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Conserved domains on  [gi|29789112|ref|NP_065765|]
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zinc finger protein 490 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 56-97 3.59e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.81  E-value: 3.59e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 29789112    56 SISLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLACIG 97
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-505 3.46e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 192 KPHKCKECGKTFTRSSSIRTHERIHTGEKPYECKECGKAFAFLF--SFRNHIRIHTGETPYECKECGKAFRYLTALR-RH 268
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSsLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 269 EKNHTGEKPYKCKQCGKAFIYYQPFLTHERTHTGEKPYECKQC-GKAFSCPTYLRSHEKTHtgekpfVCRECGRAFFSHS 347
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLP------ANSLSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 348 SLRKHVKTHTGVQPYTCKKCGEAFKSSSSCEVHERTHFgEKPYECKQCGKAFNSSSYLQLHERVHTGEKTYECKECGKAF 427
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 428 L------YSTHFRIHERTHTR-EKPYECKQCGRVFIYFSHLRRHERS--HTG--VKPCEC--KQCGKAFTCLNSLKVHKR 494
Cdd:COG5048 265 LptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                       330
                ....*....|.
gi 29789112 495 IHTGERPFQCR 505
Cdd:COG5048 345 LHTSISPAKEK 355
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 56-97 3.59e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.81  E-value: 3.59e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 29789112    56 SISLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLACIG 97
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
58-99 1.83e-14

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 68.00  E-value: 1.83e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 29789112     58 SLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLACIGEK 99
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 57-94 1.42e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 64.88  E-value: 1.42e-13
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 29789112  57 ISLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLA 94
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-505 3.46e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 192 KPHKCKECGKTFTRSSSIRTHERIHTGEKPYECKECGKAFAFLF--SFRNHIRIHTGETPYECKECGKAFRYLTALR-RH 268
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSsLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 269 EKNHTGEKPYKCKQCGKAFIYYQPFLTHERTHTGEKPYECKQC-GKAFSCPTYLRSHEKTHtgekpfVCRECGRAFFSHS 347
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLP------ANSLSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 348 SLRKHVKTHTGVQPYTCKKCGEAFKSSSSCEVHERTHFgEKPYECKQCGKAFNSSSYLQLHERVHTGEKTYECKECGKAF 427
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 428 L------YSTHFRIHERTHTR-EKPYECKQCGRVFIYFSHLRRHERS--HTG--VKPCEC--KQCGKAFTCLNSLKVHKR 494
Cdd:COG5048 265 LptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                       330
                ....*....|.
gi 29789112 495 IHTGERPFQCR 505
Cdd:COG5048 345 LHTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-289 9.24e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.24e-05
                          10        20
                  ....*....|....*....|....*.
gi 29789112   264 ALRRHEKNHTGEKPYKCKQCGKAFIY 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 56-97 3.59e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.81  E-value: 3.59e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 29789112    56 SISLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLACIG 97
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
58-99 1.83e-14

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 68.00  E-value: 1.83e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 29789112     58 SLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLACIGEK 99
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 57-94 1.42e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 64.88  E-value: 1.42e-13
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 29789112  57 ISLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLA 94
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-505 3.46e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 192 KPHKCKECGKTFTRSSSIRTHERIHTGEKPYECKECGKAFAFLF--SFRNHIRIHTGETPYECKECGKAFRYLTALR-RH 268
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSsLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 269 EKNHTGEKPYKCKQCGKAFIYYQPFLTHERTHTGEKPYECKQC-GKAFSCPTYLRSHEKTHtgekpfVCRECGRAFFSHS 347
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLP------ANSLSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 348 SLRKHVKTHTGVQPYTCKKCGEAFKSSSSCEVHERTHFgEKPYECKQCGKAFNSSSYLQLHERVHTGEKTYECKECGKAF 427
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 428 L------YSTHFRIHERTHTR-EKPYECKQCGRVFIYFSHLRRHERS--HTG--VKPCEC--KQCGKAFTCLNSLKVHKR 494
Cdd:COG5048 265 LptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                       330
                ....*....|.
gi 29789112 495 IHTGERPFQCR 505
Cdd:COG5048 345 LHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-521 1.54e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 268 HEKNHTGEKPYKCKQCGKAFIYYQPFLTHERTHTGEKPYECKQCGKAFSCPTYLRSHEKTHTGEKPFVCRECGRAFF--- 344
Cdd:COG5048 189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLpta 268

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 345 ---SHSSLRKHVKTHTG-VQPYTCKKCGEAFKSSSSCEVHERTHF----GEKPYEC--KQCGKAFNSSSYLQLHERVHTG 414
Cdd:COG5048 269 ssqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 415 EKTYECKEC-----------GKAFLYSTHFRIHERTHTREKPYECkqCGRVFIYFSHLRRHERSHTGVKPCECK--QCGK 481
Cdd:COG5048 349 ISPAKEKLLnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNS--CIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 29789112 482 AFTCLNSLKVHKRIHTGERPFQCRQCGKAFSYSKSLHVHE 521
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-341 4.93e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 138 SQIPDLNTNLETPTGLKPCD-CSVCGEVFMHQVSLNRHMRSHTEQKPNECHEYGEKPHKCKECGKTFTRSSSIRTHER-- 214
Cdd:COG5048 233 SQLSPKSLLSQSPSSLSSSDsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsv 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789112 215 IHTGE--KPYECKE--CGKAFAFLFSFRNHIRIHTGETPYECKEC-------GKAFRYLTALRRHEKNHTGEKPYKC--K 281
Cdd:COG5048 313 NHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsN 392

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29789112 282 QCGKAFIYYQPFLTHERTHTGEKPYECK--QCGKAFSCPTYLRSHEKTHTGEKPFVCRECGR 341
Cdd:COG5048 393 SCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-289 9.24e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.24e-05
                          10        20
                  ....*....|....*....|....*.
gi 29789112   264 ALRRHEKNHTGEKPYKCKQCGKAFIY 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
488-513 4.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 29789112   488 SLKVHKRIHTGERPFQCRQCGKAFSY 513
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-232 1.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|...
gi 29789112   210 RTHERIHTGEKPYECKECGKAFA 232
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-317 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|..
gi 29789112   296 HERTHTGEKPYECKQCGKAFSC 317
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-261 2.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 29789112   236 SFRNHIRIHTGETPYECKECGKAFRY 261
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-485 3.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.81e-03
                          10        20
                  ....*....|....*....|....*.
gi 29789112   460 HLRRHERSHTGVKPCECKQCGKAFTC 485
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-429 5.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 29789112   404 YLQLHERVHTGEKTYECKECGKAFLY 429
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-401 6.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.55e-03
                          10        20
                  ....*....|....*....|....
gi 29789112   378 EVHERTHFGEKPYECKQCGKAFNS 401
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-373 6.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.88e-03
                          10        20
                  ....*....|....*....|....*.
gi 29789112   348 SLRKHVKTHTGVQPYTCKKCGEAFKS 373
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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