Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 8923885    316 SLRRHMRIHKGVKPYVCHLCGKAFTQ 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 8923885    430 LTYHVRRHTGEKPYVCDTCGKAFA 453
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|.
gi 8923885    304 CNTCGKVFSEASSLRRHMRIH 324
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885     14 LNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSE--NNVFLDQSQVKADGFQKLLEFIYTGTLNLDSwN 91
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLDDVSPEDFEALLEFMYTGKLISEE-N 79

                          90       100
                  ....*....|....*....|....
gi 8923885     92 VKEIHQAADYLKVEEVVTKCKIKM 115
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFL 103

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    24 CDCTIVI--GEFQFKAHRNVLASFSEYFG-AIYRSTSENNVFLdqsQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAAD 100
Cdd:PHA03098  10 CDESIIIvnGGGIIKVHKIILSSSSEYFKkMFKNNFKENEINL---NIDYDSFNEVIKYIYTGKINITSNNVKDILSIAN 86

                         90
                 ....*....|....*
gi 8923885   101 YLKVEEVVTKCKIKM 115
Cdd:PHA03098  87 YLIIDFLINLCINYI 101

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 8923885    345 LKTHVRTHTGEKPYKCELCDKGFAQ 369
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885  354 GEKPYKCEL--CDKGFAQKCQLVFHsrMHHGEekpykcdvCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLT 431
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH--MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415

                ....*..
gi 8923885  432 YHvRRHT 438
Cdd:COG5189 416 YH-RKHS 421

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 8923885    401 NLKIHARKHSGEKPYVCDRCGQRFAQ 426
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|.
gi 8923885    304 CNTCGKVFSEASSLRRHMRIH 324
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 8923885    471 YICGICGKSFISSGELNKHFRSH 493
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    1 MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIY--RSTSENNVFLDQSQVKADGFQKLLE 78
Cdd:cd18194   1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYrdRLDKRDLVRLNSDIVTAPAFGLLLD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 8923885   79 FIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSS 126
Cdd:cd18194  81 FMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAEADST 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    1 MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYR---STSENNVFLDQSQVKADGFQKLL 77
Cdd:cd18956   1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRdrpAGGRDTVRLNGDIVTAPAFGRLL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 8923885   78 EFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMED 117
Cdd:cd18956  81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLRE 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    1 MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENN--VFLDQSQVKADGFQKLLE 78
Cdd:cd18323   1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRdlVCINNEIVTAPAFSLLLE 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 8923885   79 FIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKME 116
Cdd:cd18323  81 FMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    3 YSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFgaiyrstseNNVFLDQSQV------KADGFQKL 76
Cdd:cd18206   2 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYF---------RMLFVDQKDVvhldisNAAGLGQV 72

                        90       100       110
                ....*....|....*....|....*....|....*
gi 8923885   77 LEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18206  73 LEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTAC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQvkADGFQKLLEFIYTGTL 85
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESF--AEVFGLLLDFFYTGEL 78

                        90       100
                ....*....|....*....|....*..
gi 8923885   86 NLDSWNVKEIHQAADYLKVEEVVTKCK 112
Cdd:cd18232  79 ALTRENRDRVLLAAKELRVPEAVELCQ 105

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885      25 DCTIVIGEFQFKAHRNVLASFSEYFGAIY----RSTSENNVFLDQsqVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAAD 100
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFssdfKESDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*...
gi 8923885     101 YLKVEEVVTKCKIKMEDF 118
Cdd:smart00225  79 YLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIY-----RSTSENNV-FLDQSQVKadGFQKLLEF 79
Cdd:cd18201   4 YCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYcftnkESCDQTTVtHLDVVAVQ--GFSVILDF 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 8923885   80 IYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMED 117
Cdd:cd18201  82 MYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKD 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAI---YRSTSENNVFLDQSQVKADGFQKLLEFIYT 82
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLlshYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                        90       100       110
                ....*....|....*....|....*....|
gi 8923885   83 GTLNLDSWNVKEIHQAADYLKVEEVVTKCK 112
Cdd:cd18199  81 GKLSLTSQNVIEVMSAASYLQMTDVINVCK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQS--QVKADGFQKLLEFIYTG 83
Cdd:cd18192   4 HSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSnmKISAECFDLILQFMYLG 83

                        90       100
                ....*....|....*....|.
gi 8923885   84 TLNLDSWNVKEIHQAADYLKV 104
Cdd:cd18192  84 KIMTAPSDFEQLKVAMNYLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    4 SHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYrsTSENNVFLDQSQVKADGFQKLLEFIYTG 83
Cdd:cd18216   1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLV--LHDNLIHLDQDMVSPTVFQQILDFIYTG 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 8923885   84 TLnLDSW----NVKEIHQAADYLKVEEVVTKCKIKM 115
Cdd:cd18216  79 KL-LDSLfeepNLSEVLAAANYLQLPDLAALCRSKL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVfldQSQVKADG-----FQKLLEFI 80
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGES---ILTVKLDGldpdaVEVLVNYA 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 8923885   81 YTGTLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18306  78 YTSRLEVPADLVKSVYSAAKKLKMDRVKKAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLD-QSQVKADGFQKLLEFIYTGT 84
Cdd:cd18278  14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSlPEEVTARGFGPLLQFAYTAK 93

                        90       100
                ....*....|....*....|....*..
gi 8923885   85 LNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18278  94 LLLSRENIQEVIRCAEFLRMHNLEDSC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    4 SHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTG 83
Cdd:cd18213   2 SSHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPTDIQPDIFSYLLHIMYTG 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885   10 LLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIY----RSTSENNVFLDQSQVKADGFQKLLEFIYTGTL 85
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnynpPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                        90
                ....*....|....*..
gi 8923885   86 NLDSWNVKEIHQAADYL 102
Cdd:cd18245  81 KLSEDNIQDIVQAADLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    3 YSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRS---TSENNVFlDQSQVKADGFQKLLEF 79
Cdd:cd18198   5 FPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSgavVDQQNVY-EIDFVSPEALTALLEF 83

                        90       100       110
                ....*....|....*....|....*....|..
gi 8923885   80 IYTGTLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18198  84 AYTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYF---------GAIYRSTSENNVFLDQSQVKADGFQKL 76
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFrsklvgqasPRLVLVSPAGKCVLDLHHVTVTGFAPL 81

                        90       100       110
                ....*....|....*....|....*....|....*
gi 8923885   77 LEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18228  82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    1 MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTseNNVFLDQSQVKADGFQKLLEFI 80
Cdd:cd18225   1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDST--DTISIDASVVSPEEFALLLEMV 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 8923885   81 YTGTLNLDSWNVKEIHQAADYLKVEEVVTKCK 112
Cdd:cd18225  79 YTGKLPPGKHNFTKIISVADSLQMFDVAVSCK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQ--SQVKADGFQKLLEFIYTG 83
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTlpSGLEARGFQLLLDFMYTS 81

                        90       100
                ....*....|....*....|....*....
gi 8923885   84 TLNLDSWNVKEIHQAADYLKVEEVVTKCK 112
Cdd:cd18332  82 RLPLTPRTVPAVLAAATYLQMEHVVETCR 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    6 HCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRS--TSENNVFLDQSQVKADGFQKLLEFIYTG 83
Cdd:cd18242   4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSemSEKGKSEVELQGLTASTMEILLDFVYTE 83

                        90       100
                ....*....|....*....|....*...
gi 8923885   84 TLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18242  84 TVHVTVENVQELLPAACLLQLKGVKQAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923885    4 SHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGA--IYRSTSENNVFLDQsQVKADGFQKLLEFIY 81
Cdd:cd18277   8 SVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSriVGQADAELNITLPE-EVTVKGFEPLIQFAY 86