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Conserved domains on  [gi|13376064|ref|NP_079017|]
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zinc finger protein 408 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 53-176 4.12e-54

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


:

Pssm-ID: 380918  Cd Length: 121  Bit Score: 181.85  E-value: 4.12e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064  53 ALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEEnlsLGPWGDVCACEQSSGWTSL 132
Cdd:cd10520   1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 13376064 133 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSE 176
Cdd:cd10520  78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-507 2.00e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 2.00e-06
                          10        20
                  ....*....|....*....|....*.
gi 13376064   482 SLRNHMRLHTGEKPFLCPHCGRAFRQ 507
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
308-516 3.46e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 308 KLHSPSDQCPP--RAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGR--RYRCGECGKAFLQLCHLKKH--AFVHTG--HK 379
Cdd:COG5048 241 LSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFslPIKSKQCNISFSRSSPLTRHlrSVNHSGesLK 320

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 380 PFLCTE--CGKSYSSEESFKAHMLGHRGVRPFPCP---------QCDKAYGTQRDLKEHQVVHSgaRPFACD--QCGKAF 446
Cdd:COG5048 321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfsPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNF 398

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13376064 447 ARRPSLRLHRKTH-QVPAAPAPCPCPVCGRPLANqgSLRNHMRLHTgEKPFLCPHCGRAFRQRGNLRGHLR 516
Cdd:COG5048 399 KRDSNLSLHIITHlSFRPYNCKNPPCSKSFNRHY--NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-642 5.32e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 5.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 475 RPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPhcadafpqlpeLRRHLISHTG 548
Cdd:COG5048 297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSP 365

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 549 EAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYRCPTCGMGYTLPQSLRRHQLS 628
Cdd:COG5048 366 LLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKI 440

                       170
                ....*....|....
gi 13376064 629 HrpeaPCSPPSVPS 642
Cdd:COG5048 441 H----TNHAPLLCS 450
 
Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 53-176 4.12e-54

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 181.85  E-value: 4.12e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064  53 ALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEEnlsLGPWGDVCACEQSSGWTSL 132
Cdd:cd10520   1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 13376064 133 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSE 176
Cdd:cd10520  78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-507 2.00e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 2.00e-06
                          10        20
                  ....*....|....*....|....*.
gi 13376064   482 SLRNHMRLHTGEKPFLCPHCGRAFRQ 507
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
308-516 3.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 308 KLHSPSDQCPP--RAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGR--RYRCGECGKAFLQLCHLKKH--AFVHTG--HK 379
Cdd:COG5048 241 LSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFslPIKSKQCNISFSRSSPLTRHlrSVNHSGesLK 320

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 380 PFLCTE--CGKSYSSEESFKAHMLGHRGVRPFPCP---------QCDKAYGTQRDLKEHQVVHSgaRPFACD--QCGKAF 446
Cdd:COG5048 321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfsPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNF 398

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13376064 447 ARRPSLRLHRKTH-QVPAAPAPCPCPVCGRPLANqgSLRNHMRLHTgEKPFLCPHCGRAFRQRGNLRGHLR 516
Cdd:COG5048 399 KRDSNLSLHIITHlSFRPYNCKNPPCSKSFNRHY--NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-642 5.32e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 5.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 475 RPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPhcadafpqlpeLRRHLISHTG 548
Cdd:COG5048 297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSP 365

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 549 EAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYRCPTCGMGYTLPQSLRRHQLS 628
Cdd:COG5048 366 LLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKI 440

                       170
                ....*....|....
gi 13376064 629 HrpeaPCSPPSVPS 642
Cdd:COG5048 441 H----TNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-533 1.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....
gi 13376064   510 NLRGHLRLHTGERPYRCPHCADAF 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-392 7.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 13376064   367 HLKKHAFVHTGHKPFLCTECGKSYSS 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 523-569 4.58e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 4.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 13376064  523 PYRCPHCADAFPQLPELRRHlISHTGEAHLCPVCGKALRDPHTLRAH 569
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH-IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 53-176 4.12e-54

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 181.85  E-value: 4.12e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064  53 ALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEEnlsLGPWGDVCACEQSSGWTSL 132
Cdd:cd10520   1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 13376064 133 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSE 176
Cdd:cd10520  78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 57-170 1.86e-14

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 69.15  E-value: 1.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064  57 LPRGLALGPSLAKEQRLGVWCVgDPLQPGLLWGPLEeesaskekgegvkprqeenlslgpwGDVCaceqssgWTSLVQRG 136
Cdd:cd10534   1 LPAGLELVLSSIPEGGLGVFAR-RTIPAGTRFGPLE-------------------------GVVN-------WMRFVRPA 47

                        90       100       110
                ....*....|....*....|....*....|....
gi 13376064 137 RLESEGNVAPVRISERLHLQVYQLVLPGSELLLW 170
Cdd:cd10534  48 RNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVW 81
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-507 2.00e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 2.00e-06
                          10        20
                  ....*....|....*....|....*.
gi 13376064   482 SLRNHMRLHTGEKPFLCPHCGRAFRQ 507
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 54-170 4.72e-06

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 46.28  E-value: 4.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064  54 LKSLPRGLALGPSLAKEQRLGVWCVgDPLQPGLLWGPLEEEsaSKEKGEGVKPRQEENLSLGPWGDVC--ACEQSSG-WT 130
Cdd:cd19188   1 LMGLPEELELKPSAVDKTRIGVWAK-KSIPKGRKFGPFVGE--KKKRSQVKNNVYMWEIYGPKRGWMCvdASDPTKGnWL 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 13376064 131 SLVQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLW 170
Cdd:cd19188  78 RYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCW 117
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
308-516 3.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 308 KLHSPSDQCPP--RAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGR--RYRCGECGKAFLQLCHLKKH--AFVHTG--HK 379
Cdd:COG5048 241 LSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFslPIKSKQCNISFSRSSPLTRHlrSVNHSGesLK 320

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 380 PFLCTE--CGKSYSSEESFKAHMLGHRGVRPFPCP---------QCDKAYGTQRDLKEHQVVHSgaRPFACD--QCGKAF 446
Cdd:COG5048 321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfsPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNF 398

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13376064 447 ARRPSLRLHRKTH-QVPAAPAPCPCPVCGRPLANqgSLRNHMRLHTgEKPFLCPHCGRAFRQRGNLRGHLR 516
Cdd:COG5048 399 KRDSNLSLHIITHlSFRPYNCKNPPCSKSFNRHY--NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-642 5.32e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 5.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 475 RPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPhcadafpqlpeLRRHLISHTG 548
Cdd:COG5048 297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSP 365

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 549 EAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYRCPTCGMGYTLPQSLRRHQLS 628
Cdd:COG5048 366 LLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKI 440

                       170
                ....*....|....
gi 13376064 629 HrpeaPCSPPSVPS 642
Cdd:COG5048 441 H----TNHAPLLCS 450
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 377-457 1.19e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064 377 GHKPFLC--TECGKSYSSEESFKAHML-GHRGVRPFPCPQCDKaygtqrdlkeHQVVHSGARPFACDQCGKAFARRPSLR 453
Cdd:COG5189 346 DGKPYKCpvEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....
gi 13376064 454 LHRK 457
Cdd:COG5189 416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-533 1.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....
gi 13376064   510 NLRGHLRLHTGERPYRCPHCADAF 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 81-176 1.89e-04

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 41.56  E-value: 1.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376064  81 PLQPGLLWGP----LEEESASKEKGEGVKPRqeenLSLGPWGDVCACEQSSGWTSLVQRGRLESEGNVAPVRISERLHLQ 156
Cdd:cd19201  27 PLPEGTRFGPypgkLVKEPLDPSYEWKVEAQ----GSKGGEGLLLLTEDSGTWLKLVRSADDEDEANLILYFKGGQIWCE 102

                        90       100
                ....*....|....*....|
gi 13376064 157 VYQLVLPGSELLLWPQPSSE 176
Cdd:cd19201 103 VTKDIPPGEELILVLREPLL 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
594-617 7.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.10e-04
                          10        20
                  ....*....|....*....|....
gi 13376064   594 LRRHLKSHLEDKPYRCPTCGMGYT 617
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-392 7.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 13376064   367 HLKKHAFVHTGHKPFLCTECGKSYSS 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 496-518 1.19e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|...
gi 13376064   496 FLCPHCGRAFRQRGNLRGHLRLH 518
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 575-625 1.86e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.86e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13376064 575 GERPFPCP--QCGRAYTLATKLRRH-LKSH------------------LEDKPYRCPTCGMGYTLPQSLRRH 625
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHmLHGHqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 437-459 3.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.11e-03
                          10        20
                  ....*....|....*....|...
gi 13376064   437 FACDQCGKAFARRPSLRLHRKTH 459
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-418 4.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.32e-03
                          10        20
                  ....*....|....*....|....
gi 13376064   395 SFKAHMLGHRGVRPFPCPQCDKAY 418
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 523-569 4.58e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 4.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 13376064  523 PYRCPHCADAFPQLPELRRHlISHTGEAHLCPVCGKALRDPHTLRAH 569
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH-IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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