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Conserved domains on  [gi|27764875|ref|NP_062530|]
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beclin-1 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 265-443 2.89e-118

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


:

Pssm-ID: 461178  Cd Length: 176  Bit Score: 342.60  E-value: 2.89e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   265 TNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKS 344
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQGYKLVPMGSFSKIEKLDDDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   345 KELPLYCSGGL---RFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDtggsggsYSIKTQFNS-E 420
Cdd:pfam04111  81 QELELYGSGDFslgLFFSERKFDKAMVAFLDCLQQLGEFLEKLDPEFELPYKIDKDKGKIGD-------YSIKLQFNTsD 153

                         170       180
                  ....*....|....*....|...
gi 27764875   421 EQWTKALKFMLTNLKWGLAWVSS 443
Cdd:pfam04111 154 EEWTKALKFMLTNLKWLLAWVSS 176
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 133-259 2.12e-34

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


:

Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 124.63  E-value: 2.12e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   133 PLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENLEK 212
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLEKETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAELEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 27764875   213 VQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQL 259
Cdd:pfam17675  81 LEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
BH3 pfam15285
Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to ...
 103-127 1.93e-11

Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.


:

Pssm-ID: 464614  Cd Length: 25  Bit Score: 58.20  E-value: 1.93e-11
                          10        20
                  ....*....|....*....|....*
gi 27764875   103 DGGTMENLSRRLKVTGDLFDIMSGQ 127
Cdd:pfam15285   1 DGGTMDNLSHRLKVTGDLFDIMSGQ 25
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 265-443 2.89e-118

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 342.60  E-value: 2.89e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   265 TNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKS 344
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQGYKLVPMGSFSKIEKLDDDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   345 KELPLYCSGGL---RFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDtggsggsYSIKTQFNS-E 420
Cdd:pfam04111  81 QELELYGSGDFslgLFFSERKFDKAMVAFLDCLQQLGEFLEKLDPEFELPYKIDKDKGKIGD-------YSIKLQFNTsD 153

                         170       180
                  ....*....|....*....|...
gi 27764875   421 EQWTKALKFMLTNLKWGLAWVSS 443
Cdd:pfam04111 154 EEWTKALKFMLTNLKWLLAWVSS 176
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 133-259 2.12e-34

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 124.63  E-value: 2.12e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   133 PLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENLEK 212
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLEKETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAELEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 27764875   213 VQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQL 259
Cdd:pfam17675  81 LEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
BH3 pfam15285
Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to ...
 103-127 1.93e-11

Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.


Pssm-ID: 464614  Cd Length: 25  Bit Score: 58.20  E-value: 1.93e-11
                          10        20
                  ....*....|....*....|....*
gi 27764875   103 DGGTMENLSRRLKVTGDLFDIMSGQ 127
Cdd:pfam15285   1 DGGTMDNLSHRLKVTGDLFDIMSGQ 25
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
143-266 5.33e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.36  E-value: 5.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875 143 LDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEerliQELEDVEKNRKVVAENLEKVQAEAERLDQ 222
Cdd:COG4372  54 LEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQ----EELESLQEEAEELQEELEELQKERQDLEQ 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 27764875 223 EEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTN 266
Cdd:COG4372 130 QRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL 173
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 265-443 2.89e-118

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 342.60  E-value: 2.89e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   265 TNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKS 344
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQGYKLVPMGSFSKIEKLDDDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   345 KELPLYCSGGL---RFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDtggsggsYSIKTQFNS-E 420
Cdd:pfam04111  81 QELELYGSGDFslgLFFSERKFDKAMVAFLDCLQQLGEFLEKLDPEFELPYKIDKDKGKIGD-------YSIKLQFNTsD 153

                         170       180
                  ....*....|....*....|...
gi 27764875   421 EQWTKALKFMLTNLKWGLAWVSS 443
Cdd:pfam04111 154 EEWTKALKFMLTNLKWLLAWVSS 176
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 133-259 2.12e-34

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 124.63  E-value: 2.12e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875   133 PLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENLEK 212
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLEKETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAELEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 27764875   213 VQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQL 259
Cdd:pfam17675  81 LEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
BH3 pfam15285
Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to ...
 103-127 1.93e-11

Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.


Pssm-ID: 464614  Cd Length: 25  Bit Score: 58.20  E-value: 1.93e-11
                          10        20
                  ....*....|....*....|....*
gi 27764875   103 DGGTMENLSRRLKVTGDLFDIMSGQ 127
Cdd:pfam15285   1 DGGTMDNLSHRLKVTGDLFDIMSGQ 25
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
143-266 5.33e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.36  E-value: 5.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875 143 LDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEerliQELEDVEKNRKVVAENLEKVQAEAERLDQ 222
Cdd:COG4372  54 LEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQ----EELESLQEEAEELQEELEELQKERQDLEQ 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 27764875 223 EEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTN 266
Cdd:COG4372 130 QRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL 173
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 194-267 9.62e-04

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 41.21  E-value: 9.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27764875   194 QELEDVEKNRKVVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTNV 267
Cdd:pfam12777  33 QKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKACEEDLAKAEPALLAAQAALDTLNKNNL 106
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 143-264 9.78e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 9.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27764875 143 LDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEerliQELEDVEKNRKVVAENLEKVQAEAERLDQ 222
Cdd:COG1196 297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELE----EELEEAEEELEEAEAELAEAEEALLEAEA 372

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 27764875 223 EEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKK 264
Cdd:COG1196 373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLE 414
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
194-264 8.02e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.34  E-value: 8.02e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27764875 194 QELEDVEKNRKVVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKK 264
Cdd:COG4372  52 EELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQK 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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