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Conserved domains on  [gi|50658075|ref|NP_071754|]
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myomegalin isoform 3 [Homo sapiens]

Protein Classification

Cnn_1N and PRK12704 domain-containing protein( domain architecture ID 10546816)

Cnn_1N and PRK12704 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 143-210 4.73e-22

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


:

Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 87.58  E-value: 4.73e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50658075   143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 210
Cdd:pfam07989   1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
PRK12704 super family cl36166
phosphodiesterase; Provisional
 140-282 4.61e-04

phosphodiesterase; Provisional


The actual alignment was detected with superfamily member PRK12704:

Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075  140 QALRDFEKHLNDLKKENFSLKLriyflEERMQQKYEAS--REDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLN 217
Cdd:PRK12704  35 EAEEEAKRILEEAKKEAEAIKK-----EALLEAKEEIHklRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKRE 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50658075  218 SQNEA------ELRRQFEERQQETEhvyELLENKIQLLQEESRLAKNEAARMaALVEAEKECNLELSEKLK 282
Cdd:PRK12704 110 EELEKkekeleQKQQELEKKEEELE---ELIEEQLQELERISGLTAEEAKEI-LLEKVEEEARHEAAVLIK 176
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 143-210 4.73e-22

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 87.58  E-value: 4.73e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50658075   143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 210
Cdd:pfam07989   1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
PRK12704 PRK12704
phosphodiesterase; Provisional
 140-282 4.61e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075  140 QALRDFEKHLNDLKKENFSLKLriyflEERMQQKYEAS--REDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLN 217
Cdd:PRK12704  35 EAEEEAKRILEEAKKEAEAIKK-----EALLEAKEEIHklRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKRE 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50658075  218 SQNEA------ELRRQFEERQQETEhvyELLENKIQLLQEESRLAKNEAARMaALVEAEKECNLELSEKLK 282
Cdd:PRK12704 110 EELEKkekeleQKQQELEKKEEELE---ELIEEQLQELERISGLTAEEAKEI-LLEKVEEEARHEAAVLIK 176
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 132-259 2.34e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.62  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075   132 EKPPQVQTQaLRDFEKHLNDLKKENFSLKLRIYFLEERMQQKyeasrediyKRNIELKV-EVESLKRELQDKKQHLDKTW 210
Cdd:TIGR04523 321 KKLEEIQNQ-ISQNNKIISQLNEQISQLKKELTNSESENSEK---------QRELEEKQnEIEKLKKENQSYKQEIKNLE 390

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 50658075   211 ADVENLNS--QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 259
Cdd:TIGR04523 391 SQINDLESkiQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 140-282 3.31e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 3.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075 140 QALRDFEKHLNDLKKENFSLKLRIyfLEERMQQKyEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQ 219
Cdd:COG1196 220 EELKELEAELLLLKLRELEAELEE--LEAELEEL-EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50658075 220 ---------NEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLK 282
Cdd:COG1196 297 larleqdiaRLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALL 368
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 143-210 4.73e-22

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 87.58  E-value: 4.73e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50658075   143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 210
Cdd:pfam07989   1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
PRK12704 PRK12704
phosphodiesterase; Provisional
 140-282 4.61e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075  140 QALRDFEKHLNDLKKENFSLKLriyflEERMQQKYEAS--REDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLN 217
Cdd:PRK12704  35 EAEEEAKRILEEAKKEAEAIKK-----EALLEAKEEIHklRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKRE 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50658075  218 SQNEA------ELRRQFEERQQETEhvyELLENKIQLLQEESRLAKNEAARMaALVEAEKECNLELSEKLK 282
Cdd:PRK12704 110 EELEKkekeleQKQQELEKKEEELE---ELIEEQLQELERISGLTAEEAKEI-LLEKVEEEARHEAAVLIK 176
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 132-259 2.34e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.62  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075   132 EKPPQVQTQaLRDFEKHLNDLKKENFSLKLRIYFLEERMQQKyeasrediyKRNIELKV-EVESLKRELQDKKQHLDKTW 210
Cdd:TIGR04523 321 KKLEEIQNQ-ISQNNKIISQLNEQISQLKKELTNSESENSEK---------QRELEEKQnEIEKLKKENQSYKQEIKNLE 390

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 50658075   211 ADVENLNS--QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 259
Cdd:TIGR04523 391 SQINDLESkiQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
127-291 2.63e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 39.28  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075  127 SLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLR-IYFLEERMQqkyeaSREDIYKRNIELK----------VEVESL 195
Cdd:PRK03918 550 KLEELKKKLAELEKKLDELEEELAELLKELEELGFEsVEELEERLK-----ELEPFYNEYLELKdaekelereeKELKKL 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075  196 KRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKN---EAARMAALVEAEKE 272
Cdd:PRK03918 625 EEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKrreEIKKTLEKLKEELE 704

                        170
                 ....*....|....*....
gi 50658075  273 CNLELSEKLKGVTKNWEDV 291
Cdd:PRK03918 705 EREKAKKELEKLEKALERV 723
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 146-260 3.05e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.96  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075   146 EKHLNDLKKENFSLK-------LRIYFLEERMQQkYEASRED---IYKRNIELKVEVESLKRELQDKKQHLDKTWADVEn 215
Cdd:pfam13851  46 EKLMSEIQQENKRLTeplqkaqEEVEELRKQLEN-YEKDKQSlknLKARLKVLEKELKDLKWEHEVLEQRFEKVERERD- 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 50658075   216 lnsqneaELRRQFE----ERQQETEHVYELLENKIQLLQEEsrLAKNEA 260
Cdd:pfam13851 124 -------ELYDKFEaaiqDVQQKTGLKNLLLEKKLQALGET--LEKKEA 163
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 140-282 3.31e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 3.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075 140 QALRDFEKHLNDLKKENFSLKLRIyfLEERMQQKyEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQ 219
Cdd:COG1196 220 EELKELEAELLLLKLRELEAELEE--LEAELEEL-EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50658075 220 ---------NEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLK 282
Cdd:COG1196 297 larleqdiaRLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALL 368
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 136-272 4.01e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 4.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075 136 QVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKyEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVEN 215
Cdd:COG1196 270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARL-EERRRELEERLEELEEELAELEEELEELEEELEELEEELEE 348

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 50658075 216 LnsqnEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKE 272
Cdd:COG1196 349 A----EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ 401
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 146-252 4.22e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 38.85  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075   146 EKHLNDLKKENFSLKLRIyfleermqQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNeaelr 225
Cdd:TIGR04523 439 NSEIKDLTNQDSVKELII--------KNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEK----- 505

                          90       100
                  ....*....|....*....|....*..
gi 50658075   226 RQFEERQQETEHVYELLENKIQLLQEE 252
Cdd:TIGR04523 506 KELEEKVKDLTKKISSLKEKIEKLESE 532
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
136-272 8.21e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 37.69  E-value: 8.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658075 136 QVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNI-ELKVEVESLKRELQDKKQHLDKTWADVE 214
Cdd:COG3206 215 KLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVIqQLRAQLAELEAELAELSARYTPNHPDVI 294

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50658075 215 NLNSQnEAELRRQFeerQQETEHVYELLENKIQLLQ-EESRLAKNEA---ARMAALVEAEKE 272
Cdd:COG3206 295 ALRAQ-IAALRAQL---QQEAQRILASLEAELEALQaREASLQAQLAqleARLAELPELEAE 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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