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Conserved domains on  [gi|33359221|ref|NP_079150|]
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dyslexia-associated protein KIAA0319-like protein [Homo sapiens]

Protein Classification

myxo_dep_M36 superfamily-containing protein( domain architecture ID 1906324)

myxo_dep_M36 superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 405-787 3.91e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 152.50  E-value: 3.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   405 NRPPIAIVSPQFQEisLPTTSTVIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 475
Cdd:NF038112 1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   476 SLTVvdSDGATNSTTANLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 554
Cdd:NF038112 1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   555 RTPTLQLSAMQ---EGDYTYQLTVTDTIgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSSDDQKIIS 631
Cdd:NF038112 1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   632 YLWEKTQGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPIAKiTGNVVITLPTS 708
Cdd:NF038112 1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   709 TAELDGSKSSDDKGIVSYLWTRDEGSPAAgevLNHSDHHPILFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 786
Cdd:NF038112 1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                  .
gi 33359221   787 R 787
Cdd:NF038112 1562 R 1562
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 405-787 3.91e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 152.50  E-value: 3.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   405 NRPPIAIVSPQFQEisLPTTSTVIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 475
Cdd:NF038112 1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   476 SLTVvdSDGATNSTTANLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 554
Cdd:NF038112 1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   555 RTPTLQLSAMQ---EGDYTYQLTVTDTIgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSSDDQKIIS 631
Cdd:NF038112 1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   632 YLWEKTQGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPIAKiTGNVVITLPTS 708
Cdd:NF038112 1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   709 TAELDGSKSSDDKGIVSYLWTRDEGSPAAgevLNHSDHHPILFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 786
Cdd:NF038112 1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                  .
gi 33359221   787 R 787
Cdd:NF038112 1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 283-693 8.31e-29

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 125.15  E-value: 8.31e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   283 PSYSYATPTP---QASFQSTSAPYPVIkelvvSAGESVQItLPKNEVQLN--AYVlqePPKGETYTYDW-QLITHPRDYS 356
Cdd:NF038112 1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSF---DPDGDPLTYAWtQVSGPAVTLT 1234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   357 GEMEGKHS----QILKLSKLTpglyeFKVIV-EGQNAHGEGYVNVTVKpepRKNRPPIAivspqfqEISLPTT----STV 427
Cdd:NF038112 1235 GADTATPSftapEVTADTVLT-----FQLVVsDGTKTSAPDTVTVLVR---NVNRAPVA-------VAGAPATvderSTV 1299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   428 -IDGSQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDG-ATNSTTANLTVnKAVDYP 502
Cdd:NF038112 1300 tLDGSGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDGtASATDTVTVTV-RNVNRA 1375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   503 PVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPTLQLSA---MQEGDYTYQLTVTDti 579
Cdd:NF038112 1376 PVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSA-- 1449

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   580 GQQATAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSSDDQKIISYLWEKTQGPdGVQLENANSSVATVTGL 658
Cdd:NF038112 1450 DGQASADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAP 1527

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 33359221   659 QVG---TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 693
Cdd:NF038112 1528 EVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 273-600 2.65e-17

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 87.79  E-value: 2.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   273 TQIAVPqPVAPSySYATPTPqaSFQSTSAPYPVIK--ELVVSAGesVQITLPKN-EVQLN-------------------- 329
Cdd:NF038112 1224 TQVSGP-AVTLT-GADTATP--SFTAPEVTADTVLtfQLVVSDG--TKTSAPDTvTVLVRnvnrapvavagapatvders 1297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   330 AYVLQ---EPPKGETYTYDW-QLITHPRDYSGEMEGKHS----QILKLSKLTpglyeFKVIVEGQNAHGEGYVNVTVKPe 401
Cdd:NF038112 1298 TVTLDgsgTDADGDALTYAWtQTSGPAVTLTGATTATATftapEVTADTQLT-----FTLTVSDGTASATDTVTVTVRN- 1371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   402 prKNRPPIAIVSPQfQEISLPTTSTvIDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLT 478
Cdd:NF038112 1372 --VNRAPVANAGAD-QTVDERSTVT-LSGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLT 1446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   479 VVDSDGATNSTTANLTVNKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPT 558
Cdd:NF038112 1447 VSADGQASADVTVTVTVRN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAK 1521

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 33359221   559 LQLSAMQEG---DYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQ 600
Cdd:NF038112 1522 LTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 690-780 1.10e-11

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 61.52  E-value: 1.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221    690 NKPPIAKITGNVVITlPTSTAELDGSKSSD-DKGIVSYLWTRDEGSPAAGEVLNHSDHHPilflsnlveGTYTFHLKVTD 768
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 33359221    769 AKG---ESDTDRTTV 780
Cdd:pfam18911   71 DSGasnSTATDTVTV 85
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 695-783 4.23e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 48.60  E-value: 4.23e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221     695 AKITGNVVITLPTSTAELDGSkSSDDKGIVSYLWTRDEGSPAAGEVLNHSdhhpilFLSnlvEGTYTFHLKVTDAKGeSD 774
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGTSSTGPTVTHT------YTK---PGTYTVTLTVTNAVG-SA 70


                    ....*....
gi 33359221     775 TDRTTVEVK 783
Cdd:smart00089   71 SATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 693-782 9.07e-06

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.79  E-value: 9.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  693 PIAKITGNVVITLPTStAELDGSKSSDDKgIVSYLWTRDEGSPAAGEvlnhsdhHPILFLSNLVEGTYTFHLKVTDAKGE 772
Cdd:cd00146    1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDFGDGEVSSSG-------EPTVTHTYTKPGTYTVTLTVTNAVGS 71

                         90
                 ....*....|
gi 33359221  773 SDTDRTTVEV 782
Cdd:cd00146   72 SSTKTTTVVV 81
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
473-780 4.60e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.30  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  473 YTFSLTVVDSDGatNSTTANLTVNKAVDYPPVANAGPNQVITLPqNSITLfgN-QSTDDHGITSYEWSLSPSSKGKVVEM 551
Cdd:COG3401  205 YYYRVAATDTGG--ESAPSNEVSVTTPTTPPSAPTGLTATADTP-GSVTL--SwDPVTESDATGYRVYRSNSGDGPFTKV 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  552 QGVRTPTLQLSAMQEG-DYTYQLTVTDTIGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSSDDqKII 630
Cdd:COG3401  280 ATVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDA-DVT 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  631 SYLWEKTQGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSvNVIVKEEINKPPIAKITGNVVITLP 706
Cdd:COG3401  357 GYNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPS-EEVSATTASAASGESLTASVDAVPL 435

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33359221  707 TSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTV 780
Cdd:COG3401  436 TDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSV 509
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 405-787 3.91e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 152.50  E-value: 3.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   405 NRPPIAIVSPQFQEisLPTTSTVIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 475
Cdd:NF038112 1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   476 SLTVvdSDGATNSTTANLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 554
Cdd:NF038112 1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   555 RTPTLQLSAMQ---EGDYTYQLTVTDTIgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSSDDQKIIS 631
Cdd:NF038112 1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   632 YLWEKTQGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPIAKiTGNVVITLPTS 708
Cdd:NF038112 1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   709 TAELDGSKSSDDKGIVSYLWTRDEGSPAAgevLNHSDHHPILFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 786
Cdd:NF038112 1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                  .
gi 33359221   787 R 787
Cdd:NF038112 1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 283-693 8.31e-29

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 125.15  E-value: 8.31e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   283 PSYSYATPTP---QASFQSTSAPYPVIkelvvSAGESVQItLPKNEVQLN--AYVlqePPKGETYTYDW-QLITHPRDYS 356
Cdd:NF038112 1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSF---DPDGDPLTYAWtQVSGPAVTLT 1234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   357 GEMEGKHS----QILKLSKLTpglyeFKVIV-EGQNAHGEGYVNVTVKpepRKNRPPIAivspqfqEISLPTT----STV 427
Cdd:NF038112 1235 GADTATPSftapEVTADTVLT-----FQLVVsDGTKTSAPDTVTVLVR---NVNRAPVA-------VAGAPATvderSTV 1299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   428 -IDGSQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDG-ATNSTTANLTVnKAVDYP 502
Cdd:NF038112 1300 tLDGSGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDGtASATDTVTVTV-RNVNRA 1375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   503 PVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPTLQLSA---MQEGDYTYQLTVTDti 579
Cdd:NF038112 1376 PVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSA-- 1449

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   580 GQQATAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSSDDQKIISYLWEKTQGPdGVQLENANSSVATVTGL 658
Cdd:NF038112 1450 DGQASADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAP 1527

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 33359221   659 QVG---TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 693
Cdd:NF038112 1528 EVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 273-600 2.65e-17

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 87.79  E-value: 2.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   273 TQIAVPqPVAPSySYATPTPqaSFQSTSAPYPVIK--ELVVSAGesVQITLPKN-EVQLN-------------------- 329
Cdd:NF038112 1224 TQVSGP-AVTLT-GADTATP--SFTAPEVTADTVLtfQLVVSDG--TKTSAPDTvTVLVRnvnrapvavagapatvders 1297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   330 AYVLQ---EPPKGETYTYDW-QLITHPRDYSGEMEGKHS----QILKLSKLTpglyeFKVIVEGQNAHGEGYVNVTVKPe 401
Cdd:NF038112 1298 TVTLDgsgTDADGDALTYAWtQTSGPAVTLTGATTATATftapEVTADTQLT-----FTLTVSDGTASATDTVTVTVRN- 1371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   402 prKNRPPIAIVSPQfQEISLPTTSTvIDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLT 478
Cdd:NF038112 1372 --VNRAPVANAGAD-QTVDERSTVT-LSGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLT 1446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221   479 VVDSDGATNSTTANLTVNKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPT 558
Cdd:NF038112 1447 VSADGQASADVTVTVTVRN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAK 1521

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 33359221   559 LQLSAMQEG---DYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQ 600
Cdd:NF038112 1522 LTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 690-780 1.10e-11

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 61.52  E-value: 1.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221    690 NKPPIAKITGNVVITlPTSTAELDGSKSSD-DKGIVSYLWTRDEGSPAAGEVLNHSDHHPilflsnlveGTYTFHLKVTD 768
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 33359221    769 AKG---ESDTDRTTV 780
Cdd:pfam18911   71 DSGasnSTATDTVTV 85
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 695-783 4.23e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 48.60  E-value: 4.23e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221     695 AKITGNVVITLPTSTAELDGSkSSDDKGIVSYLWTRDEGSPAAGEVLNHSdhhpilFLSnlvEGTYTFHLKVTDAKGeSD 774
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGTSSTGPTVTHT------YTK---PGTYTVTLTVTNAVG-SA 70


                    ....*....
gi 33359221     775 TDRTTVEVK 783
Cdd:smart00089   71 SATVTVVVQ 79
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 502-589 1.35e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 47.27  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221    502 PPVANAGPNQVITLPQnSITLFGNQSTD-DHGITSYEWSLS--PSSKGKVVemqgVRTPTlqlsamQEGDYTYQLTVTDT 578
Cdd:pfam18911    3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGdgTTATGANV----SHTYA------APGTYTVTLTVTDD 71

                           90
                   ....*....|....
gi 33359221    579 IGQQ---ATAQVTV 589
Cdd:pfam18911   72 SGASnstATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 596-685 1.80e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.88  E-value: 1.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221    596 NKPPQADAGPDKELTlPVDSTTLDGSKSSD-DQKIISYLWEKtqgPDGvqlenanssvATVTGLQV-------GTYVFTL 667
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDF---GDG----------TTATGANVshtyaapGTYTVTL 66

                           90
                   ....*....|....*...
gi 33359221    668 TVKDERNLQSQSSVNVIV 685
Cdd:pfam18911   67 TVTDDSGASNSTATDTVT 84
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 504-592 5.45e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 45.52  E-value: 5.45e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221     504 VANAGPNQVITLPQNSITlFGNQSTDDHGITSYEWSLS--PSSKGKVVEMQGVRtptlqlsamqEGDYTYQLTVTDTIGq 581
Cdd:smart00089    1 VADVSASPTVGVAGESVT-FTATSSDDGSIVSYTWDFGdgTSSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 33359221     582 QATAQVTVIVQ 592
Cdd:smart00089   69 SASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 693-782 9.07e-06

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.79  E-value: 9.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  693 PIAKITGNVVITLPTStAELDGSKSSDDKgIVSYLWTRDEGSPAAGEvlnhsdhHPILFLSNLVEGTYTFHLKVTDAKGE 772
Cdd:cd00146    1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDFGDGEVSSSG-------EPTVTHTYTKPGTYTVTLTVTNAVGS 71

                         90
                 ....*....|
gi 33359221  773 SDTDRTTVEV 782
Cdd:cd00146   72 SSTKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 503-591 3.57e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 43.25  E-value: 3.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  503 PVANAGPNQVITLPQnSITLFGNqSTDDHGITSYEWSLSpsskGKVVEMQGVRTPTLqlSAMQEGDYTYQLTVTDTIGQQ 582
Cdd:cd00146    1 PTASVSAPPVAELGA-SVTFSAS-DSSGGSIVSYKWDFG----DGEVSSSGEPTVTH--TYTKPGTYTVTLTVTNAVGSS 72


                 ....*....
gi 33359221  583 ATAQVTVIV 591
Cdd:cd00146   73 STKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 601-686 3.90e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 42.82  E-value: 3.90e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221     601 ADAGPDKELTLPVDSTTLDGSkSSDDQKIISYLWekTQGpDGVQLENANssvATVTGLQVGTYVFTLTVKDErNLQSQSS 680
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTW--DFG-DGTSSTGPT---VTHTYTKPGTYTVTLTVTNA-VGSASAT 73


                    ....*.
gi 33359221     681 VNVIVK 686
Cdd:smart00089   74 VTVVVQ 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
473-780 4.60e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.30  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  473 YTFSLTVVDSDGatNSTTANLTVNKAVDYPPVANAGPNQVITLPqNSITLfgN-QSTDDHGITSYEWSLSPSSKGKVVEM 551
Cdd:COG3401  205 YYYRVAATDTGG--ESAPSNEVSVTTPTTPPSAPTGLTATADTP-GSVTL--SwDPVTESDATGYRVYRSNSGDGPFTKV 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  552 QGVRTPTLQLSAMQEG-DYTYQLTVTDTIGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSSDDqKII 630
Cdd:COG3401  280 ATVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDA-DVT 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  631 SYLWEKTQGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSvNVIVKEEINKPPIAKITGNVVITLP 706
Cdd:COG3401  357 GYNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPS-EEVSATTASAASGESLTASVDAVPL 435

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33359221  707 TSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTV 780
Cdd:COG3401  436 TDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSV 509
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
470-742 7.73e-05

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 46.20  E-value: 7.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  470 PGNYTFSLTVVDSDGATNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGkvv 549
Cdd:COG3291   49 PGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPG--- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  550 emQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKI 629
Cdd:COG3291  126 --GGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  630 ISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGNVVITLPTST 709
Cdd:COG3291  204 TSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTN 283

                        250       260       270
                 ....*....|....*....|....*....|...
gi 33359221  710 AELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLN 742
Cdd:COG3291  284 GTGGLGTTTAITPGNVSTTADVTGGTATLAVSS 316
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 460-693 1.20e-04

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 45.96  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221    460 TAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVN-KAVDYPPVANAGPNQVITLpQNSITLFGNQSTD------DHG 532
Cdd:pfam02010   42 QLTIPSGTLPYGTYVFTLTVSLSSTPSLAGTDIITVTvQPSPLVAVIDGGSSRVVGY-NQDLTLDGSESYDpdvdpgSSS 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221    533 ITSYEWS---------LSPSSKGKVVE------MQGVRTPTLQLSA-MQEGDYTYQ--LTVTDTIGQQATAQVTVIVQPE 594
Cdd:pfam02010  121 GLTYLWScrrsssgdnPLLNNDPVCFSdqnegtLLQSTSSSLTIPAsTLQANVTYTfkLTVSKGSRNSASTTQTILVVDG 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221    595 NnkPPQAD---AGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEK----TQGPDGVQLENANSSVATVTG---------- 657
Cdd:pfam02010  201 N--PPIIIlscISNCNRKNNPVDRLVLLASTCLNCSSDLSDVTYRwlslGSENTSLVLDQLNSQTSTGRSgpylvikagv 278

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 33359221    658 LQVGT-YVFTLTVKDeRNLQSQSSVNVIVKeeINKPP 693
Cdd:pfam02010  279 LQSGVsYRFTLIVTV-YPGLVSGLASISFI--TNAPP 312
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 410-495 1.63e-04

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 41.28  E-value: 1.63e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221     410 AIVSPQFQEISLPTTSTVIDgsQSTDDDKIVQYHWEELKGPLREEKisedTAILKLSKlvPGNYTFSLTVVDSDGaTNST 489
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGP----TVTHTYTK--PGTYTVTLTVTNAVG-SASA 72


                    ....*.
gi 33359221     490 TANLTV 495
Cdd:smart00089   73 TVTVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 623-685 2.23e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 40.94  E-value: 2.23e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33359221  623 SSDDQKIISYLWekTQGPDGVQLENAnsSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIV 685
Cdd:cd00146   23 DSSGGSIVSYKW--DFGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 405-495 2.76e-03

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 38.02  E-value: 2.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221    405 NRPPIAIVSPQfqEISLPTTSTVIDGSQSTDDD-KIVQYHWEelkgplreekiSEDTAILKLSKLV-----PGNYTFSLT 478
Cdd:pfam18911    1 NAAPVADAGGD--RIVAEGETVTFDASASDDPDgDILSYRWD-----------FGDGTTATGANVShtyaaPGTYTVTLT 67

                           90
                   ....*....|....*...
gi 33359221    479 VVDSDGATNST-TANLTV 495
Cdd:pfam18911   68 VTDDSGASNSTaTDTVTV 85
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 431-495 4.79e-03

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 37.09  E-value: 4.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33359221  431 SQSTDDDKIVQYHWEELKGPLreekISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTV 495
Cdd:cd00146   21 ASDSSGGSIVSYKWDFGDGEV----SSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
523-782 7.53e-03

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 39.65  E-value: 7.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  523 FGNQSTDDhgITSYEWSLSPSSKGkvvemqGVRTPTLQLSAmqEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQAD 602
Cdd:COG3291   16 FTDTSSGN--ATSYEWDFGDGTTS------TEANPSHTYTT--PGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  603 AGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVN 682
Cdd:COG3291   86 TSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVT 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33359221  683 VIVKEEINKPPIAKITGNVVITLPTSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTF 762
Cdd:COG3291  166 SDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGT 245

                        250       260
                 ....*....|....*....|
gi 33359221  763 HLKVTDAKGESDTDRTTVEV 782
Cdd:COG3291  246 PGTNTVTTSGANTAGTSTIT 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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