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Conserved domains on  [gi|10864021|ref|NP_067033|]
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trafficking protein particle complex subunit 1 [Homo sapiens]

Protein Classification

trafficking protein particle complex subunit 1 TRAPPC1/BET5( domain architecture ID 13000937)

trafficking protein particle complex subunit 1, also called BET5 homolog, or multiple myeloma protein 2 (MUM-2), may play a role in vesicular transport from endoplasmic reticulum to Golgi.

CATH:  3.30.450.70
Gene Ontology:  GO:0016192|GO:0030008
PubMed:  17110339|18585354

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 4-133 5.03e-78

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


:

Pssm-ID: 341445  Cd Length: 132  Bit Score: 227.04  E-value: 5.03e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021   4 HNLYLFDRNGVCLHYSEWHRKKQA--GIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIK 81
Cdd:cd14855   1 YSFYIFDRHGNCIYYREWNRPKQSsnGKSEEEEQKLMFGLLFSLKSFVRKISPTDDTCGFHSYTTNKYKLHYYETPTGLK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 10864021  82 VVMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQTVQSELFRSRLDSY 133
Cdd:cd14855  81 FVLLTDPNVGDLRDVLQQIYSNIYVEYVVKNPLYPPGEPITSELFRSKLDQY 132
 
Name Accession Description Interval E-value
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 4-133 5.03e-78

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 227.04  E-value: 5.03e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021   4 HNLYLFDRNGVCLHYSEWHRKKQA--GIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIK 81
Cdd:cd14855   1 YSFYIFDRHGNCIYYREWNRPKQSsnGKSEEEEQKLMFGLLFSLKSFVRKISPTDDTCGFHSYTTNKYKLHYYETPTGLK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 10864021  82 VVMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQTVQSELFRSRLDSY 133
Cdd:cd14855  81 FVLLTDPNVGDLRDVLQQIYSNIYVEYVVKNPLYPPGEPITSELFRSKLDQY 132
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 3-137 1.97e-68

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 202.93  E-value: 1.97e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021     3 VHNLYLFDRNGVCLHYSEWHRKKQAgIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIKV 82
Cdd:pfam04099   1 IFSLYIFNRAGGLIYYKEWNRPKKT-KLTTNEYKLLAGMLHSLHSISSKISPLPGSSGIESLETDTFKLHCLETLTGIKF 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 10864021    83 VMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQTVQSELFRSRLDSYVRSL 137
Cdd:pfam04099  80 VLVTDPGTGINRDSLLRKYYELYSDYVLKNPFYSLGMPIRCELFDEKLDQYVRSL 134
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
1-137 6.37e-09

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 51.05  E-value: 6.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021   1 MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEeeYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGI 80
Cdd:COG5122   1 MAVEQFFIINKSGGLIFQREFGEGETELNSNE--YLILASTLHGVSAILTQTIPLPGSSGRLVLYFRNFVMTIFQTTTGT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 10864021  81 KVVMNTDLGVGPIRDVLHHIYSaLYVELVVKNPLCPLGQTVQSELFRSRLDSYVRSL 137
Cdd:COG5122  79 KFVFVAEKRTVNALFQLQKIYS-LYSDYVTKNPFYSPEMPIQCSLFDEHLKRMFEGH 134
 
Name Accession Description Interval E-value
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 4-133 5.03e-78

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 227.04  E-value: 5.03e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021   4 HNLYLFDRNGVCLHYSEWHRKKQA--GIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIK 81
Cdd:cd14855   1 YSFYIFDRHGNCIYYREWNRPKQSsnGKSEEEEQKLMFGLLFSLKSFVRKISPTDDTCGFHSYTTNKYKLHYYETPTGLK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 10864021  82 VVMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQTVQSELFRSRLDSY 133
Cdd:cd14855  81 FVLLTDPNVGDLRDVLQQIYSNIYVEYVVKNPLYPPGEPITSELFRSKLDQY 132
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 3-137 1.97e-68

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 202.93  E-value: 1.97e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021     3 VHNLYLFDRNGVCLHYSEWHRKKQAgIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIKV 82
Cdd:pfam04099   1 IFSLYIFNRAGGLIYYKEWNRPKKT-KLTTNEYKLLAGMLHSLHSISSKISPLPGSSGIESLETDTFKLHCLETLTGIKF 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 10864021    83 VMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQTVQSELFRSRLDSYVRSL 137
Cdd:pfam04099  80 VLVTDPGTGINRDSLLRKYYELYSDYVLKNPFYSLGMPIRCELFDEKLDQYVRSL 134
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 4-133 1.97e-56

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 172.28  E-value: 1.97e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021   4 HNLYLFDRNGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIKVV 83
Cdd:cd14853   1 FYFVVVGHHGNPLYEREFTPPGQAEDDNEEEYKLLAGMLHSVRSINSKLSPNVEKYLKLSDKTNEYKVHAYVTATGLKFV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 10864021  84 MNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQ--TVQSELFRSRLDSY 133
Cdd:cd14853  81 MLTDVLMDRIEDVLKNFFSDLYVLYVKKNPNPFYEPnsPIRSRLFDSKVQSL 132
longin-like cd14818
Longin-like domains; Longin-like domains are small protein domains present in a variety of ...
 4-133 3.41e-36

Longin-like domains; Longin-like domains are small protein domains present in a variety of proteins and members of protein complexes involved in or required for different steps during the transport of proteins from the ribosome to the ER to the plasma membrane, via the Golgi apparatus. Examples are mu and sigma subunits of the heterotetrameric adaptor protein (AP) complex, zeta and delta subunits of the heterotetrameric F-COPI complex, a subgroup of R-SNARE proteins, a subfamily of the transport protein particle (TRAPP), and the signal recognition particle receptor subunit alpha (SR-alpha).


Pssm-ID: 341426  Cd Length: 117  Bit Score: 120.71  E-value: 3.41e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021   4 HNLYLFDRNGVCLHYSEWHRKKQAgipkeeeyklMYGMLFSIRSFVSKMSPLdmKDGFLAFQTSRYKLHYYETPtGIKVV 83
Cdd:cd14818   1 LQLAVFDPQGQVLAASNWLGKKPS----------VKFSLIQIKSFFSKLITS--GFDFLTLTIGSYTFHYYLNK-GLYFV 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 10864021  84 MNTDLgvGPIRDVLHHIYSALYVELVVKNPLCPLGQ--TVQSELFRSRLDSY 133
Cdd:cd14818  68 VITDE--QELRQELFQTLNLLLKEFNSLHGSEVITKniEDDLEEFESYLDIK 117
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 40-133 5.89e-19

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 76.79  E-value: 5.89e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021  40 GMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRDVLHHIYSaLYVELVVKNPLCPLGQ 119
Cdd:cd14856  35 STFHGLHAIAAQLSPVPGSSGIELLETDTFRLHCFQTLTGIKFVLVADPKQPGLDALLRRVYE-LYADYVLKNPFYELEM 113

                        90
                ....*....|....
gi 10864021 120 TVQSELFRSRLDSY 133
Cdd:cd14856 114 PIRCELFDENLQKL 127
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
1-137 6.37e-09

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 51.05  E-value: 6.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021   1 MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEeeYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGI 80
Cdd:COG5122   1 MAVEQFFIINKSGGLIFQREFGEGETELNSNE--YLILASTLHGVSAILTQTIPLPGSSGRLVLYFRNFVMTIFQTTTGT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 10864021  81 KVVMNTDLGVGPIRDVLHHIYSaLYVELVVKNPLCPLGQTVQSELFRSRLDSYVRSL 137
Cdd:COG5122  79 KFVFVAEKRTVNALFQLQKIYS-LYSDYVTKNPFYSPEMPIQCSLFDEHLKRMFEGH 134
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 56-132 1.34e-05

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 42.19  E-value: 1.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10864021  56 DMKDGFL--AFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRD-----VLHHIYSAlYVELVVkNPLCPLGQTVQSELFRS 128
Cdd:cd14854  51 DTSDMYLglLYPTEDYKVYGYVTNTKVKFILVLEDTNTPLRDndvrtLFRRLHNA-YVDAVS-NPFYPPGTPITSKKFDR 128


                ....
gi 10864021 129 RLDS 132
Cdd:cd14854 129 RVDS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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