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Conserved domains on  [gi|146198654|ref|NP_078947|]
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zinc finger protein 768 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-504 6.05e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 6.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 276 LIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCG------KAFADSSYLLRHQRTHSGQ-KPYKCP 348
Cdd:COG5048  214 SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSSSPNESDSSSEKGFsLPIKSK 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 349 HCGKAFGDSSYLLRHQRTHSHE----RPYSCTE--CGKCYSQNSSLRSHQRVHTGQRPFSC--GICGKSFSQRSALIPHA 420
Cdd:COG5048  294 QCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 421 RSHAR-----EKPFKC--PECGKRFGQSSVLAIHARTHLPGRTYSC--PDCGKTFNRSSTLIQHQRSHTGERPYRCavCG 491
Cdd:COG5048  374 SLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SI 451

                        250
                 ....*....|...
gi 146198654 492 KGFCRSSTLLQHH 504
Cdd:COG5048  452 LKSFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 513-535 7.53e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 42.67  E-value: 7.53e-06
                          10        20
                  ....*....|....*....|...
gi 146198654  513 YKCDDCGKAFSQSSDLIRHQRTH 535
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
NESP55 super family cl25759
Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian ...
 4-162 1.42e-03

Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins.


The actual alignment was detected with superfamily member pfam06390:

Pssm-ID: 115071 [Multi-domain]  Cd Length: 261  Bit Score: 40.62  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654    4 EALPWGLEPQ----DVQSSDEMRSPEgYLRGNMSENEEEEISQQEGSGDYEVE-EIPFGLEPQSPGFEPQSPEFEPQSPR 78
Cdd:pfam06390  78 QVFPEPSEPEsdheDEDFEPELARPE-CLEYDEDDFDTETDSETEPESDIESEtEFETEPETEPDTAPTTEPETEPEDEP 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654   79 --FEPESPGFES----RSPGLVPPSPEFAPRSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPGYESESSRY--E 150
Cdd:pfam06390 157 gpVVPKGATFHQslteRLHALKLQSADASPRRAPPSTQEPESAREGEEPERGPLDKDPRDPEEEEEEKEEEKQQPHRckP 236

                         170
                  ....*....|..
gi 146198654  151 SQNTELKTQSPE 162
Cdd:pfam06390 237 KKPARRRDPSPE 248
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-504 6.05e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 6.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 276 LIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCG------KAFADSSYLLRHQRTHSGQ-KPYKCP 348
Cdd:COG5048  214 SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSSSPNESDSSSEKGFsLPIKSK 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 349 HCGKAFGDSSYLLRHQRTHSHE----RPYSCTE--CGKCYSQNSSLRSHQRVHTGQRPFSC--GICGKSFSQRSALIPHA 420
Cdd:COG5048  294 QCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 421 RSHAR-----EKPFKC--PECGKRFGQSSVLAIHARTHLPGRTYSC--PDCGKTFNRSSTLIQHQRSHTGERPYRCavCG 491
Cdd:COG5048  374 SLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SI 451

                        250
                 ....*....|...
gi 146198654 492 KGFCRSSTLLQHH 504
Cdd:COG5048  452 LKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-354 6.43e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 6.43e-06
                          10        20
                  ....*....|....*....|....
gi 146198654  331 YLLRHQRTHSGQKPYKCPHCGKAF 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 513-535 7.53e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 42.67  E-value: 7.53e-06
                          10        20
                  ....*....|....*....|...
gi 146198654  513 YKCDDCGKAFSQSSDLIRHQRTH 535
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 399-450 3.35e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 3.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 146198654 399 RPFsCGICGKSFSQRSALIpharSHAREKPFKCPECGKRFGQSSVLAIHART 450
Cdd:cd20908    1 KPW-CYYCDREFDDEKILI----QHQKAKHFKCHICHKKLYTAGGLAVHCLQ 47
NESP55 pfam06390
Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian ...
 4-162 1.42e-03

Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins.


Pssm-ID: 115071 [Multi-domain]  Cd Length: 261  Bit Score: 40.62  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654    4 EALPWGLEPQ----DVQSSDEMRSPEgYLRGNMSENEEEEISQQEGSGDYEVE-EIPFGLEPQSPGFEPQSPEFEPQSPR 78
Cdd:pfam06390  78 QVFPEPSEPEsdheDEDFEPELARPE-CLEYDEDDFDTETDSETEPESDIESEtEFETEPETEPDTAPTTEPETEPEDEP 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654   79 --FEPESPGFES----RSPGLVPPSPEFAPRSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPGYESESSRY--E 150
Cdd:pfam06390 157 gpVVPKGATFHQslteRLHALKLQSADASPRRAPPSTQEPESAREGEEPERGPLDKDPRDPEEEEEEKEEEKQQPHRckP 236

                         170
                  ....*....|..
gi 146198654  151 SQNTELKTQSPE 162
Cdd:pfam06390 237 KKPARRRDPSPE 248
PHA00733 PHA00733
hypothetical protein
 288-335 1.44e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 146198654 288 PYKCEVCSKAFSQSSDLIKHQR--THTgerpYKCPRCGKAFADSSYLLRH 335
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRytEHS----KVCPVCGKEFRNTDSTLDH 118
PHA03132 PHA03132
thymidine kinase; Provisional
 17-133 4.91e-03

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 39.75  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654  17 SSDEmrSPEGYLRGNMSENEEEEISQQ---EGSGDYEVEEIPFGLEPQSPGFEPQSPEF----EPQSPRFEPESPGFESR 89
Cdd:PHA03132  16 SSDE--SPEGSRDENFDAERDDFLTPLgstSEATSEDDDDLYPPRETGSGGGVATSTIYtvprPPRGPEQTLDKPDSLPA 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 146198654  90 SPGLvPPSPEFAPRS---------PESDSQSPEFESQSPRYEPQSPGYEPRSP 133
Cdd:PHA03132  94 SREL-PPGPTPVPPGgfrgassprLGADSTSPRFLYQVNFPVILAPIGESNSS 145
ZnF_C2H2 smart00355
zinc finger;
345-367 5.37e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 5.37e-03
                           10        20
                   ....*....|....*....|...
gi 146198654   345 YKCPHCGKAFGDSSYLLRHQRTH 367
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-504 6.05e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 6.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 276 LIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCG------KAFADSSYLLRHQRTHSGQ-KPYKCP 348
Cdd:COG5048  214 SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSSSPNESDSSSEKGFsLPIKSK 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 349 HCGKAFGDSSYLLRHQRTHSHE----RPYSCTE--CGKCYSQNSSLRSHQRVHTGQRPFSC--GICGKSFSQRSALIPHA 420
Cdd:COG5048  294 QCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 421 RSHAR-----EKPFKC--PECGKRFGQSSVLAIHARTHLPGRTYSC--PDCGKTFNRSSTLIQHQRSHTGERPYRCavCG 491
Cdd:COG5048  374 SLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SI 451

                        250
                 ....*....|...
gi 146198654 492 KGFCRSSTLLQHH 504
Cdd:COG5048  452 LKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
260-535 1.97e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 260 PNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEV--CSKAFSQSSDLIKHQRTHTGERPYKC--PRCGKAFADSSYLLRH 335
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 336 QRTHSgQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCTEC----------------------GKCYSQNSSLRSHQR 393
Cdd:COG5048  113 SSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 394 VHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTF--NRSST 471
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146198654 472 LIQHQRSHTGER-----PYRCAVCGKGFCRSSTLLQH--HRVHSGE--RPYKCD--DCGKAFSQSSDLIRHQRTH 535
Cdd:COG5048  272 SSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-354 6.43e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 6.43e-06
                          10        20
                  ....*....|....*....|....
gi 146198654  331 YLLRHQRTHSGQKPYKCPHCGKAF 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 513-535 7.53e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 42.67  E-value: 7.53e-06
                          10        20
                  ....*....|....*....|...
gi 146198654  513 YKCDDCGKAFSQSSDLIRHQRTH 535
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-300 1.02e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.02e-05
                          10        20
                  ....*....|....*....|....*
gi 146198654  276 LIQHQRIHTGEKPYKCEVCSKAFSQ 300
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-531 1.10e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 372 PYSCTECGKCYSQNSSLRSHQR--VHTGQ--RPFSCGI--CGKSFSQRSALIPHARSHAREKPFKCP--ECGKRFGQSSV 443
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 444 LAIHARTH-----LPGRTYSC--PDCGKTFNRSSTLIQHQRSHTGERPY--RCAVCGKGFCRSSTLLQHHRVHSGERPYK 514
Cdd:COG5048  369 NEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 146198654 515 CDDCGKaFSQSSDLIRH 531
Cdd:COG5048  449 CSILKS-FRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-369 1.57e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 1.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 285 GEKPYKCEV--CSKAFSQSSDLiKHQRTHTGERPYKCPRCGKafadssylLRHQRTHSGQKPYKCPHCGKAFGDSSYLLR 362
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*..
gi 146198654 363 HqRTHSH 369
Cdd:COG5189  417 H-RKHSH 422
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 399-450 3.35e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 3.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 146198654 399 RPFsCGICGKSFSQRSALIpharSHAREKPFKCPECGKRFGQSSVLAIHART 450
Cdd:cd20908    1 KPW-CYYCDREFDDEKILI----QHQKAKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 345-367 3.64e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 3.64e-05
                          10        20
                  ....*....|....*....|...
gi 146198654  345 YKCPHCGKAFGDSSYLLRHQRTH 367
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-327 4.35e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.35e-05
                          10        20
                  ....*....|....*....|....*
gi 146198654  303 DLIKHQRTHTGERPYKCPRCGKAFA 327
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 457-479 5.13e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 5.13e-05
                          10        20
                  ....*....|....*....|...
gi 146198654  457 YSCPDCGKTFNRSSTLIQHQRSH 479
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 317-339 7.30e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 7.30e-05
                          10        20
                  ....*....|....*....|...
gi 146198654  317 YKCPRCGKAFADSSYLLRHQRTH 339
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 289-311 8.80e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 8.80e-05
                          10        20
                  ....*....|....*....|...
gi 146198654  289 YKCEVCSKAFSQSSDLIKHQRTH 311
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-412 1.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 146198654  387 SLRSHQRVHTGQRPFSCGICGKSFSQ 412
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-524 1.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|....*
gi 146198654  500 LLQHHRVHSGERPYKCDDCGKAFSQ 524
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 373-395 1.96e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.96e-04
                          10        20
                  ....*....|....*....|...
gi 146198654  373 YSCTECGKCYSQNSSLRSHQRVH 395
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
472-494 4.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.27e-04
                          10        20
                  ....*....|....*....|...
gi 146198654  472 LIQHQRSHTGERPYRCAVCGKGF 494
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 313-396 5.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 313 GERPYKCP--RCGKAFAdSSYLLRHQRTHSgqkpykcpHCGKAFGDSSYLLRHQRTHSHERPYSCTECGKCYSQNSSLRS 390
Cdd:COG5189  346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 146198654 391 HqRVHT 396
Cdd:COG5189  417 H-RKHS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 462-507 5.80e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 5.80e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 146198654 462 CGKTFNRSSTLIQHQRSHTgerpYRCAVCGKGFcRSSTLLQHH--RVH 507
Cdd:cd20908    7 CDREFDDEKILIQHQKAKH----FKCHICHKKL-YTAGGLAVHclQVH 49
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 370-451 5.89e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 370 ERPYSC--TECGKCYSQNSSLRSHqRVHtgqrpfscGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIH 447
Cdd:COG5189  347 GKPYKCpvEGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                 ....
gi 146198654 448 aRTH 451
Cdd:COG5189  418 -RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-535 6.87e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 6.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 307 HQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCTECGKCYSQ-- 384
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPta 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 385 NSSLRSHQRVHTGQR-----PFSCGICGKSFSQRSALIPHARS--HARE--KPFKCPE--CGKRFGQSSVLAIHARTHLP 453
Cdd:COG5048  269 SSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 454 GRTYSCP--DCGKTFNRSST-----LIQHQRSHTGERPYRCAV--CGKGFCRSSTLLQHHRVHSGERPY--KCDDCGKAF 522
Cdd:COG5048  349 ISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSF 428

                        250
                 ....*....|...
gi 146198654 523 SQSSDLIRHQRTH 535
Cdd:COG5048  429 NRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
299-368 9.31e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 146198654 299 SQSSDLIKHQRTHTGE----RPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPH--CGKAFGDSSYLLRHQRTHS 368
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-391 1.17e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654  74 PQSPRFEPESPGFESRSPGLVPPSPEFAPRSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPgyesessryesQN 153
Cdd:COG5048  162 PQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLP-----------LT 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 154 TELKTQSPEFEAQSSKFQEGAEMLLNPEEKSPLNISVGVHPLDSFTQgfgeqptgdlpigPPFEMPTGALLSTPqfeMLQ 233
Cdd:COG5048  231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNE-------------SDSSSEKGFSLPIK---SKQ 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 234 NPLGLTGALRGPGRRGGRARGGQGPRPNICGI--CGKSFGRGSTLIQHQRIHTGEKPYKC--EVCSKAFSQSSDLIKHQR 309
Cdd:COG5048  295 CNISFSRSSPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQS 374

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 310 TH-----TGERPYKC--PRCGKAFADSSYLLRHQRTHSGQKP--YKCPHCGKAFGDSSYLLRHQRTHSHERPYSCteCGK 380
Cdd:COG5048  375 LQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SIL 452

                        330
                 ....*....|.
gi 146198654 381 CYSQNSSLRSH 391
Cdd:COG5048  453 KSFRRDLDLSN 463
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 426-508 1.20e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 426 EKPFKCP--ECGKRFGQSSVLAIHART-HLPGRTYSCPDcgktfnrsstLIQHQRSHTGERPYRCAVCGKGFcRSSTLLQ 502
Cdd:COG5189  347 GKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPS----------PEKMNIFSAKDKPYRCEVCDKRY-KNLNGLK 415


                 ....*.
gi 146198654 503 HHRVHS 508
Cdd:COG5189  416 YHRKHS 421
NESP55 pfam06390
Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian ...
 4-162 1.42e-03

Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins.


Pssm-ID: 115071 [Multi-domain]  Cd Length: 261  Bit Score: 40.62  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654    4 EALPWGLEPQ----DVQSSDEMRSPEgYLRGNMSENEEEEISQQEGSGDYEVE-EIPFGLEPQSPGFEPQSPEFEPQSPR 78
Cdd:pfam06390  78 QVFPEPSEPEsdheDEDFEPELARPE-CLEYDEDDFDTETDSETEPESDIESEtEFETEPETEPDTAPTTEPETEPEDEP 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654   79 --FEPESPGFES----RSPGLVPPSPEFAPRSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPGYESESSRY--E 150
Cdd:pfam06390 157 gpVVPKGATFHQslteRLHALKLQSADASPRRAPPSTQEPESAREGEEPERGPLDKDPRDPEEEEEEKEEEKQQPHRckP 236

                         170
                  ....*....|..
gi 146198654  151 SQNTELKTQSPE 162
Cdd:pfam06390 237 KKPARRRDPSPE 248
PHA00733 PHA00733
hypothetical protein
 288-335 1.44e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 146198654 288 PYKCEVCSKAFSQSSDLIKHQR--THTgerpYKCPRCGKAFADSSYLLRH 335
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRytEHS----KVCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 343-395 1.94e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 146198654 343 KPYkCPHCGKAFGDSSYLLRHQRTHsHerpYSCTECGKCYSQNSSLRSH-QRVH 395
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAK-H---FKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 485-507 2.26e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.26e-03
                          10        20
                  ....*....|....*....|...
gi 146198654  485 YRCAVCGKGFCRSSTLLQHHRVH 507
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 456-503 2.54e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 2.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 146198654 456 TYSCPDCGKTFNRSSTLIQHQRshTGERPYRCAVCGKGFCRSSTLLQH 503
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 263-307 3.88e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 3.88e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 146198654 263 CGICGKSFGRGSTLIQHQRIHTgekpYKCEVCSKAFSQSSDLIKH 307
Cdd:cd20908    4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-438 4.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.13e-03
                          10        20
                  ....*....|....*....|
gi 146198654  419 HARSHAREKPFKCPECGKRF 438
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
PHA03132 PHA03132
thymidine kinase; Provisional
 17-133 4.91e-03

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 39.75  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654  17 SSDEmrSPEGYLRGNMSENEEEEISQQ---EGSGDYEVEEIPFGLEPQSPGFEPQSPEF----EPQSPRFEPESPGFESR 89
Cdd:PHA03132  16 SSDE--SPEGSRDENFDAERDDFLTPLgstSEATSEDDDDLYPPRETGSGGGVATSTIYtvprPPRGPEQTLDKPDSLPA 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 146198654  90 SPGLvPPSPEFAPRS---------PESDSQSPEFESQSPRYEPQSPGYEPRSP 133
Cdd:PHA03132  94 SREL-PPGPTPVPPGgfrgassprLGADSTSPRFLYQVNFPVILAPIGESNSS 145
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 5.10e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.10e-03
                          10        20
                  ....*....|....*....|...
gi 146198654  429 FKCPECGKRFGQSSVLAIHARTH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
345-367 5.37e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 5.37e-03
                           10        20
                   ....*....|....*....|...
gi 146198654   345 YKCPHCGKAFGDSSYLLRHQRTH 367
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-148 5.87e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 5.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654   16 QSSDEMRSPEGYLRGNMSENEEEEISQQEGSGDYEVEEIPFGLEPQS--PGFEPQSPEFEPQSPRFEPESPGFESRSPGl 93
Cdd:PHA03307  217 ASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPItlPTRIWEASGWNGPSSRPGPASSSSSPRERS- 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 146198654   94 vPPSPEFAPRSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPGYESESSR 148
Cdd:PHA03307  296 -PSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSR 349
dnaA PRK14086
chromosomal replication initiator protein DnaA;
44-154 6.10e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.42  E-value: 6.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654  44 EGSGDYEVEEIPFGL--EPQSPGFEPQSPEFEPQS-----PRfEPESPGFESRSPGLVPPSPefaPRSPESDSQSPEFES 116
Cdd:PRK14086 119 EGYGGPRADDRPPGLprQDQLPTARPAYPAYQQRPepgawPR-AADDYGWQQQRLGFPPRAP---YASPASYAPEQERDR 194

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 146198654 117 QSprYEPQSPGYEPRSPGYEprSPGYESESSRYESQNT 154
Cdd:PRK14086 195 EP--YDAGRPEYDQRRRDYD--HPRPDWDRPRRDRTDR 228
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-384 6.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 146198654  359 YLLRHQRTHSHERPYSCTECGKCYSQ 384
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
318-519 7.08e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 38.31  E-value: 7.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 318 KCPRCGkafadSSYLLRHQRTHSGQKPYKCPHCGKAF-GDSSYLLRHQRTHSHERpyscteCGKCYSQNSSLRSHQRVht 396
Cdd:COG3677   18 VCPHCG-----STRIVKNGKTRNGRQRYRCKDCGRTFtVTTGTIFEGSKLPLWLQ------AIRLLLNGISLRQIARV-- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146198654 397 gqrpfsCGIcgksfSQRSAL--IPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQ 474
Cdd:COG3677   85 ------LGV-----SYKTVWrwLHRIREALDELVDEVDEGEGLVGEEDEKTKSKRRRKRGKKLVKGLKKGVVVKVRARGA 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 146198654 475 HQRSHTGER--PYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCG 519
Cdd:COG3677  154 RKSKLAVRLelADLLLRRIILAALVAPLATDLAVGVDSKKHELLELA 200
PHA00733 PHA00733
hypothetical protein
 316-363 7.81e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 7.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 146198654 316 PYKCPRCGKAFADSSYLLRHQRTHSGQKpyKCPHCGKAFGDSSYLLRH 363
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
OrfB_Zn_ribbon pfam07282
Putative transposase DNA-binding domain; This putative domain is found at the C-terminus of a ...
 431-468 9.84e-03

Putative transposase DNA-binding domain; This putative domain is found at the C-terminus of a large number of transposase proteins. This domain contains four conserved cysteines suggestive of a zinc binding domain. Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesize this domain is DNA-binding.


Pssm-ID: 284650 [Multi-domain]  Cd Length: 69  Bit Score: 34.88  E-value: 9.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 146198654  431 CPECGKRfgqssvlaihARTHLPGRTYSCPDCGKTFNR 468
Cdd:pfam07282  31 CSVCGHK----------NKESLSGRTFVCPNCGFVADR 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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