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Conserved domains on  [gi|9910582|ref|NP_064365|]
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testis-expressed protein 101 precursor [Mus musculus]

Protein Classification

LU domain-containing protein( domain architecture ID 10439911)

LU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 27-124 2.08e-53

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467142  Cd Length: 99  Bit Score: 167.91  E-value: 2.08e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9910582   27 YCQVSQTLSLEDDPGRTFNWTS-KAEQCNPGELCQETVLLIKAdGTRTVVLASKSCVSQGGEAVTFIQYTAPPGLVAISY 105
Cdd:cd23622   2 YCHKGISMTIEEDPRNTFNWTTeKVETCDNGTLCQETILMIKA-GTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                        90
                ....*....|....*....
gi 9910582  106 SNYCNDSLCNNKDSLASVW 124
Cdd:cd23622  81 SNYCEDSLCNNKKSLSSFW 99
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 137-219 8.04e-43

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


:

Pssm-ID: 467798  Cd Length: 83  Bit Score: 140.21  E-value: 8.04e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9910582  137 GTRHCPTCVALGSCSSAPSMPCANGTTQCYQGRLEFSGGGMDATVQVKGCTTTIGCRLMAMIDSVGPMTVKETCSYQSFL 216
Cdd:cd23634   1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQSFL 80


                ...
gi 9910582  217 QPR 219
Cdd:cd23634  81 QPR 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 27-124 2.08e-53

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467142  Cd Length: 99  Bit Score: 167.91  E-value: 2.08e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9910582   27 YCQVSQTLSLEDDPGRTFNWTS-KAEQCNPGELCQETVLLIKAdGTRTVVLASKSCVSQGGEAVTFIQYTAPPGLVAISY 105
Cdd:cd23622   2 YCHKGISMTIEEDPRNTFNWTTeKVETCDNGTLCQETILMIKA-GTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                        90
                ....*....|....*....
gi 9910582  106 SNYCNDSLCNNKDSLASVW 124
Cdd:cd23622  81 SNYCEDSLCNNKKSLSSFW 99
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 137-219 8.04e-43

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


Pssm-ID: 467798  Cd Length: 83  Bit Score: 140.21  E-value: 8.04e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9910582  137 GTRHCPTCVALGSCSSAPSMPCANGTTQCYQGRLEFSGGGMDATVQVKGCTTTIGCRLMAMIDSVGPMTVKETCSYQSFL 216
Cdd:cd23634   1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQSFL 80


                ...
gi 9910582  217 QPR 219
Cdd:cd23634  81 QPR 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 141-215 2.59e-11

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 57.93  E-value: 2.59e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9910582    141 CPTCVALGSCSSAPSMPCANGTTQCYQGRLEFSGGGMDATVQVKGCTTTIGCRLMAMIDSVGPMTVKETCSYQSF 215
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSESCCQSDL 75
 
Name Accession Description Interval E-value
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 27-124 2.08e-53

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467142  Cd Length: 99  Bit Score: 167.91  E-value: 2.08e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9910582   27 YCQVSQTLSLEDDPGRTFNWTS-KAEQCNPGELCQETVLLIKAdGTRTVVLASKSCVSQGGEAVTFIQYTAPPGLVAISY 105
Cdd:cd23622   2 YCHKGISMTIEEDPRNTFNWTTeKVETCDNGTLCQETILMIKA-GTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                        90
                ....*....|....*....
gi 9910582  106 SNYCNDSLCNNKDSLASVW 124
Cdd:cd23622  81 SNYCEDSLCNNKKSLSSFW 99
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 137-219 8.04e-43

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


Pssm-ID: 467798  Cd Length: 83  Bit Score: 140.21  E-value: 8.04e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9910582  137 GTRHCPTCVALGSCSSAPSMPCANGTTQCYQGRLEFSGGGMDATVQVKGCTTTIGCRLMAMIDSVGPMTVKETCSYQSFL 216
Cdd:cd23634   1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQSFL 80


                ...
gi 9910582  217 QPR 219
Cdd:cd23634  81 QPR 83
TFP_LU_ECD_LYPD4_rpt1_like cd23564
first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
 27-124 2.75e-26

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.


Pssm-ID: 467094  Cd Length: 99  Bit Score: 98.27  E-value: 2.75e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9910582   27 YCQVSQTLSLEDDPGRTFNW-TSKAEQCNPGELCQETVLLIKAdGTRTVVLASKSCVSQGGEAVTFIQYTAPPGLVAISY 105
Cdd:cd23564   2 TCYRGTSLYVGANLANEPNWtTSRNETCEAGEVCQETLLLIES-GTQVLILGSKGCTPAGSQSSRVTEHVSPPGLIITSY 80

                        90
                ....*....|....*....
gi 9910582  106 SNYCNDSLCNNKDSLASVW 124
Cdd:cd23564  81 TRVCNSDFCNNLSSTSPFL 99
TFP_LU_ECD_LYPD4_rpt2_like cd23633
second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
 137-210 1.33e-18

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.


Pssm-ID: 467797  Cd Length: 76  Bit Score: 77.35  E-value: 1.33e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9910582  137 GTRHCPTCVAL-GSCSSAPSM-PCANGTTqCYQGRLEFSGGGMDATVQVKGCTTTIGCRLMAMIDSVGPMTVKETC 210
Cdd:cd23633   1 GTLQCPVCLHFkGSCSSNSNLvLCPKNTR-CYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREIL 75
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
 45-119 3.57e-17

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467144  Cd Length: 102  Bit Score: 74.26  E-value: 3.57e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9910582   45 NWTSKAEQ-CNPGELCQETVLLIKAdGTRTVVLASKSC-VSQGGEAVTFIQYTAPPGLVAISYSNYCNDSLCNNKDS 119
Cdd:cd23624  22 EWTTSGTQiCDAGEVCQETLLLIDV-GPKSLLLGSKGCsKPGAQDSQKVSIHSGPPGILVASYVHFCSSDLCNRANS 97
TFP_LU_ECD_CD177_rpt2 cd23636
second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
 136-210 1.11e-16

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.


Pssm-ID: 467800  Cd Length: 77  Bit Score: 72.39  E-value: 1.11e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9910582  136 SGTRHCPTCVALGSCSSAPSM-PCANGTTQCYQGRLEFSGGGMDATVQVKGCTTTIGCRLMAMIDSVGPMTVKETC 210
Cdd:cd23636   1 PGSLRCPVCLSTGSCPEAATLvPCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENC 76
TFP_LU_ECD_CD177_rpt4 cd23637
fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
 137-209 7.41e-13

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.


Pssm-ID: 467801 [Multi-domain]  Cd Length: 77  Bit Score: 62.33  E-value: 7.41e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9910582  137 GTRHCPTCVAL-GSCSSAPSMPCANGTTQCYQGRLEFSGGGMDATVQVKGCTTTIGCRLMAMIDSVGPMTVKET 209
Cdd:cd23637   2 GDLQCPVCVNFfGSCSDPSTVTCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTEN 75
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 141-215 2.59e-11

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 57.93  E-value: 2.59e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9910582    141 CPTCVALGSCSSAPSMPCANGTTQCYQGRLEFSGGGMDATVQVKGCTTTIGCRLMAMIDSVGPMTVKETCSYQSF 215
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSESCCQSDL 75
TFP_LU_ECD_CD177_rpt1 cd23623
first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
 44-124 2.34e-09

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467143  Cd Length: 100  Bit Score: 53.47  E-value: 2.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9910582   44 FNWTSKAEQCNPGELCQETVLLIKaDGTRTVVLASKSCVSQGGEAVTFIQYTAPPGLVAISYSNYC-NDSLCNNKDSLAS 122
Cdd:cd23623  20 LWWTAGQKTCEAGEGCQDTLMLIE-NGPQVNLVLIKGCTQAEDQEPRVTQHRAGPGLSIVSYTRVCrHQDLCNDLSSTLP 98


                ..
gi 9910582  123 VW 124
Cdd:cd23623  99 LW 100
TFP_LU_ECD_LYPD4_rpt1 cd23621
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and ...
 53-116 3.75e-05

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467141  Cd Length: 103  Bit Score: 41.77  E-value: 3.75e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9910582   53 CNPGELCQETVLLIKAdGTRTVVLASKSCVSQGGEAVTFIQYTAPPGLVAISYSNYCNDSLCNN 116
Cdd:cd23621  30 CKLNEGCEETLVFIET-GTARGVVGFKGCSPASSYPPQISYLVSPPGVSIASYSRVCRSYLCNN 92
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 139-211 6.67e-04

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 37.41  E-value: 6.67e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9910582  139 RHCPTCVALGS--CSSAPSMPCANGTTQCYQGRLEFSGGGMDATVQVKGCTTTIGCRLM--AMIDSVGPMTVKE-TCS 211
Cdd:cd23572   3 LQCPACYSEGSdsCKSEETVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGkgSLPFGGTSVNITTaTCT 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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