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Conserved domains on  [gi|981220796|ref|NP_077727|]
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mimecan isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
181-335 6.55e-07

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 6.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796 181 YLYARFNKIKKLTAkDFADIPNLRRLDFTGNLIEDIEDGtFSKLSLLEELSLAENQLLKLPVL---PPKLTLFNAKYNKI 257
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPlgnLTNLEELDLSGNQL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796 258 KSRGikaNAFKKLNNLTFLYLDHNALESVP--LNLPeSLRVIHLQFNNIASITDDTFCKandtsyirdRIEEIRLEGNPI 335
Cdd:COG4886  218 TDLP---EPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDLPPLANLT---------NLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
181-335 6.55e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 6.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796 181 YLYARFNKIKKLTAkDFADIPNLRRLDFTGNLIEDIEDGtFSKLSLLEELSLAENQLLKLPVL---PPKLTLFNAKYNKI 257
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPlgnLTNLEELDLSGNQL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796 258 KSRGikaNAFKKLNNLTFLYLDHNALESVP--LNLPeSLRVIHLQFNNIASITDDTFCKandtsyirdRIEEIRLEGNPI 335
Cdd:COG4886  218 TDLP---EPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDLPPLANLT---------NLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
201-283 2.97e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796  201 PNLRRLDFTGNLIEDIEDGTFSKlslleelslaenqllklpvlPPKLTLFNAKYNKIKSrgIKANAFKKLNNLTFLYLDH 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------LSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 981220796  281 NAL 283
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
234-309 7.20e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 7.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 981220796 234 ENQLLKLPV-LPPKLTLFNAKYNKIKsrgIKANAFKKlnNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITD 309
Cdd:PRK15370 334 ENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPE 405
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
181-335 6.55e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 6.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796 181 YLYARFNKIKKLTAkDFADIPNLRRLDFTGNLIEDIEDGtFSKLSLLEELSLAENQLLKLPVL---PPKLTLFNAKYNKI 257
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPlgnLTNLEELDLSGNQL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796 258 KSRGikaNAFKKLNNLTFLYLDHNALESVP--LNLPeSLRVIHLQFNNIASITDDTFCKandtsyirdRIEEIRLEGNPI 335
Cdd:COG4886  218 TDLP---EPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDLPPLANLT---------NLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
201-283 2.97e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796  201 PNLRRLDFTGNLIEDIEDGTFSKlslleelslaenqllklpvlPPKLTLFNAKYNKIKSrgIKANAFKKLNNLTFLYLDH 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------LSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 981220796  281 NAL 283
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
234-309 7.20e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 7.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 981220796 234 ENQLLKLPV-LPPKLTLFNAKYNKIKsrgIKANAFKKlnNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITD 309
Cdd:PRK15370 334 ENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPE 405
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
181-335 7.86e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220796 181 YLYARFNKIKKLTaKDFADIPNLRRLDFTGNLIEDIEDgTFSKLSLLEELSLAENQLLKLPVLP--PKLTLFNAKYNKIK 258
Cdd:COG4886  186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQLT 263

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 981220796 259 SrgikANAFKKLNNLTFLYLDHNALESVPL-NLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNPI 335
Cdd:COG4886  264 D----LPPLANLTNLKTLDLSNNQLTDLKLkELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR_8 pfam13855
Leucine rich repeat;
245-304 5.59e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 5.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 981220796  245 PKLTLFNAKYNKIKSrgIKANAFKKLNNLTFLYLDHNALESVPLN----LPeSLRVIHLQFNNI 304
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLP-SLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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