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transmembrane protein 185B [Homo sapiens]
Tmemb_185A domain-containing protein( domain architecture ID 10563171)
Tmemb_185A domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||||
Tmemb_185A | pfam10269 | Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ... |
31-253 | 5.06e-53 | |||||
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B. : Pssm-ID: 402059 Cd Length: 245 Bit Score: 175.34 E-value: 5.06e-53
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Name | Accession | Description | Interval | E-value | |||||
Tmemb_185A | pfam10269 | Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ... |
31-253 | 5.06e-53 | |||||
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B. Pssm-ID: 402059 Cd Length: 245 Bit Score: 175.34 E-value: 5.06e-53
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TMEM203 | cd22816 | Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ... |
154-258 | 2.69e-06 | |||||
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases. Pssm-ID: 439364 Cd Length: 131 Bit Score: 46.15 E-value: 2.69e-06
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Name | Accession | Description | Interval | E-value | |||||
Tmemb_185A | pfam10269 | Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ... |
31-253 | 5.06e-53 | |||||
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B. Pssm-ID: 402059 Cd Length: 245 Bit Score: 175.34 E-value: 5.06e-53
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TMEM203 | cd22816 | Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ... |
154-258 | 2.69e-06 | |||||
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases. Pssm-ID: 439364 Cd Length: 131 Bit Score: 46.15 E-value: 2.69e-06
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