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Conserved domains on  [gi|74136559|ref|NP_076971|]
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ERI1 exoribonuclease 3 isoform 1 [Homo sapiens]

Protein Classification

3'-5' exonuclease( domain architecture ID 10150039)

3'-5' exonuclease catalyzes the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction; similar to human ERI1 exoribonuclease 3

CATH:  3.30.420.10
EC:  3.1.-.-
Gene Ontology:  GO:0008408|GO:0003676
PubMed:  11988770|11222749
SCOP:  4000547

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ERI-1_3'hExo_like cd06133
DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and ...
 146-323 5.33e-80

DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; This subfamily is composed of Caenorhabditis elegans ERI-1, human 3' exonuclease (3'hExo), Drosophila exonuclease snipper (snp), and similar proteins from eukaryotes and bacteria. These are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ERI-1 has been implicated in the degradation of small interfering RNAs (RNAi). 3'hExo participates in the degradation of histone mRNAs. Snp is a non-essential exonuclease that efficiently degrades structured RNA and DNA substrates as long as there is a minimum of 2 nucleotides in the 3' overhang to initiate degradation. Snp is not a functional homolog of either ERI-1 or 3'hExo.


:

Pssm-ID: 99836 [Multi-domain]  Cd Length: 176  Bit Score: 241.36  E-value: 5.33e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 146 FLVLDFEATCDK---PQIHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLE 222
Cdd:cd06133   1 YLVIDFEATCWEgnsKPDYPNEIIEIGAVLVDVKTKEIIDTFSSYVKPVINPKLSDFCTELTGITQEDVDNAPSFPEVLK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 223 RVDEWMAKEGlldpnvKSIFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLKKAYSFAMGCWPKNGLLDMNKGLSLQH 302
Cdd:cd06133  81 EFLEWLGKNG------KYAFVTWGDWDLKDLLQNQCKYKIINLPPFFRQWIDLKKEFAKFYGLKKRTGLSKALEYLGLEF 154

                       170       180
                ....*....|....*....|.
gi 74136559 303 IGRPHSGIDDCKNIANIMKTL 323
Cdd:cd06133 155 EGRHHRGLDDARNIARILKRL 175
 
Name Accession Description Interval E-value
ERI-1_3'hExo_like cd06133
DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and ...
 146-323 5.33e-80

DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; This subfamily is composed of Caenorhabditis elegans ERI-1, human 3' exonuclease (3'hExo), Drosophila exonuclease snipper (snp), and similar proteins from eukaryotes and bacteria. These are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ERI-1 has been implicated in the degradation of small interfering RNAs (RNAi). 3'hExo participates in the degradation of histone mRNAs. Snp is a non-essential exonuclease that efficiently degrades structured RNA and DNA substrates as long as there is a minimum of 2 nucleotides in the 3' overhang to initiate degradation. Snp is not a functional homolog of either ERI-1 or 3'hExo.


Pssm-ID: 99836 [Multi-domain]  Cd Length: 176  Bit Score: 241.36  E-value: 5.33e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 146 FLVLDFEATCDK---PQIHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLE 222
Cdd:cd06133   1 YLVIDFEATCWEgnsKPDYPNEIIEIGAVLVDVKTKEIIDTFSSYVKPVINPKLSDFCTELTGITQEDVDNAPSFPEVLK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 223 RVDEWMAKEGlldpnvKSIFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLKKAYSFAMGCWPKNGLLDMNKGLSLQH 302
Cdd:cd06133  81 EFLEWLGKNG------KYAFVTWGDWDLKDLLQNQCKYKIINLPPFFRQWIDLKKEFAKFYGLKKRTGLSKALEYLGLEF 154

                       170       180
                ....*....|....*....|.
gi 74136559 303 IGRPHSGIDDCKNIANIMKTL 323
Cdd:cd06133 155 EGRHHRGLDDARNIARILKRL 175
PTZ00315 PTZ00315
2'-phosphotransferase; Provisional
 139-333 4.82e-51

2'-phosphotransferase; Provisional


Pssm-ID: 240356 [Multi-domain]  Cd Length: 582  Bit Score: 178.16  E-value: 4.82e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  139 PPQRYHYFLVLDFEATCDKPQ-IHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSL 217
Cdd:PTZ00315  51 APQPFDAYVVLDFEATCEADRrIEDAEVIEFPMVLVDARTATPVAEFQRYVRPVKNPVLSRFCTELTGITQSMVSRADPF 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  218 QQVLERVDEWMAKEGLLD--PNVKSIFVTCGDWDLKVMLPGQ---CQYLGLPVAdyFKQWINLKKAYS---FAMGCW--- 286
Cdd:PTZ00315 131 PVVYCEALQFLAEAGLGDapPLRSYCVVTCGDWDLKTMLPSQmrvSGQQGTPLS--FQRWCNLKKYMSqlgFGNGSGcgg 208

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74136559  287 ------PKNGLLDMNKGLSLQHIGRPHSGIDDCKNIANIMKTLAYRGFIFKQT 333
Cdd:PTZ00315 209 gatpplGPSDMPDMLQMLGLPLQGRHHSGIDDCRNIAAVLCELLRRGLVIDPT 261
KapD COG5018
3'-5' exonuclease KapD, inhibitor of KinA-controlled sporulation [Signal transduction ...
 144-323 8.97e-50

3'-5' exonuclease KapD, inhibitor of KinA-controlled sporulation [Signal transduction mechanisms];


Pssm-ID: 444042 [Multi-domain]  Cd Length: 181  Bit Score: 164.26  E-value: 8.97e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 144 HYFLVLDFEATC---DKPQIHPQEIIEFPILKLNGRTmEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQV 220
Cdd:COG5018   2 MKYLVIDLEATCwdgKPPPGFPMEIIEIGAVKVDENG-EIIDEFSSFVKPVRRPKLSPFCTELTGITQEDVDSAPSFAEA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 221 LERVDEWMAKEglldpnvKSIFVTCGDWDLKVMLPgQCQYLGLPVaDYFKQWINLKKAYSFAMGCwpkNGLLDMNKGLSL 300
Cdd:COG5018  81 IEDFKKWIGSE-------DYILCSWGDYDRKQLER-NCRFHGVPY-PFGDRHINLKKLFALYFGL---KKRIGLKKALEL 148

                       170       180
                ....*....|....*....|....*.
gi 74136559 301 QHI---GRPHSGIDDCKNIANIMKTL 323
Cdd:COG5018 149 LGLefeGTHHRALDDARNTAKLFKKI 174
RNase_T pfam00929
Exonuclease; This family includes a variety of exonuclease proteins, such as ribonuclease T ...
 147-320 1.31e-48

Exonuclease; This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;


Pssm-ID: 395743 [Multi-domain]  Cd Length: 164  Bit Score: 160.59  E-value: 1.31e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559   147 LVLDFEATCDKPQihPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDE 226
Cdd:pfam00929   1 VVIDLETTGLDPE--KDEIIEIAAVVIDGGENEIGETFHTYVKPTRLPKLTDECTKFTGITQAMLDNKPSFEEVLEEFLE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559   227 WMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCQylglPVADYFKQWINLKKAYSFAMGcwpkNGLLDMNKGLSLQHIGRP 306
Cdd:pfam00929  79 FLRKGNLLVAHNASFDVGFLRYDDKRFLKKPMP----KLNPVIDTLILDKATYKELPG----RSLDALAEKLGLEHIGRA 150

                         170
                  ....*....|....
gi 74136559   307 HSGIDDCKNIANIM 320
Cdd:pfam00929 151 HRALDDARATAKLF 164
EXOIII smart00479
exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other ...
 145-328 5.88e-41

exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases;


Pssm-ID: 214685 [Multi-domain]  Cd Length: 169  Bit Score: 140.90  E-value: 5.88e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559    145 YFLVLDFEATCDKPQIHpqEIIEFPILKLNGRtmEIESTFHMYVQPvvHPQLTPFCTELTGIIQAMVDGQPSLQQVLERV 224
Cdd:smart00479   1 TLVVIDCETTGLDPGKD--EIIEIAAVDVDGG--EIIEVFDTYVKP--DRPITDYATEIHGITPEMLDDAPTFEEVLEEL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559    225 DEWMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCQYlgLPVADYFKqwinLKKAYSFAmgcWPKNGLLDMNKGLSLQHIG 304
Cdd:smart00479  75 LEFLRGRILVAGNSAHFDLRFLKLEHPRLGIKQPPK--LPVIDTLK----LARATNPG---LPKYSLKKLAKRLLLEVIQ 145

                          170       180
                   ....*....|....*....|....
gi 74136559    305 RPHSGIDDCKNIANIMKTLAYRGF 328
Cdd:smart00479 146 RAHRALDDARATAKLFKKLLERLE 169
 
Name Accession Description Interval E-value
ERI-1_3'hExo_like cd06133
DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and ...
 146-323 5.33e-80

DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; This subfamily is composed of Caenorhabditis elegans ERI-1, human 3' exonuclease (3'hExo), Drosophila exonuclease snipper (snp), and similar proteins from eukaryotes and bacteria. These are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ERI-1 has been implicated in the degradation of small interfering RNAs (RNAi). 3'hExo participates in the degradation of histone mRNAs. Snp is a non-essential exonuclease that efficiently degrades structured RNA and DNA substrates as long as there is a minimum of 2 nucleotides in the 3' overhang to initiate degradation. Snp is not a functional homolog of either ERI-1 or 3'hExo.


Pssm-ID: 99836 [Multi-domain]  Cd Length: 176  Bit Score: 241.36  E-value: 5.33e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 146 FLVLDFEATCDK---PQIHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLE 222
Cdd:cd06133   1 YLVIDFEATCWEgnsKPDYPNEIIEIGAVLVDVKTKEIIDTFSSYVKPVINPKLSDFCTELTGITQEDVDNAPSFPEVLK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 223 RVDEWMAKEGlldpnvKSIFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLKKAYSFAMGCWPKNGLLDMNKGLSLQH 302
Cdd:cd06133  81 EFLEWLGKNG------KYAFVTWGDWDLKDLLQNQCKYKIINLPPFFRQWIDLKKEFAKFYGLKKRTGLSKALEYLGLEF 154

                       170       180
                ....*....|....*....|.
gi 74136559 303 IGRPHSGIDDCKNIANIMKTL 323
Cdd:cd06133 155 EGRHHRGLDDARNIARILKRL 175
PTZ00315 PTZ00315
2'-phosphotransferase; Provisional
 139-333 4.82e-51

2'-phosphotransferase; Provisional


Pssm-ID: 240356 [Multi-domain]  Cd Length: 582  Bit Score: 178.16  E-value: 4.82e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  139 PPQRYHYFLVLDFEATCDKPQ-IHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSL 217
Cdd:PTZ00315  51 APQPFDAYVVLDFEATCEADRrIEDAEVIEFPMVLVDARTATPVAEFQRYVRPVKNPVLSRFCTELTGITQSMVSRADPF 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  218 QQVLERVDEWMAKEGLLD--PNVKSIFVTCGDWDLKVMLPGQ---CQYLGLPVAdyFKQWINLKKAYS---FAMGCW--- 286
Cdd:PTZ00315 131 PVVYCEALQFLAEAGLGDapPLRSYCVVTCGDWDLKTMLPSQmrvSGQQGTPLS--FQRWCNLKKYMSqlgFGNGSGcgg 208

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74136559  287 ------PKNGLLDMNKGLSLQHIGRPHSGIDDCKNIANIMKTLAYRGFIFKQT 333
Cdd:PTZ00315 209 gatpplGPSDMPDMLQMLGLPLQGRHHSGIDDCRNIAAVLCELLRRGLVIDPT 261
KapD COG5018
3'-5' exonuclease KapD, inhibitor of KinA-controlled sporulation [Signal transduction ...
 144-323 8.97e-50

3'-5' exonuclease KapD, inhibitor of KinA-controlled sporulation [Signal transduction mechanisms];


Pssm-ID: 444042 [Multi-domain]  Cd Length: 181  Bit Score: 164.26  E-value: 8.97e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 144 HYFLVLDFEATC---DKPQIHPQEIIEFPILKLNGRTmEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQV 220
Cdd:COG5018   2 MKYLVIDLEATCwdgKPPPGFPMEIIEIGAVKVDENG-EIIDEFSSFVKPVRRPKLSPFCTELTGITQEDVDSAPSFAEA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 221 LERVDEWMAKEglldpnvKSIFVTCGDWDLKVMLPgQCQYLGLPVaDYFKQWINLKKAYSFAMGCwpkNGLLDMNKGLSL 300
Cdd:COG5018  81 IEDFKKWIGSE-------DYILCSWGDYDRKQLER-NCRFHGVPY-PFGDRHINLKKLFALYFGL---KKRIGLKKALEL 148

                       170       180
                ....*....|....*....|....*.
gi 74136559 301 QHI---GRPHSGIDDCKNIANIMKTL 323
Cdd:COG5018 149 LGLefeGTHHRALDDARNTAKLFKKI 174
RNase_T pfam00929
Exonuclease; This family includes a variety of exonuclease proteins, such as ribonuclease T ...
 147-320 1.31e-48

Exonuclease; This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;


Pssm-ID: 395743 [Multi-domain]  Cd Length: 164  Bit Score: 160.59  E-value: 1.31e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559   147 LVLDFEATCDKPQihPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDE 226
Cdd:pfam00929   1 VVIDLETTGLDPE--KDEIIEIAAVVIDGGENEIGETFHTYVKPTRLPKLTDECTKFTGITQAMLDNKPSFEEVLEEFLE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559   227 WMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCQylglPVADYFKQWINLKKAYSFAMGcwpkNGLLDMNKGLSLQHIGRP 306
Cdd:pfam00929  79 FLRKGNLLVAHNASFDVGFLRYDDKRFLKKPMP----KLNPVIDTLILDKATYKELPG----RSLDALAEKLGLEHIGRA 150

                         170
                  ....*....|....
gi 74136559   307 HSGIDDCKNIANIM 320
Cdd:pfam00929 151 HRALDDARATAKLF 164
EXOIII smart00479
exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other ...
 145-328 5.88e-41

exonuclease domain in DNA-polymerase alpha and epsilon chain, ribonuclease T and other exonucleases;


Pssm-ID: 214685 [Multi-domain]  Cd Length: 169  Bit Score: 140.90  E-value: 5.88e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559    145 YFLVLDFEATCDKPQIHpqEIIEFPILKLNGRtmEIESTFHMYVQPvvHPQLTPFCTELTGIIQAMVDGQPSLQQVLERV 224
Cdd:smart00479   1 TLVVIDCETTGLDPGKD--EIIEIAAVDVDGG--EIIEVFDTYVKP--DRPITDYATEIHGITPEMLDDAPTFEEVLEEL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559    225 DEWMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCQYlgLPVADYFKqwinLKKAYSFAmgcWPKNGLLDMNKGLSLQHIG 304
Cdd:smart00479  75 LEFLRGRILVAGNSAHFDLRFLKLEHPRLGIKQPPK--LPVIDTLK----LARATNPG---LPKYSLKKLAKRLLLEVIQ 145

                          170       180
                   ....*....|....*....|....
gi 74136559    305 RPHSGIDDCKNIANIMKTLAYRGF 328
Cdd:smart00479 146 RAHRALDDARATAKLFKKLLERLE 169
PRK07748 PRK07748
3'-5' exonuclease KapD;
146-321 1.18e-18

3'-5' exonuclease KapD;


Pssm-ID: 236087  Cd Length: 207  Bit Score: 82.81  E-value: 1.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  146 FLVLDFEATCDKPQIHPQ----EIIEFPILKLNGRtmEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVL 221
Cdd:PRK07748   6 FLFLDFEFTMPQHKKKPKgffpEIIEVGLVSVVGC--EVEDTFSSYVKPKTFPSLTERCKSFLGITQEDVDKGISFEELV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  222 ERVDEwmakeglLDPNVKSIFVTCGDWDLKVmLPGQCQYLGLPVAdyFK-QWINLKKAYSFAMGCWPKNGLLDMNKGLSL 300
Cdd:PRK07748  84 EKLAE-------YDKRCKPTIVTWGNMDMKV-LKHNCEKAGVPFP--FKgQCRDLSLEYKKFFGERNQTGLWKAIEEYGK 153

                        170       180
                 ....*....|....*....|.
gi 74136559  301 QHIGRPHSGIDDCKNIANIMK 321
Cdd:PRK07748 154 EGTGKHHCALDDAMTTYNIFK 174
PolC COG2176
DNA polymerase III, alpha subunit (gram-positive type) [Replication, recombination and repair]; ...
 146-228 4.40e-11

DNA polymerase III, alpha subunit (gram-positive type) [Replication, recombination and repair];


Pssm-ID: 441779 [Multi-domain]  Cd Length: 181  Bit Score: 60.93  E-value: 4.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 146 FLVLDFEATCDKPQIHpqEIIEFPILKLNGrtMEIESTFHMYVQPvvHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVD 225
Cdd:COG2176  10 YVVFDLETTGLSPKKD--EIIEIGAVKVEN--GEIVDRFSTLVNP--GRPIPPFITELTGITDEMVADAPPFEEVLPEFL 83


                ...
gi 74136559 226 EWM 228
Cdd:COG2176  84 EFL 86
DnaQ COG0847
DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination ...
 146-229 7.15e-10

DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair];


Pssm-ID: 440608 [Multi-domain]  Cd Length: 163  Bit Score: 57.11  E-value: 7.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559 146 FLVLDFEATCDKPQIHpqEIIEFPILKLNGRtmEIESTFHMYVQPvvHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVD 225
Cdd:COG0847   2 FVVLDTETTGLDPAKD--RIIEIGAVKVDDG--RIVETFHTLVNP--ERPIPPEATAIHGITDEDVADAPPFAEVLPELL 75


                ....
gi 74136559 226 EWMA 229
Cdd:COG0847  76 EFLG 79
polC PRK00448
DNA polymerase III PolC; Validated
 146-228 1.82e-09

DNA polymerase III PolC; Validated


Pssm-ID: 234767 [Multi-domain]  Cd Length: 1437  Bit Score: 59.08  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559   146 FLVLDFEATCDKPQIHpqEIIEFPILKL-NGrtmEIESTFHMYVQPvvHPQLTPFCTELTGIIQAMVDGQPSLQQVLERV 224
Cdd:PRK00448  421 YVVFDVETTGLSAVYD--EIIEIGAVKIkNG---EIIDKFEFFIKP--GHPLSAFTTELTGITDDMVKDAPSIEEVLPKF 493


                  ....
gi 74136559   225 DEWM 228
Cdd:PRK00448  494 KEFC 497
PRK06722 PRK06722
exonuclease; Provisional
 145-320 1.14e-06

exonuclease; Provisional


Pssm-ID: 180670 [Multi-domain]  Cd Length: 281  Bit Score: 49.28  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  145 YFLVLDFEATCdKP--QIHPQEIIEFPILKLNGRTMEIESTFHMYVQPvvHPQLTPFCTELTGIIQAMVDGQPSLQQVLE 222
Cdd:PRK06722   6 HFIVFDIERNF-RPykSEDPSEIVDIGAVKIEASTMKVIGEFSELVKP--GARLTRHTTKLTGITKKDLIGVEKFPQIIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  223 RVDEWMAKEglldpnvkSIFVTCGDWDLKvMLPGQCQYLGLPVADYFKQ-WINLKK----AYSFAMGCWPKngLLDMNKG 297
Cdd:PRK06722  83 KFIQFIGED--------SIFVTWGKEDYR-FLSHDCTLHSVECPCMEKErRIDLQKfvfqAYEELFEHTPS--LQSAVEQ 151

                        170       180
                 ....*....|....*....|...
gi 74136559  298 LSLQHIGRPHSGIDDCKNIANIM 320
Cdd:PRK06722 152 LGLIWEGKQHRALADAENTANIL 174
PRK08517 PRK08517
3'-5' exonuclease;
146-223 1.65e-05

3'-5' exonuclease;


Pssm-ID: 236281 [Multi-domain]  Cd Length: 257  Bit Score: 45.78  E-value: 1.65e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74136559  146 FLVLDFEATCDKPQIHpqEIIEFPILKLNGRtmEIESTFHMYVQPvvhPQLTPFCTELTGIIQAMVDGQPSLQQVLER 223
Cdd:PRK08517  70 FCFVDIETNGSKPKKH--QIIEIGAVKVKNG--EIIDRFESFVKA---KEVPEYITELTGITYEDLENAPSLKEVLEE 140
PRK07883 PRK07883
DEDD exonuclease domain-containing protein;
146-227 2.16e-05

DEDD exonuclease domain-containing protein;


Pssm-ID: 236123 [Multi-domain]  Cd Length: 557  Bit Score: 46.06  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  146 FLVLDFEATCDKPqiHPQEIIEFPILKLNGRtmEIESTFHMYVQPVVhpQLTPFCTELTGIIQAMVDGQPSLQQVLERVD 225
Cdd:PRK07883  17 FVVVDLETTGGSP--AGDAITEIGAVKVRGG--EVLGEFATLVNPGR--PIPPFITVLTGITTAMVAGAPPIEEVLPAFL 90


                 ..
gi 74136559  226 EW 227
Cdd:PRK07883  91 EF 92
PRK07740 PRK07740
hypothetical protein; Provisional
 146-223 2.36e-05

hypothetical protein; Provisional


Pssm-ID: 236085 [Multi-domain]  Cd Length: 244  Bit Score: 45.04  E-value: 2.36e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74136559  146 FLVLDFEATCDKPQiHPQEIIEFPILKLNGRTMEIEsTFHMYVQPVVHPqlTPFCTELTGIIQAMVDGQPSLQQVLER 223
Cdd:PRK07740  61 FVVFDLETTGFSPQ-QGDEILSIGAVKTKGGEVETD-TFYSLVKPKRPI--PEHILELTGITAEDVAFAPPLAEVLHR 134
PRK08074 PRK08074
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated
 146-224 1.26e-04

bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated


Pssm-ID: 236148 [Multi-domain]  Cd Length: 928  Bit Score: 43.79  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  146 FLVLDFEATCDKPQiHPQEIIEFPILKL-NGRTMEIESTFhmyvqpvVHPQ--LTPFCTELTGIIQAMVDGQPSLQQVLE 222
Cdd:PRK08074   5 FVVVDLETTGNSPK-KGDKIIQIAAVVVeDGEILERFSSF-------VNPErpIPPFITELTGISEEMVKQAPLFEDVAP 76


                 ..
gi 74136559  223 RV 224
Cdd:PRK08074  77 EI 78
PRK09182 PRK09182
DNA polymerase III subunit epsilon; Validated
 147-225 3.12e-03

DNA polymerase III subunit epsilon; Validated


Pssm-ID: 236397 [Multi-domain]  Cd Length: 294  Bit Score: 38.80  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136559  147 LVLDFEATCDKPQIHpqEIIEFPILK----LNGRTMEIESTFHMYVQPVVhpQLTPFCTELTGIIQAMVDGQ----PSLQ 218
Cdd:PRK09182  40 VILDTETTGLDPRKD--EIIEIGMVAfeydDDGRIGDVLDTFGGLQQPSR--PIPPEITRLTGITDEMVAGQtidpAAVD 115


                 ....*..
gi 74136559  219 QVLERVD 225
Cdd:PRK09182 116 ALIAPAD 122
PRK06807 PRK06807
3'-5' exonuclease;
146-221 5.09e-03

3'-5' exonuclease;


Pssm-ID: 235864 [Multi-domain]  Cd Length: 313  Bit Score: 38.26  E-value: 5.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74136559  146 FLVLDFEATCDKPqiHPQEIIEFPILKLngRTMEIESTFHMYVQPVVHpqLTPFCTELTGIIQAMVDGQPSLQQVL 221
Cdd:PRK06807  10 YVVIDFETTGFNP--YNDKIIQVAAVKY--RNHELVDQFVSYVNPERP--IPDRITSLTGITNYRVSDAPTIEEVL 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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