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Conserved domains on  [gi|605052038|ref|NP_066008|]
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protocadherin beta-16 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 2.43e-45

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 156.53  E-value: 2.43e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   31 GSYSVVEETERGSFVANLGKDLGLGLTEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDREELCGPTEPCILHFQVLM 110
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81


                  ..
gi 605052038  111 EN 112
Cdd:pfam08266  82 EN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-768 1.40e-34

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 126.49  E-value: 1.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  685 SLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGR----CSMPEGPFPGrlvdVSGTGTLSQSYQYEVCLTGGSE 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPG----NDGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 605052038  761 TSEFKFLK 768
Cdd:pfam16492  77 KSEFKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 1.45e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.49  E-value: 1.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 246 IYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDisKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGG 325
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 605052038 326 G--LSGKCTLLLQVVDVNDN 343
Cdd:cd11304   79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 1.78e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 1.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 455 SYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLplaslVSINADNGHLFALRSLDYEALQAFEFRVGAT 534
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 605052038 535 DRGSPALSREALVRVLVLDANDN 557
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 2.07e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 2.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 137 EMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKIS---PSSHFRVlihefrdGRKYPELVLDKELDREEEPQLRLTLT 213
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 605052038 214 ALDGGSPPRSGTAQVRIEVVDINDN 238
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-664 3.44e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPRSAT 655
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 605052038 656 ATLHVLLVD 664
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-447 3.79e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 356 IPENSPEI-VVAVFSVSDPDSGNNGK---TISSIQEDLPFLLKPsvkNFYTLVTERALDREARAEYNITLTVTDMGTPRL 431
Cdd:cd11304    6 VPENAPPGtVVLTVSATDPDSGENGEvtySIVSGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 605052038 432 KTEHNITVQISDVNDN 447
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 2.43e-45

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 156.53  E-value: 2.43e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   31 GSYSVVEETERGSFVANLGKDLGLGLTEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDREELCGPTEPCILHFQVLM 110
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81


                  ..
gi 605052038  111 EN 112
Cdd:pfam08266  82 EN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-768 1.40e-34

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 126.49  E-value: 1.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  685 SLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGR----CSMPEGPFPGrlvdVSGTGTLSQSYQYEVCLTGGSE 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPG----NDGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 605052038  761 TSEFKFLK 768
Cdd:pfam16492  77 KSEFKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 1.45e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.49  E-value: 1.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 246 IYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDisKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGG 325
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 605052038 326 G--LSGKCTLLLQVVDVNDN 343
Cdd:cd11304   79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 1.78e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 1.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 455 SYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLplaslVSINADNGHLFALRSLDYEALQAFEFRVGAT 534
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 605052038 535 DRGSPALSREALVRVLVLDANDN 557
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 2.07e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 2.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 137 EMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKIS---PSSHFRVlihefrdGRKYPELVLDKELDREEEPQLRLTLT 213
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 605052038 214 ALDGGSPPRSGTAQVRIEVVDINDN 238
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 474-559 1.58e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 1.58e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   474 SATDRDSGTNAQVTYSLLPPQDPHLplaslVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLD 553
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL-----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 605052038   554 ANDNSP 559
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-664 3.44e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPRSAT 655
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 605052038 656 ATLHVLLVD 664
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-447 3.79e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 356 IPENSPEI-VVAVFSVSDPDSGNNGK---TISSIQEDLPFLLKPsvkNFYTLVTERALDREARAEYNITLTVTDMGTPRL 431
Cdd:cd11304    6 VPENAPPGtVVLTVSATDPDSGENGEvtySIVSGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 605052038 432 KTEHNITVQISDVNDN 447
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-240 4.17e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 4.17e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   156 HALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGrkypELVLDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDI 235
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 605052038   236 NDNAP 240
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 1.22e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   265 SARDLDGGANGKISYTLFQPSEDISktLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGG--LSGKCTLLLQVVDVND 342
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL--FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 605052038   343 NPP 345
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
247-337 9.09e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 9.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  247 YKVQIPENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDisKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGG- 325
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG--GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|...
gi 605052038  326 -GLSGKCTLLLQV 337
Cdd:pfam00028  79 pPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
456-552 2.89e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  456 YTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLplaslVSINADNGHLFALRSLDYEALQAFEFRVGATD 535
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 605052038  536 RGSPALSREALVRVLVL 552
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 369-449 1.40e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   369 SVSDPDSGNNGK---TISSIQEDLPFLLKPSVKnfyTLVTERALDREARAEYNITLTVTDMGTPRLKTEHNITVQISDVN 445
Cdd:smart00112   1 SATDADSGENGKvtySILSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 605052038   446 DNAP 449
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-664 1.27e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 1.27e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 605052038   590 VAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPRSATATLHVLLVD 664
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 8.48e-14

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 67.75  E-value: 8.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  33 YSVVEETERGSFVANLGKDLGlgltEMSTRKARIISQGNK---QHLQLKAQTGDLLINEKLDREELcgptepCILHFQVL 109
Cdd:cd00031    4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                         90       100
                 ....*....|....*....|....*
gi 605052038 110 M-----ENPLEIFQAELRVIDINDH 129
Cdd:cd00031   74 AaslgaNVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
142-232 1.99e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  142 IPENSPLGTEFPLNHALDLDVGSNNVQNYKIS---PSSHFRVlihEFRDGrkypELVLDKELDREEEPQLRLTLTALDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRI---DPDTG----DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 605052038  219 SPPRSGTAQVRIEV 232
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
576-662 8.82e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 8.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPRSAT 655
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 605052038  656 ATLHVLL 662
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
356-441 7.75e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 7.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  356 IPENSPEIV-VAVFSVSDPDSGNNGKTISSIQEDLPFllkpsvKNFY------TLVTERALDREARAEYNITLTVTDMGT 428
Cdd:pfam00028   5 VPENAPVGTeVLTVTATDPDLGPNGRIFYSILGGGPG------GNFRidpdtgDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|...
gi 605052038  429 PRLKTEHNITVQI 441
Cdd:pfam00028  79 PPLSSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 2.43e-45

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 156.53  E-value: 2.43e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   31 GSYSVVEETERGSFVANLGKDLGLGLTEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDREELCGPTEPCILHFQVLM 110
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81


                  ..
gi 605052038  111 EN 112
Cdd:pfam08266  82 EN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-768 1.40e-34

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 126.49  E-value: 1.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  685 SLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGR----CSMPEGPFPGrlvdVSGTGTLSQSYQYEVCLTGGSE 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPG----NDGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 605052038  761 TSEFKFLK 768
Cdd:pfam16492  77 KSEFKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 1.45e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.49  E-value: 1.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 246 IYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDisKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGG 325
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 605052038 326 G--LSGKCTLLLQVVDVNDN 343
Cdd:cd11304   79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 1.78e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 1.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 455 SYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLplaslVSINADNGHLFALRSLDYEALQAFEFRVGAT 534
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 605052038 535 DRGSPALSREALVRVLVLDANDN 557
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 2.07e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 2.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 137 EMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKIS---PSSHFRVlihefrdGRKYPELVLDKELDREEEPQLRLTLT 213
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 605052038 214 ALDGGSPPRSGTAQVRIEVVDINDN 238
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 474-559 1.58e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 1.58e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   474 SATDRDSGTNAQVTYSLLPPQDPHLplaslVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLD 553
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL-----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 605052038   554 ANDNSP 559
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-664 3.44e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPRSAT 655
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 605052038 656 ATLHVLLVD 664
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-447 3.79e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038 356 IPENSPEI-VVAVFSVSDPDSGNNGK---TISSIQEDLPFLLKPsvkNFYTLVTERALDREARAEYNITLTVTDMGTPRL 431
Cdd:cd11304    6 VPENAPPGtVVLTVSATDPDSGENGEvtySIVSGNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 605052038 432 KTEHNITVQISDVNDN 447
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-240 4.17e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 4.17e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   156 HALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGrkypELVLDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDI 235
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 605052038   236 NDNAP 240
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 1.22e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   265 SARDLDGGANGKISYTLFQPSEDISktLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGG--LSGKCTLLLQVVDVND 342
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL--FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 605052038   343 NPP 345
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
247-337 9.09e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 9.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  247 YKVQIPENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDisKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGG- 325
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG--GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|...
gi 605052038  326 -GLSGKCTLLLQV 337
Cdd:pfam00028  79 pPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
456-552 2.89e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  456 YTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLplaslVSINADNGHLFALRSLDYEALQAFEFRVGATD 535
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 605052038  536 RGSPALSREALVRVLVL 552
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 369-449 1.40e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038   369 SVSDPDSGNNGK---TISSIQEDLPFLLKPSVKnfyTLVTERALDREARAEYNITLTVTDMGTPRLKTEHNITVQISDVN 445
Cdd:smart00112   1 SATDADSGENGKvtySILSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 605052038   446 DNAP 449
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-664 1.27e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 1.27e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 605052038   590 VAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPRSATATLHVLLVD 664
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 8.48e-14

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 67.75  E-value: 8.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  33 YSVVEETERGSFVANLGKDLGlgltEMSTRKARIISQGNK---QHLQLKAQTGDLLINEKLDREELcgptepCILHFQVL 109
Cdd:cd00031    4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                         90       100
                 ....*....|....*....|....*
gi 605052038 110 M-----ENPLEIFQAELRVIDINDH 129
Cdd:cd00031   74 AaslgaNVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
142-232 1.99e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  142 IPENSPLGTEFPLNHALDLDVGSNNVQNYKIS---PSSHFRVlihEFRDGrkypELVLDKELDREEEPQLRLTLTALDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRI---DPDTG----DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 605052038  219 SPPRSGTAQVRIEV 232
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
576-662 8.82e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 8.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPRSAT 655
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 605052038  656 ATLHVLL 662
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
356-441 7.75e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 7.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  356 IPENSPEIV-VAVFSVSDPDSGNNGKTISSIQEDLPFllkpsvKNFY------TLVTERALDREARAEYNITLTVTDMGT 428
Cdd:pfam00028   5 VPENAPVGTeVLTVTATDPDLGPNGRIFYSILGGGPG------GNFRidpdtgDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|...
gi 605052038  429 PRLKTEHNITVQI 441
Cdd:pfam00028  79 PPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 2.31e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.84  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052038  32 SYSVVEETERGSFVANLG-KDLGLGltEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDREELcgptepCILHFQVL- 109
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSaTDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTa 74

                         90       100
                 ....*....|....*....|....
gi 605052038 110 MENPLEIFQA----ELRVIDINDH 129
Cdd:cd11304   75 TDGGGPPLSStatvTITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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