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Conserved domains on  [gi|10946680|ref|NP_067330|]
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fibromodulin precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
147-356 4.00e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 4.00e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 147 GRKVFSKLRHLERLYLDHNNLTRMPGPLPR--SLRELHLDHNQISRVPNnALEGLENLTALYLHHNEIQEVGSSMRGLRS 224
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 225 LILLDLSYNHLRRVPDGL--PSALEQLYLEHNNVYTVPDSyFRGSPKLLYVRLSHnsltnnglatntfnssslleldlsy 302
Cdd:COG4886 184 LKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN------------------------- 237

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 10946680 303 NQLQKIPPV--NTNLENLYLQGNRINEFSISSfctvvdvmNFSKLQVLRLDGNEIK 356
Cdd:COG4886 238 NQLTDLPELgnLTNLEELDLSNNQLTDLPPLA--------NLTNLKTLDLSNNQLT 285
LRRNT smart00013
Leucine rich repeat N-terminal domain;
75-109 2.56e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.54  E-value: 2.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 10946680     75 DCPQECDCPPnfpTAMYCDNRNLKYLPF-VPSRMKY 109
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLdLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
105-167 1.06e-05

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10946680   105 SRMKYVYFQNNQISAIQEGVFDNATGLLWVALHGNQITSdkVGRKVFSKLRHLERLYLDHNNL 167
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
147-356 4.00e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 4.00e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 147 GRKVFSKLRHLERLYLDHNNLTRMPGPLPR--SLRELHLDHNQISRVPNnALEGLENLTALYLHHNEIQEVGSSMRGLRS 224
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 225 LILLDLSYNHLRRVPDGL--PSALEQLYLEHNNVYTVPDSyFRGSPKLLYVRLSHnsltnnglatntfnssslleldlsy 302
Cdd:COG4886 184 LKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN------------------------- 237

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 10946680 303 NQLQKIPPV--NTNLENLYLQGNRINEFSISSfctvvdvmNFSKLQVLRLDGNEIK 356
Cdd:COG4886 238 NQLTDLPELgnLTNLEELDLSNNQLTDLPPLA--------NLTNLKTLDLSNNQLT 285
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 160-355 5.86e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 5.86e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 160 LYLDHNNLTRMPG-PLPRSLRELHLDHNQISRVPNnaLEGLENLTALYLHHNEIQEVgSSMRGLRSLILLDLSYNHLRRV 238
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 239 pDGL--PSALEQLYLEHNNV-----YTV-PDSYFRGSPKLLYVRLSHNSLTNnglatntfnssslleldlsYNQLQKIpp 310
Cdd:cd21340  84 -EGLenLTNLEELHIENQRLppgekLTFdPRSLAALSNSLRVLNISGNNIDS-------------------LEPLAPL-- 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 10946680 311 vnTNLENLYLQGNRINEFSissfCTVVDVMNFSKLQVLRLDGNEI 355
Cdd:cd21340 142 --RNLEQLDASNNQISDLE----ELLDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-309 3.14e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.35  E-value: 3.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680   81 DCPPNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQISAIQEGVFDNATGLlwvALHGNQITSdkvgrkVFSKLRH-LE 158
Cdd:PRK15370 174 DCLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGNIKTL---YANSNQLTS------IPATLPDtIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  159 RLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLE-------NLTALYLH-----------HNEIQEVGSSM- 219
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRylsvydnSIRTLPAHlpsgithlnvqSNSLTALPETLp 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  220 RGLRSLILLDlsyNHLRRVPDGLPSALEQLYLEHNNVYTVPDSYfrgSPKLLYVRLSHNSLTNngLATNTfnSSSLLELD 299
Cdd:PRK15370 325 PGLKTLEAGE---NALTSLPASLPPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTN--LPENL--PAALQIMQ 394

                        250
                 ....*....|
gi 10946680  300 LSYNQLQKIP 309
Cdd:PRK15370 395 ASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
176-235 3.04e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.04e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946680   176 RSLRELHLDHNQISRVPNNALEGLENLTALYLHHNEIQEV-GSSMRGLRSLILLDLSYNHL 235
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
75-109 2.56e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.54  E-value: 2.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 10946680     75 DCPQECDCPPnfpTAMYCDNRNLKYLPF-VPSRMKY 109
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLdLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 75-105 6.94e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 6.94e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 10946680    75 DCPQECDCPPnfpTAMYCDNRNLKYLPFVPS 105
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
105-167 1.06e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10946680   105 SRMKYVYFQNNQISAIQEGVFDNATGLLWVALHGNQITSdkVGRKVFSKLRHLERLYLDHNNL 167
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
147-356 4.00e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 4.00e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 147 GRKVFSKLRHLERLYLDHNNLTRMPGPLPR--SLRELHLDHNQISRVPNnALEGLENLTALYLHHNEIQEVGSSMRGLRS 224
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 225 LILLDLSYNHLRRVPDGL--PSALEQLYLEHNNVYTVPDSyFRGSPKLLYVRLSHnsltnnglatntfnssslleldlsy 302
Cdd:COG4886 184 LKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN------------------------- 237

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 10946680 303 NQLQKIPPV--NTNLENLYLQGNRINEFSISSfctvvdvmNFSKLQVLRLDGNEIK 356
Cdd:COG4886 238 NQLTDLPELgnLTNLEELDLSNNQLTDLPPLA--------NLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-331 5.51e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 5.51e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 105 SRMKYVYFQNNQISAIQEGvFDNATGLLWVALHGNQITSDkvgRKVFSKLRHLERLYLDHNNLTRMPGPLPR--SLRELH 182
Cdd:COG4886 113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELD 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 183 LDHNQISRVPNnALEGLENLTALYLHHNEIQEVGSSMRGLRSLILLDLSYNHLRRVPD--GLPSaLEQLYLEHNNVYTVP 260
Cdd:COG4886 189 LSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946680 261 DSYfrGSPKLLYVRLSHNSLTNNGLATNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRINEFSIS 331
Cdd:COG4886 267 PLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-351 1.81e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 1.81e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  91 YCDNRNLKYLPFVPSRM---KYVYFQNNQISAIQEgVFDNATGLLWVALHGNQITSDKvgrKVFSKLRHLERLYLDHNNL 167
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLtnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQL 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 168 TRMPGPLPR--SLRELHLDHNQISRVPNnaLEGLENLTALYLHHNEIQEVGSSMrGLRSLILLDLSYNHLrrvpdglpSA 245
Cdd:COG4886 218 TDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA-NLTNLKTLDLSNNQL--------TD 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 246 LEQLYLEHNNVYTVPDSYFRGSPKLLYVRLSHNSLTNNGLATNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRI 325
Cdd:COG4886 287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                       250       260
                ....*....|....*....|....*.
gi 10946680 326 NEFSISSFCTVVDVMNFSKLQVLRLD 351
Cdd:COG4886 367 LTLGLLGLLEATLLTLALLLLTLLLL 392
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 160-355 5.86e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 5.86e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 160 LYLDHNNLTRMPG-PLPRSLRELHLDHNQISRVPNnaLEGLENLTALYLHHNEIQEVgSSMRGLRSLILLDLSYNHLRRV 238
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 239 pDGL--PSALEQLYLEHNNV-----YTV-PDSYFRGSPKLLYVRLSHNSLTNnglatntfnssslleldlsYNQLQKIpp 310
Cdd:cd21340  84 -EGLenLTNLEELHIENQRLppgekLTFdPRSLAALSNSLRVLNISGNNIDS-------------------LEPLAPL-- 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 10946680 311 vnTNLENLYLQGNRINEFSissfCTVVDVMNFSKLQVLRLDGNEI 355
Cdd:cd21340 142 --RNLEQLDASNNQISDLE----ELLDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-256 2.70e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.36  E-value: 2.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  88 TAMYCDNRNLKYLPFVPS--RMKYVYFQNNQISAIQEgvfdnatgllwvalhgnqitsdkvgrkvFSKLRHLERLYLDHN 165
Cdd:cd21340   5 THLYLNDKNITKIDNLSLckNLKVLYLYDNKITKIEN----------------------------LEFLTNLTHLYLQNN 56

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 166 NLTRMPG--PLPRsLRELHLDHNQISRVPNnaLEGLENLTALYLHHNEIQEVGS------SMRGL-RSLILLDLSYNHLR 236
Cdd:cd21340  57 QIEKIENleNLVN-LKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKltfdprSLAALsNSLRVLNISGNNID 133

                       170       180
                ....*....|....*....|.
gi 10946680 237 RVPDGLP-SALEQLYLEHNNV 256
Cdd:cd21340 134 SLEPLAPlRNLEQLDASNNQI 154
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-309 3.14e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.35  E-value: 3.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680   81 DCPPNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQISAIQEGVFDNATGLlwvALHGNQITSdkvgrkVFSKLRH-LE 158
Cdd:PRK15370 174 DCLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGNIKTL---YANSNQLTS------IPATLPDtIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  159 RLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLE-------NLTALYLH-----------HNEIQEVGSSM- 219
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRylsvydnSIRTLPAHlpsgithlnvqSNSLTALPETLp 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  220 RGLRSLILLDlsyNHLRRVPDGLPSALEQLYLEHNNVYTVPDSYfrgSPKLLYVRLSHNSLTNngLATNTfnSSSLLELD 299
Cdd:PRK15370 325 PGLKTLEAGE---NALTSLPASLPPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTN--LPENL--PAALQIMQ 394

                        250
                 ....*....|
gi 10946680  300 LSYNQLQKIP 309
Cdd:PRK15370 395 ASRNNLVRLP 404
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-281 4.70e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.41  E-value: 4.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680   84 PNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQISAIQEGVFDnatGLLWVALHGNQITSdkVGRKVFSKLRHLerlYL 162
Cdd:PRK15370 240 PDTIQEMELSINRITELPeRLPSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRT--LPAHLPSGITHL---NV 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  163 DHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTalyLHHNEIQEVGSSMRglRSLILLDLSYNHLRRVPDGL 242
Cdd:PRK15370 312 QSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLD---VSKNQITVLPETLP--PTITTLDVSRNALTNLPENL 386

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 10946680  243 PSALEQLYLEHNNVYTVPDS--YFRGS-PKLLYVRLSHNSLT 281
Cdd:PRK15370 387 PAALQIMQASRNNLVRLPESlpHFRGEgPQPTRIIVEYNPFS 428
LRR_8 pfam13855
Leucine rich repeat;
176-235 3.04e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.04e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946680   176 RSLRELHLDHNQISRVPNNALEGLENLTALYLHHNEIQEV-GSSMRGLRSLILLDLSYNHL 235
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
155-212 6.66e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 6.66e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946680   155 RHLERLYLDHNNLTRMPGPLPR---SLRELHLDHNQISRVPNNALEGLENLTALYLHHNEI 212
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKglsNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
81-343 1.51e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.32  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680   81 DCPPNFPTAMYCDNRNLKYLPFVPSRMKYVYFQNNQISAI--------QEGVFDNA--------TGLLWVALHGNQITSD 144
Cdd:PRK15387 218 DCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLpvlppgllELSIFSNPlthlpalpSGLCKLWIFGNQLTSL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  145 KVGRKVFSKLR--------------HLERLYLDHNNLTRMPgPLPRSLRELHLDHNQISRVPNNALEglenLTALYLHHN 210
Cdd:PRK15387 298 PVLPPGLQELSvsdnqlaslpalpsELCKLWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTLPSE----LYKLWAYNN 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  211 EIQEVGSSMRGLRSLILldlSYNHLRRVPDgLPSALEQLYLEHNNVYTVPdsyfrgspkllyvrlshnsLTNNGLATntf 290
Cdd:PRK15387 373 RLTSLPALPSGLKELIV---SGNRLTSLPV-LPSELKELMVSGNRLTSLP-------------------MLPSGLLS--- 426

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 10946680  291 nssslleLDLSYNQLQKIPPVNTNLEN---LYLQGNRINEFSISSFCTVVDVMNFS 343
Cdd:PRK15387 427 -------LSVYRNQLTRLPESLIHLSSettVNLEGNPLSERTLQALREITSAPGYS 475
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-254 2.04e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680   83 PPNFPTAM-YCD--NRNLKYLP-FVPSRMKYVYFQNNQISAIQEGVfdnATGLLWVALHGNQITSDKVgrkvfSKLRHLE 158
Cdd:PRK15370 278 PENLPEELrYLSvyDNSIRTLPaHLPSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPA-----SLPPELQ 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  159 RLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPnnaleglENLTAlylhhneiqevgssmrglrSLILLDLSYNHLRRV 238
Cdd:PRK15370 350 VLDVSKNQITVLPETLPPTITTLDVSRNALTNLP-------ENLPA-------------------ALQIMQASRNNLVRL 403

                        170       180
                 ....*....|....*....|..
gi 10946680  239 PDGLPSALEQ------LYLEHN 254
Cdd:PRK15370 404 PESLPHFRGEgpqptrIIVEYN 425
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-318 1.36e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 1.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 105 SRMKYVYFQNNQISAIQEGvFDNATGLLWVALHGNQITSdkvgRKVFSKLRHLERLYLDHNNLTRMPGPLP-RSLRELHL 183
Cdd:COG4886 205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTD----LPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDL 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 184 DHNQISRVPNNALEGLENLTALYLHHNEIQEVGSSMRGLRSLILLDLSYNHLRRVPDGLPSALEQLYLEHNNVYTVPDSY 263
Cdd:COG4886 280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLL 359

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 10946680 264 FRGSPKLLYVRLSHNSLTNNGLATNTFNSSSLLELDLSYNQLQKIPPVNTNLENL 318
Cdd:COG4886 360 SLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRRNT smart00013
Leucine rich repeat N-terminal domain;
75-109 2.56e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.54  E-value: 2.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 10946680     75 DCPQECDCPPnfpTAMYCDNRNLKYLPF-VPSRMKY 109
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLdLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 110-254 4.56e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 4.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 110 VYFQNNQISAIqEGvfdnatgllwvalhgnqitsdkvgrkvFSKLRHLERLYLDHNNLTRMPGpL--PRSLRELHLDHNQ 187
Cdd:cd21340  51 LYLQNNQIEKI-EN---------------------------LENLVNLKKLYLGGNRISVVEG-LenLTNLEELHIENQR 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 188 ISrvPNNALE-------GL-ENLTALYLHHNEIQEVgSSMRGLRSLILLDLSYNHLRRVPD------GLPSaLEQLYLEH 253
Cdd:cd21340 102 LP--PGEKLTfdprslaALsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElldllsSWPS-LRELDLTG 177


                .
gi 10946680 254 N 254
Cdd:cd21340 178 N 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 136-359 6.08e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 6.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 136 LHGNQITSDKVGRkVFSKLRHLERLYLDHNNLTRMPGPL-------PRSLRELHLDHNQISRVPNN---ALEGLEN---L 202
Cdd:cd00116   5 LKGELLKTERATE-LLPKLLCLQVLRLEGNTLGEEAAKAlasalrpQPSLKELCLSLNETGRIPRGlqsLLQGLTKgcgL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 203 TALYLHHNEIQEVGS----SMRGLRSLILLDLSYN-----HLRRVPDGL---PSALEQLYLEHNNVYTVP----DSYFRG 266
Cdd:cd00116  84 QELDLSDNALGPDGCgvleSLLRSSSLQELKLNNNglgdrGLRLLAKGLkdlPPALEKLVLGRNRLEGAScealAKALRA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 267 SPKLLYVRLSHNSLTNNGLAT------------------NTFNSSSLLeldlsynQLQKIPPVNTNLENLYLQGNRINEF 328
Cdd:cd00116 164 NRDLKELNLANNGIGDAGIRAlaeglkancnlevldlnnNGLTDEGAS-------ALAETLASLKSLEVLNLGDNNLTDA 236

                       250       260       270
                ....*....|....*....|....*....|.
gi 10946680 329 SISSFCTVVDVMNfSKLQVLRLDGNEIKRSA 359
Cdd:cd00116 237 GAAALASALLSPN-ISLLTLSLSCNDITDDG 266
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 75-105 6.94e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 6.94e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 10946680    75 DCPQECDCPPnfpTAMYCDNRNLKYLPFVPS 105
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-255 7.14e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 7.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  105 SRMKYVYFQNNQISAIQEGVFDNATGLLWVALHGNQITSdKVGRKVfSKLRHLERLYLDHNNLTrmpGPLPRSLREL--- 181
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG-QIPREL-GQMKSLKWIYLGYNNLS---GEIPYEIGGLtsl 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  182 -HLD---HNQISRVPNnALEGLENLTALYLHHNEIQ-EVGSSMRGLRSLILLDLSYNHLR-RVPDGLPS--ALEQLYLEH 253
Cdd:PLN00113 239 nHLDlvyNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQlqNLEILHLFS 317


                 ..
gi 10946680  254 NN 255
Cdd:PLN00113 318 NN 319
LRR_8 pfam13855
Leucine rich repeat;
105-167 1.06e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10946680   105 SRMKYVYFQNNQISAIQEGVFDNATGLLWVALHGNQITSdkVGRKVFSKLRHLERLYLDHNNL 167
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
129-188 2.09e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10946680   129 TGLLWVALHGNQITSdkVGRKVFSKLRHLERLYLDHNNLTRMPG----PLPrSLRELHLDHNQI 188
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-373 2.16e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  105 SRMKYVYFQNNQISA-IQEGVFdNATGLLWVALHGNQITSDKvgRKVFSKLRHLERLYLDHNNLT-RMPG---PLPRsLR 179
Cdd:PLN00113 260 KNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEI--PELVIQLQNLEILHLFSNNFTgKIPValtSLPR-LQ 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  180 ELHLDHNQIS-RVPNNaLEGLENLTALYLHHN----EIQEVGSSMRGLRSLILLDLSYNHlrRVPDGLP--SALEQLYLE 252
Cdd:PLN00113 336 VLQLWSNKFSgEIPKN-LGKHNNLTVLDLSTNnltgEIPEGLCSSGNLFKLILFSNSLEG--EIPKSLGacRSLRRVRLQ 412

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  253 HNNVYTVPDSYFRGSPKLLYVRLSHNSLTNNgLATNTFNSSSLLELDLSYNQLQKIPP---VNTNLENLYLQGNRINEFS 329
Cdd:PLN00113 413 DNSFSGELPSEFTKLPLVYFLDISNNNLQGR-INSRKWDMPSLQMLSLARNKFFGGLPdsfGSKRLENLDLSRNQFSGAV 491

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 10946680  330 ISSFctvvdvMNFSKLQVLRLDGNEIKrSAMPVDAPLCLRLANL 373
Cdd:PLN00113 492 PRKL------GSLSELMQLKLSENKLS-GEIPDELSSCKKLVSL 528
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 125-356 3.86e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 3.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 125 FDNATGLLWVALHGNQITSDKVGR-KVFSKLRHLERLYLDHNNLTRMPGP-LPRSLRELHLDhnqisrvpnnaleglenL 202
Cdd:cd00116  77 LTKGCGLQELDLSDNALGPDGCGVlESLLRSSSLQELKLNNNGLGDRGLRlLAKGLKDLPPA-----------------L 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 203 TALYLHHNEIqEVGSS------MRGLRSLILLDLSYNHLRrvPDGLP---------SALEQLYLeHNNVYTVPDSY---- 263
Cdd:cd00116 140 EKLVLGRNRL-EGASCealakaLRANRDLKELNLANNGIG--DAGIRalaeglkanCNLEVLDL-NNNGLTDEGASalae 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 264 -FRGSPKLLYVRLSHNSLTNNGLATntfnssslleldlsynQLQKIPPVNTNLENLYLQGNRINEFSISSFCTVVDvmNF 342
Cdd:cd00116 216 tLASLKSLEVLNLGDNNLTDAGAAA----------------LASALLSPNISLLTLSLSCNDITDDGAKDLAEVLA--EK 277

                       250
                ....*....|....
gi 10946680 343 SKLQVLRLDGNEIK 356
Cdd:cd00116 278 ESLLELDLRGNKFG 291
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 110-355 7.68e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 7.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 110 VYFQNNQISAIQEGVFDNA----TGLLWVALHGNQITSDKVGRkVFSKLRHLERLY-LD-HNNLTRMPG--------PLP 175
Cdd:COG5238 185 VYLGCNQIGDEGIEELAEAltqnTTVTTLWLKRNPIGDEGAEI-LAEALKGNKSLTtLDlSNNQIGDEGvialaealKNN 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 176 RSLRELHLDHNQIS----RVPNNALEGLENLTALYLHHNEIQEVGS-----SMRGLRSLILLDLSYNHLRrvPDG---LP 243
Cdd:COG5238 264 TTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGDEGAialaeGLQGNKTLHTLNLAYNGIG--AQGaiaLA 341

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680 244 SALEQLYLEHNnvytvpdsyfrgspkllyVRLSHNSLTNNGLATntfnssslleldlsynqLQKIPPVNTNLENLYLQGN 323
Cdd:COG5238 342 KALQENTTLHS------------------LDLSDNQIGDEGAIA-----------------LAKYLEGNTTLRELNLGKN 386

                       250       260       270
                ....*....|....*....|....*....|..
gi 10946680 324 RINEfsiSSFCTVVDVMNFSKLQVLRLDGNEI 355
Cdd:COG5238 387 NIGK---QGAEALIDALQTNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 151-257 1.45e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680  151 FSKLRHLERLYLDHNnltRMPGPLPRSLR------ELHLDHNQISRVPNNALEGLENLTALYLHHNEIQ-EVGSSMRGLR 223
Cdd:PLN00113 471 SFGSKRLENLDLSRN---QFSGAVPRKLGslselmQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMP 547

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 10946680  224 SLILLDLSYNHLR-RVPDGLPS--ALEQLYLEHNNVY 257
Cdd:PLN00113 548 VLSQLDLSQNQLSgEIPKNLGNveSLVQVNISHNHLH 584
LRR_8 pfam13855
Leucine rich repeat;
223-280 1.39e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946680   223 RSLILLDLSYNHLRRVPDGL---PSALEQLYLEHNNVYTVPDSYFRGSPKLLYVRLSHNSL 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 177-210 3.09e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 3.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 10946680   177 SLRELHLDHNQISRVPNnaLEGLENLTALYLHHN 210
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
246-325 9.51e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 9.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946680   246 LEQLYLEHNNVYTVPDSYFRGSPKLLYVRLSHNSLTnnGLATNTFnssslleldlsynqlQKIPpvntNLENLYLQGNRI 325
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAF---------------SGLP----SLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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