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Conserved domains on  [gi|23111007|ref|NP_076957|]
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glucose-induced degradation protein 4 homolog isoform 1 [Homo sapiens]

Protein Classification

GID4/VID24 family protein( domain architecture ID 10561119)

GID4/VID24 family protein similar to human glucose-induced degradation protein 4 homolog, also called vacuolar import and degradation protein 24 homolog, the substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
 121-289 8.30e-95

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


:

Pssm-ID: 462897  Cd Length: 162  Bit Score: 277.10  E-value: 8.30e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007   121 LLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTR--KWDADEDVD 198
Cdd:pfam09783   1 FLRPGSRFVGTQQSGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPEITTFFEGEIIDGKYGFLTRkpEWGADEETD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007   199 RKHWGKFLAFyqyaKSFNSDDFdyeelKNGDYVFMRWKEQFLVPDHTIKDISGASFAGFYYICFQKSAASIEGYYYHRSS 278
Cdd:pfam09783  81 LEHWSKFPPF----RPLFAKDL-----LNFRYIFMRWKEKFLVPDHRVKTINGASFEGFYYICFDQSTGSIEGYYYHPSS 151

                         170
                  ....*....|.
gi 23111007   279 EWYQSLNLTHV 289
Cdd:pfam09783 152 EKFQQLELKPV 162
 
Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
 121-289 8.30e-95

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


Pssm-ID: 462897  Cd Length: 162  Bit Score: 277.10  E-value: 8.30e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007   121 LLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTR--KWDADEDVD 198
Cdd:pfam09783   1 FLRPGSRFVGTQQSGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPEITTFFEGEIIDGKYGFLTRkpEWGADEETD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007   199 RKHWGKFLAFyqyaKSFNSDDFdyeelKNGDYVFMRWKEQFLVPDHTIKDISGASFAGFYYICFQKSAASIEGYYYHRSS 278
Cdd:pfam09783  81 LEHWSKFPPF----RPLFAKDL-----LNFRYIFMRWKEKFLVPDHRVKTINGASFEGFYYICFDQSTGSIEGYYYHPSS 151

                         170
                  ....*....|.
gi 23111007   279 EWYQSLNLTHV 289
Cdd:pfam09783 152 EKFQQLELKPV 162
VID24 COG5073
Vacuolar import and degradation protein [Intracellular trafficking and secretion];
108-299 9.38e-45

Vacuolar import and degradation protein [Intracellular trafficking and secretion];


Pssm-ID: 227405  Cd Length: 272  Bit Score: 153.11  E-value: 9.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007 108 PPINTQQPGVATSLLYSGSKFRGHQKSKGNSYDVEVVLQHVD------TGNSYLCGYLKIKGLTEEYPTLTTFFEGEIIS 181
Cdd:COG5073  65 KRRLFSSYTRRSGFLRNGAQFGGVQISGYPPLTVEVNIDTVDlpkkddYSLPHLCGTLNIQNLTDPSSTLTTYFEGEIIG 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007 182 -KKHPFLTRKW---DADEDVDRKHWGKFLAFYQYAKSFNSDDF---DYEELKNGDYVFMRWKEQFLVPD-HTIKDISGAS 253
Cdd:COG5073 145 fNKLPFATEKWsmaPASEEIDVCHWKRFPPFRMDNGTFIERIFnqkSKDYKINQRYIYMKWKELFLLPDpLQLDTISGAS 224

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 23111007 254 FAGFYYICFQKSAASIEGYYYHRSS-EWYQSLNLTHVPEHSAPIYEF 299
Cdd:COG5073 225 IDGFYYCCLDQETGYIQGYYYHPKHaEKSQQLELVPEQPRKSPSYSF 271
 
Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
 121-289 8.30e-95

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


Pssm-ID: 462897  Cd Length: 162  Bit Score: 277.10  E-value: 8.30e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007   121 LLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTR--KWDADEDVD 198
Cdd:pfam09783   1 FLRPGSRFVGTQQSGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPEITTFFEGEIIDGKYGFLTRkpEWGADEETD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007   199 RKHWGKFLAFyqyaKSFNSDDFdyeelKNGDYVFMRWKEQFLVPDHTIKDISGASFAGFYYICFQKSAASIEGYYYHRSS 278
Cdd:pfam09783  81 LEHWSKFPPF----RPLFAKDL-----LNFRYIFMRWKEKFLVPDHRVKTINGASFEGFYYICFDQSTGSIEGYYYHPSS 151

                         170
                  ....*....|.
gi 23111007   279 EWYQSLNLTHV 289
Cdd:pfam09783 152 EKFQQLELKPV 162
VID24 COG5073
Vacuolar import and degradation protein [Intracellular trafficking and secretion];
108-299 9.38e-45

Vacuolar import and degradation protein [Intracellular trafficking and secretion];


Pssm-ID: 227405  Cd Length: 272  Bit Score: 153.11  E-value: 9.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007 108 PPINTQQPGVATSLLYSGSKFRGHQKSKGNSYDVEVVLQHVD------TGNSYLCGYLKIKGLTEEYPTLTTFFEGEIIS 181
Cdd:COG5073  65 KRRLFSSYTRRSGFLRNGAQFGGVQISGYPPLTVEVNIDTVDlpkkddYSLPHLCGTLNIQNLTDPSSTLTTYFEGEIIG 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111007 182 -KKHPFLTRKW---DADEDVDRKHWGKFLAFYQYAKSFNSDDF---DYEELKNGDYVFMRWKEQFLVPD-HTIKDISGAS 253
Cdd:COG5073 145 fNKLPFATEKWsmaPASEEIDVCHWKRFPPFRMDNGTFIERIFnqkSKDYKINQRYIYMKWKELFLLPDpLQLDTISGAS 224

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 23111007 254 FAGFYYICFQKSAASIEGYYYHRSS-EWYQSLNLTHVPEHSAPIYEF 299
Cdd:COG5073 225 IDGFYYCCLDQETGYIQGYYYHPKHaEKSQQLELVPEQPRKSPSYSF 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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