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Conserved domains on  [gi|38045952|ref|NP_066358|]
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zinc finger protein 14 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.65e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.65e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 38045952     3 SVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-633 2.52e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 249 KPYECKQCGKAFSCPTYFRTHERTHTGEKPYKC--KECGKAFSFLSSFRRHKRTHSGEKPYEC-KECGKAFFYSASFRAH 325
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 326 VIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSI-SLRLHERTHTGEkpyeckQCHKTFSFSS 404
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANS------LSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 405 SLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERtHNAEKPYECKQCGKAFRCSSYFRIH------ERSHTGEKPYECK 478
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 479 QCGKVFIRSSSFRLHERTHTG-EKPYECKLCGKTFSFSSSLREH--EKIHTG--NKPFEC--KQCGKAFLRSSQIRLHER 551
Cdd:COG5048 265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 552 THTGEKPYQCK-------------------------------------QCGKAFISSSKFRMHERTHTGEKP--YRCKQC 592
Cdd:COG5048 345 LHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 38045952 593 GKAFRFSSSVRIHERSHTGEKPYECKQCGKaFISSSHFRLH 633
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-180 9.17e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|....*
gi 38045952   156 FRKHERTHTGVKPYECKQCGKAFIY 180
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.65e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.65e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 38045952     3 SVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 1.24e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 1.24e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 38045952      4 VSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 4.03e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.20  E-value: 4.03e-16
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 38045952   4 VSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLV 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-633 2.52e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 249 KPYECKQCGKAFSCPTYFRTHERTHTGEKPYKC--KECGKAFSFLSSFRRHKRTHSGEKPYEC-KECGKAFFYSASFRAH 325
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 326 VIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSI-SLRLHERTHTGEkpyeckQCHKTFSFSS 404
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANS------LSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 405 SLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERtHNAEKPYECKQCGKAFRCSSYFRIH------ERSHTGEKPYECK 478
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 479 QCGKVFIRSSSFRLHERTHTG-EKPYECKLCGKTFSFSSSLREH--EKIHTG--NKPFEC--KQCGKAFLRSSQIRLHER 551
Cdd:COG5048 265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 552 THTGEKPYQCK-------------------------------------QCGKAFISSSKFRMHERTHTGEKP--YRCKQC 592
Cdd:COG5048 345 LHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 38045952 593 GKAFRFSSSVRIHERSHTGEKPYECKQCGKaFISSSHFRLH 633
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-262 6.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 38045952   237 SFQRHKRTHTGEKPYECKQCGKAFSC 262
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-180 9.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|....*
gi 38045952   156 FRKHERTHTGVKPYECKQCGKAFIY 180
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.65e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.65e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 38045952     3 SVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 1.24e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 1.24e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 38045952      4 VSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 4.03e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.20  E-value: 4.03e-16
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 38045952   4 VSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLV 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-633 2.52e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 249 KPYECKQCGKAFSCPTYFRTHERTHTGEKPYKC--KECGKAFSFLSSFRRHKRTHSGEKPYEC-KECGKAFFYSASFRAH 325
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 326 VIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSI-SLRLHERTHTGEkpyeckQCHKTFSFSS 404
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANS------LSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 405 SLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERtHNAEKPYECKQCGKAFRCSSYFRIH------ERSHTGEKPYECK 478
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 479 QCGKVFIRSSSFRLHERTHTG-EKPYECKLCGKTFSFSSSLREH--EKIHTG--NKPFEC--KQCGKAFLRSSQIRLHER 551
Cdd:COG5048 265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 552 THTGEKPYQCK-------------------------------------QCGKAFISSSKFRMHERTHTGEKP--YRCKQC 592
Cdd:COG5048 345 LHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 38045952 593 GKAFRFSSSVRIHERSHTGEKPYECKQCGKaFISSSHFRLH 633
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-606 2.47e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 101 KPHECSFCGRDFIHHSSLNRHMRSHTGQKPneyqeyekqpckckavgktfsyHHCFRkherthtgvkpyecKQCGKAFIY 180
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKP----------------------SQCSY--------------SGCDKSFSR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 181 YQPFQRHERTHAGQKPYECKQCGKTFIYYQSFQKHAHTGKKPYE---CKQCGKAFICYQSFQRHKRTHTGEKPYECKQC- 256
Cdd:COG5048  76 PLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNn 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 257 GKAFSCPTYFRTHERTHTGEKpykckeCGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFRAHVIIHtgarpyk 336
Cdd:COG5048 156 SSSVNTPQSNSLHPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN------- 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 337 ckecgkaFNSSNSCrvHERTHIGEKPYecKRCGKSFSWSISLRLHERTHtgekpYECKQCHKTFSFSSSLREHETTHTG- 415
Cdd:COG5048 223 -------SSSSLPL--TTNSQLSPKSL--LSQSPSSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGf 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 416 EKPYECKQCGKTFSFSSSLQRHERTHNaekpyeckqcgkafrcssyfrihersHTGE--KPYEC--KQCGKVFIRSSSFR 491
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSVN--------------------------HSGEslKPFSCpySLCGKLFSRNDALK 340

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 492 LHERTHTGEKPYECKLCGKTFSFSSSL-------REHEKIHTGNKPFEC--KQCGKAFLRSSQIRLHERTHTGEKPYQCK 562
Cdd:COG5048 341 RHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 38045952 563 --QCGKAFISSSKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRIHE 606
Cdd:COG5048 421 npPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-639 6.24e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 361 KPYECKRCGKSFSWSISLRLHERTHTGEKPYEC--KQCHKTFSFSSSLREHETTHTGEKPYEC-KQCGKTFSFSSSLQRH 437
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 438 ERTHNAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYECKQCGKVFIRSS----------------------SFRLHER 495
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 496 THTGEKPYECKLCGKTFSFSSSLREHEKIHTGNKPFECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQCG------KAFI 569
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38045952 570 SSSKFRMHERTHTG-EKPYRCKQCGKAFRFSSSVRIHERS--HTGE--KPYEC--KQCGKAFISSSHFRLHERTHMG 639
Cdd:COG5048 272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-262 6.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 38045952   237 SFQRHKRTHTGEKPYECKQCGKAFSC 262
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
442-630 2.49e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 442 NAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYEC--KQCGKVFIRSSSFRLHERTHTGEKPYEC-KLCGKTFSFSSSL 518
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSS 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045952 519 REHEKIHTGNKPFECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQC---GKAFISSSKFRM-HERTHTGEKPYRCkqcgk 594
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnssSVNTPQSNSLHPpLPANSLSKDPSSN----- 183

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 38045952 595 afrfsSSVRIHERSHTGEKPYECKQCGKAFISSSHF 630
Cdd:COG5048 184 -----LSLLISSNVSTSIPSSSENSPLSSSYSIPSS 214
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-316 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|....
gi 38045952   293 SFRRHKRTHSGEKPYECKECGKAF 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-289 2.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.66e-03
                          10        20
                  ....*....|....*....|....*
gi 38045952   265 YFRTHERTHTGEKPYKCKECGKAFS 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-401 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*
gi 38045952   377 SLRLHERTHTGEKPYECKQCHKTFS 401
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-596 6.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|...
gi 38045952   574 FRMHERTHTGEKPYRCKQCGKAF 596
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
433-458 7.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 38045952   433 SLQRHERTHNAEKPYECKQCGKAFRC 458
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-429 7.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.84e-03
                          10        20
                  ....*....|....*....|....*
gi 38045952   405 SLREHETTHTGEKPYECKQCGKTFS 429
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-542 8.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 38045952   517 SLREHEKIHTGNKPFECKQCGKAFLR 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-180 9.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|....*
gi 38045952   156 FRKHERTHTGVKPYECKQCGKAFIY 180
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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