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Conserved domains on  [gi|11968023|ref|NP_071918|]
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zinc finger protein 106 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1525-1802 3.79e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.59  E-value: 3.79e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1525 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 1602
Cdd:cd00200    3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1603 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 1679
Cdd:cd00200   80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1680 CTISVRDARNGLLLRTLEGHSKTILCMKVVNDL--VFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 1755
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 11968023 1756 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 1802
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1525-1802 3.79e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.59  E-value: 3.79e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1525 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 1602
Cdd:cd00200    3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1603 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 1679
Cdd:cd00200   80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1680 CTISVRDARNGLLLRTLEGHSKTILCMKVVNDL--VFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 1755
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 11968023 1756 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 1802
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
1527-1803 3.74e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 3.74e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1527 FEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYNVK 1604
Cdd:COG2319  116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1605 SRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFECHGPRaVSCLATAQEGarKLLVVGSYD 1679
Cdd:COG2319  193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1680 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 1755
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 11968023 1756 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 1803
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1560-1602 1.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 11968023    1560 SRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 1602
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKY---LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1525-1557 8.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 8.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 11968023   1525 GSFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYN 1557
Cdd:pfam00400    5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1525-1802 3.79e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.59  E-value: 3.79e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1525 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 1602
Cdd:cd00200    3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1603 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 1679
Cdd:cd00200   80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1680 CTISVRDARNGLLLRTLEGHSKTILCMKVVNDL--VFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 1755
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 11968023 1756 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 1802
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
1527-1803 3.74e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 3.74e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1527 FEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYNVK 1604
Cdd:COG2319  116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1605 SRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFECHGPRaVSCLATAQEGarKLLVVGSYD 1679
Cdd:COG2319  193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1680 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 1755
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 11968023 1756 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 1803
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
1518-1803 3.87e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 3.87e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1518 DDDEPTEGSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQtSGKnaALYTGSSD 1595
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGK--TLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1596 HTIRCYNVKSRECVeqlqledRVLCLHSRW----------RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATA 1665
Cdd:COG2319  142 GTVRLWDLATGKLL-------RTLTGHSGAvtsvafspdgKLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1666 QEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAV 1743
Cdd:COG2319  214 PDG--KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11968023 1744 TVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIH--KSMIYTGCYDGSIQ 1803
Cdd:COG2319  292 NSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
1526-1769 2.66e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 2.66e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1526 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQtSGKNAAlyTGSSDHTIRCYNV 1603
Cdd:COG2319  157 TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLA--SGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1604 KSRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFEcHGPRAVSCLATAQEGarKLLVVGSY 1678
Cdd:COG2319  234 ATGKLLRTLTGhSGSVRSV--AFspdgRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDG--KLLASGSD 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1679 DCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMV 1754
Cdd:COG2319  309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLA 388

                        250
                 ....*....|....*
gi 11968023 1755 TACLDKFVRVYELQS 1769
Cdd:COG2319  389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1526-1766 2.70e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 2.70e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1526 SFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGknaALYTGSSDHTIRCYNV 1603
Cdd:cd00200   46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDV 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1604 KSRECVEQLQL-EDRVLCL--HSRWRILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGARklLVVGSYDC 1680
Cdd:cd00200  123 ETGKCLTTLRGhTDWVNSVafSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEK--LLSSSSDG 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1681 TISVRDARNGLLLRTLEGHSKTILCMKV--VNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVTA 1756
Cdd:cd00200  200 TIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLASG 279

                        250
                 ....*....|
gi 11968023 1757 CLDKFVRVYE 1766
Cdd:cd00200  280 SADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1563-1802 1.41e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 1.41e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1563 CIGVFEGHTSKVNCLlvtQTSGKNAALYTGSSDHTIRCYNVKSRECVEQLQLE----DRVLCLHSRWRILYAGLaNGTVV 1638
Cdd:cd00200    1 LRRTLKGHTGGVTCV---AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpvRDVAASADGTYLASGSS-DKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1639 TFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKV--VNDLVFSG 1716
Cdd:cd00200   77 LWDLETGECVRTLTGH-TSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1717 SSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--M 1792
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDgyL 233

                        250
                 ....*....|
gi 11968023 1793 IYTGCYDGSI 1802
Cdd:cd00200  234 LASGSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
1654-1803 1.13e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023 1654 HGPRAVSCLATAQEGARklLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGE 1731
Cdd:COG2319   34 GLAAAVASLAASPDGAR--LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 11968023 1732 LVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 1803
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1560-1602 1.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.06e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 11968023    1560 SRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 1602
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKY---LASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1526-1557 1.96e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.96e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 11968023    1526 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYN 1557
Cdd:smart00320    7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1525-1557 8.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 8.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 11968023   1525 GSFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYN 1557
Cdd:pfam00400    5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
1561-1602 1.13e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 11968023   1561 RKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYN 1602
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 1659-1734 7.51e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.83  E-value: 7.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11968023   1659 VSCLATAQEGArkLLVVGSYDCTISV-------------RDARNGLL----------LRTLEGHSKTILCMKVVN--DLV 1713
Cdd:pfam20426  127 VSCVAVTSDGS--ILATGSYDTTVMVwevlrgrssekrsRNTQTEFPrkdhviaetpFHILCGHDDIITCLYVSVelDIV 204

                           90       100
                   ....*....|....*....|.
gi 11968023   1714 FSGSSDQSVHAHNIHTGELVR 1734
Cdd:pfam20426  205 ISGSKDGTCIFHTLREGRYVR 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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