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Conserved domains on  [gi|117938268|ref|NP_060923|]
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E2F-associated phosphoprotein isoform 1 [Homo sapiens]

Protein Classification

E2F-associated phosphoprotein( domain architecture ID 10562989)

E2F-associated phosphoprotein (EAPP) may play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eapp_C pfam10238
E2F-associated phosphoprotein; This entry represents the conserved C-terminal portion of an ...
 139-283 6.64e-78

E2F-associated phosphoprotein; This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis.


:

Pssm-ID: 463015  Cd Length: 133  Bit Score: 232.54  E-value: 6.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938268  139 YDPEKDNRDQAWVDAQRRGyhglgpqrsrqqQPVPNSDAVLNCPACMTTLCLDCQRHESYKTQYRAMFVMNCSINKEEVL 218
Cdd:pfam10238   1 YDPDLDDEDEAWVNKQRRG------------KGLPSSDAVLSCPACFTTLCLDCQRHETYVNQYRAMFVMNCRVDTDEVL 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117938268  219 RYKASENRKKRRVHKKMRSNREDAAEKAETDVEEIYHPVMCTECSTEVAVYDKDEVFHFFNVLAS 283
Cdd:pfam10238  69 RYKEPKLKKGKRGKRKKSGSSSSTAADAEGQTSEIYHPVKCSECSTEVAVFDKDEVYHFFNVLAS 133
 
Name Accession Description Interval E-value
Eapp_C pfam10238
E2F-associated phosphoprotein; This entry represents the conserved C-terminal portion of an ...
 139-283 6.64e-78

E2F-associated phosphoprotein; This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis.


Pssm-ID: 463015  Cd Length: 133  Bit Score: 232.54  E-value: 6.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938268  139 YDPEKDNRDQAWVDAQRRGyhglgpqrsrqqQPVPNSDAVLNCPACMTTLCLDCQRHESYKTQYRAMFVMNCSINKEEVL 218
Cdd:pfam10238   1 YDPDLDDEDEAWVNKQRRG------------KGLPSSDAVLSCPACFTTLCLDCQRHETYVNQYRAMFVMNCRVDTDEVL 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117938268  219 RYKASENRKKRRVHKKMRSNREDAAEKAETDVEEIYHPVMCTECSTEVAVYDKDEVFHFFNVLAS 283
Cdd:pfam10238  69 RYKEPKLKKGKRGKRKKSGSSSSTAADAEGQTSEIYHPVKCSECSTEVAVFDKDEVYHFFNVLAS 133
 
Name Accession Description Interval E-value
Eapp_C pfam10238
E2F-associated phosphoprotein; This entry represents the conserved C-terminal portion of an ...
 139-283 6.64e-78

E2F-associated phosphoprotein; This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis.


Pssm-ID: 463015  Cd Length: 133  Bit Score: 232.54  E-value: 6.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938268  139 YDPEKDNRDQAWVDAQRRGyhglgpqrsrqqQPVPNSDAVLNCPACMTTLCLDCQRHESYKTQYRAMFVMNCSINKEEVL 218
Cdd:pfam10238   1 YDPDLDDEDEAWVNKQRRG------------KGLPSSDAVLSCPACFTTLCLDCQRHETYVNQYRAMFVMNCRVDTDEVL 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117938268  219 RYKASENRKKRRVHKKMRSNREDAAEKAETDVEEIYHPVMCTECSTEVAVYDKDEVFHFFNVLAS 283
Cdd:pfam10238  69 RYKEPKLKKGKRGKRKKSGSSSSTAADAEGQTSEIYHPVKCSECSTEVAVFDKDEVYHFFNVLAS 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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