSSQDGTIKLW------------DLRTGKCV--------------------ATLTGHTGEVNSVAF 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  292 QPvfykDGvlqqpVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqn 371
Cdd:cd00200 186 SP----DG-----EKLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVW--- 246

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 8922735  372 tvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFA 416
Cdd:cd00200 247 --DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-414 1.94e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 1.94e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIEDNQLLK 99
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPdGKTLASGSADGTVRLWDLATGKLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  100 AvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALCLSflPNTDvpILA 179
Cdd:COG2319 157 T--LTGHSGAVTSV-AF----SPDG---KLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFS--PDGK--LLA 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  180 CGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQDddnirlkent 259
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGR--LLASGSADGTVRLW-------DLATGE---------- 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  260 ftienesvkiafavtLETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWAPDEESgvwleqvRVGEVGG 339
Cdd:COG2319 280 ---------------LLRTLTGHSGGVNSVAFSP----DG-----KLLASGSDDGTVRLWDLATGK-------LLRTLTG 328

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8922735  340 NTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRL 414
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
21-467 2.55e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 2.55e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWIckqdgSPSTELVSGGSDNQVIHWEIEDNQLLka 100
Cdd:COG2319  41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLWDLATGLLL-- 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  101 VHLQGHEGPVYAVhAVyqrrTSDpalCTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALclSFLPNTDvpILAC 180
Cdd:COG2319 114 RTLTGHTGAVRSV-AF----SPD---GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSV--AFSPDGK--LLAS 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  181 GNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkentf 260
Cdd:COG2319 180 GSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPDGK--LLASGSADGTVRLW-------DLATG------------ 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  261 tienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVggn 340
Cdd:COG2319 237 -------------KLLRTLTGHSGSVRSVAFSP----DG-----RLLASGSADGTVRLWDLATGELLRTLTGHSGGV--- 291

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  341 tlgfYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKR 420
Cdd:COG2319 292 ----NSVAFSPDGKLLASGSDDGTVRLW-----DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL---WDL 359

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 8922735  421 KdqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGADEKVLRVFSAP 467
Cdd:COG2319 360 A-----TGELLRTLTGHTGAVTSVA----FspdgrTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
15-319 4.02e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 4.02e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   15 PNRVRGVlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIE 93
Cdd:COG2319 120 TGAVRSV-AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLA 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   94 DNQLLKAvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALclSFLPnt 173
Cdd:COG2319 193 TGKLLRT--LTGHTGAVRSV-AF----SPDG---KLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSV--AFSP-- 256

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  174 DVPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWKLyikstsletqdDDNI 253
Cdd:COG2319 257 DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGK--LLASGSDDGTVRLWDL-----------ATGK 321

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  254 RLKenTFTIENESVK-IAFA----------------------VTLETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSA 310
Cdd:COG2319 322 LLR--TLTGHTGAVRsVAFSpdgktlasgsddgtvrlwdlatGELLRTLTGHTGAVTSVAFSP----DG-----RTLASG 390


                ....*....
gi 8922735  311 SMDKTMILW 319
Cdd:COG2319 391 SADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
274-696 9.05e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 9.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  274 TLETVLAGHENWVNAVHWQPVfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFNEDG 353
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRSVAFSPDG 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  354 SMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 433
Cdd:COG2319 133 KTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRT 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  434 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKA 508
Cdd:COG2319 200 LTGHTGAVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGS 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  509 VFqgDIASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 583
Cdd:COG2319 249 VR--SVAFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLA 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  584 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnk 663
Cdd:COG2319 305 SGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG---- 370

                       410       420       430
                ....*....|....*....|....*....|...
gi 8922735  664 itsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
Cdd:COG2319 371 ----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-320 1.18e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.03  E-value: 1.18e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   42 LYDPLKRVVVTNLNGHTARVNCIQWickqdgSPSTELVSGGS-DNQVIHWEIEDNQLLKAvhLQGHEGPVYAVhavyqrR 120
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAF------SPDGRILSSSSrDKTIKVWDVETGKCLTT--LRGHTDWVNSV------A 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  121 TSDPAlcTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALCLSflpNTDVPILACGNDDCrIHIFAQQNDQFQKV 200
Cdd:cd00200 143 FSPDG--TFVASSSQDGTIKLWDLRTGK--CVATLTGHTGEVNSVAFS---PDGEKLLSSSSDGT-IKLWDLSTGKCLGT 214

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  201 LSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWKLYIKSTSletqdddnirlkentftienesvkiafavtleTVLA 280
Cdd:cd00200 215 LR--GHENGVNSVAFSPDGY--LLASGSEDGTIRVWDLRTGECV--------------------------------QTLS 258

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 8922735  281 GHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWA 320
Cdd:cd00200 259 GHTNSVTSLAWSP----DG-----KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
82-641 2.25e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 2.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   82 GSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGF 161
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  162 ALALCLSFlpntDVPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyik 241
Cdd:COG2319  81 VLSVAFSP----DGRLLASASADGTVRLWDLATGLLLRTLT--GHTGAVRSVAFSPDGK--TLASGSADGTVRLW----- 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  242 stSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKTMILWap 321
Cdd:COG2319 148 --DLATG-------------------------KLLRTLTGHSGAVTSVAFSP----DGK-----LLASGSDDGTVRLW-- 189

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  322 DEESGVWLEQVRvgevgGNTLGFYDCQFNEDGSMIIAHAFHGALHLWkqntvNPREWTPEIVISGHFDGVQDLVWDPEGE 401
Cdd:COG2319 190 DLATGKLLRTLT-----GHTGAVRSVAFSPDGKLLASGSADGTVRLW-----DLATGKLLRTLTGHSGSVRSVAFSPDGR 259

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  402 FIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGADEKVLRVFSAPrnfvenfca 476
Cdd:COG2319 260 LLASGSADGTVRL---WDLA-----TGELLRTLTGHSGGVNSVA----FspdgkLLASGSDDGTVRLWDLA--------- 318

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  477 iTGQslnhvlcnqdsdlpegatvpalglsnkavfqgdiasqpsdeeelltstgfeyqqvafqpsiltepptedhllqntl 556
Cdd:COG2319 319 -TGK---------------------------------------------------------------------------- 321

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  557 wpEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDR 636
Cdd:COG2319 322 --LLRTLTGHTGAVRSVAFSPDGKTLASGS-----DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394


                ....*
gi 8922735  637 TWSLW 641
Cdd:COG2319 395 TVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-237 6.61e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 6.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735    8 TSHVFCCpnrvrgvlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSPSTELVSGGSDNQV 87
Cdd:cd00200  93 TSYVSSV--------AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF------SPDGTFVASSSQDGT 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   88 IH-WEIEDNQLLKAvhLQGHEGPVYAVHAVYQRRTsdpalctlIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFalALC 166
Cdd:cd00200 159 IKlWDLRTGKCVAT--LTGHTGEVNSVAFSPDGEK--------LLSSSSDGTIKLWDLSTGK--CLGTLRGHENG--VNS 224

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8922735  167 LSFLPNTDvpILACGNDDCRIHIFaqQNDQFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 237
Cdd:cd00200 225 VAFSPDGY--LLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGK--RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
15-238 1.04e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 1.04e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   15 PNRVRGVlNWSsgPRG-LLAFGTS-CSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWE 91
Cdd:COG2319 204 TGAVRSV-AFS--PDGkLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAF------SPdGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735   92 IEDNQLLKAvhLQGHEGPVYAVHAVYQRRTsdpalctlIVSAAADSAVRLWSKKGPEvmCLQTLNFGNGFALALCLSflp 171
Cdd:COG2319 275 LATGELLRT--LTGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFS--- 339

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8922735  172 nTDVPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWKL 238
Cdd:COG2319 340 -PDGKTLASGSDDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGR--TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-696 1.72e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 1.72e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  205 GHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQDddnirlkentftienesvkiafavtLETVLAGHEN 284
Cdd:cd00200   7 GHTGGVTCVAFSPDGK--LLATGSGDGTIKVW-------DLETGE-------------------------LLRTLKGHTG 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  285 WVNAVHWQPVFYKdgvlqqpvrLLSASMDKTMILWapDEESGVwleqvRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGA 364
Cdd:cd00200  53 PVRDVAASADGTY---------LASGSSDKTIRLW--DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  365 LHLWKQNTVnprewTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapwkrkdqsqvtwheiarpqihgYDLKCL 444
Cdd:cd00200 117 IKVWDVETG-----KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL------------------------WDLRTG 167

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  445 aminrfqfvsgadeKVLRVFSAPRNFVeNFCAITGQSLNHVLCNQDSDlpegatvpalglsnkavfqgdiasqpsdeeel 524
Cdd:cd00200 168 --------------KCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGT-------------------------------- 200

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  525 ltstgfeyqqvafqpsiltepptedhllqntlwpevqklyghgyeifcvtcnssktllasackaakkehaaIILWNTTSW 604
Cdd:cd00200 201 -----------------------------------------------------------------------IKLWDLSTG 209

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  605 KQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRT---WSLWKKqdtispefEPVFSLFAftnkitsvHSRIIWSCDWSPDS 681
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTirvWDLRTG--------ECVQTLSG--------HTNSVTSLAWSPDG 273

                       490
                ....*....|....*
gi 8922735  682 KYFFTGSRDKKVVVW 696
Cdd:cd00200 274 KRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
559-818 5.03e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 5.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  559 EVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 638
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  639 SLWKKQDTispefEPVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLD 718
Cdd:COG2319 187 RLWDLATG-----KLLRTL--------TGHTGAVRSVAFSPDGKLLASGSADGTVRLW---DLAT-------GKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  719 V-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWkncS--GKTe 795
Cdd:COG2319 244 GhSGSVRSVAF----SPDGRLLASGSAD-GTVRLWDLATGELLRTL------------TGHSGGVNSVAF---SpdGKL- 302

                       250       260
                ....*....|....*....|...
gi 8922735  796 qkeaegaewlhFASCGEDHTVKI 818
Cdd:COG2319 303 -----------LASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
299-696 7.68e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 7.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  299 GVLQQPVRLLSASMDKTMILWAPDEESGVWLE--QVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTvnpr 376
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAaaGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT---- 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  377 eWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----Q 451
Cdd:COG2319 110 -GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL---WDLA-----TGKLLRTLTGHSGAVTSVA----FspdgkL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  452 FVSGADEKVLRVFSAPrnfvenfcaiTGQslnhvlcnqdsdlpegatvpalglsnkavfqgdiasqpsdeeelltstgfe 531
Cdd:COG2319 177 LASGSDDGTVRLWDLA----------TGK--------------------------------------------------- 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  532 yqqvafqpsiltepptedhllqntlwpEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLV 611
Cdd:COG2319 196 ---------------------------LLRTLTGHTGAVRSVAFSPDGKLLASGS-----ADGTVRLWDLATGKLLRTLT 243

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  612 FHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDK 691
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDG 310


                ....*
gi 8922735  692 KVVVW 696
Cdd:COG2319 311 TVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
556-818 8.64e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 8.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  556 LW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 630
Cdd:COG2319 146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  631 AVSRDRTWSLWkkqDTISPEfePVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 710
Cdd:COG2319 221 SGSADGTVRLW---DLATGK--LLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLAT------- 277

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  711 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWKN 789
Cdd:COG2319 278 GELLRTLTGhSGGVNSVAF----SPDGKLLASGSDD-GTVRLWDLATGKLLRTLTG------------HTGAVRSVAFSP 340

                       250       260
                ....*....|....*....|....*....
gi 8922735  790 cSGKTeqkeaegaewlhFASCGEDHTVKI 818
Cdd:COG2319 341 -DGKT------------LASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-818 2.42e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 2.42e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  559 EVQKLYGHGYEIFCVTCNSSKTLLASAckaakKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 638
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  639 SLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVLD 718
Cdd:cd00200 160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLR 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  719 V-GGAVTAVSVCPvlhpsQRYVVAVGLECGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqk 797
Cdd:cd00200 217 GhENGVNSVAFSP-----DGYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAWSP-DGKR--- 275

                       250       260
                ....*....|....*....|.
gi 8922735  798 eaegaewlhFASCGEDHTVKI 818
Cdd:cd00200 276 ---------LASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-818 3.94e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 3.94e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  559 EVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 638
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-----IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  639 SLWKKQDTispefEPVFSLFAFTNKitsvhsriIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVL- 717
Cdd:cd00200  76 RLWDLETG-----ECVRTLTGHTSY--------VSSVAFSPDGRILSSSSRDKTIKVW----------DVETGKCLTTLr 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  718 DVGGAVTAVSVcpvlHPSQRYVVAVGLECgkiCLYTWkktdqvpEINDWtHCVETsqSQSHTLAIRKLCWkncSGKTEqk 797
Cdd:cd00200 133 GHTDWVNSVAF----SPDGTFVASSSQDG---TIKLW-------DLRTG-KCVAT--LTGHTGEVNSVAF---SPDGE-- 190

                       250       260
                ....*....|....*....|.
gi 8922735  798 eaegaewlHFASCGEDHTVKI 818
Cdd:cd00200 191 --------KLLSSSSDGTIKL 203
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 383-716 2.00e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 2.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  383 VISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKDQSQVTwheiaRPQIH-GYDLKCLAMINRFQFVSGADEKVL 461
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKV---WDLETGELLR-----TLKGHtGPVRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  462 RVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKAVFQGDIasqpSDEEELLTSTGFeyqqvafqpsi 541
Cdd:cd00200  76 RLW---------------------------DLETGECVRTLTGHTSYVSSVAF----SPDGRILSSSSR----------- 113

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  542 ltepptedhllQNTLW-------PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHS 614
Cdd:cd00200 114 -----------DKTIKvwdvetgKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-----IKLWDLRTGKCVATLTGHT 177

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  615 LTVTQMAFSPNEKFLLAVSRDRTWSLWKKQdtispEFEPVFSLFAftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVV 694
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-----TGKCLGTLRG--------HENGVNSVAFSPDGYLLASGSEDGTIR 244

                       330       340
                ....*....|....*....|....*.
gi 8922735  695 VW----GECDSTddCIEHNiGPCSSV 716
Cdd:cd00200 245 VWdlrtGECVQT--LSGHT-NSVTSL 267
WD40 COG2319
WD40 repeat [General function prediction only];
551-822 2.18e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 2.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  551 LLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 630
Cdd:COG2319  62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  631 AVSRDRTWSLWkkqDTISPEFEPVFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 710
Cdd:COG2319 137 SGSADGTVRLW---DLATGKLLRTL----------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLAT------- 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  711 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkn 789
Cdd:COG2319 194 GKLLRTLTGhTGAVRSVAF----SPDGKLLASGSAD-GTVRLWDLATGKLLRTLTG------------HSGSVRSVAF-- 254

                       250       260       270
                ....*....|....*....|....*....|....*
gi 8922735  790 cS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 822
Cdd:COG2319 255 -SpdGRL------------LASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
595-822 5.30e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  595 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 674
Cdd:COG2319  59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  675 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 753
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8922735  754 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 822
Cdd:COG2319 191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 668-696 1.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.21e-05
                           10        20
                   ....*....|....*....|....*....
gi 8922735     668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
668-696 1.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.69e-05
                          10        20
                  ....*....|....*....|....*....
gi 8922735    668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 603-642 1.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.55e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 8922735     603 SWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWK 642
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-237 3.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 8922735     196 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 237
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
197-236 4.65e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 8922735    197 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 668-823 6.01e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 6.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922735  668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 746
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8922735  747 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 823
Cdd:cd00200  73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
WD40 pfam00400
WD domain, G-beta repeat;
604-641 8.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 8.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 8922735    604 WKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLW 641
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
378-415 9.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 9.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 8922735    378 WTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLF 415
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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