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Conserved domains on  [gi|296179431|ref|NP_068765|]
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BCL-6 corepressor-like protein 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
 1592-1705 9.31e-68

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


:

Pssm-ID: 271223  Cd Length: 115  Bit Score: 223.57  E-value: 9.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1592 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1671
Cdd:cd14260     2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 296179431 1672 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1705
Cdd:cd14260    82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1424-1529 1.55e-23

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.72  E-value: 1.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1424 TKHMATVSEEAKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLE 1503
Cdd:COG0666   122 TPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                          90       100
                  ....*....|....*....|....*.
gi 296179431 1504 TIWLLLSYGADPTLATYSGQTAMKLA 1529
Cdd:COG0666   201 IVKLLLEAGADVNAKDNDGKTALDLA 226
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 198-636 3.58e-16

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 85.38  E-value: 3.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247 2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247 2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247 2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247 2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296179431  577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
 
Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
 1592-1705 9.31e-68

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


Pssm-ID: 271223  Cd Length: 115  Bit Score: 223.57  E-value: 9.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1592 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1671
Cdd:cd14260     2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 296179431 1672 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1705
Cdd:cd14260    82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
PUFD pfam16553
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ...
 1593-1707 4.29e-61

BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.


Pssm-ID: 465171  Cd Length: 114  Bit Score: 204.54  E-value: 4.29e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  1593 EDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERP 1672
Cdd:pfam16553    1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 296179431  1673 GGlddrSPPGSSETVELVRYEPDLLRLLGSEVEFQ 1707
Cdd:pfam16553   81 EA----FNPDSKELVELVEFTPELQTLLGSSVEFL 111
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1424-1529 1.55e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.72  E-value: 1.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1424 TKHMATVSEEAKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLE 1503
Cdd:COG0666   122 TPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                          90       100
                  ....*....|....*....|....*.
gi 296179431 1504 TIWLLLSYGADPTLATYSGQTAMKLA 1529
Cdd:COG0666   201 IVKLLLEAGADVNAKDNDGKTALDLA 226
PHA03247 PHA03247
large tegument protein UL36; Provisional
 198-636 3.58e-16

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 85.38  E-value: 3.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247 2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247 2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247 2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247 2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296179431  577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1426-1517 6.92e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.60  E-value: 6.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  1426 HMAtVSEEAKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHgANVNCSAQDGTrPVHDAVVNDNLETI 1505
Cdd:pfam12796    2 HLA-AKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 296179431  1506 WLLLSYGADPTL 1517
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1434-1514 1.33e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.38  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1434 AKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGA 1513
Cdd:PHA03100  171 AKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249


                  .
gi 296179431 1514 D 1514
Cdd:PHA03100  250 S 250
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 218-664 1.46e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.70  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   218 PDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAP-PSGPVP 296
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPsPHPPLQ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   297 LSAPAPAPLSVPVSAPPLALIQAPVPP------SAPTLVLAPVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPSTP 370
Cdd:pfam03154  251 PMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQRI 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   371 TLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpsq 447
Cdd:pfam03154  326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL---- 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   448 plvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLTSDSKLVSLEVNRLP 527
Cdd:pfam03154  391 -----PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASHP 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   528 CTSPSGSTTTQP-------APDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPphpakMPSGTEQQTEGTSVTFSP 600
Cdd:pfam03154  449 PTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPPVQIKEEA 523

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296179431   601 LKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154  524 LDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1456-1484 6.87e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.12  E-value: 6.87e-06
                            10        20
                    ....*....|....*....|....*....
gi 296179431   1456 GYTALHEACSRGWTDILNILLEHGANVNC 1484
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 272-337 7.49e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 7.49e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296179431   272 SNPLSVSASVlvPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTlvlAPVPTPV 337
Cdd:TIGR00601   75 SKPKTGTGKV--APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESAT---ATAPESP 135
 
Name Accession Description Interval E-value
PUFD_like_1 cd14260
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ...
 1592-1705 9.31e-68

PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.


Pssm-ID: 271223  Cd Length: 115  Bit Score: 223.57  E-value: 9.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1592 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1671
Cdd:cd14260     2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 296179431 1672 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1705
Cdd:cd14260    82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
PUFD pfam16553
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ...
 1593-1707 4.29e-61

BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.


Pssm-ID: 465171  Cd Length: 114  Bit Score: 204.54  E-value: 4.29e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  1593 EDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERP 1672
Cdd:pfam16553    1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 296179431  1673 GGlddrSPPGSSETVELVRYEPDLLRLLGSEVEFQ 1707
Cdd:pfam16553   81 EA----FNPDSKELVELVEFTPELQTLLGSSVEFL 111
PUFD_like cd14259
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ...
 1594-1705 1.18e-42

PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271222  Cd Length: 106  Bit Score: 151.31  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1594 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPg 1673
Cdd:cd14259     1 DDFEFEFSDEPLPPLYNLRISPNDGPRNWHLLSDVLTRLKLKSRDFLLKQICLELTSIPIEDFLEQASCLQLLCAGEKL- 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 296179431 1674 glddrSPPGSSETVELVRYEPDLLRLLGSEVE 1705
Cdd:cd14259    80 -----TNNVSSSKVELVEYNDSLRSLLGIEVE 106
PUFD cd14261
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ...
 1594-1705 1.15e-36

PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.


Pssm-ID: 271224  Cd Length: 117  Bit Score: 134.59  E-value: 1.15e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1594 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPG 1673
Cdd:cd14261     6 DVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSCPKDLE 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 296179431 1674 GLDdrspPGSSETVELVRYEPDLLRLLGSEVE 1705
Cdd:cd14261    86 AFN----PDSKELLDLVEFTNELQTLLGSSLE 113
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1424-1529 1.55e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.72  E-value: 1.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1424 TKHMATVSEEAKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLE 1503
Cdd:COG0666   122 TPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                          90       100
                  ....*....|....*....|....*.
gi 296179431 1504 TIWLLLSYGADPTLATYSGQTAMKLA 1529
Cdd:COG0666   201 IVKLLLEAGADVNAKDNDGKTALDLA 226
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1424-1531 3.90e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.79  E-value: 3.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1424 TKHMATVSEEAKDVVLYCLQKDsEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLE 1503
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLE 167

                          90       100
                  ....*....|....*....|....*...
gi 296179431 1504 TIWLLLSYGADPTLATYSGQTAMKLASS 1531
Cdd:COG0666   168 IVKLLLEAGADVNARDNDGETPLHLAAE 195
PHA03247 PHA03247
large tegument protein UL36; Provisional
 198-636 3.58e-16

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 85.38  E-value: 3.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247 2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247 2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247 2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247 2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296179431  577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1399-1529 2.71e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 2.71e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1399 FLPNNLEEPACLENSEKPSGKRKCKTKHMATVSEEAKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEH 1478
Cdd:COG0666    30 LLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 296179431 1479 GANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1529
Cdd:COG0666   110 GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1448-1529 1.77e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 1.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1448 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMK 1527
Cdd:COG0666   178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257


                  ..
gi 296179431 1528 LA 1529
Cdd:COG0666   258 LA 259
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1426-1517 6.92e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.60  E-value: 6.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  1426 HMAtVSEEAKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHgANVNCSAQDGTrPVHDAVVNDNLETI 1505
Cdd:pfam12796    2 HLA-AKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 296179431  1506 WLLLSYGADPTL 1517
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1434-1514 1.33e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.38  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1434 AKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGA 1513
Cdd:PHA03100  171 AKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249


                  .
gi 296179431 1514 D 1514
Cdd:PHA03100  250 S 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1460-1531 5.22e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 5.22e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296179431  1460 LHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAdpTLATYSGQTAMKLASS 1531
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAAR 70
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1426-1526 8.77e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.73  E-value: 8.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1426 HMAtVSEEAKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI 1505
Cdd:COG0666   191 HLA-AENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

                          90       100
                  ....*....|....*....|.
gi 296179431 1506 WLLLSYGADPTLATYSGQTAM 1526
Cdd:COG0666   269 KLLLLALLLLAAALLDLLTLL 289
PHA03247 PHA03247
large tegument protein UL36; Provisional
 181-609 1.20e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  181 TGVPVEGTLPLVTTNFSPLP-APICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPvqvatsvPAPSPPLAPVPALA 259
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP-------AAGPPRRLTRPAVA 2789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  260 PAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPlaliqAPVPPSAPTLVLAPVPTPVLA 339
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-----GPPPPSLPLGGSVAPGGDVRR 2864

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  340 PMPASTPPAapappsvpmptptpssgppstptlipafaptpvpaptpapifTPAPTPMPAATPAAIPTSAPIPASFSLSR 419
Cdd:PHA03247 2865 RPPSRSPAA------------------------------------------KPAAPARPPVRRLARPAVSRSTESFALPP 2902

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  420 VCFPAAQAPAMQKVPLSFQPgtvlTPSQPLVYIPPPSCGQPLSVATlPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPEL 499
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQ----PPPPPQPQPPPPPPPRPQPPLA-PTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRF 2977

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  500 RSYPYAFSVARPLTSDSKLVSLEVNRL------------PCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKV-LPTPQP 566
Cdd:PHA03247 2978 RVPQPAPSREAPASSTPPLTGHSLSRVsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSdLEALDP 3057

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 296179431  567 LLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLER 609
Cdd:PHA03247 3058 LPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSR 3100
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 218-664 1.46e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.70  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   218 PDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAP-PSGPVP 296
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPsPHPPLQ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   297 LSAPAPAPLSVPVSAPPLALIQAPVPP------SAPTLVLAPVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPSTP 370
Cdd:pfam03154  251 PMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQRI 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   371 TLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpsq 447
Cdd:pfam03154  326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL---- 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   448 plvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLTSDSKLVSLEVNRLP 527
Cdd:pfam03154  391 -----PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASHP 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   528 CTSPSGSTTTQP-------APDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPphpakMPSGTEQQTEGTSVTFSP 600
Cdd:pfam03154  449 PTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPPVQIKEEA 523

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296179431   601 LKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154  524 LDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
205-419 1.74e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 56.04  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  205 PPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSvptlisdsnPLSVSASVLVP 284
Cdd:PRK12323  374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL---------AAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  285 VPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAptlvlAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSS 364
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAP-----AAAPAPADDDPPPWEELPPEFASPAPAQPDAAPA 519

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 296179431  365 GPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAaiPTSAPIPASFSLSR 419
Cdd:PRK12323  520 GWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATE--PVVAPRPPRASASG 572
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1448-1529 6.23e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 6.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1448 DVNHRDNAGYTALHEA--CSRGWTDILNILLEHGANVNcsAQD------------------GTRPVHDAVVNDNLETIWL 1507
Cdd:PHA03100  133 NVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVDIN--AKNrvnyllsygvpinikdvyGFTPLHYAVYNNNPEFVKY 210

                          90       100
                  ....*....|....*....|..
gi 296179431 1508 LLSYGADPTLATYSGQTAMKLA 1529
Cdd:PHA03100  211 LLDLGANPNLVNKYGDTPLHIA 232
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1448-1539 7.67e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 7.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1448 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMK 1527
Cdd:COG0666    46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                          90
                  ....*....|....*.
gi 296179431 1528 LASS----DTMKRFLS 1539
Cdd:COG0666   126 LAAYngnlEIVKLLLE 141
Ank_4 pfam13637
Ankyrin repeats (many copies);
1456-1508 1.05e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 1.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 296179431  1456 GYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI-WLL 1508
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLkLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1448-1525 1.08e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.10  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1448 DVNHRDNAGYTALHeACSRGW---TDILNILLEHGANVNCSAQDGTRPVHDAVVNDN--LETIWLLLSYGADPTLATYSG 1522
Cdd:PHA03095  109 DVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRF 187


                  ...
gi 296179431 1523 QTA 1525
Cdd:PHA03095  188 RSL 190
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1474-1553 1.34e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.36  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1474 ILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLSDHLSDLQGRA 1549
Cdd:PTZ00322  100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEEngfrEVVQLLSRHSQCHFELGA 179


                  ....
gi 296179431 1550 EGDP 1553
Cdd:PTZ00322  180 NAKP 183
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1421-1545 1.41e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1421 KCKTKHmatvSEEAKDVVLYCLQKDS-EDVNHRDNagYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH----- 1494
Cdd:PHA03100    5 IVLTKS----RIIKVKNIKYIIMEDDlNDYSYKKP--VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsni 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 296179431 1495 DAVVNDNLETIWLLLSYGADPTLATYSGQT-----AMKLASSDTMKRFLSDHLSDL 1545
Cdd:PHA03100   79 KYNLTDVKEIVKLLLEYGANVNAPDNNGITpllyaISKKSNSYSIVEYLLDNGANV 134
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1448-1526 2.49e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 2.49e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 296179431 1448 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1526
Cdd:PHA02874  116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1430-1529 3.42e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 3.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1430 VSEEAKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWT-DILNILLEHGANVNC-SAQDGTRPVHDAVVNDnlETIWL 1507
Cdd:PHA02878  209 VKHYNKPIVHILLENGA-STDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAkSYILGLTALHSSIKSE--RKLKL 285

                          90       100
                  ....*....|....*....|..
gi 296179431 1508 LLSYGADPTLATYSGQTAMKLA 1529
Cdd:PHA02878  286 LLEYGADINSLNSYKLTPLSSA 307
Ank_5 pfam13857
Ankyrin repeats (many copies);
1442-1494 5.65e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 5.65e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 296179431  1442 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1494
Cdd:pfam13857    2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PHA03247 PHA03247
large tegument protein UL36; Provisional
 287-649 5.96e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  287 ASAPPSGPVPLSAPAPAPL----SVPVS-------------------APPL-ALIQAPV-PPSAPTLVLAPVPTPVLAPM 341
Cdd:PHA03247 2544 ASDDAGDPPPPLPPAAPPAapdrSVPPPrpaprpsepavtsrarrpdAPPQsARPRAPVdDRGDPRGPAPPSPLPPDTHA 2623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  342 PASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAfaptPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVC 421
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA----PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  422 FPAAQAPAMQKVPLSFQPGTVLTP---SQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYlqdrclPGVLASPE 498
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPgpaAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG------PPAPAPPA 2773

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  499 LRSYPYAFSVARPLTSdsklvSLEVNRLPCTSPSGSTttqPAPDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPP 578
Cdd:PHA03247 2774 APAAGPPRRLTRPAVA-----SLSESRESLPSPWDPA---DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296179431  579 HPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTP 649
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP 2916
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1442-1514 6.42e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 6.42e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 296179431 1442 LQKDSEDVNHRDNAGYTALHEACSRGW---TDILNILLEHGANVNCSAQDGTRPVHDAVVNDN-LETIWLLLSYGAD 1514
Cdd:PHA03095   33 LLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1456-1484 6.87e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.12  E-value: 6.87e-06
                            10        20
                    ....*....|....*....|....*....
gi 296179431   1456 GYTALHEACSRGWTDILNILLEHGANVNC 1484
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1456-1484 4.40e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.89  E-value: 4.40e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 296179431  1456 GYTALHEACSR-GWTDILNILLEHGANVNC 1484
Cdd:pfam00023    2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1448-1511 4.71e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 4.71e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296179431 1448 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSY 1511
Cdd:PTZ00322  107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1448-1514 1.07e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 1.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 296179431 1448 DVNHRDNAGYTALHEACSRG-WTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAD 1514
Cdd:PHA02876  333 DVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1456-1484 1.07e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.70  E-value: 1.07e-04
                           10        20
                   ....*....|....*....|....*....
gi 296179431  1456 GYTALHEACSRGWTDILNILLEHGANVNC 1484
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1448-1531 1.41e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.41  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1448 DVNHRD-NAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1526
Cdd:PHA02878  159 DINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238


                  ....*
gi 296179431 1527 KLASS 1531
Cdd:PHA02878  239 HISVG 243
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1442-1505 1.61e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 1.61e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296179431 1442 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI 1505
Cdd:PHA02876  164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTI 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1448-1543 3.87e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1448 DVNHRDNAGYTALHEA---CSRGWTDILNiLLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQT 1524
Cdd:PHA03095  214 DPAATDMLGNTPLHSMatgSSCKRSLVLP-LLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNT 292

                          90       100
                  ....*....|....*....|...
gi 296179431 1525 AMKLA----SSDTMKRFLSDHLS 1543
Cdd:PHA03095  293 PLSLMvrnnNGRAVRAALAKNPS 315
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1429-1538 4.31e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 4.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1429 TVSEEAKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLL 1508
Cdd:PLN03192  531 TVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610

                          90       100       110
                  ....*....|....*....|....*....|..
gi 296179431 1509 LSYGA--DPTLATYSGQTAMKLASSDTMKRFL 1538
Cdd:PLN03192  611 YHFASisDPHAAGDLLCTAAKRNDLTAMKELL 642
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1427-1516 6.99e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 6.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1427 MATVSEEAKDVVLyCLQKDSEDVNHRDNAGYTALH-EACSRGWTDILNILLEHGANVNCSAQDGTRPVHD--AVVNDNLE 1503
Cdd:PHA03095   55 LHYSSEKVKDIVR-LLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPK 133

                          90
                  ....*....|...
gi 296179431 1504 TIWLLLSYGADPT 1516
Cdd:PHA03095  134 VIRLLLRKGADVN 146
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1421-1519 7.37e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 7.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1421 KCKTKHMATVSEEAKDVVLycLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDG-TRPVHDAVVN 1499
Cdd:PHA02875  135 KFSPLHLAVMMGDIKGIEL--LIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIEN 212

                          90       100
                  ....*....|....*....|
gi 296179431 1500 DNLETIWLLLSYGADPTLAT 1519
Cdd:PHA02875  213 NKIDIVRLFIKRGADCNIMF 232
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 271-322 7.64e-04

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 41.77  E-value: 7.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 296179431  271 DSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSApplALIQAPVP 322
Cdd:PRK05641   44 DLSAVQEQVPTPAPAPAPAVPSAPTPVAPAAPAPAPASAGE---NVVTAPMP 92
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 197-336 9.80e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.93  E-value: 9.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  197 SPLPAPICPPAPGSASVPHSVPdafqVPLSVPAPVPHsglvPVQVATSVPAPSPPLAPVPALApappsvptlisdSNPLS 276
Cdd:PRK14951  372 AAAPAEKKTPARPEAAAPAAAP----VAQAAAAPAPA----AAPAAAASAPAAPPAAAPPAPV------------AAPAA 431

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296179431  277 VSASVLVPVPASAPPSGPVPLSAPAPAPLSVPV-SAPPLALIQAPVPPSAPTLVLAPVPTP 336
Cdd:PRK14951  432 AAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVrVAPEPAVASAAPAPAAAPAAARLTPTE 492
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1448-1529 1.44e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1448 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMK 1527
Cdd:PHA02874  149 DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLH 228


                  ..
gi 296179431 1528 LA 1529
Cdd:PHA02874  229 NA 230
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
274-569 1.54e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  274 PLSVSASVLVPVPASAPPSG--PVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPvptpvlapmpastppaapa 351
Cdd:PRK12323  375 ATAAAAPVAQPAPAAAAPAAaaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAA------------------- 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  352 ppsvpmptptpssgppstptlipafaptpvpaPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQ 431
Cdd:PRK12323  436 --------------------------------ARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA 483

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  432 KVPLSFQPGTVLTPsqPLVYIPPpscgqplsvatlpttlgvsstlTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARP 511
Cdd:PRK12323  484 APAAAPAPADDDPP--PWEELPP----------------------EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE 539

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 296179431  512 ltsdsklvSLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQPLLP 569
Cdd:PRK12323  540 --------TLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLP 589
Ank_4 pfam13637
Ankyrin repeats (many copies);
1426-1476 2.27e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 2.27e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 296179431  1426 HMAtVSEEAKDVVLYCLQKdSEDVNHRDNAGYTALHEACSRGWTDILNILL 1476
Cdd:pfam13637    6 HAA-AASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 274-337 2.52e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 2.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296179431  274 PLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLAlIQAPVPPSAPTLVLAPVPTPV 337
Cdd:PRK14951  391 AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA-APAAAPAAAPAAVALAPAPPA 453
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1448-1514 2.59e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.34  E-value: 2.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296179431 1448 DVNHRDNAGYTALHEACSR--GWTDILNILLEHGANVNCSAQDGTRPVHDAV--VNDNLETIWLLLSYGAD 1514
Cdd:PHA03100   98 NVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVD 168
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 273-471 2.84e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  273 NPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPtpvlapmpastppaapap 352
Cdd:PRK14951  372 AAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAA------------------ 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  353 psvpmptptpssgppstptlipafaptpvpaptpapiftPAPTPMPAATPAAIPTSAPIPAsfslsrvcfpaaqAPAMQK 432
Cdd:PRK14951  434 ---------------------------------------PAAAPAAAPAAVALAPAPPAQA-------------APETVA 461

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 296179431  433 VPLSFQPGTVLTPSqplvyiPPPSCGQPLSVATLPTTLG 471
Cdd:PRK14951  462 IPVRVAPEPAVASA------APAPAAAPAAARLTPTEEG 494
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1426-1531 2.92e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1426 HMATVSEEAKDV-VLYCLQKDSEDVNHRDnaGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLET 1504
Cdd:PHA02875   73 HDAVEEGDVKAVeELLDLGKFADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKG 150

                          90       100
                  ....*....|....*....|....*..
gi 296179431 1505 IWLLLSYGADPTLATYSGQTAMKLASS 1531
Cdd:PHA02875  151 IELLIDHKACLDIEDCCGCTPLIIAMA 177
Ank_5 pfam13857
Ankyrin repeats (many copies);
1475-1529 2.97e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 2.97e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 296179431  1475 LLEHG-ANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1529
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
206-335 3.04e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  206 PAPGSASVPHSVPDAfQVPLSVPAPVPHSGLVPvqvATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASvlVPV 285
Cdd:PRK07003  360 PAVTGGGAPGGGVPA-RVAGAVPAPGARAAAAV---GASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAP--APP 433

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 296179431  286 PASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPT 335
Cdd:PRK07003  434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASD 483
PHA02795 PHA02795
ankyrin-like protein; Provisional
 1447-1489 3.17e-03

ankyrin-like protein; Provisional


Pssm-ID: 165157 [Multi-domain]  Cd Length: 437  Bit Score: 41.90  E-value: 3.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 296179431 1447 EDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDG 1489
Cdd:PHA02795  212 EDINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNG 254
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
180-353 3.79e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  180 GTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPdafqVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALA 259
Cdd:PRK07003  363 TGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTA----VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  260 PAPPSVPTLisdsnPLSVSASVLVPVPASAPPSGPVPLSAPAPAplSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLA 339
Cdd:PRK07003  439 GDDAADGDA-----PVPAKANARASADSRCDERDAQPPADSGSA--SAPASDAPPDAAFEPAPRAAAPSAATPAAVPDAR 511

                         170
                  ....*....|....
gi 296179431  340 PMPASTPPAAPAPP 353
Cdd:PRK07003  512 APAAASREDAPAAA 525
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1470-1531 3.98e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 3.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296179431 1470 DILNILLEHGANVNCSAQDGTRPVHDAVVN--DNLETIWLLLSYGADPTLATYSGQTAMKLASS 1531
Cdd:PHA03100   87 EIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLE 150
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1427-1501 4.09e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.55  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1427 MATVSEEAKDVVLYCLQKDSeDVNHRDNAGYTALH--------EACSRgwtdilniLLEHGANVNCSAQDGTRPVHDAVV 1498
Cdd:PHA03095  229 MATGSSCKRSLVLPLLIAGI-SINARNRYGQTPLHyaavfnnpRACRR--------LIALGADINAVSSDGNTPLSLMVR 299


                  ...
gi 296179431 1499 NDN 1501
Cdd:PHA03095  300 NNN 302
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
197-338 5.30e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 41.51  E-value: 5.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  197 SPLPAPICPPAPGSASVPHSVPDAFQ---------VPLSVPAPVPHSGLVPVQV-ATSVPAPSPPLAPVPALAPAPPSVP 266
Cdd:PRK12727   77 TKPAAPVHAPLKLSANANMSQRQRVAsaaedmiaaMALRQPVSVPRQAPAAAPVrAASIPSPAAQALAHAAAVRTAPRQE 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  267 TLISdSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLA-------------------LIQAPVPPSAPT 327
Cdd:PRK12727  157 HALS-AVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAyaqdddeqldddgfdlddaLPQILPPAALPP 235

                         170
                  ....*....|.
gi 296179431  328 LVLAPVPTPVL 338
Cdd:PRK12727  236 IVVAPAAPAAL 246
PHA03247 PHA03247
large tegument protein UL36; Provisional
 74-336 5.34e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431   74 ADPDGSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGLLVPLSSPGDGLKLPASDSAEASNSRADCSwTPLNTQMSKQVD 153
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT-RPAVASLSESRE 2796

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  154 CSPAGVKALDSRQGVGEKNTFILATLGTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPH 233
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  234 SGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPP 313
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                         250       260
                  ....*....|....*....|....*.
gi 296179431  314 LALIQAPVPPSAPTLVLAP---VPTP 336
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPrfrVPQP 2982
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 284-337 6.29e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 40.68  E-value: 6.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 296179431   284 PVPASAPPS--GPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPV 337
Cdd:pfam07174   41 PEPAPPPPStaTAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPPPPADPNAPPPPPA 96
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 272-337 7.49e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 7.49e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296179431   272 SNPLSVSASVlvPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTlvlAPVPTPV 337
Cdd:TIGR00601   75 SKPKTGTGKV--APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESAT---ATAPESP 135
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 197-329 7.67e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 7.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  197 SPLPAPICPPA---PGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSN 273
Cdd:PRK07994  363 APLPEPEVPPQsaaPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSE 442

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296179431  274 PLSVSASV--------LVPVPASAPPSGPVPLSAPA-------PAPLSVPVSAPPLALIQAPVPPSAPTLV 329
Cdd:PRK07994  443 PAAASRARpvnsalerLASVRPAPSALEKAPAKKEAyrwkatnPVEVKKEPVATPKALKKALEHEKTPELA 513
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1471-1540 7.96e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 7.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296179431 1471 ILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLSD 1540
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDskniDTIKAIIDN 233
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 206-351 8.44e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  206 PAPGSASVPHSVPDAFQVPlSVPAPVPHSGLVPVQVATSVPAPspplapvpalapappsvptlisdsnPLSVSASVLVPV 285
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARP-EAAAPAAAPVAQAAAAPAPAAAP-------------------------AAAASAPAAPPA 419

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296179431  286 PASAPPSGPVPLSAPAPAPLSVPVSAPPlalIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPA 351
Cdd:PRK14951  420 AAPPAPVAAPAAAAPAAAPAAAPAAVAL---APAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAA 482
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 1438-1526 8.73e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 41.05  E-value: 8.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431 1438 VLYCLQKDSEDVNHRDNAGYTALHEACSRGW--TDILNILLEHGANVNCSAQDGTRPVHD-----AVVND---------N 1501
Cdd:PHA02716  299 VVYSFLQPGVKLHYKDSAGRTCLHQYILRHNisTDIIKLLHEYGNDLNEPDNIGNTVLHTylsmlSVVNIldpetdndiR 378

                          90       100
                  ....*....|....*....|....*
gi 296179431 1502 LETIWLLLSYGADPTLATYSGQTAM 1526
Cdd:PHA02716  379 LDVIQCLISLGADITAVNCLGYTPL 403
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 278-406 9.59e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 9.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296179431  278 SASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPM 357
Cdd:PRK14951  367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVA 446

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 296179431  358 PTPTPSSGPPSTPTLIPAFAPTPVPaptpapifTPAPTPMPAATPAAIP 406
Cdd:PRK14951  447 LAPAPPAQAAPETVAIPVRVAPEPA--------VASAAPAPAAAPAAAR 487
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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