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Conserved domains on  [gi|40806225|ref|NP_071371|]
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zinc finger protein 64 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
107-132 1.18e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.18e-05
                          10        20
                  ....*....|....*....|....*.
gi 40806225   107 DMERHLKIHTGDKPHKCEVCGKCFSR 132
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
136-157 7.30e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.30e-05
                          10        20
                  ....*....|....*....|..
gi 40806225   136 LKTHMRCHTGVKPYKCKTCDYA 157
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
317-341 7.70e-05

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.84  E-value: 7.70e-05
                          10        20
                  ....*....|....*....|....*
gi 40806225   317 FKCNYCSFDTKQPSNLSKHMKKFHG 341
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-238 1.15e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.15e-04
                          10        20
                  ....*....|....*....|
gi 40806225   219 DLKRHMRVHSGEKPFKCEFC 238
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
149-172 7.06e-04

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.06e-04
                          10        20
                  ....*....|....*....|....
gi 40806225   149 YKCKTCDYAAADSSSLNKHLRIHS 172
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
97-396 1.36e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225  97 CQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERP 176
Cdd:COG5048 175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 177 FKCQICPYASRNSSQLTVHLRSHtgdapfqcwLCSAKFKISSdlkrhmrvhsgeKPFKCEFCNVRCTMKGNLKSHIRIKH 256
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNE---------SDSSSEKGFS------------LPIKSKQCNISFSRSSPLTRHLRSVN 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 257 sgnnfkcphcdflgdskatlrkHSRVHQSEHPEKCSECSYSCSSKAALRIHERIHCTDRPFKCNYCSFDTKQPSNL---- 332
Cdd:COG5048 314 ----------------------HSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40806225 333 ---------SKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKRQHSEY 396
Cdd:COG5048 372 pqslqqykdLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
107-132 1.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.18e-05
                          10        20
                  ....*....|....*....|....*.
gi 40806225   107 DMERHLKIHTGDKPHKCEVCGKCFSR 132
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
136-157 7.30e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.30e-05
                          10        20
                  ....*....|....*....|..
gi 40806225   136 LKTHMRCHTGVKPYKCKTCDYA 157
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
317-341 7.70e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.84  E-value: 7.70e-05
                          10        20
                  ....*....|....*....|....*
gi 40806225   317 FKCNYCSFDTKQPSNLSKHMKKFHG 341
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-238 1.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.15e-04
                          10        20
                  ....*....|....*....|
gi 40806225   219 DLKRHMRVHSGEKPFKCEFC 238
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
149-172 7.06e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.06e-04
                          10        20
                  ....*....|....*....|....
gi 40806225   149 YKCKTCDYAAADSSSLNKHLRIHS 172
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
97-396 1.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225  97 CQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERP 176
Cdd:COG5048 175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 177 FKCQICPYASRNSSQLTVHLRSHtgdapfqcwLCSAKFKISSdlkrhmrvhsgeKPFKCEFCNVRCTMKGNLKSHIRIKH 256
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNE---------SDSSSEKGFS------------LPIKSKQCNISFSRSSPLTRHLRSVN 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 257 sgnnfkcphcdflgdskatlrkHSRVHQSEHPEKCSECSYSCSSKAALRIHERIHCTDRPFKCNYCSFDTKQPSNL---- 332
Cdd:COG5048 314 ----------------------HSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40806225 333 ---------SKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKRQHSEY 396
Cdd:COG5048 372 pqslqqykdLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
261-283 2.06e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.99  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|...
gi 40806225   261 FKCPHCDFLGDSKATLRKHSRVH 283
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
ZnF_C2H2 smart00355
zinc finger;
121-143 5.58e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 5.58e-03
                           10        20
                   ....*....|....*....|...
gi 40806225    121 HKCEVCGKCFSRKDKLKTHMRCH 143
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
107-132 1.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.18e-05
                          10        20
                  ....*....|....*....|....*.
gi 40806225   107 DMERHLKIHTGDKPHKCEVCGKCFSR 132
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
136-157 7.30e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.30e-05
                          10        20
                  ....*....|....*....|..
gi 40806225   136 LKTHMRCHTGVKPYKCKTCDYA 157
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
317-341 7.70e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.84  E-value: 7.70e-05
                          10        20
                  ....*....|....*....|....*
gi 40806225   317 FKCNYCSFDTKQPSNLSKHMKKFHG 341
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-238 1.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.15e-04
                          10        20
                  ....*....|....*....|
gi 40806225   219 DLKRHMRVHSGEKPFKCEFC 238
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
149-172 7.06e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.06e-04
                          10        20
                  ....*....|....*....|....
gi 40806225   149 YKCKTCDYAAADSSSLNKHLRIHS 172
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
97-396 1.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225  97 CQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERP 176
Cdd:COG5048 175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 177 FKCQICPYASRNSSQLTVHLRSHtgdapfqcwLCSAKFKISSdlkrhmrvhsgeKPFKCEFCNVRCTMKGNLKSHIRIKH 256
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNE---------SDSSSEKGFS------------LPIKSKQCNISFSRSSPLTRHLRSVN 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 257 sgnnfkcphcdflgdskatlrkHSRVHQSEHPEKCSECSYSCSSKAALRIHERIHCTDRPFKCNYCSFDTKQPSNL---- 332
Cdd:COG5048 314 ----------------------HSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40806225 333 ---------SKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKRQHSEY 396
Cdd:COG5048 372 pqslqqykdLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 173-257 1.43e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 173 DERPFKCQI--CPYASRNSSQLTVH-LRSHtgdapfqcwlCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLK 249
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....*...
gi 40806225 250 SHirIKHS 257
Cdd:COG5189 416 YH--RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 121-141 1.62e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|.
gi 40806225   121 HKCEVCGKCFSRKDKLKTHMR 141
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLR 21
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
112-236 1.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 112 LKIHTG--DKPHKC--EVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNK----HLRIHSDERPFKCQICP 183
Cdd:COG5048 311 SVNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETL 390

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806225 184 YASRNS-----SQLTVHLRSHTGDAP--FQCWLCSAKFKISSDLKRHMRVHSGEKPFKCE 236
Cdd:COG5048 391 SNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
261-283 2.06e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.99  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|...
gi 40806225   261 FKCPHCDFLGDSKATLRKHSRVH 283
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
163-188 4.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 40806225   163 SLNKHLRIHSDERPFKCQICPYASRN 188
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
121-143 5.58e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 5.58e-03
                           10        20
                   ....*....|....*....|...
gi 40806225    121 HKCEVCGKCFSRKDKLKTHMRCH 143
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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