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Conserved domains on  [gi|28416949|ref|NP_060854|]
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GTPase IMAP family member 5 [Homo sapiens]

Protein Classification

GTPase IMAP family protein( domain architecture ID 10111261)

GTPase immunity-associated protein (IMAP) family protein may function as regulator of lymphocyte survival and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 28-228 2.94e-106

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 307.92  E-value: 2.94e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949  28 LRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLS 107
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949 108 APGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDnCSLKDLVRECERRYCAF 187
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28416949 188 NNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQ 228
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 28-228 2.94e-106

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 307.92  E-value: 2.94e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949  28 LRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLS 107
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949 108 APGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDnCSLKDLVRECERRYCAF 187
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28416949 188 NNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQ 228
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 28-233 4.53e-98

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 287.20  E-value: 4.53e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949    28 LRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLS 107
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949   108 APGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVREcerrycaf 187
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT-------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 28416949   188 nnwGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRT 233
Cdd:pfam04548 153 ---ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGER 195
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 13-152 4.29e-11

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 63.43  E-value: 4.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949    13 AEGRSEDNLSatppaLRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVkTGTWNGRKVLVVDTPSIFESQAD 92
Cdd:TIGR00993 109 AEGQDPLDFS-----LNILVLGKSGVGKSATINSIFGEVKFSTDAFGMGTTSVQEI-EGLVQGVKIRVIDTPGLKSSASD 182

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28416949    93 --TQELYKNIGDCYLLSAPgPHVLLLVIQLGRFT--AQDTVAIRKVKEVFGTGAMRHVVILFTH 152
Cdd:TIGR00993 183 qsKNEKILSSVKKFIKKNP-PDIVLYVDRLDMQTrdSNDLPLLRTITDVLGPSIWFNAIVTLTH 245
YeeP COG3596
Predicted GTPase [General function prediction only];
26-156 1.34e-07

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 52.08  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949  26 PALRIILVGKTGCGKSATGNSILGQPVFE-SKLRAqsVTRTCQVKT-GTWNGRKVLVVDTPSIFESQADTQE--LYKNIg 101
Cdd:COG3596  38 PPPVIALVGKTGAGKSSLINALFGAEVAEvGVGRP--CTREIQRYRlESDGLPGLVLLDTPGLGEVNERDREyrELREL- 114

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28416949 102 dcyllsAPGPHVLLLVIQ-LGRFTAQDTVAIRKVKEvfgTGAMRHVVILFTHKEDL 156
Cdd:COG3596 115 ------LPEADLILWVVKaDDRALATDEEFLQALRA---QYPDPPVLVVLTQVDRL 161
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 28-228 2.94e-106

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 307.92  E-value: 2.94e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949  28 LRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLS 107
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949 108 APGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDnCSLKDLVRECERRYCAF 187
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 28416949 188 NNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQ 228
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 28-233 4.53e-98

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 287.20  E-value: 4.53e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949    28 LRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLS 107
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949   108 APGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVREcerrycaf 187
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT-------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 28416949   188 nnwGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRT 233
Cdd:pfam04548 153 ---ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGER 195
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 12-152 1.12e-16

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 77.74  E-value: 1.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949  12 MAEGRSEDNLSatppaLRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVkTGTWNGRKVLVVDTPSIFESQa 91
Cdd:cd01853  21 EAKLKKELDFS-----LTILVLGKTGVGKSSTINSIFGERKVSVSAFQSETLRPREV-SRTVDGFKLNIIDTPGLLESQ- 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28416949  92 dTQELYKNIGDC---YLLSAPgPHVLLLViqlGRFTAQ-----DTVAIRKVKEVFGTGAMRHVVILFTH 152
Cdd:cd01853  94 -DQRVNRKILSIikrFLKKKT-IDVVLYV---DRLDMYrvdnlDVPLLRAITDSFGPSIWRNAIVVLTH 157
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 13-152 4.29e-11

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 63.43  E-value: 4.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949    13 AEGRSEDNLSatppaLRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVkTGTWNGRKVLVVDTPSIFESQAD 92
Cdd:TIGR00993 109 AEGQDPLDFS-----LNILVLGKSGVGKSATINSIFGEVKFSTDAFGMGTTSVQEI-EGLVQGVKIRVIDTPGLKSSASD 182

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28416949    93 --TQELYKNIGDCYLLSAPgPHVLLLVIQLGRFT--AQDTVAIRKVKEVFGTGAMRHVVILFTH 152
Cdd:TIGR00993 183 qsKNEKILSSVKKFIKKNP-PDIVLYVDRLDMQTrdSNDLPLLRTITDVLGPSIWFNAIVTLTH 245
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 32-199 1.16e-07

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 50.53  E-value: 1.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949  32 LVGKTGCGKSATGNSILGQPVFEsKLRAQSVTRTCQVKTGTW--NGRKVLVVDTPSIFESQADTQElyknigDCYLLSAP 109
Cdd:cd00882   2 VVGRGGVGKSSLLNALLGGEVGE-VSDVPGTTRDPDVYVKELdkGKVKLVLVDTPGLDEFGGLGRE------ELARLLLR 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949 110 GPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAmrHVVILFTHKEDLGGQALDDYVANTDNCSLKDL-VRECerryCAFN 188
Cdd:cd00882  75 GADLILLVVDSTDRESEEDAKLLILRRLRKEGI--PIILVGNKIDLLEEREVEELLRLEELAKILGVpVFEV----SAKT 148

                       170
                ....*....|.
gi 28416949 189 NWGsVEEQRQQ 199
Cdd:cd00882 149 GEG-VDELFEK 158
YeeP COG3596
Predicted GTPase [General function prediction only];
26-156 1.34e-07

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 52.08  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949  26 PALRIILVGKTGCGKSATGNSILGQPVFE-SKLRAqsVTRTCQVKT-GTWNGRKVLVVDTPSIFESQADTQE--LYKNIg 101
Cdd:COG3596  38 PPPVIALVGKTGAGKSSLINALFGAEVAEvGVGRP--CTREIQRYRlESDGLPGLVLLDTPGLGEVNERDREyrELREL- 114

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28416949 102 dcyllsAPGPHVLLLVIQ-LGRFTAQDTVAIRKVKEvfgTGAMRHVVILFTHKEDL 156
Cdd:COG3596 115 ------LPEADLILWVVKaDDRALATDEEFLQALRA---QYPDPPVLVVLTQVDRL 161
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 29-118 6.36e-07

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 47.23  E-value: 6.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949    29 RIILVGKTGCGKSATGNSILGQPVFESKlRAQsVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQEL---YKNIGDCyl 105
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSD-YPG-TTRDPNEGRLELKGKQIILVDTPGLIEGASEGEGLgraFLAIIEA-- 76

                          90
                  ....*....|...
gi 28416949   106 lsapgpHVLLLVI 118
Cdd:pfam01926  77 ------DLILFVV 83
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 27-154 3.38e-06

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 47.97  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949    27 ALRIILVGKTGCGKSATGNSILGQPV-----FESK-LRAQSVTRTcqvKTG-TWNgrkvlVVDTPSIFESqADTQELYKN 99
Cdd:TIGR00991  38 SLTILVMGKGGVGKSSTVNSIIGERIatvsaFQSEgLRPMMVSRT---RAGfTLN-----IIDTPGLIEG-GYINDQAVN 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 28416949   100 IGDCYLLSAPgPHVLLLVIQLG--RFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKE 154
Cdd:TIGR00991 109 IIKRFLLGKT-IDVLLYVDRLDayRVDTLDGQVIRAITDSFGKDIWRKSLVVLTHAQ 164
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 32-122 2.73e-03

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 37.61  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949  32 LVGKTGCGKSATGNSILGQPVFESKLRAQsVTRTCQVKTGTWNG-RKVLVVDTPSIFESQAD----TQELYKNIGDCyll 106
Cdd:cd00880   2 IFGRPNVGKSSLLNALLGQNVGIVSPIPG-TTRDPVRKEWELLPlGPVVLIDTPGLDEEGGLgrerVEEARQVADRA--- 77

                        90
                ....*....|....*.
gi 28416949 107 sapgpHVLLLVIQLGR 122
Cdd:cd00880  78 -----DLVLLVVDSDL 88
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 29-166 7.53e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 36.58  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416949    29 RIILVGKTGCGKSATGNSILGQPVFESKLRAQsVTRTCQVKTGTWNGRKVLV--VDTPSifesqadtQELYKNIGDCYLl 106
Cdd:TIGR00231   3 KIVIVGHPNVGKSTLLNSLLGNKGSITEYYPG-TTRNYVTTVIEEDGKTYKFnlLDTAG--------QEDYDAIRRLYY- 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28416949   107 saPGPHVLLLVIQLGRF--TAQDTVAiRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVA 166
Cdd:TIGR00231  73 --PQVERSLRVFDIVILvlDVEEILE-KQTKEIIHHADSGVPIILVGNKIDLKDADLKTHVA 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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