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Conserved domains on  [gi|21313478|ref|NP_079812|]
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COMM domain-containing protein 5 [Mus musculus]

Protein Classification

COMM domain-containing protein 5( domain architecture ID 10140833)

COMM domain-containing protein 5 (COMMD5) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and negatively regulates cell proliferation.

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 3.02e-56

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240101  Cd Length: 110  Bit Score: 174.55  E-value: 3.02e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313478 115 ELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPI 194
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 21313478 195 AKFQELRYSVALVLKEMAELERKCERKLQD 224
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 3.02e-56

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 174.55  E-value: 3.02e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313478 115 ELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPI 194
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 21313478 195 AKFQELRYSVALVLKEMAELERKCERKLQD 224
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 148-205 1.63e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 65.65  E-value: 1.63e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21313478   148 SLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGS----AHRFEVPIAKFQELRYSVA 205
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgsseEVTFELSKEQLQDLLNELE 62
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 3.02e-56

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 174.55  E-value: 3.02e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313478 115 ELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPI 194
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 21313478 195 AKFQELRYSVALVLKEMAELERKCERKLQD 224
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 148-205 1.63e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 65.65  E-value: 1.63e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21313478   148 SLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGS----AHRFEVPIAKFQELRYSVA 205
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgsseEVTFELSKEQLQDLLNELE 62
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 148-200 7.56e-11

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 56.55  E-value: 7.56e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21313478 148 SLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDG-----SAHRFEVPIAKFQEL 200
Cdd:cd04748  19 SLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGdnnssEKICFEMTKEELQNF 76
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 35-185 1.71e-07

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 49.69  E-value: 1.71e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313478  35 AVAQLLKDLDRSTFRKLLKLVVGALHGKDCR----EAVQHLGASANLSEERLAVLLAGTHTLLQQALRLppaSLKPDAFQ 110
Cdd:cd04758   3 EAVSLINSIDTEKFPRLLSRLFQKLHLKAERsfseEEEEKLQEAFKLLSQDLKLLLETISFILEQAAYH---NLKPSNLQ 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21313478 111 DELQELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSS--LPRVSnfrWRVDVAISTSAQSRSLQPSVLMQLKLTDG 185
Cdd:cd04758  80 QQLRNILLLEDKASAFVNAWEAEGEDVLEKLRSRILAPnqLEDVS---WRLNLQMSSSTQAKLKSPLAVLELGVTSE 153
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 62-192 9.38e-07

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 47.31  E-value: 9.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313478  62 KDCREAVQHLGASANLSEERLAVLLAgthtLLQQALRLppaSLKPDAFQDELQELGIPQDMIGDLASLAFgSQRPLLDSV 141
Cdd:cd04750  17 KKYEGAARKLEVEVETVQHGVEALVY----LLIESTKL---KLSERDFQDSIEFLGFSDDLNEILLQLYE-SNRKEIRNI 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21313478 142 AQQQGSSLPRVSNFRWRVDVAIStsaqSRSLQ----PSVLMQLKLTDGSAHRFEV 192
Cdd:cd04750  89 LKELSPDLPHYHNLEWRLDVQIA----SRSLRsqvkPVITMKLHLEDENKKIETH 139
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 107-202 2.36e-05

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 43.19  E-value: 2.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313478 107 DAFQDELQELGIPQDMIGDLaSLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGS 186
Cdd:cd04752  63 ESLSSELQQLGLPKEHATSL-CRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNAD 141

                        90       100
                ....*....|....*....|.
gi 21313478 187 -----AHRFEVPIAKFQELRY 202
Cdd:cd04752 142 tgeitPHPFSVSADKFRVLLA 162
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 140-187 1.52e-04

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 39.86  E-value: 1.52e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21313478 140 SVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSA 187
Cdd:cd04757  22 SEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPS 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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