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Conserved domains on  [gi|164518925|ref|NP_075632|]
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complement C1r-A subcomponent precursor [Mus musculus]

Protein Classification

CUB domain-containing protein( domain architecture ID 12185826)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein similar to Sus scrofa major seminal plasma glycoprotein PSP-II

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 462-699 1.26e-72

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


:

Pssm-ID: 214473  Cd Length: 229  Bit Score: 234.88  E-value: 1.26e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   462 RIIRGQPARPGNFPWQAFTTTHGRG---GGALLGDRWILTAAHTIYpkhhnkenDNANPKMLVFLGHTNVEQIKKLGHHP 538
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRhfcGGSLISPRWVLTAAHCVR--------GSDPSNIRVRLGSHDLSSGEEGQVIK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   539 VRRVIIHPDYRqdePNNFEGDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGITED---KLAFDLRFVRLP 615
Cdd:smart00020  73 VSKVIIHPNYN---PSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEgagSLPDTLQEVNVP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   616 VADSEACQRwlqTKKDTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRnrdIWVATGIVSWGIGCGEG--YGFYTKVL 693
Cdd:smart00020 150 IVSNATCRR---AYSGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGSGCARPgkPGVYTRVS 223


                   ....*.
gi 164518925   694 NYVDWI 699
Cdd:smart00020 224 SYLDWI 229
CUB pfam00431
CUB domain;
192-301 8.73e-36

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 130.49  E-value: 8.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  192 CSSELyTEPSGYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDpFEIDDHQQvhCPYDQLQIY----ANGKNLGEFC 267
Cdd:pfam00431   1 CGGVL-TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 164518925  268 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLHY 301
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 26-137 3.73e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


:

Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 111.33  E-value: 3.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925    26 GEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKI----SADKQTLGRFCGQLDSPlgnppgs 101
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSEAPP------- 73

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 164518925   102 KEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 137
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQ-------KRGFSARY 102
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 160-188 3.95e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.33  E-value: 3.95e-10
                          10        20
                  ....*....|....*....|....*....
gi 164518925  160 CQHLCHNYVGGYFCSCHPGYELQKDGQSC 188
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Sushi pfam00084
Sushi repeat (SCR repeat);
308-370 5.44e-10

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 5.44e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 164518925  308 CPQPKALdEFTIIQDPQPQYQFRDYFIVTCKQGYQlMEGNqallsFTAVCQNDGTWHRAMPRC 370
Cdd:pfam00084   1 CPPPPDI-PNGKVSATKNEYNYGASVSYECDPGYR-LVGS-----PTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 375-446 8.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.91  E-value: 8.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164518925 375 CGQPQSLSNGDFRYitTKGVTTYEASIQYHCHEPYykmlTRAGSSESmrgiyTCTAQGIWKNEeegekMPRC 446
Cdd:cd00033    1 CPPPPVPENGTVTG--SKGSYSYGSTVTYSCNEGY----TLVGSSTI-----TCTENGGWSPP-----PPTC 56
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 462-699 1.26e-72

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 234.88  E-value: 1.26e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   462 RIIRGQPARPGNFPWQAFTTTHGRG---GGALLGDRWILTAAHTIYpkhhnkenDNANPKMLVFLGHTNVEQIKKLGHHP 538
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRhfcGGSLISPRWVLTAAHCVR--------GSDPSNIRVRLGSHDLSSGEEGQVIK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   539 VRRVIIHPDYRqdePNNFEGDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGITED---KLAFDLRFVRLP 615
Cdd:smart00020  73 VSKVIIHPNYN---PSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEgagSLPDTLQEVNVP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   616 VADSEACQRwlqTKKDTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRnrdIWVATGIVSWGIGCGEG--YGFYTKVL 693
Cdd:smart00020 150 IVSNATCRR---AYSGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGSGCARPgkPGVYTRVS 223


                   ....*.
gi 164518925   694 NYVDWI 699
Cdd:smart00020 224 SYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 463-701 1.47e-71

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 232.17  E-value: 1.47e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 463 IIRGQPARPGNFPWQAFTTTHGRG---GGALLGDRWILTAAHTIYPKHHNKendnanpkMLVFLGHTNVEQIKKLG-HHP 538
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTGGRhfcGGSLISPRWVLTAAHCVYSSAPSN--------YTVRLGSHDLSSNEGGGqVIK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 539 VRRVIIHPDYRqdePNNFEGDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGITED--KLAFDLRFVRLPV 616
Cdd:cd00190   73 VKKVIVHPNYN---PSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYNLPAGTTCTVSGWGRTSEggPLPDVLQEVNVPI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 617 ADSEACQRWLQTKkdtSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRNRdiWVATGIVSWGIGCGEG--YGFYTKVLN 694
Cdd:cd00190  150 VSNAECKRAYSYG---GTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNGR--GVLVGIVSWGSGCARPnyPGVYTRVSS 224


                 ....*..
gi 164518925 695 YVDWIKK 701
Cdd:cd00190  225 YLDWIQK 231
Trypsin pfam00089
Trypsin;
463-699 1.40e-51

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 178.40  E-value: 1.40e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  463 IIRGQPARPGNFPWQAF---TTTHGRGGGALLGDRWILTAAHTIYpkhhnkendnANPKMLVFLG-HTNVEQIKKLGHHP 538
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSlqlSSGKHFCGGSLISENWVLTAAHCVS----------GASDVKVVLGaHNIVLREGGEQKFD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  539 VRRVIIHPDYRQDEPNNfegDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGIT-EDKLAFDLRFVRLPVA 617
Cdd:pfam00089  71 VEKIIVHPNYNPDTLDN---DIALLKLESPVTLGDTVRPICLPDASSDLPVGTTCTVSGWGNTkTLGPSDTLQEVTVPVV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  618 DSEACQRWLQTKkdtspFSQNMFCSGdpAVQQDACQGDSGGVFAVRDRnrdiwVATGIVSWGIGCGEG--YGFYTKVLNY 695
Cdd:pfam00089 148 SRETCRSAYGGT-----VTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGnyPGVYTPVSSY 215


                  ....
gi 164518925  696 VDWI 699
Cdd:pfam00089 216 LDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 447-704 1.71e-47

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 168.67  E-value: 1.71e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 447 LPVCGKPVNPVTQkeRIIRGQPARPGNFPWQ-AFTTTHGRG----GGALLGDRWILTAAHTIYpkhhnkenDNANPKMLV 521
Cdd:COG5640   17 LALAAAPAADAAP--AIVGGTPATVGEYPWMvALQSSNGPSgqfcGGTLIAPRWVLTAAHCVD--------GDGPSDLRV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 522 FLGHTNV-----EQIKklghhpVRRVIIHPDYRqdePNNFEGDIALLELENSVTLGPellPICLPDNETFYGQGLMGYVS 596
Cdd:COG5640   87 VIGSTDLstsggTVVK------VARIVVHPDYD---PATPGNDIALLKLATPVPGVA---PAPLATSADAAAPGTPATVA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 597 GFGITED---KLAFDLRFVRLPVADSEACQRWlqtkkdTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRNRdiWVAT 673
Cdd:COG5640  155 GWGRTSEgpgSQSGTLRKADVPVVSDATCAAY------GGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDGGG--WVLV 226

                        250       260       270
                 ....*....|....*....|....*....|...
gi 164518925 674 GIVSWGIG-CGEG-YGFYTKVLNYVDWIKKEMG 704
Cdd:COG5640  227 GVVSWGGGpCAAGyPGVYTRVSAYRDWIKSTAG 259
CUB pfam00431
CUB domain;
192-301 8.73e-36

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 130.49  E-value: 8.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  192 CSSELyTEPSGYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDpFEIDDHQQvhCPYDQLQIY----ANGKNLGEFC 267
Cdd:pfam00431   1 CGGVL-TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 164518925  268 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLHY 301
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-303 3.69e-29

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 112.12  E-value: 3.69e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 192 CSSELYTEPSGYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDpFEIDDHQQvhCPYDQLQIY----ANGKNLGEFC 267
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYdgpsTSSPLLGRFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 164518925 268 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLHYTT 303
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 26-137 3.73e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 111.33  E-value: 3.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925    26 GEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKI----SADKQTLGRFCGQLDSPlgnppgs 101
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSEAPP------- 73

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 164518925   102 KEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 137
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQ-------KRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 16-139 3.89e-28

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 109.04  E-value: 3.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  16 GSIYLPQklYGEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKI----SADKQTLGRFCGQl 91
Cdd:cd00041    3 GTLTAST--SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGS- 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 164518925  92 dsplgNPPGSkeFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYYQA 139
Cdd:cd00041   80 -----TLPPP--IISSGNSLTVRFRSDSSVT-------GRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 202-301 6.08e-26

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 102.47  E-value: 6.08e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   202 GYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDpFEIDDHQQvhCPYDQLQIY----ANGKNLGEFCGKQRPPD-LD 276
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 164518925   277 TSSNAVDLLFFTDESGDSRGWKLHY 301
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
23-137 2.17e-23

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 95.44  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   23 KLYGEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKI----SADKQTLGRFCGQldsplGNP 98
Cdd:pfam00431   7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGS-----GIP 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 164518925   99 PgskEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 137
Cdd:pfam00431  82 E---DIVSSSNQMTIKFVSDASVQ-------KRGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 160-188 3.95e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.33  E-value: 3.95e-10
                          10        20
                  ....*....|....*....|....*....
gi 164518925  160 CQHLCHNYVGGYFCSCHPGYELQKDGQSC 188
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Sushi pfam00084
Sushi repeat (SCR repeat);
308-370 5.44e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 5.44e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 164518925  308 CPQPKALdEFTIIQDPQPQYQFRDYFIVTCKQGYQlMEGNqallsFTAVCQNDGTWHRAMPRC 370
Cdd:pfam00084   1 CPPPPDI-PNGKVSATKNEYNYGASVSYECDPGYR-LVGS-----PTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 308-370 4.93e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.14  E-value: 4.93e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 164518925   308 CPQPKALdEFTIIQDPQPQYQFRDYFIVTCKQGYQLMEgnqallSFTAVCQNDGTWHRAMPRC 370
Cdd:smart00032   1 CPPPPDI-ENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
141-189 5.26e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 5.26e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 164518925   141 DLDECASQPNsveeglqprCQH--LCHNYVGGYFCSCHPGYElqkDGQSCQ 189
Cdd:smart00179   1 DIDECASGNP---------CQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 308-371 6.70e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.99  E-value: 6.70e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 164518925 308 CPQPKALdEFTIIQDPQPQYQFRDYFIVTCKQGYQLMEgnqallSFTAVCQNDGTWHRAMPRCK 371
Cdd:cd00033    1 CPPPPVP-ENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTCE 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 141-189 1.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.05e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 164518925 141 DLDECASQPNsveeglqprCQH--LCHNYVGGYFCSCHPGYElqkdGQSCQ 189
Cdd:cd00054    1 DIDECASGNP---------CQNggTCVNTVGSYRCSCPPGYT----GRNCE 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 375-446 8.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.91  E-value: 8.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164518925 375 CGQPQSLSNGDFRYitTKGVTTYEASIQYHCHEPYykmlTRAGSSESmrgiyTCTAQGIWKNEeegekMPRC 446
Cdd:cd00033    1 CPPPPVPENGTVTG--SKGSYSYGSTVTYSCNEGY----TLVGSSTI-----TCTENGGWSPP-----PPTC 56
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 462-699 1.26e-72

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 234.88  E-value: 1.26e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   462 RIIRGQPARPGNFPWQAFTTTHGRG---GGALLGDRWILTAAHTIYpkhhnkenDNANPKMLVFLGHTNVEQIKKLGHHP 538
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRhfcGGSLISPRWVLTAAHCVR--------GSDPSNIRVRLGSHDLSSGEEGQVIK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   539 VRRVIIHPDYRqdePNNFEGDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGITED---KLAFDLRFVRLP 615
Cdd:smart00020  73 VSKVIIHPNYN---PSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEgagSLPDTLQEVNVP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   616 VADSEACQRwlqTKKDTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRnrdIWVATGIVSWGIGCGEG--YGFYTKVL 693
Cdd:smart00020 150 IVSNATCRR---AYSGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGSGCARPgkPGVYTRVS 223


                   ....*.
gi 164518925   694 NYVDWI 699
Cdd:smart00020 224 SYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 463-701 1.47e-71

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 232.17  E-value: 1.47e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 463 IIRGQPARPGNFPWQAFTTTHGRG---GGALLGDRWILTAAHTIYPKHHNKendnanpkMLVFLGHTNVEQIKKLG-HHP 538
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTGGRhfcGGSLISPRWVLTAAHCVYSSAPSN--------YTVRLGSHDLSSNEGGGqVIK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 539 VRRVIIHPDYRqdePNNFEGDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGITED--KLAFDLRFVRLPV 616
Cdd:cd00190   73 VKKVIVHPNYN---PSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYNLPAGTTCTVSGWGRTSEggPLPDVLQEVNVPI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 617 ADSEACQRWLQTKkdtSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRNRdiWVATGIVSWGIGCGEG--YGFYTKVLN 694
Cdd:cd00190  150 VSNAECKRAYSYG---GTITDNMLCAGGLEGGKDACQGDSGGPLVCNDNGR--GVLVGIVSWGSGCARPnyPGVYTRVSS 224


                 ....*..
gi 164518925 695 YVDWIKK 701
Cdd:cd00190  225 YLDWIQK 231
Trypsin pfam00089
Trypsin;
463-699 1.40e-51

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 178.40  E-value: 1.40e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  463 IIRGQPARPGNFPWQAF---TTTHGRGGGALLGDRWILTAAHTIYpkhhnkendnANPKMLVFLG-HTNVEQIKKLGHHP 538
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSlqlSSGKHFCGGSLISENWVLTAAHCVS----------GASDVKVVLGaHNIVLREGGEQKFD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  539 VRRVIIHPDYRQDEPNNfegDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGIT-EDKLAFDLRFVRLPVA 617
Cdd:pfam00089  71 VEKIIVHPNYNPDTLDN---DIALLKLESPVTLGDTVRPICLPDASSDLPVGTTCTVSGWGNTkTLGPSDTLQEVTVPVV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  618 DSEACQRWLQTKkdtspFSQNMFCSGdpAVQQDACQGDSGGVFAVRDRnrdiwVATGIVSWGIGCGEG--YGFYTKVLNY 695
Cdd:pfam00089 148 SRETCRSAYGGT-----VTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGnyPGVYTPVSSY 215


                  ....
gi 164518925  696 VDWI 699
Cdd:pfam00089 216 LDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 447-704 1.71e-47

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 168.67  E-value: 1.71e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 447 LPVCGKPVNPVTQkeRIIRGQPARPGNFPWQ-AFTTTHGRG----GGALLGDRWILTAAHTIYpkhhnkenDNANPKMLV 521
Cdd:COG5640   17 LALAAAPAADAAP--AIVGGTPATVGEYPWMvALQSSNGPSgqfcGGTLIAPRWVLTAAHCVD--------GDGPSDLRV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 522 FLGHTNV-----EQIKklghhpVRRVIIHPDYRqdePNNFEGDIALLELENSVTLGPellPICLPDNETFYGQGLMGYVS 596
Cdd:COG5640   87 VIGSTDLstsggTVVK------VARIVVHPDYD---PATPGNDIALLKLATPVPGVA---PAPLATSADAAAPGTPATVA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 597 GFGITED---KLAFDLRFVRLPVADSEACQRWlqtkkdTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRNRdiWVAT 673
Cdd:COG5640  155 GWGRTSEgpgSQSGTLRKADVPVVSDATCAAY------GGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDGGG--WVLV 226

                        250       260       270
                 ....*....|....*....|....*....|...
gi 164518925 674 GIVSWGIG-CGEG-YGFYTKVLNYVDWIKKEMG 704
Cdd:COG5640  227 GVVSWGGGpCAAGyPGVYTRVSAYRDWIKSTAG 259
CUB pfam00431
CUB domain;
192-301 8.73e-36

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 130.49  E-value: 8.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  192 CSSELyTEPSGYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDpFEIDDHQQvhCPYDQLQIY----ANGKNLGEFC 267
Cdd:pfam00431   1 CGGVL-TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 164518925  268 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLHY 301
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-303 3.69e-29

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 112.12  E-value: 3.69e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 192 CSSELYTEPSGYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDpFEIDDHQQvhCPYDQLQIY----ANGKNLGEFC 267
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYdgpsTSSPLLGRFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 164518925 268 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLHYTT 303
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 26-137 3.73e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 111.33  E-value: 3.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925    26 GEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKI----SADKQTLGRFCGQLDSPlgnppgs 101
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSEAPP------- 73

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 164518925   102 KEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 137
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQ-------KRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 16-139 3.89e-28

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 109.04  E-value: 3.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925  16 GSIYLPQklYGEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKI----SADKQTLGRFCGQl 91
Cdd:cd00041    3 GTLTAST--SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGS- 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 164518925  92 dsplgNPPGSkeFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYYQA 139
Cdd:cd00041   80 -----TLPPP--IISSGNSLTVRFRSDSSVT-------GRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 202-301 6.08e-26

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 102.47  E-value: 6.08e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   202 GYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDpFEIDDHQQvhCPYDQLQIY----ANGKNLGEFCGKQRPPD-LD 276
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 164518925   277 TSSNAVDLLFFTDESGDSRGWKLHY 301
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
23-137 2.17e-23

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 95.44  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925   23 KLYGEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKI----SADKQTLGRFCGQldsplGNP 98
Cdd:pfam00431   7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGS-----GIP 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 164518925   99 PgskEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 137
Cdd:pfam00431  82 E---DIVSSSNQMTIKFVSDASVQ-------KRGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 160-188 3.95e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.33  E-value: 3.95e-10
                          10        20
                  ....*....|....*....|....*....
gi 164518925  160 CQHLCHNYVGGYFCSCHPGYELQKDGQSC 188
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Sushi pfam00084
Sushi repeat (SCR repeat);
308-370 5.44e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 5.44e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 164518925  308 CPQPKALdEFTIIQDPQPQYQFRDYFIVTCKQGYQlMEGNqallsFTAVCQNDGTWHRAMPRC 370
Cdd:pfam00084   1 CPPPPDI-PNGKVSATKNEYNYGASVSYECDPGYR-LVGS-----PTITCQEDGTWSPPFPEC 56
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 488-687 7.98e-09

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 55.84  E-value: 7.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 488 GALLGDRWILTAAHTIYPKHhnkenDNANPKMLVFL-GHTNveqiKKLGHHPVRRVIIHPDYRQDEPNNFegDIALLELE 566
Cdd:COG3591   16 GTLIGPNLVLTAGHCVYDGA-----GGGWATNIVFVpGYNG----GPYGTATATRFRVPPGWVASGDAGY--DYALLRLD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164518925 567 NSVTLGPELLPIcLPDNETFYGQGLmgYVSGFGitEDKlafdlrfvrlpvadseacqrwlqtkkdtsPFSQNMFCSGDPA 646
Cdd:COG3591   85 EPLGDTTGWLGL-AFNDAPLAGEPV--TIIGYP--GDR-----------------------------PKDLSLDCSGRVT 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 164518925 647 VQQ--------DACQGDSGG-VFAVRDrnrDIWVATGIVSWGIGCGEGYG 687
Cdd:COG3591  131 GVQgnrlsydcDTTGGSSGSpVLDDSD---GGGRVVGVHSAGGADRANTG 177
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 308-370 4.93e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.14  E-value: 4.93e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 164518925   308 CPQPKALdEFTIIQDPQPQYQFRDYFIVTCKQGYQLMEgnqallSFTAVCQNDGTWHRAMPRC 370
Cdd:smart00032   1 CPPPPDI-ENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
141-189 5.26e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 5.26e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 164518925   141 DLDECASQPNsveeglqprCQH--LCHNYVGGYFCSCHPGYElqkDGQSCQ 189
Cdd:smart00179   1 DIDECASGNP---------CQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 308-371 6.70e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.99  E-value: 6.70e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 164518925 308 CPQPKALdEFTIIQDPQPQYQFRDYFIVTCKQGYQLMEgnqallSFTAVCQNDGTWHRAMPRCK 371
Cdd:cd00033    1 CPPPPVP-ENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTCE 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 141-189 1.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.05e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 164518925 141 DLDECASQPNsveeglqprCQH--LCHNYVGGYFCSCHPGYElqkdGQSCQ 189
Cdd:cd00054    1 DIDECASGNP---------CQNggTCVNTVGSYRCSCPPGYT----GRNCE 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 375-446 8.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.91  E-value: 8.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164518925 375 CGQPQSLSNGDFRYitTKGVTTYEASIQYHCHEPYykmlTRAGSSESmrgiyTCTAQGIWKNEeegekMPRC 446
Cdd:cd00033    1 CPPPPVPENGTVTG--SKGSYSYGSTVTYSCNEGY----TLVGSSTI-----TCTENGGWSPP-----PPTC 56
EGF smart00181
Epidermal growth factor-like domain;
160-184 3.66e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.57  E-value: 3.66e-03
                           10        20
                   ....*....|....*....|....*.
gi 164518925   160 CQH-LCHNYVGGYFCSCHPGYELQKD 184
Cdd:smart00181   8 CSNgTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA pfam07645
Calcium-binding EGF domain;
141-178 4.80e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 4.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 164518925  141 DLDECASQPNSveeglqprCQH--LCHNYVGGYFCSCHPG 178
Cdd:pfam07645   1 DVDECATGTHN--------CPAntVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 160-189 7.73e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 34.76  E-value: 7.73e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 164518925 160 CQH--LCHNYVGGYFCSCHPGYELQKdgqSCQ 189
Cdd:cd00053    8 CSNggTCVNTPGSYRCVCPPGYTGDR---SCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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