|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
86-1051 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1170.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 86 IPTKPGEKKDVSGPLPPAYSPRYVEAAWYPWWVREGFFKP-EYQARLPQatGETFSMCIPPPNVTGSLHIGHALTVAIQD 164
Cdd:PTZ00419 10 SKDEKKNKKRNISSMAASYDPKEVESGWYEWWEKSGFFKPaEDAKSLNS--GKKFVIVLPPPNVTGYLHIGHALTGAIQD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 165 ALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDR 244
Cdd:PTZ00419 88 SLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 245 ECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHTQLRLPGCPTPVSFGLLFSVAFPV 324
Cdd:PTZ00419 168 EVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 325 DGEPDAEVVVGTTRPETLPGDVAVAVHPDDSRYTHLHGRQLRHPLM-GQPLPLITD-YAVQPHVGTGAVKVTPAHSPADA 402
Cdd:PTZ00419 248 EDSGQEEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIpDRKIPIIADdELVDMEFGTGAVKITPAHDPNDY 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 403 EMGARHGLSPLNVIAEDGTMTSLCGDWlQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFV 482
Cdd:PTZ00419 328 EIAKRHNLPFINIFTLDGKINENGGEF-AGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYV 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 483 RCQEMGARAAKAVESGALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVV---EDHAQGEEDCWVVGRSEAEA 559
Cdd:PTZ00419 407 NCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVIskgPETDPSDEEPWVVARSEEEA 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 560 REVAAELTGRPGAELTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQ 639
Cdd:PTZ00419 487 LEKAKKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDK 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 640 LPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISGVEMQVLQEKLRSGNLDPAELAIVAAAQKKDFPHGIPECGTDALR 719
Cdd:PTZ00419 567 LPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDALR 646
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 720 FTLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNALRFILNALGEKFVPQPAEELSPSSP-----MDAWILSRLALAAQECE 794
Cdd:PTZ00419 647 FGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNVeslpwEDKWILHRLNVAIKEVT 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 795 RGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWH---SPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLppR 871
Cdd:PTZ00419 727 EGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKqsdGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL--P 804
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 872 PGCPPAPSISVAPYPSacSLEHWRQPELERRFSRVQEVVQVLRALRATYQLT-KARPRVLLQSSEPGDQGLFEAFLEPLG 950
Cdd:PTZ00419 805 NYLRKSESISIAKYPQ--PNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPnKTKPDCYVTAKDAELIELIESAENLIS 882
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 951 TLGYCGAVGLLPP---GAAAPSGWAQAPLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSL---------TARTP 1018
Cdd:PTZ00419 883 TLAKIGSVSVIPPieeEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYlkkisipnyEDKVP 962
|
970 980 990
....*....|....*....|....*....|...
gi 268370293 1019 SegEAGTQRQQKLSSLQLELSKLDKAASHLRQL 1051
Cdd:PTZ00419 963 E--DVRKLNDEKIDELNEEIKQLEQAIEELKSL 993
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
100-1032 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 988.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 100 LPPAYSPRYVEAAWYPWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 179
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKAD-----PDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 180 VPGSDHAGIATQAVVEKQLwKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTE 259
Cdd:COG0525 78 QPGTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 260 AFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDGEPDaEVVVGTTRP 339
Cdd:COG0525 157 VFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGH----------------LWHIRYPLADGSG-YIVVATTRP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 340 ETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAED 419
Cdd:COG0525 220 ETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDED 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 420 GTMTSLCGDwLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGA 499
Cdd:COG0525 300 GTINENAGK-YRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 500 LElspsFHQKNWQ----HWFSHIGDWCVSRQLWWGHQIPAYLvvedHAQGEEdcwVVGRSEAearevaaelTGRPGAELT 575
Cdd:COG0525 379 IK----FVPERWEktyfHWMENIRDWCISRQLWWGHRIPAWY----CPDGEV---YVARTEP---------EACAKAGSV 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 576 -LERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDR 654
Cdd:COG0525 439 nLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDE 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 655 QGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSHGVQAGDLHL 734
Cdd:COG0525 519 QGRKMSKSKGNVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIKF 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 735 SVSEVQSCRHFCNKIWNALRFIL-NalGEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHF- 812
Cdd:COG0525 562 DEERVEGYRNFANKLWNASRFVLmN--LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFv 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 813 WlHNLCDVYLEAVKPVLWH--SPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprPGCPPAPSISVAPYPSAcs 890
Cdd:COG0525 640 W-NEFCDWYLELAKPRLYGgdEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKL---PPRKEGESIMLAPWPEA-- 713
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 891 LEHWRQPELERRFSRVQEVVQVLRALRATYQLT-KARPRVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGLLppGAAAPS 969
Cdd:COG0525 714 DEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPpSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITIL--VDEKPE 791
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268370293 970 GWAQApLSDTAQVYMELQGLVDpqiqlplLAARRYKLQKQLDSLtartpsEGE-AGTQRqqKLS 1032
Cdd:COG0525 792 GAASA-VVGGAEVFLPLEGLID-------VEAERARLEKELAKL------EKEiARVEK--KLS 839
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
100-1015 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 970.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 100 LPPAYSPRYVEAAWYPWWVREGFFKPEyqarlpQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 179
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPD------DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 180 VPGSDHAGIATQAVVEKQLwKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTE 259
Cdd:PRK05729 79 LPGTDHAGIATQMVVERQL-AAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 260 AFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDgEPDAEVVVGTTRP 339
Cdd:PRK05729 158 VFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGK----------------LWHIRYPLA-DGSDYLVVATTRP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 340 ETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAED 419
Cdd:PRK05729 221 ETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDED 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 420 GTMTSLCGDwLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGA 499
Cdd:PRK05729 301 GTINENPGE-YQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 500 LELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYlvvedhaQGEEDCWVVGRSEAEarevaaeltgrPGAELTLERD 579
Cdd:PRK05729 380 IKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAW-------YDEDGEVYVGREEPE-----------AREKALLTQD 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 580 PDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKM 659
Cdd:PRK05729 442 EDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKM 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 660 SKSLGNVLDPRDIIsgvemqvlqEKLrsgnldpaelaivaaaqkkdfphgipecGTDALRFTLCSHGVQAGDLHLSVSEV 739
Cdd:PRK05729 522 SKSKGNVIDPLDLI---------DKY----------------------------GADALRFTLAALASPGRDIRFDEERV 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 740 QSCRHFCNKIWNALRFILNALGEKFVPQPAEELSpSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCD 819
Cdd:PRK05729 565 EGYRNFANKLWNASRFVLMNLEGADVGELPDPEE-LSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCD 643
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 820 VYLEAVKPVLWHSPRPlGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprPGCPPAPSISVAPYPSAcslEHWRQPEL 899
Cdd:PRK05729 644 WYLELAKPVLQEAAKR-ATRATLAYVLEQILRLLHPFMPFITEELWQKL---APLGIEESIMLAPWPEA---DEAIDEAA 716
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 900 ERRFSRVQEVVQVLRALRATYQLTKARP-RVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGLLPPGAAAPSGWAQApLSD 978
Cdd:PRK05729 717 EAEFEWLKELITAIRNIRAEMNIPPSKKlPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPEGAASA-VVG 795
|
890 900 910
....*....|....*....|....*....|....*..
gi 268370293 979 TAQVYMELQGLVDpqiqlplLAARRYKLQKQLDSLTA 1015
Cdd:PRK05729 796 GAELFLPLEGLID-------VEAELARLEKELAKLEK 825
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
44-1048 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 950.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 44 REAKQKRLREKQATLEAEIAGESKSPAESIKAWRPK-----------ELVLYEIPTKPGEKKDVSGPLPPAYSPRYVEAA 112
Cdd:PLN02381 29 KEKELKKLKAAQKEAKAKLQAQQASDGTNVPKKSEKksrkrdvedenPEDFIDPDTPFGQKKRLSSQMAKQYSPSAVEKS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 113 WYPWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQA 192
Cdd:PLN02381 109 WYAWWEKSGYFGAD-----AKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 193 VVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYR 272
Cdd:PLN02381 184 VVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 273 NHQLVNWSCALRSAISDIEVENRPLPGHTQLRLPGCPTPVSFGLLFSVAFPVDGEPdAEVVVGTTRPETLPGDVAVAVHP 352
Cdd:PLN02381 264 DIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPLEGGL-GEIVVATTRIETMLGDTAIAIHP 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 353 DDSRYTHLHGRQLRHPLMGQPLPLITDYA-VQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCGDWLQ 431
Cdd:PLN02381 343 DDERYKHLHGKFAVHPFNGRKLPIICDAIlVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSEFA 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 432 GLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAV---ESGALELSPSFHQ 508
Cdd:PLN02381 423 GMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAidgENKKLEFIPKQYL 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 509 KNWQHWFSHIGDWCVSRQLWWGHQIPA-YLVVEDHAQGE----EDCWVVGRSEAEAREVAAEltGRPGAELTLERDPDVL 583
Cdd:PLN02381 503 AEWKRWLENIRDWCISRQLWWGHRIPAwYVTLEDDQLKElgsyNDHWVVARNESDALLEASQ--KFPGKKFELSQDPDVL 580
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 584 DTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSL 663
Cdd:PLN02381 581 DTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSL 660
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 664 GNVLDPRDIISGVEMQVLQEKLRSGNLDPAELAIVAAAQKKDFPHGIPECGTDALRFTLCSHGVQAGDLHLSVSEVQSCR 743
Cdd:PLN02381 661 GNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGTDALRFALVSYTAQSDKINLDILRVVGYR 740
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 744 HFCNKIWNALRFILNALGEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLE 823
Cdd:PLN02381 741 QWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIE 820
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 824 AVKPVL------WHSPRPlGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAPSISVAPYPSAcsLEHWRQP 897
Cdd:PLN02381 821 AIKPYFagdnpeFASERA-AAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHTRKDSIMISEYPSA--VEAWTNE 897
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 898 ELERRFSRVQEVVQVLRALRATYQLTKARPRV----LLQSSEPGDqgLFEAFLEPLGTLGYCGAVGLLPPGA-AAPSGWA 972
Cdd:PLN02381 898 KVEYEMDLVLSTVKCLRSLRAEVLEKQKNERLpafaLCRNQEIAA--IIKSHQLEILTLANLSSLKVLLSENdAPPAGCA 975
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 973 QAPLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSLTARTPSEG-------EAGTQRQQKLSSLQLELSKLDKAA 1045
Cdd:PLN02381 976 FENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGykekvpaNIQEEDARKLTKLLQELEFFEKES 1055
|
...
gi 268370293 1046 SHL 1048
Cdd:PLN02381 1056 KRL 1058
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
100-1015 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 842.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 100 LPPAYSPRYVEAAWYPWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 179
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPD-----GNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 180 VPGSDHAGIATQAVVEKQLWKErGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTE 259
Cdd:TIGR00422 76 LPGTDHAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 260 AFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDGEPDAEVVVGTTRP 339
Cdd:TIGR00422 155 AFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGK----------------LYYIRYPLANGSKDYLVVATTRP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 340 ETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAED 419
Cdd:TIGR00422 219 ETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDED 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 420 GTMTSLCGDWlQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGA 499
Cdd:TIGR00422 299 GLLNENAGKY-QGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 500 LELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVVEDhaqGEedcWVVGRSEAEAREVAaeltgRPGAELTLERD 579
Cdd:TIGR00422 378 IKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKEC---GE---VYVAKEEPLPDDKT-----NTGPSVELEQD 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 580 PDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKM 659
Cdd:TIGR00422 447 TDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKM 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 660 SKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSHGVQAGDLHLSVSEV 739
Cdd:TIGR00422 527 SKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDDINFDWKRV 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 740 QSCRHFCNKIWNALRFILNALGEKFVPQPAEElsPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCD 819
Cdd:TIGR00422 570 ESARNFLNKLWNASRFVLMNLSDDLELSGGEE--KLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCD 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 820 VYLEAVKPVLWHSPRPLGPP--QVLFSCADLGLRLLAPLMPFLAEELWQRLpprpgCPPAPSISVAPYPSAcsLEHWRQP 897
Cdd:TIGR00422 648 WYIELVKYRLYNGNEAEKKAarDTLYYVLDKALRLLHPFMPFITEEIWQHF-----KEGADSIMLQSYPVV--DAEFVDE 720
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 898 ELERRFSRVQEVVQVLRALRATYQLTKARP-RVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGLLPpgAAAPSGWAQAPL 976
Cdd:TIGR00422 721 EAEKAFELLKEIIVSIRNLKAESNIPPNAPlKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVI--EKPEVTEAVVEL 798
|
890 900 910
....*....|....*....|....*....|....*....
gi 268370293 977 SDTAQVYMELQGLVDpqiqlplLAARRYKLQKQLDSLTA 1015
Cdd:TIGR00422 799 VPGFEIIIPVKGLIN-------KAKELARLQKQLDKEKK 830
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
100-1010 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 735.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 100 LPPAYSPRYVEAAWYPWWVREGFFKPEYQARlpqaTGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 179
Cdd:PRK14900 15 LAKGYEHREVEARWYPFWQERGYFHGDEHDR----TRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 180 VPGSDHAGIATQAVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTE 259
Cdd:PRK14900 91 LPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVRE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 260 AFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVEnrplpgHTQLRLpgcptpvsfGLLFSVAFPV-DGepDAEVVVGTTR 338
Cdd:PRK14900 171 VFVRLHEEGLIYREKKLINWCPDCRTALSDLEVE------HEEAHQ---------GELWSFAYPLaDG--SGEIVVATTR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 339 PETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYA-VQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIA 417
Cdd:PRK14900 234 PETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAIlVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 418 EDGTMTSLCGDwLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVES 497
Cdd:PRK14900 314 PDGRMTAEAGP-LAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQ 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 498 GALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVVEDHAqgeedcwVVGRSEAEarevaaelTGRPGAELTLE 577
Cdd:PRK14900 393 GRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHV-------TVARETPE--------ACSTCGKAELR 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 578 RDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGR 657
Cdd:PRK14900 458 QDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQ 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 658 KMSKSLGNVLDPRDIisgvemqvlqeklrsgnldpaelaivaaaqkkdfphgIPECGTDALRFTLCSHGVQAGDLHLSVS 737
Cdd:PRK14900 538 KMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGRDIKLAKE 580
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 738 EVQSCRHFCNKIWNALRFILNALGEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNL 817
Cdd:PRK14900 581 RIEGYRAFANKLWNASRFALMNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHEL 660
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 818 CDVYLEAVKPVLWHS-PRPLGPPQ-VLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAP-SISVAPYPSACSLEHw 894
Cdd:PRK14900 661 CDWYIELAKEALASEdPEARRSVQaVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAWAdSVLAAEYPRKGEADE- 739
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 895 rqpELERRFSRVQEVVQVLRALRATYQLT-----KARPRVLLQSSEPGDQGLFE----AFLEPLGTLgycGAVGLLPPGA 965
Cdd:PRK14900 740 ---AAEAAFRPVLGIIDAVRNIRGEMGIPwkvklGAQAPVEIAVADPALRDLLQagelARVHRVAGV---EGSRLVVAAA 813
|
890 900 910 920
....*....|....*....|....*....|....*....|....*
gi 268370293 966 AAPSGWAQAPLSDTAQVYMELQGLVDpqiqlplLAARRYKLQKQL 1010
Cdd:PRK14900 814 TAPAPQSAVGVGPGFEVRVPLAGVID-------LAAETARVDKEI 851
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
114-1019 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 641.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 114 YPWWVREGFFKPEYQArlpqaTGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAV 193
Cdd:PLN02943 70 YNWWESQGYFKPNFDR-----GGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 194 VEKQLWKErGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRN 273
Cdd:PLN02943 145 VEKMLASE-GIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQG 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 274 HQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDGEPDAEVVVGTTRPETLPGDVAVAVHPD 353
Cdd:PLN02943 224 SYMVNWSPNLQTAVSDLEVEYSEEPGT----------------LYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPE 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 354 DSRYTHLHGRQLRHPLM-GQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCgdwlqG 432
Cdd:PLN02943 288 DDRYSKYIGKMAIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVA-----G 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 433 LHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGALELSPSFHQKNWQ 512
Cdd:PLN02943 363 LYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERFEKIYN 442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 513 HWFSHIGDWCVSRQLWWGHQIPAYLVVEDHAqgEEDcWVVGRSEAEAREVAAEltgRPGAELTLERDPDVLDTWFSSALF 592
Cdd:PLN02943 443 HWLSNIKDWCISRQLWWGHRIPVWYIVGKDC--EED-YIVARSAEEALEKARE---KYGKDVEIYQDPDVLDTWFSSALW 516
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 593 PFSALGWPQ-ETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRD 671
Cdd:PLN02943 517 PFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLD 596
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 672 IIsgvemqvlqeklrsgnldpaelaivaaaqkKDFphgipecGTDALRFTLcSHGVQAGDLHLSVSEVQSCRHFCNKIWN 751
Cdd:PLN02943 597 TI------------------------------KEF-------GTDALRFTL-ALGTAGQDLNLSTERLTSNKAFTNKLWN 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 752 ALRFIL-------------NALGEKFvpqPAEELSPSSPM-DAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNL 817
Cdd:PLN02943 639 AGKFVLqnlpsqsdtsaweHILACKF---DKEESLLSLPLpECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDF 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 818 CDVYLEAVKPVLWHS---PRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprpgCPPAPSISVAPYPSAcSLEhw 894
Cdd:PLN02943 716 ADWYIEASKTRLYHSgdnSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQAL-----PYRKEALIVSPWPQT-SLP-- 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 895 RQPELERRFSRVQEVVQVLRALRATYQLTKARPrvlLQSSEPGDQGLFEAFLEPLGTLGYCGAVGL-------LPPGAAA 967
Cdd:PLN02943 788 KDLKSIKRFENLQSLTRAIRNARAEYSVEPAKR---ISASIVASAEVIEYISKEKEVLALLSRLDLqnvhftdSPPGDAN 864
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 268370293 968 PSgwAQAPLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSLTARTPS 1019
Cdd:PLN02943 865 QS--VHLVASEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSS 914
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
112-724 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 603.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 112 AWYPWWVREGFFKPEYQARLPQatgETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQ 191
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGK---PSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 192 AVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLY 271
Cdd:pfam00133 78 QVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 272 RNHQLVNWSCALRSAISDIEVENRPlpghtqlrlpgcptpvSFGLLFSVAFPVDGEPDAEVVVGTTRPETLPGDVAVAVH 351
Cdd:pfam00133 158 RGKKLVNWSPALNTALSNLEVEYKD----------------VKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVN 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 352 PD-------------------------------DSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPA 400
Cdd:pfam00133 222 PEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGEN 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 401 DAEMGARHGLSPLNVIAEDGTMTSLCGDWlQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQW 480
Cdd:pfam00133 302 DYEVGQRHNLEVINPVDDDGTFTEEAPDF-QGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQW 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 481 FVRCQEMGARAAKAVESgaLELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYlVVED----HAQGEEDCWVVGRSE 556
Cdd:pfam00133 381 FVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAW-VSKDteevVCRGELFELVAGRFE 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 557 AEAREVAAELTG----RPGAElTLERDPDVLDTWFSSALFPFSALGWP-QETPDLARFYPLSLLETGSDLLLFWVGRMVM 631
Cdd:pfam00133 458 EEGSIKWLHREAkdklGYGKG-TLEQDEDVLDTWFSSGSWPFSTLGWPfVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 632 LGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgip 711
Cdd:pfam00133 537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID------------------------------------- 579
|
650
....*....|...
gi 268370293 712 ECGTDALRFTLCS 724
Cdd:pfam00133 580 KYGADALRLWLAN 592
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
137-734 |
1.46e-175 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 517.96 E-value: 1.46e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 137 ETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKErGVRRHELSREAFLR 216
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 217 EVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVenrp 296
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 297 lpghtqlrlpgcptpvsfgllfsvafpvdgepdaevvvgttrpetlpgdvavavhpddsrythlhgrqlrhplmgqplpl 376
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 377 itdyavqphvgtgavkvtpahspadaemgarhglsplnviaedgtmtslcgdwlqglhrfvarekimsvlsewglfrglq 456
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 457 nhpmvlpiCSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAY 536
Cdd:cd00817 156 --------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAW 227
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 537 LVVEDHAqgeedcWVVGRSEAEAREVAAELTGRPGAELTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLE 616
Cdd:cd00817 228 YCKDGGH------WVVAREEDEAIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLV 301
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 617 TGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISGvemqvlqeklrsgnldpaela 696
Cdd:cd00817 302 TGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDG--------------------- 360
|
570 580 590
....*....|....*....|....*....|....*...
gi 268370293 697 ivaaaqkkdfphgipeCGTDALRFTLCSHGVQAGDLHL 734
Cdd:cd00817 361 ----------------YGADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
100-914 |
3.88e-134 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 424.99 E-value: 3.88e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 100 LPPAYSPRYVEAAWYPWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 179
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFD-----PDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 180 VPGSDHAGIATQAVVEKqlwkERGVRRHELSREAFL---REV-WQWKEakggEICEQLRALGASLDWDRECFTMDVgSSV 255
Cdd:PRK13208 81 PQGWDDNGLPTERKVEK----YYGIRKDDISREEFIelcRELtDEDEK----KFRELWRRLGLSVDWSLEYQTISP-EYR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 256 AVT-EAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDGepDAEVVV 334
Cdd:PRK13208 152 RISqKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGK----------------LNYIKFPVED--GEEIEI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 335 GTTRPETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLN 414
Cdd:PRK13208 214 ATTRPELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 415 VIAEDGTMTSLCGDwLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKA 494
Cdd:PRK13208 294 IIDEDGRMTEAAGK-LAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLER 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 495 VESgaLELSPSFHQKNWQHWFSHI-GDWCVSRQ--------LWW----GHQIPA----YLVV--EDHAQGEEDCwvvgrs 555
Cdd:PRK13208 373 GKE--INWYPEHMRVRLENWIEGLnWDWCISRQryfgtpipVWYckdcGHPILPdeedLPVDptKDEPPGYKCP------ 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 556 eaearevaaeltgRPGAElTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFW----VGRMVm 631
Cdd:PRK13208 445 -------------QCGSP-GFEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRAY- 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 632 lgtQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIisgvemqvlqeklrsgnldpaelaivaaaqkkdfphgIP 711
Cdd:PRK13208 510 ---LLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEEL-------------------------------------LE 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 712 ECGTDALRFTLCShGVQAGDLHLSVSEVQSCRHFCNKIWNALRFILNaLGEKFVPQPAEELspsSPMDAWILSRLALAAQ 791
Cdd:PRK13208 550 KYGADAVRYWAAS-ARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLH-FSADPEPDKAEVL---EPLDRWILAKLAKVVE 624
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 792 ECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWHSPrplGPPQVLFSCADLG------LRLLAPLMPFLAEELW 865
Cdd:PRK13208 625 KATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYGED---EEEEQKSARYTLYtvldtlLRLLAPFLPFITEEVW 701
|
810 820 830 840
....*....|....*....|....*....|....*....|....*....
gi 268370293 866 QRLpprpgcpPAPSISVAPYPSAcsLEHWRQPELERRFSRVQEVVQVLR 914
Cdd:PRK13208 702 SWL-------YGGSVHRASWPEP--DEELIDEEDEELGELAKEILSAVR 741
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
145-918 |
4.80e-84 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 292.75 E-value: 4.80e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 145 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSD-HaG--IATQavVEKQLWKERGVRrHELSREAFLRE---- 217
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GlpIELK--VEKELGIKKKDI-EKVGIAEFREKcrey 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 218 VWQWKEakggEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPl 297
Cdd:COG0060 130 ALKYVD----EQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKD- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 298 pgHTqlrlpgCPTPVsfgllfsVAFPVDGEP------DAEVVVGTTRPETLPGDVAVAVHPD----------DSRY---- 357
Cdd:COG0060 205 --VT------SPSIY-------VKFPVKDEKalllleDAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtgGERLilae 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 358 -----------------------THLHGRQLRHPLMGQPlplITDYAVQ----PHV----GTGAVKVTPAHSPADAEMGA 406
Cdd:COG0060 270 alveavlkelgiedyevlatfkgAELEGLRYEHPFYYVV---GYDRAHPvilgDYVttedGTGIVHTAPGHGEDDFEVGK 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 407 RHGLSPLNVIAEDGTMTSLCGDWlQGLHRFVAREKIMSVLSEWG-LFRglqnHPMVL---PICSRSGD-VIeYLLKNQWF 481
Cdd:COG0060 347 KYGLPVLNPVDDDGRFTEEAPLF-AGLFVKDANPAIIEDLKERGaLLA----REKIThsyPHCWRCKTpLI-YRATPQWF 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 482 VRCQEMGARAAKAVEsgalelspsfhQKNWQ---------HWFSHIGDWCVSRQLWWGHQIPAYL--------------- 537
Cdd:COG0060 421 ISMDKLRDRALEAIE-----------KVNWIpewgegrfgNMLENRPDWCISRQRYWGVPIPIWVcedcgelhrteevig 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 538 -VVEDHAQGEEDCW--------VVGRseaearevaaELTGRPGAElTLERDPDVLDTWFSSALFPFSALGWPQETPDLAR 608
Cdd:COG0060 490 sVAELLEEEGADAWfeldlhrpFLDE----------TLKCPKCGG-TMRRVPDVLDVWFDSGSMHFAVLENREELHFPAD 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 609 FYplslLEtGSD--------LLLfwvgrmvmLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIIsgvemqv 680
Cdd:COG0060 559 FY----LE-GSDqtrgwfysSLL--------TSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVI------- 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 681 lqEKLrsgnldpaelaivaaaqkkdfphgipecGTDALRFTLCSHGvQAGDLHLSVSEVQSCRHFCNKIWNALRFILNAL 760
Cdd:COG0060 619 --DKY----------------------------GADILRLWVASSD-YWGDLRFSDEILKEVRDVYRRLRNTYRFLLANL 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 761 gEKFVPQ----PAEELspsSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFwlhnlCDV-----YLEAVKPVLW- 830
Cdd:COG0060 668 -DDFDPAedavPYEDL---PELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNF-----CVEdlsnwYLDISKDRLYt 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 831 ---HSPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprpGCPPAPSISVAPYPSAcsLEHWRQPELERRFSRVQ 907
Cdd:COG0060 739 eaaDSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNL----PGEAEESVHLADWPEV--DEELIDEELEAKWDLVR 812
|
890
....*....|..
gi 268370293 908 EVVQ-VLRALRA 918
Cdd:COG0060 813 EVRSaVLKALEA 824
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
138-673 |
1.59e-48 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 175.30 E-value: 1.59e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 138 TFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKERGVRrhelSREAFLRE 217
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTI----WIEEFRED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 218 VWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHqlvnwscalrsaisdievenrpl 297
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGT----------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 298 pghtqlrlpgcptpvsfgllfsvafpvdgepdaevvvgttrpetlpgdvavavHPddsrythlhgrqlrhplmgqplpli 377
Cdd:cd00668 134 -----------------------------------------------------HP------------------------- 135
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 378 tdyavqphvgtgavkvtpahspadaemgarhglsplnVIAEDgtmtslcgdwlqglHRFVArekiMSVLSEWgLFRGLQN 457
Cdd:cd00668 136 -------------------------------------VRITE--------------QWFFD----MPKFKEK-LLKALRR 159
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 458 HPMVlpicsrsgdvieyllKNQWFVRCQEmgaraakavesgalelspsfhqknwqhWFSHIGDWCVSRQLWWGHQIPayl 537
Cdd:cd00668 160 GKIV---------------PEHVKNRMEA---------------------------WLESLLDWAISRQRYWGTPLP--- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 538 vvedhaqgeedcwvvgrseaearevaaeltgrpgaeltlerdPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLET 617
Cdd:cd00668 195 ------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLI 232
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 268370293 618 GSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDII 673
Cdd:cd00668 233 GKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV 288
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
734-868 |
3.94e-48 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 167.35 E-value: 3.94e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 734 LSVSEVQSCRHFCNKIWNALRFILNALGEKFVPQPAEElsPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFW 813
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE--SLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFF 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 268370293 814 LHNLCDVYLEAVKPVLWH--SPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRL 868
Cdd:cd07962 79 WNDFCDWYLELVKPRLYGedEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
116-909 |
7.08e-48 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 185.75 E-value: 7.08e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 116 WWVREGFFKpeyqaRL-PQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVV 194
Cdd:PLN02843 15 LWEENQVYK-----RVsDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 195 EKQLWKERgvrRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNH 274
Cdd:PLN02843 90 LQSLDQEA---RKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 275 QLVNWSCALRSAISDIEVEnrpLP-GHTQ----LRLPGCPTPVSFGLLFSVAFPvdgepDAEVVVGTTRPETLPGDVAVA 349
Cdd:PLN02843 167 KPVHWSPSSRTALAEAELE---YPeGHVSksiyVAFPVVSPSETSPEELEEFLP-----GLSLAIWTTTPWTMPANAAVA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 350 VHP--------------DDSRYTH----------------------------------------------LHGRQLRHPL 369
Cdd:PLN02843 239 VNDklqysvvevqsfseDESTSGGnkkkrpgnvlkeqqklflivatdlvpaleakwgvklvvlktfpgsdLEGCRYIHPL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 370 MGQPLPLIT--DYaVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCGDwLQGLHRFVA-REKIMSVL 446
Cdd:PLN02843 319 YNRESPVVIggDY-ITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-FSGLSVLGEgNAAVVEAL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 447 SEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESgaLELSPSFHQKNWQHWFSHIGDWCVSRQ 526
Cdd:PLN02843 397 DEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDK--VKWIPAQGENRIRAMVSGRSDWCISRQ 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 527 LWWGHQIPAYLVVE-----------DH-----AQGEEDCWVVGRSEAEAREVAAELTGRpgaeltLERDPDVLDTWFSSA 590
Cdd:PLN02843 475 RTWGVPIPVFYHVEtkeplmneetiAHvksivAQKGSDAWWYMDVEDLLPEKYRDKASD------YEKGTDTMDVWFDSG 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 591 LfpfSALGWPQETPDLArfYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPR 670
Cdd:PLN02843 549 S---SWAGVLGSREGLS--YPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPR 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 671 DIISGvemqvlqeklrsGNldpaelaivaaAQKKDfphgiPECGTDALRFTLCSHGVqAGDLHLSVSEVQSCRHFCNKIW 750
Cdd:PLN02843 624 LVIEG------------GK-----------NQKQE-----PAYGADVLRLWVASVDY-TGDVLIGPQILKQMSDIYRKLR 674
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 751 NALRFILNALGEkFVPQ---PAEELsPSspMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKP 827
Cdd:PLN02843 675 GTLRYLLGNLHD-WKPDnavPYEDL-PS--IDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKD 750
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 828 VLW----HSPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAPSISVAPYPSAcsLEHWRQ-PELERR 902
Cdd:PLN02843 751 RLYvggtTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAESVFEAGWPTP--NEEWLSfPAEDVD 828
|
....*...
gi 268370293 903 F-SRVQEV 909
Cdd:PLN02843 829 FwSLLLEV 836
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
779-927 |
1.17e-33 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 126.36 E-value: 1.17e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 779 DAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWHSPRPLGPPQVLFSCADLGLRLLAPLMP 858
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268370293 859 FLAEELWQRLpprpgcppapSISVAPYPSACSLEhwrQPELERRFSRVQEVVQVLRALRATYQLTKARP 927
Cdd:pfam08264 81 FITEELWQKE----------SIHLAPWPEDAELE---EAELEEAFELRQEIVQAIRKLRSELKIKKSLP 136
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
145-917 |
1.09e-28 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 124.84 E-value: 1.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 145 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKER-------GVRRH-ELSREAFLR 216
Cdd:PLN02882 46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLGIKRrddvlkmGIDKYnEECRSIVTR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 217 EVWQWKEAkggeiceqLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVenrp 296
Cdd:PLN02882 126 YSKEWEKT--------VTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEA---- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 297 lpghtQLRLPGCPTPVSFgllfsVAFPVDGEPD-AEVVVGTTRPETLPGDVAVAVHPD------------------DSRY 357
Cdd:PLN02882 194 -----GLNYKDVSDPAVM-----VSFPIVGDPDnASFVAWTTTPWTLPSNLALCVNPNftyvkvrnkytgkvyivaESRL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 358 THLHGRQLRHP----------------------LMG---QPL------------PLITDYAVQPHVGTGAVKVTPAHSPA 400
Cdd:PLN02882 264 SALPTAKPKSKkgskpenaaegyevlakvpgssLVGkkyEPLfdyfsefsdtafRVVADDYVTDDSGTGVVHCAPAFGED 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 401 DAEMGARHGL-----SPLNVIAEDGTMTSLCGDWlQGLHRFVAREKIMSVLSEWGlfRGLQNHPMV--LPICSRSGDVIE 473
Cdd:PLN02882 344 DYRVCLANGIiekggNLPVPVDDDGCFTEKVTDF-SGRYVKDADKDIIAAIKAKG--RLVKSGSIThsYPFCWRSDTPLI 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 474 YLLKNQWFVRCQEMGARAakaVESGAL-ELSPSF-HQKNWQHWFSHIGDWCVSRQLWWGHQIPAYlVVEDhaqGEEdcWV 551
Cdd:PLN02882 421 YRAVPSWFVKVEEIKDRL---LENNKQtYWVPDYvKEKRFHNWLENARDWAVSRSRFWGTPLPIW-ISDD---GEE--VV 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 552 VGRSEAEAREvaaeLTGRPGAEL-------------------TLERDPDVLDTWFSSALFPFSALGWPQETPDL-ARFYP 611
Cdd:PLN02882 492 VIGSIAELEK----LSGVKVTDLhrhfidhitipssrgpefgVLRRVDDVFDCWFESGSMPYAYIHYPFENKELfEKNFP 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 612 LSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnld 691
Cdd:PLN02882 568 ADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVID----------------- 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 692 paelaivaaaqkkdfphgipECGTDALRFTLC-SHGVQAGDLHLSVSEVQSCRHFCNKIW-NALRFIL-NAL------GE 762
Cdd:PLN02882 631 --------------------KYGADALRLYLInSPVVRAEPLRFKEEGVFGVVKDVFLPWyNAYRFLVqNAKrlevegGA 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 763 KFVPQPAEEL-SPSSPMDAWILSrlalAAQECERgFLTRE-----LSLVTHALHHFwLHNLCDVYleavkpVLWHSPRPL 836
Cdd:PLN02882 691 PFVPLDLAKLqNSANVLDRWINS----ATQSLVK-FVREEmgayrLYTVVPYLVKF-IDNLTNIY------VRFNRKRLK 758
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 837 GPP---------QVLFSCADLGLRLLAPLMPFLAEELWQRLpPRPGCPPAPSISVAPYPSACSLEhwRQPELERRFSRVQ 907
Cdd:PLN02882 759 GRTgeedcrtalSTLYNVLLTSCKVMAPFTPFFTEVLYQNL-RKVLPGSEESIHYCSFPQVDEGE--LDERIEQSVSRMQ 835
|
890
....*....|
gi 268370293 908 EVVQVLRALR 917
Cdd:PLN02882 836 TVIELARNIR 845
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
104-868 |
6.00e-26 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 115.23 E-value: 6.00e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 104 YSPRYVEAAWYPWWVREGFFKPEYQARLPQATgeTFSMcIPPPnvTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGS 183
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYY--ILSM-FPYP--SGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 184 DHAGI-ATQAVVEK----QLWKERGVrrhelsreAFLREvwqwkeakggeiceQLRALGASLDWDRECFTMDVGSSVAVT 258
Cdd:TIGR00396 76 DAFGLpAENAAIKRgihpAKWTYENI--------ANMKK--------------QLQALGFSYDWDREIATCDPEYYKWTQ 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 259 EAFVRLYKAGLLYRNHQLVNWSCAL-------------RSAISDIEVENRPLP----GHT----QL-----RLPGCPTPV 312
Cdd:TIGR00396 134 WIFLELFEKGLAYVKEADVNWCPNDgtvlaneqvdsdgRSWRGDTPVEKKELKqwflKITayaeELlndleELDHWPESV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 313 ----------SFGLlfSVAFPVDGePDAEVVVGTTRPETLPGDVAVAV---HP----------------DDSRYTHLHGR 363
Cdd:TIGR00396 214 kemqrnwigkSEGV--EITFKIAD-HDEKITVFTTRPDTIFGVTYLALapeHPlvekaaennpkvaafiKKILNKTVAER 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 364 QLR--------------HPLMGQPLPL-ITDYAVQpHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCGD 428
Cdd:TIGR00396 291 TKAtkekkgvdtgikaiHPLTGEKIPIwVANYVLM-EYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLSLTAA 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 429 WLQ-----------GLHRFVAREKIMSVLSEWGLfrglqnhpmvlpicsrSGDVIEYLLKnqwfvrcqemgaraakaves 497
Cdd:TIGR00396 370 YTEdgvlvnsgefnGLNSSEARNAIIDMLEKEGK----------------GKRKVNYRLR-------------------- 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 498 galelspsfhqknwqhwfshigDWCVSRQLWWGHQIPaylVVEDhaqgeEDCWVV--------------------GRSEA 557
Cdd:TIGR00396 414 ----------------------DWGFSRQRYWGEPIP---IIHC-----EDGGVVpvpeedlpvilpedvvydgdGGSPL 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 558 EAREVAAELTgRPGAELTLERDPDVLDTWFSSALFPFSALGwPQET-----PDLARFY-PLSLLETGSD-----LLL--F 624
Cdd:TIGR00396 464 SRIPEWVNVT-CPSCGKPALRETDTMDTFAGSSWYYLRYLD-PKNTdgpfdKEKAEYWlPVDLYIGGIEhailhLLYarF 541
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 625 WVGRMVMLGTqLTGQLPFSKVLLHPMV-----------------------RDRQGR--------KMSKSLGNVLDPRDII 673
Cdd:TIGR00396 542 FHKFLRDIGY-VNTKEPFKKLINQGMVlgfyyppngkvpadvlterdekgKDKAGGelvyvgyeKMSKSKGNGIDPQEIV 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 674 SgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNal 753
Cdd:TIGR00396 621 E-------------------------------------SYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWN-- 661
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 754 rFILNALGEKFVPQPAEELspsspmdawilsrLALAAQECERGF----------LTRELSLVT------HALHHFWLHNL 817
Cdd:TIGR00396 662 -LVYEITGELDAASLTVTA-------------LEEAQKELRRDVhkflkkvtedLEKRESFNTaisammELLNKLYKAKK 727
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|.
gi 268370293 818 CDVYLEAVKPVlwhsprplgppqvlfscadlgLRLLAPLMPFLAEELWQRL 868
Cdd:TIGR00396 728 EALMLEYLKGF---------------------VTVLSPFAPHLAEELWEKL 757
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
447-732 |
1.49e-24 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 106.16 E-value: 1.49e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 447 SEWGLF-----RGL---QNHPMVLPICSRSGDvieyllknQWFVRCQEMGARAAKAVESgaLELSPSFHQKNWQHWFSHI 518
Cdd:cd00818 120 SVWWVFkqlheKGLlyrGYKVVPWPLIYRATP--------QWFIRVTKIKDRLLEANDK--VNWIPEWVKNRFGNWLENR 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 519 GDWCVSRQLWWGHQIPayLVVEDHAqGEEDCwvvgrseaearevaaeltgrpgaeltlERDPDVLDTWFSSALFPFSALG 598
Cdd:cd00818 190 RDWCISRQRYWGTPIP--VWYCEDC-GEVLV---------------------------RRVPDVLDVWFDSGSMPYAQLH 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 599 WPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIisgvem 678
Cdd:cd00818 240 YPFENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEV------ 313
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 268370293 679 qvlqeklrsgnldpaelaivaaaqkkdfphgIPECGTDALRFTLCSHGVQAGDL 732
Cdd:cd00818 314 -------------------------------VDKYGADALRLWVASSDVYAEDL 336
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
145-868 |
6.40e-24 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 109.29 E-value: 6.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 145 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIAtqavVEKQLWKERGVRRHE--------LSREAFLR 216
Cdd:PTZ00427 110 PPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLP----IEYEIEKENNINKKEdilkmgidVYNEKCRG 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 217 EVWQWKEakggEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVenrp 296
Cdd:PTZ00427 186 IVLKYSN----EWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFEL---- 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 297 lpghtQLRLPGCPTP---VSFGLL----------------------FSVAFPVDGEP----------------DAEVVVG 335
Cdd:PTZ00427 258 -----NLNYKDTPDPsiiISFVLCsdfpkveeecnieedkqllgekYSVLYNNKRENsnngnnnstnnvcyaqHSEILAW 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 336 TTRPETLPGDVAVAV---------HPDDS-----------------------------RYTHLHGRQLRH-PLMG----- 371
Cdd:PTZ00427 333 TTTPWTLPSNLALCVnehftylriHHVKSnrvvivgecrlewimkelkwnvedlkivnRFKGKELKGLRYkPLFTnfyek 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 372 -----QPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHG-LSP-----LNVIAEDGTMTSLCgDWLQGLHRFVARE 440
Cdd:PTZ00427 413 ynfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGvIDPeknifIDPLDANGYFTNEV-EEVQNLYIKEADN 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 441 KIMSVLSEWGlfRGLQNHPMV--LPICSRSGDVIEYLLKNQWFVRcqeMGARAAKAVESGALELSPSFH--QKNWQHWFS 516
Cdd:PTZ00427 492 VIKKKLKNEN--RLLSNNTIVhsYPFCWRSDTPLIYRAIPAWFIR---VSNSTNELVKNNETTYWIPAHikEKKFHNWIK 566
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 517 HIGDWCVSRQLWWGHQIPAY--------LVVEDHAQGEEDCWVVGRSEAEAREVAAELTGRPGAEL--TLERDPDVLDTW 586
Cdd:PTZ00427 567 DAKDWCISRNRYWGTPIPIWadekmetvICVESIKHLEELSGVKNINDLHRHFIDHIEIKNPKGKTypKLKRIPEVFDCW 646
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 587 FSSALFPFSALGWP--QETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLG 664
Cdd:PTZ00427 647 FESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLK 726
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 665 NVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLC-SHGVQAGDLHLS---VSEVq 740
Cdd:PTZ00427 727 NYPDPLYILD-------------------------------------KYGADSLRLYLInSVAVRAENLKFQekgVNEV- 768
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 741 sCRHFCNKIWNALRFILNAL-------GEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFw 813
Cdd:PTZ00427 769 -VKSFILPFYHSFRFFSQEVtryeclnKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQF- 846
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268370293 814 LHNLCDVYLEAVKPVLWHSprpLGPPQVLFS----CADLGL--RLLAPLMPFLAEELWQRL 868
Cdd:PTZ00427 847 IENLTNWYIRLNRDRMRGS---LGEENCLQSlcttYRTLHLftVLMAPFTPFITEYIYQQL 904
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
152-911 |
8.98e-22 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 101.87 E-value: 8.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 152 LHIGHALTVAIQDALVRWHRMRGDQVLW-----VPGSDHAGIA--TQAVVEKQLW---KERGVRRHELSR--------EA 213
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIAerIARGDPETIElykSLYGIPEEELEKfkdpeyivEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 214 FLREvwqWKEAkggeiceqLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWsCAlrsaisdieVE 293
Cdd:PRK12300 81 FSEE---AKED--------MKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRY-CP---------ND 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 294 NRPLPGHTQLRLPGcPTPVSFGLLFsvaFPVDGepDAEVVVGTTRPETLPGDVAVAVHPDD--------------SRYTH 359
Cdd:PRK12300 140 NNPVGDHDLLDGEE-PEIVEYTLIK---FEESE--DLILPAATLRPETIFGVTNLWVNPDAtyvkaevdgekwivSKEAA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 360 --------------------LHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPAD--------AEMGARHGLS 411
Cdd:PRK12300 214 eklsfqdrdveiieeikgseLIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDyvalrdlkKNKELLDVIE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 412 PLNVI---------AED-----------------------------GTMTSLCGDwLQGLHRFVAREKIMSVLSEWGL-- 451
Cdd:PRK12300 294 PIPLIevegygefpAKEvveklgiksqedpeleeatkevyraefhkGVLKENTGE-YAGKPVREAREKITKDLIEKGIad 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 452 -FRGLQNHPMVlpicSRSG-DVIEYLLKNQWFVRC--QEMGARAAKAVESgaLELSPSFHQKNwqhwFSHIGDW-----C 522
Cdd:PRK12300 373 iMYEFSNRPVY----CRCGtECVVKVVKDQWFIDYsdPEWKELAHKALDN--MEIIPEEYRKE----FENTIDWlkdraC 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 523 vSRQLWWGHQIP-----------------AYLVVEDHAQGeedcwvvgrseaearevaaelTGRPGAELTlerdPDVLDT 585
Cdd:PRK12300 443 -ARRRGLGTRLPwdeewiieslsdstiymAYYTIAHKIRE---------------------YGIKPEQLT----PEFFDY 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 586 WFSSALFP---FSALGWPQETPDLAR-----FYPLSLLETGSDL----LLF-------------WVGRMVMLGtqltgql 640
Cdd:PRK12300 497 VFLGKGDPeevSKKTGIPKEILEEMReeflyWYPVDWRHSGKDLipnhLTFfifnhvaifpeekWPRGIVVNG------- 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 641 pfskvllhpMVRdRQGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRF 720
Cdd:PRK12300 570 ---------FVL-LEGKKMSKSKGNVIPLRKAIE-------------------------------------EYGADVVRL 602
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 721 TLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNalrFILNALGekfvpqpAEELSPSSPMDAWILSRLALA---AQECERGF 797
Cdd:PRK12300 603 YLTSSAELLQDADWREKEVESVRRQLERFYE---LAKELIE-------IGGEEELRFIDKWLLSRLNRIikeTTEAMESF 672
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 798 LTRELslVTHALhhFWLHNLCDVYLEAVKpvlwhsprplGPPQ-VLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGcpp 876
Cdd:PRK12300 673 QTRDA--VQEAF--YELLNDLRWYLRRVG----------EANNkVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGF--- 735
|
890 900 910
....*....|....*....|....*....|....*
gi 268370293 877 apsISVAPYPSACslEHWRQPELERRFSRVQEVVQ 911
Cdd:PRK12300 736 ---VSLEKWPEPD--ESKIDEEAELAEEYVKRLIE 765
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
104-888 |
9.69e-21 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 98.58 E-value: 9.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 104 YSPRYVEAAWYPWWVREGFFKPEyqarlPQATGETF---SMcIPPPnvTGSLHIGHALTVAIQDALVRWHRMRGDQVL-- 178
Cdd:COG0495 5 YNPKEIEKKWQKYWEENGTFKAD-----EDSSKPKYyvlDM-FPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLhp 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 179 --WvpgsDHAGI-ATQAVVEkqlwkeRGVrrHElsreaflrEVWQWK---EAKggeicEQLRALGASLDWDREcftmdvg 252
Cdd:COG0495 77 mgW----DAFGLpAENAAIK------NGV--HP--------AEWTYEniaNMR-----RQLKRLGLSYDWSRE------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 253 ssVAVTEA---------FVRLYKAGLLYRNHQLVNW--SCA--L--------RSAISDIEVENRPLPghtQ--LR----- 304
Cdd:COG0495 125 --IATCDPeyykwtqwiFLQLYEKGLAYRKEAPVNWcpVDQtvLaneqvidgRCWRCGAPVEKKELP---QwfLKitdya 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 305 ---------LPGCPTPV----------SFGLlfSVAFPVDGePDAEVVVGTTRPETLPGD--VAVAV-HP-------DDS 355
Cdd:COG0495 200 dellddldkLDGWPEKVktmqrnwigrSEGA--EVDFPVEG-SDEKITVFTTRPDTLFGAtfMVLAPeHPlvkelatPEQ 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 356 R----------------------------YThlhGRQLRHPLMGQPLPL-ITDYaVQPHVGTGAVKVTPAHSPADAEMGA 406
Cdd:COG0495 277 NaavaafieeakkkseiertsetkektgvFT---GLYAINPLTGEKIPIwIADY-VLMDYGTGAVMAVPAHDQRDFEFAK 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 407 RHGLSPLNVIA---------------EDGTMT-SlcgDWLQGLHRFVAREKIMSVLSEWGLFRGlqnhpmvlpicsrsgd 470
Cdd:COG0495 353 KYGLPIKQVIApedgddpdileeaytGDGVLInS---GEFDGLDSEEAKEAIIEWLEEKGLGKR---------------- 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 471 VIEYLLKnqwfvrcqemgaraakavesgalelspsfhqknwqhwfshigDWCVSRQLWWGHQIP--------AYLVVEDH 542
Cdd:COG0495 414 KVNYRLR------------------------------------------DWLISRQRYWGEPIPiihcedcgVVPVPEDQ 451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 543 -------------------AQGEEdcWVvgrseaearEVAAELTGRPGaeltlERDPDVLDTWF-SSalfpfsalgW--- 599
Cdd:COG0495 452 lpvelpedvdfdptggsplARAPE--WV---------NVTCPKCGGPA-----RRETDTMDTFVdSS---------Wyyl 506
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 600 ----PQET-----PDLARFY-PLslletgsDL-----------LL---FWVgrMVM--LGtQLTGQLPFSKVLLHPMVRD 653
Cdd:COG0495 507 rytdPHNDeapfdPEAANYWlPV-------DQyiggiehailhLLyarFFT--KVLrdLG-LVSFDEPFKRLLTQGMVLE 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 654 --RQGR------KMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSh 725
Cdd:COG0495 577 vgKDGVviggieKMSKSKGNVVDPDEIIE-------------------------------------KYGADTLRLFEMF- 618
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 726 gvqAGDLHLSV--SE--VQSCRHFCNKIWNalrfilnaLGEKFVPQPAEELSPSSPMDAWILSRL----ALAAQECER-G 796
Cdd:COG0495 619 ---AGPPERDLewSDsgVEGAYRFLNRVWR--------LVVDEAEALKLDVADLSEADKELRRALhktiKKVTEDIERlR 687
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 797 FLT-----RELslvTHALHHFWLHNLCD--VYLEAVKPVlwhsprplgppqvlfscadlgLRLLAPLMPFLAEELWQRLp 869
Cdd:COG0495 688 FNTaiaalMEL---VNALYKAKDSGEADraVLREALETL---------------------VLLLAPFAPHIAEELWERL- 742
|
970
....*....|....*....
gi 268370293 870 prpgcPPAPSISVAPYPSA 888
Cdd:COG0495 743 -----GHEGSVADAPWPEA 756
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
91-450 |
3.01e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 97.20 E-value: 3.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 91 GEKKDVSGPLPPAYSPRYVEAAWYPWWVREGFFKPEYQARLPQATGETFSMcIPPPNVTGsLHIGHALTVAIQDALVRWH 170
Cdd:PLN02563 67 STTAKTTPAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDM-FPYPSGAG-LHVGHPEGYTATDILARYK 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 171 RMRGDQVLWVPGSDHAGIATQavvekQLWKERGVRrhelSREAFLREVWQWKEakggeiceQLRALGASLDWDRECFTMD 250
Cdd:PLN02563 145 RMQGYNVLHPMGWDAFGLPAE-----QYAIETGTH----PKITTLKNIARFRS--------QLKSLGFSYDWDREISTTE 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 251 VGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVEN--RPLPGHTQLRLP--------------------GC 308
Cdd:PLN02563 208 PEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVDglSERGGHPVIRKPmrqwmlkitayadrlledldDL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 309 PTPVSFGLL----------FSVAFPVDG----EPDAEVVVGTTRPETLPGDVAVAVHPDD-------------------- 354
Cdd:PLN02563 288 DWPESIKEMqrnwigrsegAELDFSVLDgegkERDEKITVYTTRPDTLFGATYLVVAPEHpllsslttaeqkeaveeyvd 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 355 --SRYTHLHGRQL-------------RHPLMGQPLPL-ITDYaVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIA- 417
Cdd:PLN02563 368 aaSRKSDLERTELqkektgvftgsyaINPATGEAIPIwVADY-VLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKp 446
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 268370293 418 -------------EDGTM--TSLCGDWLQGLHRFVAREKIMSVLSEWG 450
Cdd:PLN02563 447 adgneddaekaytGEGVIvnSSSSGLDINGLSSKEAAKKVIEWLEETG 494
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
736-910 |
4.05e-19 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 86.07 E-value: 4.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 736 VSEVQscRHFCNKIWNALRF-ILNALGEKFVP-QPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFW 813
Cdd:cd07961 6 VREVV--RKVLLPLWNAYRFfVTYANLDGFDPgKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 814 LhNLCDVYLEAVKPVLWHSprpLGPP------QVLFSCADLGLRLLAPLMPFLAEELWQRLpPRPGCPPAPSISVAPYPS 887
Cdd:cd07961 84 D-ELTNWYIRRNRKRFWGE---EGDDdklaayATLYEVLLTLSRLMAPFTPFITEEIYQNL-RRELGDAPESVHLLDWPE 158
|
170 180
....*....|....*....|...
gi 268370293 888 AcsLEHWRQPELERRFSRVQEVV 910
Cdd:cd07961 159 V--DESLIDEELEEAMELVREIV 179
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
748-909 |
3.00e-18 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 83.73 E-value: 3.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 748 KIWNALRFILNALG---EKFVPQPAEELSPsspMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEA 824
Cdd:cd07960 15 KIRNTFRFLLGNLNdfdPAKDAVPYEELLE---LDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 825 VKPVLW----HSPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprPGCPPAPSISVAPYPSAcsLEHWRQPELE 900
Cdd:cd07960 92 IKDRLYcdakDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHL---PGEKKEESVFLEDWPEL--PEEWKDEELE 166
|
....*....
gi 268370293 901 RRFSRVQEV 909
Cdd:cd07960 167 EKWEKLLAL 175
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
144-283 |
1.76e-14 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 75.75 E-value: 1.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 144 PPPNvtGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKqlwkergVRRHELSreaflrevwqWKE 223
Cdd:cd00812 9 PYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIK-------IGRDPED----------WTE 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 224 AKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWsCAL 283
Cdd:cd00812 70 YNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW-CKL 128
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
143-216 |
2.07e-09 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 61.28 E-value: 2.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 143 IPPPNvtGSLHIGHALTVaIQ-DALVRWHRMRGDQVLWVPGSD-H----------AGIATQAVVE------KQLWKERGV 204
Cdd:COG0143 9 IPYAN--GPPHIGHLYTY-IPaDILARYQRLRGHDVLFVTGTDeHgtkielaaekEGITPQELVDrihaefKELFEKLGI 85
|
90 100
....*....|....*....|...
gi 268370293 205 -----------RRHELSREAFLR 216
Cdd:COG0143 86 sfdnfirttspEHKELVQEIFQR 108
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
146-271 |
3.21e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.85 E-value: 3.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 146 PNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAG--IATQAvvekqlwKERGVRRHELSRE--AFLREVWQW 221
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGtkIEQKA-------EEEGVTPQELCDKyhEIFKDLFKW 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 268370293 222 keakggeiceqlralgASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLY 271
Cdd:cd00814 82 ----------------LNISFDYFIRTTSPRHKEIVQEFFKKLYENGYIY 115
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
146-214 |
4.07e-09 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 60.00 E-value: 4.07e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268370293 146 PNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAG--IATQAvvekqlwKERGV-------RRHELSREAF 214
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGtpIELKA-------EKEGItpeelvdRYHEIHREDF 78
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
137-231 |
2.57e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 57.58 E-value: 2.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 137 ETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSD-H----------AGIATQAVVE------KQLW 199
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeHgqkiqrkaeeAGISPQELADrnsaafKRLW 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 268370293 200 K------ERGVRRHELSREAFLREVWQWKEAKgGEICE 231
Cdd:PRK11893 81 EalnisyDDFIRTTDPRHKEAVQEIFQRLLAN-GDIYL 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
579-868 |
1.43e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 55.27 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 579 DPD-VLDTWFSsALFPF-SALGWPQETPDLA----RFYP--LSLLetGSDLLLF----WVGRMVMLGtqltGQLPfSKVL 646
Cdd:PRK11893 217 DPKhVIYVWFD-ALTNYlTALGYPDDEELLAelfnKYWPadVHLI--GKDILRFhavyWPAFLMAAG----LPLP-KRVF 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 647 LHPMVRdRQGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSHG 726
Cdd:PRK11893 289 AHGFLT-LDGEKMSKSLGNVIDPFDLVD-------------------------------------EYGVDAVRYFLLREI 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 727 VQAGDLHLSVSEVQSCR--HFCNKIWNALRFILNALGEKF---VPQPAEELSPsspmDAWILSRLALAAQECERGFLTRE 801
Cdd:PRK11893 331 PFGQDGDFSREAFINRInaDLANDLGNLAQRTLSMIAKNFdgkVPEPGALTEA----DEALLEAAAALLERVRAAMDNLA 406
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268370293 802 LSLVTHALHHfwLHNLCDVYLEAVKPVLWHSPRPLGPPQVLFSCADlGLR----LLAPLMPFLAEELWQRL 868
Cdd:PRK11893 407 FDKALEAILA--LVRAANKYIDEQAPWSLAKTDPERLATVLYTLLE-VLRgiavLLQPVMPELAAKILDQL 474
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
656-868 |
2.58e-07 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 54.73 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 656 GRKMSKSLGNVLDPRDIIsgvemqvlqeklrsgnldpaelaivaaaqkKDFphgipecGTDALRFTLCSHGVQAGDLHLS 735
Cdd:COG0143 325 GEKMSKSRGNVIDPDDLL------------------------------DRY-------GPDALRYYLLREVPFGQDGDFS 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 736 VSEVQScRH---FCNKIWN----ALRFILNALGEKfVPQPAEElspsSPMDAWILSRLALAAQECERGFLTRELSlvtHA 808
Cdd:COG0143 368 WEDFVA-RVnsdLANDLGNlasrTLSMIHKYFDGK-VPEPGEL----TEADEELLAEAEAALEEVAEAMEAFEFR---KA 438
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268370293 809 LHHFW-LHNLCDVYLEAVKP-VLWHSPRP--LGppQVLFSCADLgLR----LLAPLMPFLAEELWQRL 868
Cdd:COG0143 439 LEEIMaLARAANKYIDETAPwKLAKDEDPerLA--TVLYTLLEA-LRilaiLLKPFLPETAEKILEQL 503
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
148-201 |
1.31e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.50 E-value: 1.31e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268370293 148 VTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSD-H----------AGIATQAVVE------KQLWKE 201
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDeHgqkiqqaaekAGKTPQEYVDeisagfKELWKK 85
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
146-196 |
6.50e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 50.15 E-value: 6.50e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 268370293 146 PNVTGSLHIGHALTVaIQ-DALVRWHRMRGDQVLWVPGSD-H----------AGIATQAVVEK 196
Cdd:PRK00133 11 PYANGPIHLGHLVEY-IQaDIWVRYQRMRGHEVLFVCADDaHgtpimlkaekEGITPEELIAR 72
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
770-868 |
2.03e-05 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 44.89 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 770 EELSPSSPMDAWILSRL---ALAAQECERGFLTRElslvthALHHFW--LHNLCDVYLEAVKPVLwHSprplgppQVLFS 844
Cdd:cd07959 28 GELEELTFIDRWLLSRLnrlIKETTEAYENMQFRE------ALKEGLyeLQNDLDWYRERGGAGM-NK-------DLLRR 93
|
90 100
....*....|....*....|....
gi 268370293 845 CADLGLRLLAPLMPFLAEELWQRL 868
Cdd:cd07959 94 FIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
476-673 |
4.98e-05 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 46.47 E-value: 4.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 476 LKNQWFVR--CQEMGARAAKAVEsgALELSPSFHQKNWQHWfshIGdwcVSRQLWWGHQIPaylvvedhaqgeedcWVvg 553
Cdd:cd00812 128 LLDQWFLKysETEWKEKLLKDLE--KLDGWPEEVRAMQENW---IG---CSRQRYWGTPIP---------------WT-- 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 554 rseaearevaaeltgrpgaeltlerdpDVLDTWFSSALFPF----------SALGWPQETPDLAR-FYPLSLLETGSDL- 621
Cdd:cd00812 183 ---------------------------DTMESLSDSTWYYArytdahnleqPYEGDLEFDREEFEyWYPVDIYIGGKEHa 235
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 268370293 622 ---LLFWV-GRMVMLGTQLTGQLPFSKVLLHPMVRdRQGRKMSKSLGNVLDPRDII 673
Cdd:cd00812 236 pnhLLYSRfNHKALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAI 290
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
109-178 |
8.04e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 46.99 E-value: 8.04e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 109 VEAAWYPWWVREGFFKPEYQARLPqATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVL 178
Cdd:PLN02959 18 IEVAVQKWWEEEKVFEAEAGDEPP-KPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVL 86
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
136-272 |
2.70e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 45.09 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 136 GETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAG--IATQAVVEKqlwkeRGVRRH-ELSRE 212
Cdd:PLN02224 68 ADTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATSAAANG-----RNPPEHcDIISQ 142
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 213 AFlREVWQwkeakggeiceqlralGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYR 272
Cdd:PLN02224 143 SY-RTLWK----------------DLDIAYDKFIRTTDPKHEAIVKEFYARVFANGDIYR 185
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
850-868 |
4.71e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 41.05 E-value: 4.71e-04
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
576-673 |
7.01e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 43.64 E-value: 7.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 576 LERDPD-VLDTWFSsALFPF-SALGWPQETPDL-ARFYPLSLLETGSDLL----LFWVGRMVMLGtqltgqLPFSKV--- 645
Cdd:PRK12267 217 VPFDPKhVVYVWID-ALLNYiTALGYGSDDDELfKKFWPADVHLVGKDILrfhaIYWPIMLMALG------LPLPKKvfa 289
|
90 100 110
....*....|....*....|....*....|.
gi 268370293 646 ---LLhpmvrdRQGRKMSKSLGNVLDPRDII 673
Cdd:PRK12267 290 hgwWL------MKDGKMSKSKGNVVDPEELV 314
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
144-206 |
1.78e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 39.77 E-value: 1.78e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268370293 144 PPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAG--IATQAVVEKQLWK---ERGVRR 206
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGglIGDPANKKGENAKafvERWIER 71
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
738-857 |
1.83e-03 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 39.41 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 738 EVQSCRHFCNKIWNALRFILNALGEKfvpQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFwLHNL 817
Cdd:cd07375 3 RLKQARAFLNRLYRLLSFFRKALGGT---QPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKF-TNEL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 268370293 818 cDVYLEAVKPVLWHSPRPLGPPQVLFSCADLGLRLLAPLM 857
Cdd:cd07375 79 -NWYLDELKPALQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
146-272 |
3.13e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 41.29 E-value: 3.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370293 146 PNVTGSLHIGHALTVAIQDALVRWHRMRGDQVL-------WvpGSdHAGIATQAVveKQLWKeRGVrrhELSREaflrev 218
Cdd:PRK01611 120 ANPTGPLHVGHLRSAVIGDALARILEFAGYDVTreyyvndA--GT-QIGMLIASL--ELLWR-KAV---DISLD------ 184
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 268370293 219 wqwkeakggEICEQLRALGASLD-WDREcftmdvGSSV---AVTEAFVRLYKAGLLYR 272
Cdd:PRK01611 185 ---------EIKEDLDRLGVHFDvWFSE------SELYyngKVDEVVEDLKEKGLLYV 227
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
636-681 |
5.50e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 40.47 E-value: 5.50e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 268370293 636 LTGQlPFSKVLLHP-MVRDRqGRKMSKSLGNVLDPRDIISGVEMQVL 681
Cdd:COG0215 244 ATGK-PFARYWMHNgFLTVN-GEKMSKSLGNFFTVRDLLKKYDPEVL 288
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
146-178 |
5.93e-03 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 39.47 E-value: 5.93e-03
10 20 30
....*....|....*....|....*....|...
gi 268370293 146 PNVTGSLHIGHALTVAIQDALVRWHRMRGDQVL 178
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| |
