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Conserved domains on  [gi|113205085|ref|NP_079003|]
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leucine-rich repeat-containing protein 31 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 91-349 4.22e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 94.34  E-value: 4.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085  91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWN--GFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALgEAFEM 168
Cdd:cd00116   28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 169 IPELEELNLSwNSKVGGNLPLILQKFQKGSKIQMIELV--DCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSI 246
Cdd:cd00116  107 SSSLQELKLN-NNGLGDRGLRLLAKGLKDLPPALEKLVlgRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRAL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 247 AQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLS-CNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTAD 325
Cdd:cd00116  186 AEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGdNNLTDAGAAALASALLSPNISLLTLSLSCNDITDD 265

                        250       260
                 ....*....|....*....|....
gi 113205085 326 DVMSLTQVIPLLSNLQELDLSANK 349
Cdd:cd00116  266 GAKDLAEVLAEKESLLELDLRGNK 289
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 233-498 9.34e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 9.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 233 LSINRDIVGSLNSiAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN---------KDLGGGFEDSP 303
Cdd:cd00116    3 LSLKGELLKTERA-TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetgriprglQSLLQGLTKGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 304 AqlvmlkhLQVLDLHQCSLTADDVMSLtQVIPLLSNLQELDLSaNKKMGSSSENLLSR-LRFL-PALKSLVINNCALESE 381
Cdd:cd00116   82 G-------LQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLN-NNGLGDRGLRLLAKgLKDLpPALEKLVLGRNRLEGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 382 TFTALAEASVHLSALEVFNLSWNkcvggnlkllletlklsmslqvlrlsscSLVTEDVALLASVIQtgHLAKLQKLDLSy 461
Cdd:cd00116  153 SCEALAKALRANRDLKELNLANN----------------------------GIGDAGIRALAEGLK--ANCNLEVLDLN- 201

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 113205085 462 NDSICDAGwtmfcqnVRFLKELIELDISLRPSNFRDC 498
Cdd:cd00116  202 NNGLTDEG-------ASALAETLASLKSLEVLNLGDN 231
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-349 4.22e-21

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 94.34  E-value: 4.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085  91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWN--GFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALgEAFEM 168
Cdd:cd00116   28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 169 IPELEELNLSwNSKVGGNLPLILQKFQKGSKIQMIELV--DCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSI 246
Cdd:cd00116  107 SSSLQELKLN-NNGLGDRGLRLLAKGLKDLPPALEKLVlgRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRAL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 247 AQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLS-CNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTAD 325
Cdd:cd00116  186 AEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGdNNLTDAGAAALASALLSPNISLLTLSLSCNDITDD 265

                        250       260
                 ....*....|....*....|....
gi 113205085 326 DVMSLTQVIPLLSNLQELDLSANK 349
Cdd:cd00116  266 GAKDLAEVLAEKESLLELDLRGNK 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
154-510 1.16e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 154 LTTDDVQALGEAFEMIPELEELNLSWNskvggnlplilQKFQKGSKIQMIELVDCSLTSedgtfLGQLLPMLQSLEVLDL 233
Cdd:COG4886   80 LLLSLLLLGLTDLGDLTNLTELDLSGN-----------EELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 234 SINRdivgsLNSIAQGLKSTSNLKVLKLHSCGLSQksvkiLDAAFRYLGELRKLDLSCNKdlgggFEDSPAQLVMLKHLQ 313
Cdd:COG4886  144 SNNQ-----LTDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQ-----ITDLPEPLGNLTNLE 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 314 VLDLHQCSLTaddvmSLTQVIPLLSNLQELDLSANKkmgsssENLLSRLRFLPALKSLVINNCALESETFTAlaeasvHL 393
Cdd:COG4886  209 ELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQ------LTDLPELGNLTNLEELDLSNNQLTDLPPLA------NL 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 394 SALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMF 473
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 113205085 474 CQNVRFLKELIELDISLRPSNFRDCGQWFRHLLYAVT 510
Cdd:COG4886  352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 233-498 9.34e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 9.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 233 LSINRDIVGSLNSiAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN---------KDLGGGFEDSP 303
Cdd:cd00116    3 LSLKGELLKTERA-TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetgriprglQSLLQGLTKGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 304 AqlvmlkhLQVLDLHQCSLTADDVMSLtQVIPLLSNLQELDLSaNKKMGSSSENLLSR-LRFL-PALKSLVINNCALESE 381
Cdd:cd00116   82 G-------LQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLN-NNGLGDRGLRLLAKgLKDLpPALEKLVLGRNRLEGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 382 TFTALAEASVHLSALEVFNLSWNkcvggnlkllletlklsmslqvlrlsscSLVTEDVALLASVIQtgHLAKLQKLDLSy 461
Cdd:cd00116  153 SCEALAKALRANRDLKELNLANN----------------------------GIGDAGIRALAEGLK--ANCNLEVLDLN- 201

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 113205085 462 NDSICDAGwtmfcqnVRFLKELIELDISLRPSNFRDC 498
Cdd:cd00116  202 NNGLTDEG-------ASALAETLASLKSLEVLNLGDN 231
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-381 9.50e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 9.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 112 FLPDLEELDISWNGFVGgtllSITQQMHLVSKLKILRLGSCRLTTDDVQALGEafemIPELEELNLSWNSKVGGnlplIL 191
Cdd:PLN00113 138 SIPNLETLDLSNNMLSG----EIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTN----LTSLEFLTLASNQLVGQ----IP 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 192 QKFQKGSKIQMIELVDCSLTSEDGTFLGQllpmLQSLEVLDLSINrDIVGslnSIAQGLKSTSNLKVLKLHSCGLSQksv 271
Cdd:PLN00113 206 RELGQMKSLKWIYLGYNNLSGEIPYEIGG----LTSLNHLDLVYN-NLTG---PIPSSLGNLKNLQYLFLYQNKLSG--- 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 272 KILDAAFRyLGELRKLDLSCNKdLGGgfeDSPAQLVMLKHLQVLDLHQCSLTADDVMSLT-----QVIPLLS-------- 338
Cdd:PLN00113 275 PIPPSIFS-LQKLISLDLSDNS-LSG---EIPELVIQLQNLEILHLFSNNFTGKIPVALTslprlQVLQLWSnkfsgeip 349

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 113205085 339 -------NLQELDLSANKKMGSSSENLLSRLRflpaLKSLVINNCALESE 381
Cdd:PLN00113 350 knlgkhnNLTVLDLSTNNLTGEIPEGLCSSGN----LFKLILFSNSLEGE 395
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-349 4.22e-21

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 94.34  E-value: 4.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085  91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWN--GFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALgEAFEM 168
Cdd:cd00116   28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 169 IPELEELNLSwNSKVGGNLPLILQKFQKGSKIQMIELV--DCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSI 246
Cdd:cd00116  107 SSSLQELKLN-NNGLGDRGLRLLAKGLKDLPPALEKLVlgRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRAL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 247 AQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLS-CNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTAD 325
Cdd:cd00116  186 AEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGdNNLTDAGAAALASALLSPNISLLTLSLSCNDITDD 265

                        250       260
                 ....*....|....*....|....
gi 113205085 326 DVMSLTQVIPLLSNLQELDLSANK 349
Cdd:cd00116  266 GAKDLAEVLAEKESLLELDLRGNK 289
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 220-489 8.77e-20

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 90.49  E-value: 8.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 220 QLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHS--CGLSQKSVKILDAAFRYLGELRKLDLSCN---KD 294
Cdd:cd00116   17 ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLneTGRIPRGLQSLLQGLTKGCGLQELDLSDNalgPD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 295 LGGGFEDspaqLVMLKHLQVLDLHQCSLTADDVMSLTQVI-PLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVI 373
Cdd:cd00116   97 GCGVLES----LLRSSSLQELKLNNNGLGDRGLRLLAKGLkDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 374 NNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGhLAK 453
Cdd:cd00116  173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSP-NIS 251

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 113205085 454 LQKLDLSYNDsICDAGWTMFCQNVRFLKELIELDIS 489
Cdd:cd00116  252 LLTLSLSCND-ITDDGAKDLAEVLAEKESLLELDLR 286
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 201-463 6.02e-19

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 87.80  E-value: 6.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 201 QMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSIN--RDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILdAAF 278
Cdd:cd00116   26 QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 279 RYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKH-LQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSEN 357
Cdd:cd00116  105 LRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 358 LLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKC-VGGNLKLLLETLKLSMSLQVLRLSSCSLVT 436
Cdd:cd00116  185 LAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLtDAGAAALASALLSPNISLLTLSLSCNDITD 264

                        250       260
                 ....*....|....*....|....*..
gi 113205085 437 EDVALLASVIQtgHLAKLQKLDLSYND 463
Cdd:cd00116  265 DGAKDLAEVLA--EKESLLELDLRGNK 289
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 135-405 6.67e-19

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 87.80  E-value: 6.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 135 TQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWN--SKVGGNLPLILQKFQKGSKIQMIELVDCSLtS 212
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGLTKGCGLQELDLSDNAL-G 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 213 EDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKS-TSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSC 291
Cdd:cd00116   95 PDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDlPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLAN 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 292 NKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFL-PALKS 370
Cdd:cd00116  175 NGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPnISLLT 254

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 113205085 371 LVINNCALESETFTALAEASVHLSALEVFNLSWNK 405
Cdd:cd00116  255 LSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNK 289
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 79-322 2.90e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 77.01  E-value: 2.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085  79 LQKLGKKAVNKCLDLNNCGLTtADMKEMVALLPFLPDLEELDISWNGF-VGGTLLSITQQMHLVSKLKILRLGSCRLTTD 157
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALG-PDGCGVLESLLRSSSLQELKLNNNGLgDRGLRLLAKGLKDLPPALEKLVLGRNRLEGA 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 158 DVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINR 237
Cdd:cd00116  153 SCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNN 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 238 DIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKH-LQVL 315
Cdd:cd00116  233 LTDAGAAALASALLSPNiSLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNeLESL 312


                 ....*..
gi 113205085 316 DLHQCSL 322
Cdd:cd00116  313 WVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
154-510 1.16e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 154 LTTDDVQALGEAFEMIPELEELNLSWNskvggnlplilQKFQKGSKIQMIELVDCSLTSedgtfLGQLLPMLQSLEVLDL 233
Cdd:COG4886   80 LLLSLLLLGLTDLGDLTNLTELDLSGN-----------EELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 234 SINRdivgsLNSIAQGLKSTSNLKVLKLHSCGLSQksvkiLDAAFRYLGELRKLDLSCNKdlgggFEDSPAQLVMLKHLQ 313
Cdd:COG4886  144 SNNQ-----LTDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQ-----ITDLPEPLGNLTNLE 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 314 VLDLHQCSLTaddvmSLTQVIPLLSNLQELDLSANKkmgsssENLLSRLRFLPALKSLVINNCALESETFTAlaeasvHL 393
Cdd:COG4886  209 ELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQ------LTDLPELGNLTNLEELDLSNNQLTDLPPLA------NL 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 394 SALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMF 473
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 113205085 474 CQNVRFLKELIELDISLRPSNFRDCGQWFRHLLYAVT 510
Cdd:COG4886  352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-404 2.02e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 2.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 113 LPDLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCrlttddvqalgEAFEMIPELEELNLSWNSKVggNLPLILQ 192
Cdd:COG4886   67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----------EELSNLTNLESLDLSGNQLT--DLPEELA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 193 KFqkgSKIQMIELVDCSLTSedgtfLGQLLPMLQSLEVLDLSINRdivgsLNSIAQGLKSTSNLKVLKLHSCGLSQksvk 272
Cdd:COG4886  134 NL---TNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQ-----LTDLPEELGNLTNLKELDLSNNQITD---- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 273 iLDAAFRYLGELRKLDLSCNKdlgggFEDSPAQLVMLKHLQVLDLHQCSLTadDVMSLTQviplLSNLQELDLSANKKMG 352
Cdd:COG4886  197 -LPEPLGNLTNLEELDLSGNQ-----LTDLPEPLANLTNLETLDLSNNQLT--DLPELGN----LTNLEELDLSNNQLTD 264

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 113205085 353 sssenlLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
Cdd:COG4886  265 ------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
209-462 1.32e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 209 SLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHscgLSQKSVKILDAAFRYLGELRKLD 288
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSL---LLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 289 LSCNKDLGGgfedspaqlvmLKHLQVLDLHQCSLTaddvmSLTQVIPLLSNLQELDLSANKkmgssSENLLSRLRFLPAL 368
Cdd:COG4886  103 LSGNEELSN-----------LTNLESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQ-----LTDLPEPLGNLTNL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 369 KSLVINNCALESetftaLAEASVHLSALEVFNLSWNK------CVGGNLkllletlklsmSLQVLRLSSCSLVTEDVALl 442
Cdd:COG4886  162 KSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQitdlpePLGNLT-----------NLEELDLSGNQLTDLPEPL- 224

                        250       260
                 ....*....|....*....|
gi 113205085 443 asviqtGHLAKLQKLDLSYN 462
Cdd:COG4886  225 ------ANLTNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-410 4.30e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 4.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085  91 LDLNNCGLTtadmkEMVALLPFLPDLEELDISWNGFVggtllSITQQMHLVSKLKILRLGSCRLTTddvqaLGEAFEMIP 170
Cdd:COG4886  118 LDLSGNQLT-----DLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLT 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 171 ELEELNLSWNskvggnlplilqkfqkgsKIqmielvdcsltsedgTFLGQLLPMLQSLEVLDLSINRdivgsLNSIAQGL 250
Cdd:COG4886  183 NLKELDLSNN------------------QI---------------TDLPEPLGNLTNLEELDLSGNQ-----LTDLPEPL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 251 KSTSNLKVLKLHSCGLSQKSvkildaAFRYLGELRKLDLSCNKdlgggFEDSPAqLVMLKHLQVLDLHQCSLTADDVMSL 330
Cdd:COG4886  225 ANLTNLETLDLSNNQLTDLP------ELGNLTNLEELDLSNNQ-----LTDLPP-LANLTNLKTLDLSNNQLTDLKLKEL 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 331 TQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGN 410
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 233-498 9.34e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 9.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 233 LSINRDIVGSLNSiAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN---------KDLGGGFEDSP 303
Cdd:cd00116    3 LSLKGELLKTERA-TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetgriprglQSLLQGLTKGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 304 AqlvmlkhLQVLDLHQCSLTADDVMSLtQVIPLLSNLQELDLSaNKKMGSSSENLLSR-LRFL-PALKSLVINNCALESE 381
Cdd:cd00116   82 G-------LQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLN-NNGLGDRGLRLLAKgLKDLpPALEKLVLGRNRLEGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 382 TFTALAEASVHLSALEVFNLSWNkcvggnlkllletlklsmslqvlrlsscSLVTEDVALLASVIQtgHLAKLQKLDLSy 461
Cdd:cd00116  153 SCEALAKALRANRDLKELNLANN----------------------------GIGDAGIRALAEGLK--ANCNLEVLDLN- 201

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 113205085 462 NDSICDAGwtmfcqnVRFLKELIELDISLRPSNFRDC 498
Cdd:cd00116  202 NNGLTDEG-------ASALAETLASLKSLEVLNLGDN 231
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-381 9.50e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 9.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 112 FLPDLEELDISWNGFVGgtllSITQQMHLVSKLKILRLGSCRLTTDDVQALGEafemIPELEELNLSWNSKVGGnlplIL 191
Cdd:PLN00113 138 SIPNLETLDLSNNMLSG----EIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTN----LTSLEFLTLASNQLVGQ----IP 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 192 QKFQKGSKIQMIELVDCSLTSEDGTFLGQllpmLQSLEVLDLSINrDIVGslnSIAQGLKSTSNLKVLKLHSCGLSQksv 271
Cdd:PLN00113 206 RELGQMKSLKWIYLGYNNLSGEIPYEIGG----LTSLNHLDLVYN-NLTG---PIPSSLGNLKNLQYLFLYQNKLSG--- 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 272 KILDAAFRyLGELRKLDLSCNKdLGGgfeDSPAQLVMLKHLQVLDLHQCSLTADDVMSLT-----QVIPLLS-------- 338
Cdd:PLN00113 275 PIPPSIFS-LQKLISLDLSDNS-LSG---EIPELVIQLQNLEILHLFSNNFTGKIPVALTslprlQVLQLWSnkfsgeip 349

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 113205085 339 -------NLQELDLSANKKMGSSSENLLSRLRflpaLKSLVINNCALESE 381
Cdd:PLN00113 350 knlgkhnNLTVLDLSTNNLTGEIPEGLCSSGN----LFKLILFSNSLEGE 395
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 174-463 1.25e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 174 ELNLSWNSKVGGNLPLILQ-----------KFQKGSKIQMIELVDCSLtSEDGTFLGQLLPMLQSLEVLDLSINRDIVGS 242
Cdd:COG5238  118 DLRRIMAKTLEDSLILYLAlprrinliqvlKDPLGGNAVHLLGLAARL-GLLAAISMAKALQNNSVETVYLGCNQIGDEG 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 243 LNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSL 322
Cdd:COG5238  197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQI 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 323 TADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLS 402
Cdd:COG5238  277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113205085 403 WNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGhlaKLQKLDLSYND 463
Cdd:COG5238  357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN---RLHTLILDGNL 414
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 143-327 3.56e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.24  E-value: 3.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 143 KLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNsKVGGN-LPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQL 221
Cdd:COG5238  237 SLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGN-QIGAEgAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEG 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 222 LPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFED 301
Cdd:COG5238  316 LQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEA 395

                        170       180
                 ....*....|....*....|....*.
gi 113205085 302 spaqlvMLKHLQVLDLHQCSLTADDV 327
Cdd:COG5238  396 ------LIDALQTNRLHTLILDGNLI 415
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-374 3.41e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085  91 LDLNNCGLTTADmkemvALLPFLPDLEELDISWNGfvggtLLSITQQMHLVSKLKILRLGSCRLTTddvqaLGEAFEMIP 170
Cdd:COG4886  141 LDLSNNQLTDLP-----EPLGNLTNLKSLDLSNNQ-----LTDLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLT 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 171 ELEELNLSwNSKVgGNLPLILQKFqkgSKIQMIELVDCSLTSEDGtflgqlLPMLQSLEVLDLSINRdiVGSLNSIAQgl 250
Cdd:COG4886  206 NLEELDLS-GNQL-TDLPEPLANL---TNLETLDLSNNQLTDLPE------LGNLTNLEELDLSNNQ--LTDLPPLAN-- 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 251 ksTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSL 330
Cdd:COG4886  271 --LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 113205085 331 TQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVIN 374
Cdd:COG4886  349 LLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 222-348 3.46e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113205085 222 LPMLQSLEVLDLSINRdIvgslnSIAQGLKSTSNLKVLKLhSCGLSQKSVKIL--DAAFRYLGE-LRKLDLSCNKdlggg 298
Cdd:cd21340   64 LENLVNLKKLYLGGNR-I-----SVVEGLENLTNLEELHI-ENQRLPPGEKLTfdPRSLAALSNsLRVLNISGNN----- 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 113205085 299 fEDSPAQLVMLKHLQVLDLHQCSLtaDDVMSLTQVIPLLSNLQELDLSAN 348
Cdd:cd21340  132 -IDSLEPLAPLRNLEQLDASNNQI--SDLEELLDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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