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Conserved domains on  [gi|41152506|ref|NP_065173|]
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prostaglandin F2 receptor negative regulator precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10647953)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and pattern recognition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IGv smart00406
Immunoglobulin V-Type;
39-121 1.36e-06

Immunoglobulin V-Type;


:

Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.99  E-value: 1.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506     39 LVIPCNVSDYDgPSEQNFDWSFSSLGSSfVELASTWE---VGFPAQLYQERLQrgeiLLRRTANDAVELHIKNVQPSDQG 115
Cdd:smart00406   2 VTLSCKFSGST-FSSYYVSWVRQPPGKG-LEWLGYIGsngSSYYQESYKGRFT----ISKDTSKNDVSLTISNLRVEDTG 75


                   ....*.
gi 41152506    116 HYKCST 121
Cdd:smart00406  76 TYYCAV 81
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 283-375 2.13e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506   283 VPKNVSVAEGKELDLTCNITTDRADDVrPEVTWSfsRMPDSTLPGSRVLARLDRDSLVHSSPHVALS-HVDARSYHLLVR 361
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAS-TSVYWY--RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRgDPSNGDGSLTIQ 78

                          90
                  ....*....|....
gi 41152506   362 DVSKENSGYYYCHV 375
Cdd:pfam07686  79 NLTLSDSGTYTCAV 92
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 153-252 1.24e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 42.32  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506 153 PPPSLSLREGEPFELRCTAASaspLHTHLALLWEVHR-GPARRSVLALTHEGRFHPGlGYEQRYHSgdvrlDTVGSDAYR 231
Cdd:cd00099   4 SPRSLSVQEGESVTLSCEVSS---SFSSTYIYWYRQKpGQGPEFLIYLSSSKGKTKG-GVPGRFSG-----SRDGTSSFS 74

                        90       100
                ....*....|....*....|.
gi 41152506 232 LSVSRALSADQGSYRCIVSEW 252
Cdd:cd00099  75 LTISNLQPEDSGTYYCAVSES 95
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 104-140 4.12e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16091:

Pssm-ID: 472250  Cd Length: 107  Bit Score: 37.75  E-value: 4.12e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 41152506 104 LHIKNVQPSDQGHYKCSTpstdATVQGNYEDTVQVKV 140
Cdd:cd16091  75 LLLRRVQLQDEGRYKCYT----STIIGNQESFVNLKV 107
 
Name Accession Description Interval E-value
IGv smart00406
Immunoglobulin V-Type;
39-121 1.36e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.99  E-value: 1.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506     39 LVIPCNVSDYDgPSEQNFDWSFSSLGSSfVELASTWE---VGFPAQLYQERLQrgeiLLRRTANDAVELHIKNVQPSDQG 115
Cdd:smart00406   2 VTLSCKFSGST-FSSYYVSWVRQPPGKG-LEWLGYIGsngSSYYQESYKGRFT----ISKDTSKNDVSLTISNLRVEDTG 75


                   ....*.
gi 41152506    116 HYKCST 121
Cdd:smart00406  76 TYYCAV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 283-375 2.13e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506   283 VPKNVSVAEGKELDLTCNITTDRADDVrPEVTWSfsRMPDSTLPGSRVLARLDRDSLVHSSPHVALS-HVDARSYHLLVR 361
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAS-TSVYWY--RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRgDPSNGDGSLTIQ 78

                          90
                  ....*....|....
gi 41152506   362 DVSKENSGYYYCHV 375
Cdd:pfam07686  79 NLTLSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 284-376 6.83e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.19  E-value: 6.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506    284 PKNVSVAEGKELDLTCNITTDRAddvrPEVTWSFsrmpdstlpgsrvlarlDRDSLVHSSPHVALSHvDARSYHLLVRDV 363
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP----PEVTWYK-----------------QGGKLLAESGRFSVSR-SGSTSTLTISNV 58

                           90
                   ....*....|...
gi 41152506    364 SKENSGYYYCHVS 376
Cdd:smart00410  59 TPEDSGTYTCAAT 71
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-141 6.43e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.83  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506    26 VPTATLVrVVGTELVIPCNVSDYDGPSEQNFDWSFSSLGSSFVELASTWEVGFPAQLYQERLQrgeiLLRRTANDAVELH 105
Cdd:pfam07686   2 TPREVTV-ALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFS----GRGDPSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 41152506   106 IKNVQPSDQGHYKCSTPSTDATVQGNyedTVQVKVL 141
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIPSGEGVFGK---GTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 153-252 1.24e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 42.32  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506 153 PPPSLSLREGEPFELRCTAASaspLHTHLALLWEVHR-GPARRSVLALTHEGRFHPGlGYEQRYHSgdvrlDTVGSDAYR 231
Cdd:cd00099   4 SPRSLSVQEGESVTLSCEVSS---SFSSTYIYWYRQKpGQGPEFLIYLSSSKGKTKG-GVPGRFSG-----SRDGTSSFS 74

                        90       100
                ....*....|....*....|.
gi 41152506 232 LSVSRALSADQGSYRCIVSEW 252
Cdd:cd00099  75 LTISNLQPEDSGTYYCAVSES 95
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 104-140 4.12e-03

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 37.75  E-value: 4.12e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 41152506 104 LHIKNVQPSDQGHYKCSTpstdATVQGNYEDTVQVKV 140
Cdd:cd16091  75 LLLRRVQLQDEGRYKCYT----STIIGNQESFVNLKV 107
IgI_Myomesin_like_C cd05737
C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of ...
 283-371 9.10e-03

C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein (also known as myomesin-2). Myomesin and M-protein are both structural proteins localized to the M-band, a transverse structure in the center of the sarcomere, and are candidates for M-band bridges. Both proteins are modular, consisting mainly of repetitive Ig-like and fibronectin type III (FnIII) domains. Myomesin is expressed in all types of vertebrate striated muscle; M-protein has a muscle-type specific expression pattern. Myomesin is present in both slow and fast fibers; M-protein is present only in fast fibers. It has been suggested that myomesin acts as a molecular spring with alternative splicing as a means of modifying its elasticity.


Pssm-ID: 319300  Cd Length: 92  Bit Score: 36.41  E-value: 9.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506 283 VPKNVSVAEGKELDLTCNITTDRAddvrPEVTWsfsrmpdstlpgsrvlarLDRDSLVHSSPHVALSHVDARSYHLLVRD 362
Cdd:cd05737   7 LPDVVTIMEGKTLNLTCNVWGDPP----PEVSW------------------LKNDQALAFLDHCNLKVEAGRTVYFTING 64


                ....*....
gi 41152506 363 VSKENSGYY 371
Cdd:cd05737  65 VSSEDSGKY 73
 
Name Accession Description Interval E-value
IGv smart00406
Immunoglobulin V-Type;
39-121 1.36e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.99  E-value: 1.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506     39 LVIPCNVSDYDgPSEQNFDWSFSSLGSSfVELASTWE---VGFPAQLYQERLQrgeiLLRRTANDAVELHIKNVQPSDQG 115
Cdd:smart00406   2 VTLSCKFSGST-FSSYYVSWVRQPPGKG-LEWLGYIGsngSSYYQESYKGRFT----ISKDTSKNDVSLTISNLRVEDTG 75


                   ....*.
gi 41152506    116 HYKCST 121
Cdd:smart00406  76 TYYCAV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 283-375 2.13e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506   283 VPKNVSVAEGKELDLTCNITTDRADDVrPEVTWSfsRMPDSTLPGSRVLARLDRDSLVHSSPHVALS-HVDARSYHLLVR 361
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAS-TSVYWY--RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRgDPSNGDGSLTIQ 78

                          90
                  ....*....|....
gi 41152506   362 DVSKENSGYYYCHV 375
Cdd:pfam07686  79 NLTLSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 284-376 6.83e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.19  E-value: 6.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506    284 PKNVSVAEGKELDLTCNITTDRAddvrPEVTWSFsrmpdstlpgsrvlarlDRDSLVHSSPHVALSHvDARSYHLLVRDV 363
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP----PEVTWYK-----------------QGGKLLAESGRFSVSR-SGSTSTLTISNV 58

                           90
                   ....*....|...
gi 41152506    364 SKENSGYYYCHVS 376
Cdd:smart00410  59 TPEDSGTYTCAAT 71
I-set pfam07679
Immunoglobulin I-set domain;
283-373 3.64e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.01  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506   283 VPKNVSVAEGKELDLTCNITTDRAddvrPEVTWSFsrmpdstlpgsrvlarldRDSLVHSSPHVALSHVDARsYHLLVRD 362
Cdd:pfam07679   6 KPKDVEVQEGESARFTCTVTGTPD----PEVSWFK------------------DGQPLRSSDRFKVTYEGGT-YTLTISN 62

                          90
                  ....*....|.
gi 41152506   363 VSKENSGYYYC 373
Cdd:pfam07679  63 VQPDDSGKYTC 73
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-141 6.43e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.83  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506    26 VPTATLVrVVGTELVIPCNVSDYDGPSEQNFDWSFSSLGSSFVELASTWEVGFPAQLYQERLQrgeiLLRRTANDAVELH 105
Cdd:pfam07686   2 TPREVTV-ALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFS----GRGDPSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 41152506   106 IKNVQPSDQGHYKCSTPSTDATVQGNyedTVQVKVL 141
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIPSGEGVFGK---GTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 153-252 1.24e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 42.32  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506 153 PPPSLSLREGEPFELRCTAASaspLHTHLALLWEVHR-GPARRSVLALTHEGRFHPGlGYEQRYHSgdvrlDTVGSDAYR 231
Cdd:cd00099   4 SPRSLSVQEGESVTLSCEVSS---SFSSTYIYWYRQKpGQGPEFLIYLSSSKGKTKG-GVPGRFSG-----SRDGTSSFS 74

                        90       100
                ....*....|....*....|.
gi 41152506 232 LSVSRALSADQGSYRCIVSEW 252
Cdd:cd00099  75 LTISNLQPEDSGTYYCAVSES 95
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 284-376 1.49e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.01  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506   284 PKNVSVAEGKELDLTCNITTDRaddvRPEVTWSfsrmpdstlpgsrvlarldRDSLVHSSPHVALSHVDARSYHLLVRDV 363
Cdd:pfam13927   8 PSSVTVREGETVTLTCEATGSP----PPTITWY-------------------KNGEPISSGSTRSRSLSGSNSTLTISNV 64

                          90
                  ....*....|...
gi 41152506   364 SKENSGYYYCHVS 376
Cdd:pfam13927  65 TRSDAGTYTCVAS 77
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-140 1.86e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506     30 TLVRVVGTELVIPCNVSdydGPSEQNFDWSFSSLgssfvelastwevgfpaqlyQERLQRGEILLRRTANDAVeLHIKNV 109
Cdd:smart00410   3 SVTVKEGESVTLSCEAS---GSPPPEVTWYKQGG--------------------KLLAESGRFSVSRSGSTST-LTISNV 58

                           90       100       110
                   ....*....|....*....|....*....|.
gi 41152506    110 QPSDQGHYKCSTPSTdatvQGNYEDTVQVKV 140
Cdd:smart00410  59 TPEDSGTYTCAATNS----SGSASSGTTLTV 85
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 283-376 2.89e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.56  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506   283 VPKNVSVAEGKELDLTCNIttdRADDVRPEVTWSFSrmpDSTLPGSRVLARLDRDSLVHSsphvalshvdarsyhLLVRD 362
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSA---STGSPGPDVTWSKE---GGTLIESLKVKHDNGRTTQSS---------------LLISN 60

                          90
                  ....*....|....
gi 41152506   363 VSKENSGYYYCHVS 376
Cdd:pfam00047  61 VTKEDAGTYTCVVN 74
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 104-140 4.12e-03

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 37.75  E-value: 4.12e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 41152506 104 LHIKNVQPSDQGHYKCSTpstdATVQGNYEDTVQVKV 140
Cdd:cd16091  75 LLLRRVQLQDEGRYKCYT----STIIGNQESFVNLKV 107
IgI_Myomesin_like_C cd05737
C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of ...
 283-371 9.10e-03

C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of myomesin and M-protein (also known as myomesin-2). Myomesin and M-protein are both structural proteins localized to the M-band, a transverse structure in the center of the sarcomere, and are candidates for M-band bridges. Both proteins are modular, consisting mainly of repetitive Ig-like and fibronectin type III (FnIII) domains. Myomesin is expressed in all types of vertebrate striated muscle; M-protein has a muscle-type specific expression pattern. Myomesin is present in both slow and fast fibers; M-protein is present only in fast fibers. It has been suggested that myomesin acts as a molecular spring with alternative splicing as a means of modifying its elasticity.


Pssm-ID: 319300  Cd Length: 92  Bit Score: 36.41  E-value: 9.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152506 283 VPKNVSVAEGKELDLTCNITTDRAddvrPEVTWsfsrmpdstlpgsrvlarLDRDSLVHSSPHVALSHVDARSYHLLVRD 362
Cdd:cd05737   7 LPDVVTIMEGKTLNLTCNVWGDPP----PEVSW------------------LKNDQALAFLDHCNLKVEAGRTVYFTING 64


                ....*....
gi 41152506 363 VSKENSGYY 371
Cdd:cd05737  65 VSSEDSGKY 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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