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Conserved domains on  [gi|124378037|ref|NP_064357|]
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protein SON isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rne super family cl35953
ribonuclease E; Reviewed
 1323-1501 2.46e-10

ribonuclease E; Reviewed


The actual alignment was detected with superfamily member PRK10811:

Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 66.22  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1323 PAVTISQPAENSLELPSMTVPAPstmTTTESPVVAVTEippVAVPEPPIMAVPELPTMAVVKTPAVAVPEPLVAAPEPPT 1402
Cdd:PRK10811  846 PVVRPQDVQVEEQREAEEVQVQP---VVAEVPVAAAVE---PVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEV 919

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1403 MATPelcslsvseppvaVSELPALADPEHAITAVSGVSSLEPSVPILEPAVSVLQPV----MIVSEPSVPVQEPTVAVSE 1478
Cdd:PRK10811  920 IAAP-------------VTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAetaeVVVAEPEVVAQPAAPVVAE 986

                         170       180
                  ....*....|....*....|...
gi 124378037 1479 PAVIVSEHtqiTSPEMAVESSPV 1501
Cdd:PRK10811  987 VAAEVETV---TAVEPEVAPAQV 1006
PspC_subgroup_2 super family cl41463
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 173-456 2.95e-08

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


The actual alignment was detected with superfamily member NF033839:

Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 59.01  E-value: 2.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  173 GLSEASETALVLEPPVVSMEVQESHVLETLKPATKAA---ELSVVSTSVISEQSEQPMPGmLEPSMTKILDSFTaaPVPM 249
Cdd:NF033839  146 DSSSSSSSGSSTKPETPQPENPEHQKPTTPAPDTKPSpqpEGKKPSVPDINQEKEKAKLA-VATYMSKILDDIQ--KHHL 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  250 STAALKSPEPVVTMSVEYQKSVLKSLETMPPETSKTTLVELPIAKV--VEPSETLTIVSETPTE-VHPEPS---PSTMDF 323
Cdd:NF033839  223 QKEKHRQIVALIKELDELKKQALSEIDNVNTKVEIENTVHKIFADMdaVVTKFKKGLTQDTPKEpGNKKPSapkPGMQPS 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  324 PESSTTDVQRLPEQPVEAPSEIADSSMTRPQESLELPKTTA---VELQESTVASALELPGPPATSILELQGPPVTPVPEL 400
Cdd:NF033839  303 PQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVkpqLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPET 382

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124378037  401 PGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVTPVPQLSQE--LPGPPAPSM 456
Cdd:NF033839  383 PKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPevKPQPEKPKP 440
PHA03379 super family cl33730
EBNA-3A; Provisional
 333-641 8.31e-05

EBNA-3A; Provisional


The actual alignment was detected with superfamily member PHA03379:

Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 47.75  E-value: 8.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  333 RLPEQPVEAPSEIADSSMTRPQESLELPKTTAVE-LQESTVASALELPGPPATSILElQGP---------------PVTP 396
Cdd:PHA03379  396 KLTERAREALEKASEPTYGTPRPPVEKPRPEVPQsLETATSHGSAQVPEPPPVHDLE-PGPlhdqhsmapcpvaqlPPGP 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  397 VPEL------------PGPSATPVPELSGPLSTP----VPELPG-PPATVVPELPGPSVTPVPQLSQELPGPPAPSMGLE 459
Cdd:PHA03379  475 LQDLepgdqlpgvvqdGRPACAPVPAPAGPIVRPweasLSQVPGvAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAM 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  460 PPQEVPEPPVMAQELSGVPAVS-------AAIELTGQPA----------VTVAMELTEQPVTTTE--FEQPVAMTTVEHP 520
Cdd:PHA03379  555 QGPGETSGIVRVRERWRPAPWTpnpprspSQMSVRDRLArlraeaqpyqASVEVQPPQLTQVSPQqpMEYPLEPEQQMFP 634

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  521 GHP-----EVTTATGL--LGQPEAAMVLELP---GQPVATTALELSGQPSVTG-------VPELSGLPSATRALELSGQS 583
Cdd:PHA03379  635 GSPfsqvaDVMRAGGVpaMQPQYFDLPLQQPisqGAPLAPLRASMGPVPPVPAtqpqyfdIPLTEPINQGASAAHFLPQQ 714

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124378037  584 VATGALeLPGQLMATGALEFSGQSGAAGALELLGQPLATGVLElpGQPGAPELPGQPV 641
Cdd:PHA03379  715 PMEGPL-VPERWMFQGATLSQSVRPGVAQSQYFDLPLTQPINH--GAPAAHFLHQPPM 769
rne super family cl35953
ribonuclease E; Reviewed
 1191-1393 2.82e-04

ribonuclease E; Reviewed


The actual alignment was detected with superfamily member PRK10811:

Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.19  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1191 TEVTLSTGESLSQPEPPVSQSEISEPMAVPAnysmsesETSMLASEAVMTVPEPAREPEssVTSAPVESAVVAEHEMVPE 1270
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAA-------VEPVVSAPVVEAVAEVVEEPV--VVAEPQPEEVVVVETTHPE 918

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1271 rpmtymVSETTMSVEPAVLT-SEASVISETSETydsmrpsGHAISEVtmsllEPAVTISQPAENSLElpsMTVPAPSTMT 1349
Cdd:PRK10811  919 ------VIAAPVTEQPQVITeSDVAVAQEVAEH-------AEPVVEP-----QDETADIEEAAETAE---VVVAEPEVVA 977

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124378037 1350 TTESPVVAVTEIPPVAVPEPPIMAVPELPTMAVV----------KTPAVA-VPEP 1393
Cdd:PRK10811  978 QPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVehnhatapmtRAPAPEyVPEA 1032
 
Name Accession Description Interval E-value
rne PRK10811
ribonuclease E; Reviewed
 1323-1501 2.46e-10

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 66.22  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1323 PAVTISQPAENSLELPSMTVPAPstmTTTESPVVAVTEippVAVPEPPIMAVPELPTMAVVKTPAVAVPEPLVAAPEPPT 1402
Cdd:PRK10811  846 PVVRPQDVQVEEQREAEEVQVQP---VVAEVPVAAAVE---PVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEV 919

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1403 MATPelcslsvseppvaVSELPALADPEHAITAVSGVSSLEPSVPILEPAVSVLQPV----MIVSEPSVPVQEPTVAVSE 1478
Cdd:PRK10811  920 IAAP-------------VTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAetaeVVVAEPEVVAQPAAPVVAE 986

                         170       180
                  ....*....|....*....|...
gi 124378037 1479 PAVIVSEHtqiTSPEMAVESSPV 1501
Cdd:PRK10811  987 VAAEVETV---TAVEPEVAPAQV 1006
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 173-456 2.95e-08

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 59.01  E-value: 2.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  173 GLSEASETALVLEPPVVSMEVQESHVLETLKPATKAA---ELSVVSTSVISEQSEQPMPGmLEPSMTKILDSFTaaPVPM 249
Cdd:NF033839  146 DSSSSSSSGSSTKPETPQPENPEHQKPTTPAPDTKPSpqpEGKKPSVPDINQEKEKAKLA-VATYMSKILDDIQ--KHHL 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  250 STAALKSPEPVVTMSVEYQKSVLKSLETMPPETSKTTLVELPIAKV--VEPSETLTIVSETPTE-VHPEPS---PSTMDF 323
Cdd:NF033839  223 QKEKHRQIVALIKELDELKKQALSEIDNVNTKVEIENTVHKIFADMdaVVTKFKKGLTQDTPKEpGNKKPSapkPGMQPS 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  324 PESSTTDVQRLPEQPVEAPSEIADSSMTRPQESLELPKTTA---VELQESTVASALELPGPPATSILELQGPPVTPVPEL 400
Cdd:NF033839  303 PQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVkpqLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPET 382

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124378037  401 PGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVTPVPQLSQE--LPGPPAPSM 456
Cdd:NF033839  383 PKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPevKPQPEKPKP 440
PHA03247 PHA03247
large tegument protein UL36; Provisional
 233-482 1.53e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  233 PSMTKILDSFTAAPVPMSTAALKSPEPVVTMSVEYQKSVlksleTMPPETSKTTLVELPIAKVVEPSETLTIVSETPTEV 312
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL-----PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  313 HPEPSPSTMDFPESSTT---------DVQRLP--EQPV---EAPSEIADSSMTRPQeslelpkttaveLQESTVASALEL 378
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPlggsvapggDVRRRPpsRSPAakpAAPARPPVRRLARPA------------VSRSTESFALPP 2902

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  379 PGPPATSILELQGPPVTPVPELPGPSATPVPElsgplSTPVPELPGPPATVVPELPGPS-VTPVPQLSQELPG------- 450
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP-----PPPRPQPPLAPTTDPAGAGEPSgAVPQPWLGALVPGrvavprf 2977

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 124378037  451 ---PPAPSMgleppqEVPEPPVMAQELSGVPAVSA 482
Cdd:PHA03247 2978 rvpQPAPSR------EAPASSTPPLTGHSLSRVSS 3006
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 209-454 1.27e-05

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 50.15  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  209 AELSVVSTSVISEQSEQPMPGMLEPSMTKILDSFTA-APVPMSTAALKSPEPVVTMSVEYQKSVLKSlETMPPETSKTTL 287
Cdd:NF033839  246 SEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQdTPKEPGNKKPSAPKPGMQPSPQPEKKEVKP-EPETPKPEVKPQ 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  288 VELPIAKVVEPSETltivseTPTEVHPE---PSPSTMDFPESSTTDVQRLPEQPVEAPSEIADSSMTRPQESLELPK--- 361
Cdd:NF033839  325 LEKPKPEVKPQPEK------PKPEVKPQletPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKpev 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  362 TTAVELQESTVASALELPGPPATSILELQGPPVTPVPELPGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVTPV 441
Cdd:NF033839  399 KPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQ 478

                         250
                  ....*....|...
gi 124378037  442 PQLSQELPGPPAP 454
Cdd:NF033839  479 PEKPKPDNSKPQA 491
PHA03379 PHA03379
EBNA-3A; Provisional
 333-641 8.31e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 47.75  E-value: 8.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  333 RLPEQPVEAPSEIADSSMTRPQESLELPKTTAVE-LQESTVASALELPGPPATSILElQGP---------------PVTP 396
Cdd:PHA03379  396 KLTERAREALEKASEPTYGTPRPPVEKPRPEVPQsLETATSHGSAQVPEPPPVHDLE-PGPlhdqhsmapcpvaqlPPGP 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  397 VPEL------------PGPSATPVPELSGPLSTP----VPELPG-PPATVVPELPGPSVTPVPQLSQELPGPPAPSMGLE 459
Cdd:PHA03379  475 LQDLepgdqlpgvvqdGRPACAPVPAPAGPIVRPweasLSQVPGvAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAM 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  460 PPQEVPEPPVMAQELSGVPAVS-------AAIELTGQPA----------VTVAMELTEQPVTTTE--FEQPVAMTTVEHP 520
Cdd:PHA03379  555 QGPGETSGIVRVRERWRPAPWTpnpprspSQMSVRDRLArlraeaqpyqASVEVQPPQLTQVSPQqpMEYPLEPEQQMFP 634

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  521 GHP-----EVTTATGL--LGQPEAAMVLELP---GQPVATTALELSGQPSVTG-------VPELSGLPSATRALELSGQS 583
Cdd:PHA03379  635 GSPfsqvaDVMRAGGVpaMQPQYFDLPLQQPisqGAPLAPLRASMGPVPPVPAtqpqyfdIPLTEPINQGASAAHFLPQQ 714

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124378037  584 VATGALeLPGQLMATGALEFSGQSGAAGALELLGQPLATGVLElpGQPGAPELPGQPV 641
Cdd:PHA03379  715 PMEGPL-VPERWMFQGATLSQSVRPGVAQSQYFDLPLTQPINH--GAPAAHFLHQPPM 769
rne PRK10811
ribonuclease E; Reviewed
 1191-1393 2.82e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.19  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1191 TEVTLSTGESLSQPEPPVSQSEISEPMAVPAnysmsesETSMLASEAVMTVPEPAREPEssVTSAPVESAVVAEHEMVPE 1270
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAA-------VEPVVSAPVVEAVAEVVEEPV--VVAEPQPEEVVVVETTHPE 918

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1271 rpmtymVSETTMSVEPAVLT-SEASVISETSETydsmrpsGHAISEVtmsllEPAVTISQPAENSLElpsMTVPAPSTMT 1349
Cdd:PRK10811  919 ------VIAAPVTEQPQVITeSDVAVAQEVAEH-------AEPVVEP-----QDETADIEEAAETAE---VVVAEPEVVA 977

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124378037 1350 TTESPVVAVTEIPPVAVPEPPIMAVPELPTMAVV----------KTPAVA-VPEP 1393
Cdd:PRK10811  978 QPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVehnhatapmtRAPAPEyVPEA 1032
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1272-1511 5.36e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.29  E-value: 5.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  1272 PMTYMVSETTMSVEPAVLTSEASVISETSETYDSMRPSGHAISEVTMSLLEPA---VTISQPAEN--SLELPSMTVPAPS 1346
Cdd:pfam05109  400 PKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSThvpTNLTAPASTgpTVSTADVTSPTPA 479

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  1347 TMTTTESPVVAvteiPPVAVPEPPIMAVPEL--PTMAVVK-TPAVAVPEPLVAAPEP----PTMATPELCSLSVSEPPVA 1419
Cdd:pfam05109  480 GTTSGASPVTP----SPSPRDNGTESKAPDMtsPTSAVTTpTPNATSPTPAVTTPTPnatsPTLGKTSPTSAVTTPTPNA 555

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  1420 VSELPALADPEhaitavsgvsslePSVPIlePAVSVLQPVMIVSEPSVPVQEPTVAVSEPAVIVSEHT-QITSPEMAVES 1498
Cdd:pfam05109  556 TSPTPAVTTPT-------------PNATI--PTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTlGGTSSTPVVTS 620

                          250
                   ....*....|...
gi 124378037  1499 SPVIVDSSVMSSQ 1511
Cdd:pfam05109  621 PPKNATSAVTTGQ 633
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 82-574 2.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037    82 DLKEASRKSRCVSV--QTDPTDEVPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESE--SKLKSHHDGNLESDSFLKFD 157
Cdd:pfam03154   38 DLRSSGRNSPSAAStsSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGASDTEEPEraTAKKSKTQEISRPNSPSEGE 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   158 SEPSAAALEHPVRAFGLSEASETALVLEPPVVSMEVQESHvletlkpATKAAELSVVSTSVISEQSEQPMPGMLEPSMTK 237
Cdd:pfam03154  118 GESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESD-------SDSSAQQQILQTQPPVLQAQSGAASPPSPPPPG 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   238 ILDSFTAAPVPMSTAALKSPEPVVTMSVEYQKSvlksleTMPPETSKTTLVELPIAKVVEPSETLTIV------SETPTE 311
Cdd:pfam03154  191 TTQAATAGPTPSAPSVPPQGSPATSQPPNQTQS------TAAPHTLIQQTPTLHPQRLPSPHPPLQPMtqppppSQVSPQ 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   312 VHPEPSPSTMDFP-----ESSTTDVQR-LPEQPVEAPSEIADS------SMTRPQESLELPKTTAVELQESTVASALELP 379
Cdd:pfam03154  265 PLPQPSLHGQMPPmphslQTGPSHMQHpVPPQPFPLTPQSSQSqvppgpSPAAPGQSQQRIHTPPSQSQLQSQQPPREQP 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   380 GPPA-TSILELQGPPVTPVPELPGPSATPVP-ELSGPLSTPVP-ELPGPPA----TVVPELPGPSVTPVP-QL---SQEL 448
Cdd:pfam03154  345 LPPApLSMPHIKPPPTTPIPQLPNPQSHKHPpHLSGPSPFQMNsNLPPPPAlkplSSLSTHHPPSAHPPPlQLmpqSQQL 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   449 PGPPAPSMGLEPPQEVPEPPVMAQELSGVPAVSAAIELTGQPAVTVAMELTEQPvTTTEFEQPVAMTTVEHPGHPEVTTA 528
Cdd:pfam03154  425 PPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPP-SGPPTSTSSAMPGIQPPSSASVSSS 503

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 124378037   529 TGLLGQPEAAmvleLPGQPVATTALELSGQPSVTGVPELSGLPSAT 574
Cdd:pfam03154  504 GPVPAAVSCP----LPPVQIKEEALDEAEEPESPPPPPRSPSPEPT 545
 
Name Accession Description Interval E-value
rne PRK10811
ribonuclease E; Reviewed
 1323-1501 2.46e-10

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 66.22  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1323 PAVTISQPAENSLELPSMTVPAPstmTTTESPVVAVTEippVAVPEPPIMAVPELPTMAVVKTPAVAVPEPLVAAPEPPT 1402
Cdd:PRK10811  846 PVVRPQDVQVEEQREAEEVQVQP---VVAEVPVAAAVE---PVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEV 919

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1403 MATPelcslsvseppvaVSELPALADPEHAITAVSGVSSLEPSVPILEPAVSVLQPV----MIVSEPSVPVQEPTVAVSE 1478
Cdd:PRK10811  920 IAAP-------------VTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAetaeVVVAEPEVVAQPAAPVVAE 986

                         170       180
                  ....*....|....*....|...
gi 124378037 1479 PAVIVSEHtqiTSPEMAVESSPV 1501
Cdd:PRK10811  987 VAAEVETV---TAVEPEVAPAQV 1006
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 173-456 2.95e-08

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 59.01  E-value: 2.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  173 GLSEASETALVLEPPVVSMEVQESHVLETLKPATKAA---ELSVVSTSVISEQSEQPMPGmLEPSMTKILDSFTaaPVPM 249
Cdd:NF033839  146 DSSSSSSSGSSTKPETPQPENPEHQKPTTPAPDTKPSpqpEGKKPSVPDINQEKEKAKLA-VATYMSKILDDIQ--KHHL 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  250 STAALKSPEPVVTMSVEYQKSVLKSLETMPPETSKTTLVELPIAKV--VEPSETLTIVSETPTE-VHPEPS---PSTMDF 323
Cdd:NF033839  223 QKEKHRQIVALIKELDELKKQALSEIDNVNTKVEIENTVHKIFADMdaVVTKFKKGLTQDTPKEpGNKKPSapkPGMQPS 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  324 PESSTTDVQRLPEQPVEAPSEIADSSMTRPQESLELPKTTA---VELQESTVASALELPGPPATSILELQGPPVTPVPEL 400
Cdd:NF033839  303 PQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVkpqLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPET 382

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124378037  401 PGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVTPVPQLSQE--LPGPPAPSM 456
Cdd:NF033839  383 PKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPevKPQPEKPKP 440
PHA03247 PHA03247
large tegument protein UL36; Provisional
 233-482 1.53e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  233 PSMTKILDSFTAAPVPMSTAALKSPEPVVTMSVEYQKSVlksleTMPPETSKTTLVELPIAKVVEPSETLTIVSETPTEV 312
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL-----PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  313 HPEPSPSTMDFPESSTT---------DVQRLP--EQPV---EAPSEIADSSMTRPQeslelpkttaveLQESTVASALEL 378
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPlggsvapggDVRRRPpsRSPAakpAAPARPPVRRLARPA------------VSRSTESFALPP 2902

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  379 PGPPATSILELQGPPVTPVPELPGPSATPVPElsgplSTPVPELPGPPATVVPELPGPS-VTPVPQLSQELPG------- 450
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP-----PPPRPQPPLAPTTDPAGAGEPSgAVPQPWLGALVPGrvavprf 2977

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 124378037  451 ---PPAPSMgleppqEVPEPPVMAQELSGVPAVSA 482
Cdd:PHA03247 2978 rvpQPAPSR------EAPASSTPPLTGHSLSRVSS 3006
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1299-1502 9.59e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 51.24  E-value: 9.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1299 TSETYDSMRP--SGHAISEvTMSLLEPAVTISQPAENSLELPSMTVPAPSTMTTTESPVVAVTEIPPVAVPEPPIMAVPE 1376
Cdd:PRK10263  300 TQPEYDEYDPllNGAPITE-PVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPE 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1377 -LPTMAVVKTPAVAVPEPLvAAPEPPTMATPELCSLSVSEPPVAVSELPALADPEHAITAVSGVSSLEPSVPilEPAVSV 1455
Cdd:PRK10263  379 gYPQQSQYAQPAVQYNEPL-QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQA--EEQQST 455

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 124378037 1456 LQPvmivsepsVPVQEPTVAVSEPAVIVSEHT--QITSPEMAVESSPVI 1502
Cdd:PRK10263  456 FAP--------QSTYQTEQTYQQPAAQEPLYQqpQPVEQQPVVEPEPVV 496
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 209-454 1.27e-05

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 50.15  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  209 AELSVVSTSVISEQSEQPMPGMLEPSMTKILDSFTA-APVPMSTAALKSPEPVVTMSVEYQKSVLKSlETMPPETSKTTL 287
Cdd:NF033839  246 SEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQdTPKEPGNKKPSAPKPGMQPSPQPEKKEVKP-EPETPKPEVKPQ 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  288 VELPIAKVVEPSETltivseTPTEVHPE---PSPSTMDFPESSTTDVQRLPEQPVEAPSEIADSSMTRPQESLELPK--- 361
Cdd:NF033839  325 LEKPKPEVKPQPEK------PKPEVKPQletPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKpev 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  362 TTAVELQESTVASALELPGPPATSILELQGPPVTPVPELPGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVTPV 441
Cdd:NF033839  399 KPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQ 478

                         250
                  ....*....|...
gi 124378037  442 PQLSQELPGPPAP 454
Cdd:NF033839  479 PEKPKPDNSKPQA 491
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 1318-1495 2.08e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 49.86  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1318 MSLL-----EPAVTISQPAENSLELPSMTVPAPSTMTTTESPVVAVTEIPPVAVPEPPIMAVPelptmavvktPAVAVPE 1392
Cdd:PRK07994  351 MTLLrmlafHPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAV----------PLPETTS 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1393 PLVAAPEPPTMATPELcSLSVSEPPVAVSELPAlADPEHAITAVSGVSSLEPSVPILEPAVSVlqpvmivsEPSVPVQEP 1472
Cdd:PRK07994  421 QLLAARQQLQRAQGAT-KAKKSEPAAASRARPV-NSALERLASVRPAPSALEKAPAKKEAYRW--------KATNPVEVK 490

                         170       180
                  ....*....|....*....|...
gi 124378037 1473 TVAVSEPAVIVSEHTQITSPEMA 1495
Cdd:PRK07994  491 KEPVATPKALKKALEHEKTPELA 513
rne PRK10811
ribonuclease E; Reviewed
 1311-1492 2.15e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 50.04  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1311 HAISEVTMSLLEPAVTISQPAEnsleLPSMTVPAPSTMTTTESPVVAVTEIPPVAVPEPPIMAV-PELPTMAVVKTPAVA 1389
Cdd:PRK10811  856 EEQREAEEVQVQPVVAEVPVAA----AVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETThPEVIAAPVTEQPQVI 931

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1390 VPEPLVAAPEPPTMATPelcslsVSEPPVAVSELPALADPEHAITAVSGVSSLEPSVPILEPAVSVLQPvmivsepsvPV 1469
Cdd:PRK10811  932 TESDVAVAQEVAEHAEP------VVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETV---------TA 996

                         170       180
                  ....*....|....*....|...
gi 124378037 1470 QEPTVAVSEPAVIVSEHTQITSP 1492
Cdd:PRK10811  997 VEPEVAPAQVPEATVEHNHATAP 1019
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1363-1481 3.73e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.94  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1363 PVAVPEPPIMAVPELPTMAVVKTPAvAVPEPLVAAPEPPTMATPELCSLSVSEPPVAVSE---LPALADPEHAITAVSGV 1439
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPA-AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPApvaAPAAAAPAAAPAAAPAA 444

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 124378037 1440 SSLEPSVPILEPAVSVLQPVMIVSEPSVPVQEPTVAVSEPAV 1481
Cdd:PRK14951  445 VALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAA 486
PHA03247 PHA03247
large tegument protein UL36; Provisional
 203-520 3.84e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 3.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  203 KPATKAAELSVVSTSVISEQSEQPMPGMLEPSMTKildsfTAAPVPMSTAALKSPEPVVTmsveyqksvlksLETMPPET 282
Cdd:PHA03247 2682 RPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALV-----SATPLPPGPAAARQASPALP------------AAPAPPAV 2744

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  283 SKTTLVELPIAKVVEPSETLTIVSETPTEVHPEPSPSTMDFPESSTTDVQR--LPEQPVEAPSEIADSSMTRPQESLELP 360
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESResLPSPWDPADPPAAVLAPAAALPPAASP 2824

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  361 KTTAVELQESTVASALELPGPPATSI-----------LELQGPPVTPVPELPGPSATPVPELSGPLSTPVPELPGPPATV 429
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPPGPPPPSLplggsvapggdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ 2904

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  430 VPELPGPSVTPVPQLSQELPGPPAPSMGLEPPQEVPEPPVMAQELSGVPAVSAAIELTGQPA-----VTVAMELTEQPVT 504
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAlvpgrVAVPRFRVPQPAP 2984

                         330
                  ....*....|....*.
gi 124378037  505 TTEFEQPVAMTTVEHP 520
Cdd:PHA03247 2985 SREAPASSTPPLTGHS 3000
PHA03379 PHA03379
EBNA-3A; Provisional
 333-641 8.31e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 47.75  E-value: 8.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  333 RLPEQPVEAPSEIADSSMTRPQESLELPKTTAVE-LQESTVASALELPGPPATSILElQGP---------------PVTP 396
Cdd:PHA03379  396 KLTERAREALEKASEPTYGTPRPPVEKPRPEVPQsLETATSHGSAQVPEPPPVHDLE-PGPlhdqhsmapcpvaqlPPGP 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  397 VPEL------------PGPSATPVPELSGPLSTP----VPELPG-PPATVVPELPGPSVTPVPQLSQELPGPPAPSMGLE 459
Cdd:PHA03379  475 LQDLepgdqlpgvvqdGRPACAPVPAPAGPIVRPweasLSQVPGvAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAM 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  460 PPQEVPEPPVMAQELSGVPAVS-------AAIELTGQPA----------VTVAMELTEQPVTTTE--FEQPVAMTTVEHP 520
Cdd:PHA03379  555 QGPGETSGIVRVRERWRPAPWTpnpprspSQMSVRDRLArlraeaqpyqASVEVQPPQLTQVSPQqpMEYPLEPEQQMFP 634

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  521 GHP-----EVTTATGL--LGQPEAAMVLELP---GQPVATTALELSGQPSVTG-------VPELSGLPSATRALELSGQS 583
Cdd:PHA03379  635 GSPfsqvaDVMRAGGVpaMQPQYFDLPLQQPisqGAPLAPLRASMGPVPPVPAtqpqyfdIPLTEPINQGASAAHFLPQQ 714

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124378037  584 VATGALeLPGQLMATGALEFSGQSGAAGALELLGQPLATGVLElpGQPGAPELPGQPV 641
Cdd:PHA03379  715 PMEGPL-VPERWMFQGATLSQSVRPGVAQSQYFDLPLTQPINH--GAPAAHFLHQPPM 769
rne PRK10811
ribonuclease E; Reviewed
 1354-1503 1.15e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 47.34  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1354 PVVAVTEIPPVAVPEPPimavpelptmAVVKTPAVAVPEPLVAAPEPPTMATPELCSLSVSEPPVAVSELPALADP-EHA 1432
Cdd:PRK10811  846 PVVRPQDVQVEEQREAE----------EVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVvETT 915

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124378037 1433 ITAVSGVSSLEPSVPILEPAVSVLQPVMIVSEPSVPVQEPTVAVSEPA----VIVSEHTQITSPEMAVESSPVIV 1503
Cdd:PRK10811  916 HPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAetaeVVVAEPEVVAQPAAPVVAEVAAE 990
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 315-672 1.23e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  315 EPSPSTMDFPESSTTDVQRLPeQPVEAPSEIADSSMTRPQESL---ELPKTTAVELQESTVASALELP-GPPATSILELQ 390
Cdd:PHA03307    2 DNAPDLYDLIEAAAEGGEFFP-RPPATPGDAADDLLSGSQGQLvsdSAELAAVTVVAGAAACDRFEPPtGPPPGPGTEAP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  391 GPPVTPVPELPGPSATPVPELSGPLSTP--VPELPGPPATVVPELPGPSvtPVPQLSQELPGPPAPSmgleppqeVPEPP 468
Cdd:PHA03307   81 ANESRSTPTWSLSTLAPASPAREGSPTPpgPSSPDPPPPTPPPASPPPS--PAPDLSEMLRPVGSPG--------PPPAA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  469 VMAQELSGVPAVSAAIELTGQPAVTVAM-ELTEQPVTTTEFEQPVAMTTVEHPGHPEVttatglLGQPEAAMVLELPGQP 547
Cdd:PHA03307  151 SPPAAGASPAAVASDAASSRQAALPLSSpEETARAPSSPPAEPPPSTPPAAASPRPPR------RSSPISASASSPAPAP 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  548 VATTALELSGQPSVTGVPELSGLPSATRAlELSGQSVATGALELPGQLMATGALEFSG---QSGAAGALELLGQPlatgv 624
Cdd:PHA03307  225 GRSAADDAGASSSDSSSSESSGCGWGPEN-ECPLPRPAPITLPTRIWEASGWNGPSSRpgpASSSSSPRERSPSP----- 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 124378037  625 leLPGQPGAPELPGQPVAtVALEISVQSVVTTSELSTMTVSQSLEVPS 672
Cdd:PHA03307  299 --SPSSPGSGPAPSSPRA-SSSSSSSRESSSSSTSSSSESSRGAAVSP 343
PHA03247 PHA03247
large tegument protein UL36; Provisional
 247-516 1.74e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  247 VPMSTAALKSPEPVVTmsveyqksvlkSLETMPPETSKTTLVELPIAKVVEPSETLTIVSETPTEVHPEPSPSTMDFPES 326
Cdd:PHA03247 2568 VPPPRPAPRPSEPAVT-----------SRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN 2636

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  327 STTDVQRLPEQPVEAPSEIADSSMTRPqeslelPKTTAVELQESTVASALELPGPPAT-----SILELQGPPVTPVPELP 401
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSR------PRRARRLGRAAQASSPPQRPRRRAArptvgSLTSLADPPPPPPTPEP 2710

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  402 GP----SATPVPELSG------------PLSTPVPELPG----------PPATVVPELPGPSVTPVPQLSQELPGPPAPS 455
Cdd:PHA03247 2711 APhalvSATPLPPGPAaarqaspalpaaPAPPAVPAGPAtpggparparPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124378037  456 MGLEPPQEVPEPPVmAQELSGVPAVSAAIELTGQPAVTVAMELTEQPVTTTEFEQPVAMTT 516
Cdd:PHA03247 2791 LSESRESLPSPWDP-ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850
rne PRK10811
ribonuclease E; Reviewed
 1191-1393 2.82e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.19  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1191 TEVTLSTGESLSQPEPPVSQSEISEPMAVPAnysmsesETSMLASEAVMTVPEPAREPEssVTSAPVESAVVAEHEMVPE 1270
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAA-------VEPVVSAPVVEAVAEVVEEPV--VVAEPQPEEVVVVETTHPE 918

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1271 rpmtymVSETTMSVEPAVLT-SEASVISETSETydsmrpsGHAISEVtmsllEPAVTISQPAENSLElpsMTVPAPSTMT 1349
Cdd:PRK10811  919 ------VIAAPVTEQPQVITeSDVAVAQEVAEH-------AEPVVEP-----QDETADIEEAAETAE---VVVAEPEVVA 977

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124378037 1350 TTESPVVAVTEIPPVAVPEPPIMAVPELPTMAVV----------KTPAVA-VPEP 1393
Cdd:PRK10811  978 QPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVehnhatapmtRAPAPEyVPEA 1032
rne PRK10811
ribonuclease E; Reviewed
 1213-1418 3.43e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 45.80  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1213 ISEPMAVPANYSMSESETSMLASEAVMTVPEPAREPESSVTSAPVESAVVAehemVPERPMTymVSETTMSVEPAVLTSE 1292
Cdd:PRK10811  843 IRYPVVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAE----VVEEPVV--VAEPQPEEVVVVETTH 916

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1293 ASVISETSETydsmrpSGHAISEVTMSLLEPAVTISQPAEnslelpsmtvpapsTMTTTESPVVAVTEIPPVAVPEPPim 1372
Cdd:PRK10811  917 PEVIAAPVTE------QPQVITESDVAVAQEVAEHAEPVV--------------EPQDETADIEEAAETAEVVVAEPE-- 974

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 124378037 1373 avpelptmAVVKTPAVAVPEPLVAAPEPPTmATPELCSLSVSEPPV 1418
Cdd:PRK10811  975 --------VVAQPAAPVVAEVAAEVETVTA-VEPEVAPAQVPEATV 1011
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1272-1511 5.36e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.29  E-value: 5.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  1272 PMTYMVSETTMSVEPAVLTSEASVISETSETYDSMRPSGHAISEVTMSLLEPA---VTISQPAEN--SLELPSMTVPAPS 1346
Cdd:pfam05109  400 PKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSThvpTNLTAPASTgpTVSTADVTSPTPA 479

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  1347 TMTTTESPVVAvteiPPVAVPEPPIMAVPEL--PTMAVVK-TPAVAVPEPLVAAPEP----PTMATPELCSLSVSEPPVA 1419
Cdd:pfam05109  480 GTTSGASPVTP----SPSPRDNGTESKAPDMtsPTSAVTTpTPNATSPTPAVTTPTPnatsPTLGKTSPTSAVTTPTPNA 555

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  1420 VSELPALADPEhaitavsgvsslePSVPIlePAVSVLQPVMIVSEPSVPVQEPTVAVSEPAVIVSEHT-QITSPEMAVES 1498
Cdd:pfam05109  556 TSPTPAVTTPT-------------PNATI--PTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTlGGTSSTPVVTS 620

                          250
                   ....*....|...
gi 124378037  1499 SPVIVDSSVMSSQ 1511
Cdd:pfam05109  621 PPKNATSAVTTGQ 633
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1317-1500 1.18e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1317 TMSLL-----EPAVTI-SQPAENSLELPSMTVPAPSTMTTTESPVVAVTEIPPVAVPePPIMAVPE--LPTMAVVKTPAV 1388
Cdd:PRK07003  349 TMTLLrmlafEPAVTGgGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGA-AGAALAPKaaAAAAATRAEAPP 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1389 AVPEPLVAAPEPPTMATPELCSLSVSEPPVAVSELPALAD--PEHAITAVSGVSSLEPSVPILEPAVSVLQPVMIVSEPS 1466
Cdd:PRK07003  428 AAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDaqPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAV 507

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 124378037 1467 VPVQEPTVA--VSEPAVIVSEHTQITSPEMAVESSP 1500
Cdd:PRK07003  508 PDARAPAAAsrEDAPAAAAPPAPEARPPTPAAAAPA 543
rne PRK10811
ribonuclease E; Reviewed
 1254-1439 1.88e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 43.49  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1254 SAPVesAVVAEHEMVPERPmtymvsETTMSVEPAVLTSEASVISETSETYDSMRpsghaisEVTMSLLEPAVTISQPAEN 1333
Cdd:PRK10811  844 RYPV--VRPQDVQVEEQRE------AEEVQVQPVVAEVPVAAAVEPVVSAPVVE-------AVAEVVEEPVVVAEPQPEE 908

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1334 SLELPSMTVPAPSTMTTTESPVVAVTEIPPVAVPEPPIMAVPELPTMAVVKTPAVAVPEPLVAAPEPPTMATPElcslSV 1413
Cdd:PRK10811  909 VVVVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAP----VV 984

                         170       180
                  ....*....|....*....|....*.
gi 124378037 1414 SEPPVAVSELPALADPEHAITAVSGV 1439
Cdd:PRK10811  985 AEVAAEVETVTAVEPEVAPAQVPEAT 1010
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 82-574 2.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037    82 DLKEASRKSRCVSV--QTDPTDEVPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESE--SKLKSHHDGNLESDSFLKFD 157
Cdd:pfam03154   38 DLRSSGRNSPSAAStsSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGASDTEEPEraTAKKSKTQEISRPNSPSEGE 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   158 SEPSAAALEHPVRAFGLSEASETALVLEPPVVSMEVQESHvletlkpATKAAELSVVSTSVISEQSEQPMPGMLEPSMTK 237
Cdd:pfam03154  118 GESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESD-------SDSSAQQQILQTQPPVLQAQSGAASPPSPPPPG 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   238 ILDSFTAAPVPMSTAALKSPEPVVTMSVEYQKSvlksleTMPPETSKTTLVELPIAKVVEPSETLTIV------SETPTE 311
Cdd:pfam03154  191 TTQAATAGPTPSAPSVPPQGSPATSQPPNQTQS------TAAPHTLIQQTPTLHPQRLPSPHPPLQPMtqppppSQVSPQ 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   312 VHPEPSPSTMDFP-----ESSTTDVQR-LPEQPVEAPSEIADS------SMTRPQESLELPKTTAVELQESTVASALELP 379
Cdd:pfam03154  265 PLPQPSLHGQMPPmphslQTGPSHMQHpVPPQPFPLTPQSSQSqvppgpSPAAPGQSQQRIHTPPSQSQLQSQQPPREQP 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   380 GPPA-TSILELQGPPVTPVPELPGPSATPVP-ELSGPLSTPVP-ELPGPPA----TVVPELPGPSVTPVP-QL---SQEL 448
Cdd:pfam03154  345 LPPApLSMPHIKPPPTTPIPQLPNPQSHKHPpHLSGPSPFQMNsNLPPPPAlkplSSLSTHHPPSAHPPPlQLmpqSQQL 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037   449 PGPPAPSMGLEPPQEVPEPPVMAQELSGVPAVSAAIELTGQPAVTVAMELTEQPvTTTEFEQPVAMTTVEHPGHPEVTTA 528
Cdd:pfam03154  425 PPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPP-SGPPTSTSSAMPGIQPPSSASVSSS 503

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 124378037   529 TGLLGQPEAAmvleLPGQPVATTALELSGQPSVTGVPELSGLPSAT 574
Cdd:pfam03154  504 GPVPAAVSCP----LPPVQIKEEALDEAEEPESPPPPPRSPSPEPT 545
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 382-553 5.27e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.77  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  382 PATSILELQGPPVTPVPeLPGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVTPVPQLSQELPGPPAPSMGLEPP 461
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAP-AASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAK 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037  462 QEVPEPPVMAQELSGV-----PAVSAAIELTGQPAVTVAMELTEQP---VTTTEFEQPVAMT-TVEHPGHPEVTTATGLL 532
Cdd:PRK07994  440 KSEPAAASRARPVNSAlerlaSVRPAPSALEKAPAKKEAYRWKATNpveVKKEPVATPKALKkALEHEKTPELAAKLAAE 519

                         170       180
                  ....*....|....*....|....*.
gi 124378037  533 GQPE---AAMV--LELPGqPVATTAL 553
Cdd:PRK07994  520 AIERdpwAALVsqLGLPG-LVEQLAL 544
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1342-1445 8.78e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 8.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124378037 1342 VPAPSTMTTTESPVVAVTEIPPVAVPEPPIMAVPELPTMAVVKTPAVA-VPEPLVAAPEPPTMATPElcslsVSEPPVAV 1420
Cdd:PRK14951  392 APVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAaAPAAVALAPAPPAQAAPE-----TVAIPVRV 466

                          90       100
                  ....*....|....*....|....*
gi 124378037 1421 SELPALADPEHAITAVSGVSSLEPS 1445
Cdd:PRK14951  467 APEPAVASAAPAPAAAPAAARLTPT 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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