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Conserved domains on  [gi|13376846|ref|NP_079513|]
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sclerostin precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 28-210 1.41e-91

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member pfam05463:

Pssm-ID: 473907  Cd Length: 198  Bit Score: 266.77  E-value: 1.41e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376846    28 AFKNDATEIIPELGEYPEPPPEleNNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSG 107
Cdd:pfam05463  18 AFKNDATEILYSHVEKPEPEPE--NNSTLNRARNGGRHPHSPYDRTDVHQVGCRELRSTKYISDGQCTSIKPVKELVCAG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376846   108 QCGPARLLPNAIGRGK-WWRPSGPDFRCIPDRYRAQRVQLLCPGGEApRARKVRLVASCKCKRLTRFHNQSELKDFGTEA 186
Cdd:pfam05463  96 ECLPLPLLPNWIGGGYyWSRRSSQEWRCVNDRTRTQRIQLQCQDGTT-RTYKVTVVTSCKCKRYTRQHNESSHNDEGPSP 174

                         170       180
                  ....*....|....*....|....
gi 13376846   187 ARPQKGRKPRPRARSAKANQAELE 210
Cdd:pfam05463 175 AKPQKGRHPRPKKRGSKASKHELS 198
 
Name Accession Description Interval E-value
Sclerostin pfam05463
Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is ...
 28-210 1.41e-91

Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.


Pssm-ID: 398883  Cd Length: 198  Bit Score: 266.77  E-value: 1.41e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376846    28 AFKNDATEIIPELGEYPEPPPEleNNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSG 107
Cdd:pfam05463  18 AFKNDATEILYSHVEKPEPEPE--NNSTLNRARNGGRHPHSPYDRTDVHQVGCRELRSTKYISDGQCTSIKPVKELVCAG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376846   108 QCGPARLLPNAIGRGK-WWRPSGPDFRCIPDRYRAQRVQLLCPGGEApRARKVRLVASCKCKRLTRFHNQSELKDFGTEA 186
Cdd:pfam05463  96 ECLPLPLLPNWIGGGYyWSRRSSQEWRCVNDRTRTQRIQLQCQDGTT-RTYKVTVVTSCKCKRYTRQHNESSHNDEGPSP 174

                         170       180
                  ....*....|....*....|....
gi 13376846   187 ARPQKGRKPRPRARSAKANQAELE 210
Cdd:pfam05463 175 AKPQKGRHPRPKKRGSKASKHELS 198
 
Name Accession Description Interval E-value
Sclerostin pfam05463
Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is ...
 28-210 1.41e-91

Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.


Pssm-ID: 398883  Cd Length: 198  Bit Score: 266.77  E-value: 1.41e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376846    28 AFKNDATEIIPELGEYPEPPPEleNNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSG 107
Cdd:pfam05463  18 AFKNDATEILYSHVEKPEPEPE--NNSTLNRARNGGRHPHSPYDRTDVHQVGCRELRSTKYISDGQCTSIKPVKELVCAG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376846   108 QCGPARLLPNAIGRGK-WWRPSGPDFRCIPDRYRAQRVQLLCPGGEApRARKVRLVASCKCKRLTRFHNQSELKDFGTEA 186
Cdd:pfam05463  96 ECLPLPLLPNWIGGGYyWSRRSSQEWRCVNDRTRTQRIQLQCQDGTT-RTYKVTVVTSCKCKRYTRQHNESSHNDEGPSP 174

                         170       180
                  ....*....|....*....|....
gi 13376846   187 ARPQKGRKPRPRARSAKANQAELE 210
Cdd:pfam05463 175 AKPQKGRHPRPKKRGSKASKHELS 198
DAN pfam03045
DAN domain; This domain contains 9 conserved cysteines and is extracellular. Therefore the ...
 54-168 2.37e-34

DAN domain; This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonize different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.


Pssm-ID: 460786  Cd Length: 108  Bit Score: 118.16  E-value: 2.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13376846    54 KTMNRAENGGRpphHPFETKDVSEYSCRELHFTRYVTDGPCRSaKPVTELVCSGQCGpARLLPNAIGRGKWWRPSgpDFR 133
Cdd:pfam03045   1 NFLNRAKPGAL---LPTKRRELKRDWCRTQPFTQTITEEGCLS-RTVQNRFCYGQCN-SFYIPNSIGRGKWSFAS--CSR 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 13376846   134 CIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCK 168
Cdd:pfam03045  74 CKPSKFTTVTVTLNCPGGPPTRTKRVMRVKECKCK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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