NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27229004|ref|NP_080083|]
View 

monocarboxylate transporter 9 [Mus musculus]

Protein Classification

monocarboxylate transporter 9( domain architecture ID 13024529)

monocarboxylate transporter 9 (MCT9) is proton-linked monocarboxylate transporter that may catalyze the transport of monocarboxylates across the plasma membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
12-479 0e+00

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 565.98  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17428   1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17428  81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17428 179 ----------------------------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARS 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17428 213 ENIIEEIALIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS 292
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 412 IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17428 293 IFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLLA 360
 
Name Accession Description Interval E-value
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
12-479 0e+00

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 565.98  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17428   1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17428  81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17428 179 ----------------------------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARS 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17428 213 ENIIEEIALIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS 292
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 412 IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17428 293 IFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLLA 360
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
7-493 1.97e-58

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 199.97  E-value: 1.97e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004     7 PDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:TIGR00892  12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004    87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:TIGR00892  92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   167 LDGCLLIVGALALNILACGSLMRPLQTSDCPFPEKTapenvpdrysmyneKEknpeetmnfqdkgyssedkCLPNGDwgr 246
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKS--------------KE-------------------GLPPDG--- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   247 etslpkslaiaahtKEPETYKKKVVEQTNfcKQLAkrkwqlyrnycgetASLFKNKVFSALFIAILLFDIGGFPPSLLME 326
Cdd:TIGR00892 216 --------------STKKLSKKSTAEKIN--RFLD--------------FSLFTHRGFLVYLSGNVIMFLGFFAPIIFLV 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   327 DVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWI--NTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILG 404
Cdd:TIGR00892 266 PYAKDKGVDEYEAAF-LLSIIGFVDIFARPSCGLIAGLKWIrpHVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFG 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   405 FLTGNWSIFPY-VTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAILPC 483
Cdd:TIGR00892 345 LSFGSVGALLFeVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYIN 424
                         490
                  ....*....|
gi 27229004   484 WDMCNKKLPK 493
Cdd:TIGR00892 425 YRLLAKEQKA 434
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-478 2.29e-23

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 101.88  E-value: 2.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGG 92
Cdd:COG2223   4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  93 LMLSSLAPNiYFLFFSYGIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:COG2223  84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkcLPNGDWGRETSLP 251
Cdd:COG2223 163 LILGILLLVVAVLAWLF--------------------------------------------------LRDPPAGAAAAAK 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 KSLAiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgETASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:COG2223 193 ASLR--------------------------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVD 234
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIpFAKSYVTLAILSGILGFLTGNWS 411
Cdd:COG2223 235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL-ALGSLWLFLVLFLLLGLALGGGN 313
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 412 -IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:COG2223 314 gAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
MFS_1 pfam07690
Major Facilitator Superfamily;
20-445 7.77e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.53  E-value: 7.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004    20 FFTQFLSYGSPLAVGVLYVEWL-DAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSL 98
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004    99 APNIYFLFFSyGIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGAL 177
Cdd:pfam07690  82 ASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   178 ALNILACGSLMRPlqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslpkslaia 257
Cdd:pfam07690 161 SLLAAVLLLLPRP------------------------------------------------------------------- 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   258 ahtkEPETYKKKVVEQTNFCKQLAKRkwqlyrnycgetaSLFKNKVFSaLFIAILLFDIGGFPPSLLMEDVARSYHVREE 337
Cdd:pfam07690 174 ----PPESKRPKPAEEARLSLIVAWK-------------ALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   338 dLTMPLISIFGIMTAVGKLLLGILAD-FKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPY 415
Cdd:pfam07690 236 -LAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGlVFPALNA 314
                         410       420       430
                  ....*....|....*....|....*....|
gi 27229004   416 VTTKTVGIDKLAHAYGILMFFAGLGNSLGP 445
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
12-479 0e+00

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 565.98  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17428   1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17428  81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17428 179 ----------------------------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARS 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17428 213 ENIIEEIALIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS 292
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 412 IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17428 293 IFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLLA 360
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
12-479 4.96e-117

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 349.79  E-value: 4.96e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17314   1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17314  81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRPLQTSDCPFPEktapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARL--------------------------------------------------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwQLYRNYCGETASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17314 190 ----------------------------------HVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRS 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKwINTLYLYVATLIITGLALCAIPFAKSY--VTLAILSGILGFLTGN 409
Cdd:cd17314 236 LQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSYGG 314
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27229004 410 WSIFPYVTTKTV-GIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17314 315 LFTVYPATVSTVfGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
12-479 8.12e-102

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 309.87  E-value: 8.12e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17352   1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17352  81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17352 179 ----------------------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKS 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVrEEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17352 213 LGI-DESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYS 291
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27229004 412 IFPYVT-TKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17352 292 SLTPVIlADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
12-478 7.77e-66

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 217.01  E-value: 7.77e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17429   1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17429  81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17429 179 ----------------------------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKL 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17429 213 YGLSEQNDKFPLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYFS 292
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27229004 412 IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17429 293 LMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLL 359
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
7-493 1.97e-58

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 199.97  E-value: 1.97e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004     7 PDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:TIGR00892  12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004    87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:TIGR00892  92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   167 LDGCLLIVGALALNILACGSLMRPLQTSDCPFPEKTapenvpdrysmyneKEknpeetmnfqdkgyssedkCLPNGDwgr 246
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKS--------------KE-------------------GLPPDG--- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   247 etslpkslaiaahtKEPETYKKKVVEQTNfcKQLAkrkwqlyrnycgetASLFKNKVFSALFIAILLFDIGGFPPSLLME 326
Cdd:TIGR00892 216 --------------STKKLSKKSTAEKIN--RFLD--------------FSLFTHRGFLVYLSGNVIMFLGFFAPIIFLV 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   327 DVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWI--NTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILG 404
Cdd:TIGR00892 266 PYAKDKGVDEYEAAF-LLSIIGFVDIFARPSCGLIAGLKWIrpHVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFG 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   405 FLTGNWSIFPY-VTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAILPC 483
Cdd:TIGR00892 345 LSFGSVGALLFeVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYIN 424
                         490
                  ....*....|
gi 27229004   484 WDMCNKKLPK 493
Cdd:TIGR00892 425 YRLLAKEQKA 434
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
12-477 2.72e-53

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 184.52  E-value: 2.72e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17423   1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17423  81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRPLQTSD---CPFPEKTAPenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgret 248
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGdppAPPRSLSAA-------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 249 slpkslaiaahtkepetykkkvveqtnfckqlakrkWQLyrnycgetaSLFKNKVFSALFIAILLFDIGGFPPSLLMEDV 328
Cdd:cd17423 197 ------------------------------------FGL---------SLLTHRAFLRYALATTLINTGYFIPYVHLVAH 231
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 329 ARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG 408
Cdd:cd17423 232 ARALGLGEYQAAF-VVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAG 310
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 409 NWS-IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17423 311 ALApLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILL 380
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
12-478 2.29e-46

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 165.31  E-value: 2.29e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17422   1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17422  81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRPLqtsdcpfpektapenvpdrysmynekeKNPEetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17422 161 LVVGALQLNIVVCGALLRVL---------------------------KEPG----------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetaslFKNKVFSALFIAillfdIGGFPPSLLMEDVARS 331
Cdd:cd17422 185 -----------------------------------------------FICYALFGLFAT-----LGFFAPQLYIIPLSLS 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVrEEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17422 213 LGI-DQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVA 291
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 412 ---IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17422 292 gthIPLLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLAL 361
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
12-478 2.71e-42

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 155.38  E-value: 2.71e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFG-----EGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:cd17420   1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTklgdpEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:cd17420  81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 167 LDGCLLIVGALALNILACGSLMRPLQTSDCPFPEKtapenvPDRYSMYNEKEKNPEETMNFQdkgyssedkclpngdwgr 246
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSK------PGRRTLHSRINLFLRKIFNVE------------------ 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 247 etslpkslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLME 326
Cdd:cd17420 217 ---------------------------------------------------IFKRKRYVIWALGIPLALFGYFVPYVHLM 245
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 327 DVARSYHVREEDLTMPLISIfGIMTAVGKLLLGILADF-KWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGF 405
Cdd:cd17420 246 KFVKEEFFPGKDVNVPLMCI-GITSGIGRLIFGVIADMpPGVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGL 324
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27229004 406 LTGNW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17420 325 FDGCFiSIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFF 398
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
12-478 1.56e-39

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 147.28  E-value: 1.56e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17421   1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGssVGL-FIYAALQRMLIEFYGLDGC 170
Cdd:cd17421  81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSG--MGLtFALAPFTQLLLDEYDWQGA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 171 LLIVGALALNILACGSLMRPLQTsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretsl 250
Cdd:cd17421 159 LLIFGGIMLNLVASGMLLRPIDF--------------------------------------------------------- 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 251 pkslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetaSLFKNKVFSALFIAILLFDIGGFPPSLLMEDVAR 330
Cdd:cd17421 182 ----------------------------------------------SLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARAR 215
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 331 SYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNW 410
Cdd:cd17421 216 TLGIDPMDASF-IISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGY 294
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27229004 411 -SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17421 295 lALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFL 363
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
12-479 8.00e-36

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 136.78  E-value: 8.00e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17430   1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17430  81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRPLqtsdcpfpektapenvpdrysmynekeknpeetmNFqdkgyssedkclpngdwgretslp 251
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPL----------------------------------DF------------------------ 182
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetaSLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17430 183 ---------------------------------------------SVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKD 217
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWI--NTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGN 409
Cdd:cd17430 218 IGVPDTEAAF-LLSILGFIDIFARPACGVVAGLKWVrpRVVYLFSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISYGM 296
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27229004 410 WSIFPY-VTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17430 297 VGALQFeVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLALG 367
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
12-479 3.61e-35

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 134.94  E-value: 3.61e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17424   1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17424  81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRPLQTSDcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFLLMPD-------------------------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetaslfknkvFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17424 185 ----------------------------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALS 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTlYLYVATLIITGL-ALCA--IPFAKSYVTLAILSGILGFLTG 408
Cdd:cd17424 213 VGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRRCLKK-YRYFCYLFAVGMdGLCClfLPILKTFPLLVPFSFTFGYFDG 290
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27229004 409 NW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17424 291 AYvALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSA 362
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
12-476 3.12e-29

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 118.74  E-value: 3.12e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFG-----EGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:cd17464   1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGskddaQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:cd17464  81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 167 LDGCLLIVGALALNILACGSLMRPLqtsdcpfpektapenVPDRYSMYNEKEKNpeetmnfqdkgyssedKCLPngdwgr 246
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPL---------------VPMKKDKEGKKRKF----------------KCPP------ 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 247 etslpkslaiaahtkepetykKKVVEQTNFCKQLAKRKWQLyrnycGETASLFknkvfsalfiaillfdiGGFPPSL-LM 325
Cdd:cd17464 204 ---------------------LKKIFNFNIWKSTGYRIWAF-----GIPAALF-----------------GYFVPYVhLM 240
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 326 EDVARSY--HVREEDLTMPLisifGIMTAVGKLLLGILADF-KWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGI 402
Cdd:cd17464 241 NHVKERFgeDVNKEVLLMCI----GITSGIGRLIFGRVADYiPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLF 316
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27229004 403 LGFLTGNW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFIL 476
Cdd:cd17464 317 MGLFDGCFiSIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIIL 391
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
12-479 6.79e-28

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 114.48  E-value: 6.79e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17425   1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17425  81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRPlqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP------------------------------------------------------------- 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17425 180 ----------------------------------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATS 213
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWIN--TLYLYVATLIITGLA--LCAI----PFAKSYVTLAILSgil 403
Cdd:cd17425 214 NGMDESKAAL-LLSILGFINIFMRPLAGLLSGLPVFKgrRIYLFSLALLLNGLSnlICAIsasfPVLLVYCLLYSIS--- 289
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27229004 404 gfLTGNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17425 290 --MSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGLS 363
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
12-480 2.13e-27

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 113.43  E-value: 2.13e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17426   1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17426  81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRPLQTSdcPFPEKTapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPK--PFLDLT------------------------------------------------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17426 190 ----------------------------------------------LFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKS 223
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWI--NTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGN 409
Cdd:cd17426 224 KQISNESAAF-LLSILAFVDMVARPSMGIVANTKWVrpRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGW 302
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27229004 410 WSIFPYVT-TKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAI 480
Cdd:cd17426 303 LSSVLFETlMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYLFIGM 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
20-477 7.22e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 111.75  E-value: 7.22e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  20 FFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLA 99
Cdd:cd06174   2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 100 PNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLIEF--YGLDGCLLIVGA 176
Cdd:cd06174  82 PSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 177 LALNILACGSLMRPLQTSdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslpkslai 256
Cdd:cd06174 161 LALLAAILLLLVVPDPPE-------------------------------------------------------------- 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 257 aahtkepetykkkvveqtnfcKQLAKRKWQLYRNYCGETASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVRE 336
Cdd:cd06174 179 ---------------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 337 EDLTMPLISIFGIMTAVGKLLLGILADfKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWSIFPYV 416
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSD-RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27229004 417 -TTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd06174 317 lIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
12-477 1.14e-24

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 105.43  E-value: 1.14e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17355   1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLY-TATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGC 170
Cdd:cd17355  81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAaVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 171 LLIVGALALNILACGSLMRPLQTSDcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretsL 250
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPAD------------------------------------------------------L 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 251 PKSLAIAAHTKEPETYKKKVVEQTNFckqlakrkWQLyrnycgetaslfknkvfsALFIAILLFDIGGFPPSLLMEDVAR 330
Cdd:cd17355 187 ALRAYDDASPASPGSTLKEALRSASF--------WLL------------------ALAFFLCGFAVVGLIVHLVPYLADR 240
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 331 SYHVREEDLTMPLISIFGImtaVGKLLLGILADFkwINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGIL-GFLTGN 409
Cdd:cd17355 241 GISPAAAAVALALIGLFNI---VGRLLSGWLGDR--YSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGA 315
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27229004 410 WSIFP-YVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17355 316 TVPLTaALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
42-480 2.13e-24

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 105.00  E-value: 2.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  42 DAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLY 121
Cdd:cd17353  31 SALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGY 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 122 TATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILA-CGSLMRplqtsdcpfpe 200
Cdd:cd17353 111 ITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIViGAFLIR----------- 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 201 ktapenvpdrysmynekeknpeetmnfqdkgyssedkcLPNGDWGRETSLPKslaiaAHTKEPETYKKKVVEQtnfckql 280
Cdd:cd17353 180 --------------------------------------DPPKGWVPPGVDPL-----ANNAENSPRDYTPREM------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 281 akrkwqlyrnycgetaslFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVrEEDLTMPL-ISIFGIMTAVGKLLLG 359
Cdd:cd17353 210 ------------------LRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAG-LDAGIAALaVSILSIFNGGGRPFWG 270
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 360 ILADFkwINTLYLYVATLIITGLALCAIPFAKS-YVTLAILSGILGF-LTGNWSIFPYVTTKTVGIDKLAHAYGILMFFA 437
Cdd:cd17353 271 WLSDK--IGRKNTLSIAFLIQGVAMFLLPFIGSvAVLFVLGVALIGFcYGGGFALFPALTADFFGTKNAGTNYGLLYTAK 348
                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 27229004 438 GLGNSLGPPIVGwFYDWTQTYDIAFYFSGfCVLLGGFILLLAI 480
Cdd:cd17353 349 GVGGLIGPIIAA-YVLYTGGYNAAFIIAA-ALSLVALALALLL 389
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
12-191 9.05e-24

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 102.58  E-value: 9.05e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17427   1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17427  81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
                       170       180
                ....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMRPL 191
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPL 180
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-478 2.29e-23

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 101.88  E-value: 2.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGG 92
Cdd:COG2223   4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  93 LMLSSLAPNiYFLFFSYGIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:COG2223  84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 172 LIVGALALNILACGSLMrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkcLPNGDWGRETSLP 251
Cdd:COG2223 163 LILGILLLVVAVLAWLF--------------------------------------------------LRDPPAGAAAAAK 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 252 KSLAiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgETASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:COG2223 193 ASLR--------------------------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVD 234
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIpFAKSYVTLAILSGILGFLTGNWS 411
Cdd:COG2223 235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL-ALGSLWLFLVLFLLLGLALGGGN 313
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 412 -IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:COG2223 314 gAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
5-480 2.81e-19

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 89.16  E-value: 2.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   5 KSPDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIF 84
Cdd:COG2271   1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  85 SGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIE 163
Cdd:COG2271  81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 164 FYGLDGCLLIVGALALnilacgslmrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngd 243
Cdd:COG2271 160 AFGWRAAFLILGLPGL---------------------------------------------------------------- 175
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 244 wgretslpksLAIAAHTkepetykkkvveqtnfckqlakrkWQLYrnycgetaslfknkvFSALFIAILLFDIGGFPPSL 323
Cdd:COG2271 176 ----------LLALLRF------------------------WLLA---------------LAYFLVYFALYGFLTWLPTY 206
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 324 LMEdvarSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGIL 403
Cdd:COG2271 207 LVE----VRGLSLAQAGL-LLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLA 281
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 404 GFLT-GNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLGGFILLLAI 480
Cdd:COG2271 282 GFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
12-477 1.43e-17

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 84.08  E-value: 1.43e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKG-----KTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:cd17465   1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDqavqfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:cd17465  81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 167 LDGCLLIVGALALnILACGSLmrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgr 246
Cdd:cd17465 161 LAHTFQVLSLFMF-IQIFLSL----------------------------------------------------------- 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 247 etslpkslaiaahtkepeTYKkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSL-LM 325
Cdd:cd17465 181 ------------------TYK------------------------------VFRRKTYRIWAFGIATAVLGYFVPYVhLM 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 326 EDVARSYHVREEDLTMPLisIFGIMTAVGKLLLGILAD-FKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILG 404
Cdd:cd17465 213 KYVEEEFKENKREWVLLV--CIGASSGIGRLMSGKIGDlIPGLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLG 290
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27229004 405 FLTGNW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17465 291 LCDGCFiTIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLF 364
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-443 5.21e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 79.25  E-value: 5.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   6 SPDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFS 85
Cdd:COG2814   2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  86 GFLVAGGLMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLIEF 164
Cdd:COG2814  82 LLLFALGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 165 YGLDGCLLIVGALALNILACGSLMrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdw 244
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRL-------------------------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 245 gretsLPKSLAIAAHTKEpetykkkvveqtnfckqlakrkwqlyrnycGETASLFKNKVFSALFIAILLFDIGGFPPSLL 324
Cdd:COG2814 185 -----LPESRPAARARLR------------------------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 325 MEDVARSYHVREEDLTMPLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILG 404
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG 307
                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 27229004 405 FLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSL 443
Cdd:COG2814 308 FGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
20-445 7.77e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.53  E-value: 7.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004    20 FFTQFLSYGSPLAVGVLYVEWL-DAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSL 98
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004    99 APNIYFLFFSyGIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGAL 177
Cdd:pfam07690  82 ASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   178 ALNILACGSLMRPlqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslpkslaia 257
Cdd:pfam07690 161 SLLAAVLLLLPRP------------------------------------------------------------------- 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   258 ahtkEPETYKKKVVEQTNFCKQLAKRkwqlyrnycgetaSLFKNKVFSaLFIAILLFDIGGFPPSLLMEDVARSYHVREE 337
Cdd:pfam07690 174 ----PPESKRPKPAEEARLSLIVAWK-------------ALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   338 dLTMPLISIFGIMTAVGKLLLGILAD-FKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPY 415
Cdd:pfam07690 236 -LAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGlVFPALNA 314
                         410       420       430
                  ....*....|....*....|....*....|
gi 27229004   416 VTTKTVGIDKLAHAYGILMFFAGLGNSLGP 445
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
32-479 1.38e-12

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 69.13  E-value: 1.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  32 AVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgI 111
Cdd:COG2807  36 SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT-A 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 112 VVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILACGSlmrpL 191
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWL----P 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 192 QTSDCPFPEKTAPENVPDRysmynekeknpeetmnfqdkgyssedkclpngdwgretSLPKSlaiaahtkepetykkkvv 271
Cdd:COG2807 191 LLRRRPAAAAAAPAAASLR--------------------------------------SLWRS------------------ 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 272 eqtnfckqlaKRKWQLyrnycgeTASLFknkVFSALFIAILlfdigGFPPSLLMEdvarsYHVREEDLTMpLISIFGIMT 351
Cdd:COG2807 215 ----------PLAWLL-------TLFFG---LQSLLYYAVV-----AWLPPILRD-----AGLSAATAGL-LLSLFQLAG 263
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 352 AVGKLLLGILADfKWINTLYLYVATLIITGLALCAIPFAKSYVTLaILSGILGFLTGnwSIFP----YVTTKTVGIDKLA 427
Cdd:COG2807 264 IPGSLLVPLLAD-RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGLGQG--GLFPlaltLIGLRARTPAEAA 339
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 27229004 428 HAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:COG2807 340 ALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
16-478 1.96e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.76  E-value: 1.96e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  16 VVVSFFTQFLSYGSPLAVGVLYVEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLML 95
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAE---SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  96 SSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIV 174
Cdd:cd17325  78 FAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 175 GALALNILACGSLMRPlqtsdcpfpektapenvpdrysmynEKEKNPEETmnfqdkgyssEDKCLPNGDWGRETSLPKSL 254
Cdd:cd17325 157 AALALLALVLALLLLP-------------------------EPRPPPNKR----------AVSAARLRSGLRLLLRDRRL 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 255 AIAAhtkepetykkkvveqtnfckqlakrkwqlyrnycgeTASLFKNKVFSAL--FIAILLFDIGGFPPSllmedvarsy 332
Cdd:cd17325 202 LALF------------------------------------LAIFVLAFAFGALepFLPLYAAELGGLSPA---------- 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 333 hvreeDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG--NW 410
Cdd:cd17325 236 -----QIGL-LFGAQGLASALSQPPAGKLSD--RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlvFP 307
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 411 SIFPYVtTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDwTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17325 308 ATLALL-ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLL 373
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
295-480 5.99e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 66.92  E-value: 5.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 295 TASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYV 374
Cdd:COG2814   3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGL-VVTAYLLGAALGAPLAGRLAD--RFGRRRVLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 375 ATLIITGLALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYD 453
Cdd:COG2814  80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
                       170       180
                ....*....|....*....|....*..
gi 27229004 454 WTqTYDIAFYFSGFCVLLGGFILLLAI 480
Cdd:COG2814 160 LF-GWRWVFLVNAVLALLALLLLLRLL 185
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
302-484 8.46e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 66.43  E-value: 8.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 302 KVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITG 381
Cdd:COG2271  10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGL-LASAFFLGYALGQIPAGLLAD--RFGRRRVLAIGLLLWG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 382 LALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWF---YDWTqt 457
Cdd:COG2271  87 LATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLlaaFGWR-- 164
                       170       180
                ....*....|....*....|....*..
gi 27229004 458 ydIAFYFSGFCVLLGGFILLLAILPCW 484
Cdd:COG2271 165 --AAFLILGLPGLLLALLRFWLLALAY 189
MFS_1 pfam07690
Major Facilitator Superfamily;
307-478 1.15e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 59.74  E-value: 1.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   307 LFIAILLFDIGGFPPSLLM-EDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFkwINTLYLYVATLIITGLALC 385
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGL-LLTLFSLGYALAQPLAGRLSDR--FGRRRVLLIGLLLFALGLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   386 AIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYF 464
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLI 156
                         170
                  ....*....|....
gi 27229004   465 SGFCVLLGGFILLL 478
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
52-481 2.22e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.10  E-value: 2.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  52 AWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQY 131
Cdd:cd17324  37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHGGFWAIAAAYAADL 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 132 F-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALAlniLACGSLMRPLqtsdcpfpektapenvpdr 210
Cdd:cd17324 116 VpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLA---LLAALLLWRL------------------- 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 211 ysmynekeknpeetmnfqdkgyssedkcLPNGDWGRETSLPKSLAIAAHTKEPetykkkvveqtnfckqlakRKWQLYRN 290
Cdd:cd17324 174 ----------------------------LPSLPPKKPGSLGLLSSLLLLLRNP-------------------RLRLAYLI 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 291 YCGETASLFknKVFSalFIAILLFDIGGFPPSLLmedvarsyhvreedltMPLISIFGIMTAVGKLLLGILADFKWINTL 370
Cdd:cd17324 207 TFLLFGGFF--ALYT--YLAPFLTDVPGFSSSAI----------------IGLLLLFGVAGVVGSPLAGRLADRGGRRAL 266
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 371 YLYVATLIITGLALCAIPFAksyvTLAILSGILGFLTGNWSIFPYVTTKTVGI--DKLAHAYGILMFFAGLGNSLGPPIV 448
Cdd:cd17324 267 LIALLLLAAALLLLTLLGPS----PLLLLVGLVLWGLGFFAAHSALQTRVLRLapEARGLASSLYLAAYNLGGALGAALG 342
                       410       420       430
                ....*....|....*....|....*....|...
gi 27229004 449 GWFYDWtqtydiafYFSGFCVLLGGFILLLAIL 481
Cdd:cd17324 343 GLVLDH--------GGWAGVGWVGAALLLLALL 367
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
307-480 5.49e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 57.82  E-value: 5.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 307 LFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCA 386
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGL-LFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 387 IPFAKSYVTLAILSGILGFLTGN-WSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDW-TQTYDIAFYF 464
Cdd:cd06174  78 FAFAPSFWLLLLGRFLLGLGSGLiDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLI 157
                       170
                ....*....|....*.
gi 27229004 465 SGFCVLLGGFILLLAI 480
Cdd:cd06174 158 AAALALLAAILLLLVV 173
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
13-190 7.17e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 57.58  E-value: 7.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGSPLAVGVLYVEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGG 92
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQE---RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  93 LMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLI-EFYGLDGC 170
Cdd:cd17473 277 FLLLALASGLWVVLLG-AILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGA 355
                       170       180
                ....*....|....*....|
gi 27229004 171 LLIVGALALnILACGSLMRP 190
Cdd:cd17473 356 FLILGVLAL-VLAIVLLLLR 374
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
14-179 1.71e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.43  E-value: 1.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  14 VIVVVSFFTQFLSYGSPLAVGVLYVEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGL 93
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAA--ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  94 MLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLL 172
Cdd:cd17325 280 LLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358

                ....*..
gi 27229004 173 IVGALAL 179
Cdd:cd17325 359 AAAALLL 365
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-190 1.79e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.42  E-value: 1.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGsPLAVGVLYVEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGAR--PVTIFSGFLVA 90
Cdd:COG2271 183 WLLALAYFLVYFALYG-FLTWLPTYLV--EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  91 GGLMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRMLIEFYGLDG 169
Cdd:COG2271 260 LALLLLALLPSPALAIAL-LFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
                       170       180
                ....*....|....*....|.
gi 27229004 170 CLLIVGALALNILACGSLMRP 190
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
343-478 1.88e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.04  E-value: 1.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILAD-FKWINTLYLYVATLIITGLALCAIPFAKS-YVTLAILSGILGFLTGNWSIFPYVTTKT 420
Cdd:cd17319 220 LAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLLLAYLTTSpVVAVILLSLAGFGIGAASPVFWSLPADL 299
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 421 VGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17319 300 LPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
5-179 1.97e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.43  E-value: 1.97e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   5 KSPDGGWGWVIVVVSFFTQ--FLSYGSPLAVgvlyvewlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVT 82
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSFigFSSWLPPYLV--------DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL 274
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  83 IFSGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRML 161
Cdd:COG2223 275 LIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKnAGAVYGLVGAAGGLGGFLGPLLFGAL 354
                       170
                ....*....|....*....
gi 27229004 162 IEFYG-LDGCLLIVGALAL 179
Cdd:COG2223 355 LDATGsYTAAFLVFAVLAL 373
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
301-477 3.94e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 55.24  E-value: 3.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 301 NKVFSALFIAILLFDIGGFPPSLLMedvarsYHVREEDLTMPLI----SIFGIMTAVGKLLLGILADFkwINTLYLYVAT 376
Cdd:cd17370 199 PKAFWLYLLAVALFALGNFSFAFLI------LRAQELGLSAALIpllyALFNLVYALAAYPAGRLSDR--IGRKKLLILG 270
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 377 LIITGLALCAIPFAKSYVTLAILSGILGFLTGNW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWT 455
Cdd:cd17370 271 YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
                       170       180
                ....*....|....*....|..
gi 27229004 456 QtYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17370 351 S-PSAAFLFSAVLALIALLLLL 371
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
296-484 5.59e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.91  E-value: 5.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 296 ASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMPLISIFGIMTAVGKLLLGILAdfKWINTLYLYVA 375
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA--KRFGKKKAFII 299
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 376 TLIITGLALCAIPFAK--SYVTLAILSGILGFLTG-----NWSIF----PYVTTKTvGIDKLAHAYGILMFFAGLGNSLG 444
Cdd:COG2211 300 GLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGailvlPWAMLadvvDYDEWKT-GRRREGLYFGIFTFAIKLGQALA 378
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 27229004 445 PPIVGWFYDWT-------QTYDIAFYFSGFCVLLGGFILLLAILPCW 484
Cdd:COG2211 379 GALAGLLLALFgyvagaaQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
343-480 6.53e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.50  E-value: 6.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILADFkwINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTV 421
Cdd:cd17325  36 IVAAYALAQLLFSPPAGRLSDR--FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIA 113
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 27229004 422 GIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLGGFILLLAI 480
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALLLL 171
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
1-179 7.64e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.05  E-value: 7.64e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   1 MEFQKSPDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSlasgVGLLASPVCSLFVSS----F 76
Cdd:COG0477   1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVS----AYLLGRAIGLLLFGRlgdrY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  77 GARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYA 155
Cdd:COG0477  77 GRKRVLLIGLLLFGLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGP 155
                       170       180
                ....*....|....*....|....
gi 27229004 156 ALQRMLIEFYGLDGCLLIVGALAL 179
Cdd:COG0477 156 LLGGLLVAALGWRWIFLINAPLGL 179
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
306-482 1.12e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.71  E-value: 1.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 306 ALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALC 385
Cdd:cd17324   3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGL-LVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 386 AipFAKSYVTLAILSGILGFLTGN-WSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYF 464
Cdd:cd17324  82 A--LAPSFALLLLARALAGLAHGGfWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-GWRAAFLA 158
                       170
                ....*....|....*...
gi 27229004 465 SGFCVLLgGFILLLAILP 482
Cdd:cd17324 159 IAVLALL-AALLLWRLLP 175
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
14-481 6.29e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.39  E-value: 6.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  14 VIVVVSFFTQFLSYGSplaVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGL 93
Cdd:COG0738  11 IAIYLLFFLWGFATAL---WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  94 MLSSLAPNIYFLFFSYgIVVGLGCGLLYTAT----VTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDG 169
Cdd:COG0738  88 LLFALAPSYPLLLLAL-FLLGLGLGLLDVAAnpyvAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLP 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 170 CLLIVGALALNILACGSlmrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgreTS 249
Cdd:COG0738 167 YLILAVLLLLLALLFLR-------------------------------------------------------------SK 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 250 LPKSLAIAAHTKEPETykkkvveqtnfckqlakrkwqlyrnycgETASLFKNKVFSALFIAILLF-----DIGGFPPSLL 324
Cdd:COG0738 186 LPEIEEEEEEAAGSAA----------------------------SLKSLLKNPRLLLGGLAIFLYvgaegAIGDWLPLYL 237
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 325 MEDVARSyhvreEDLTMPLISIFGIMTAVGKLLLGILAD-FKWINTLYLYvaTLIITGLALCAIPFAKSYVTLAILsGIL 403
Cdd:COG0738 238 KDVLGLS-----EATAALGLSLFWGGMTIGRFLGGFLLKrFGPVRLLRLS--ALLAAVGLLLALLAPGPWLALIGL-ALV 309
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 404 GFLTGNwsIFPyvTTKTVGIDKL----AHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLggfILLLA 479
Cdd:COG0738 310 GLGLSL--MFP--TIFSLALDGLgkrtAAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLL---ILLLA 381

                ..
gi 27229004 480 IL 481
Cdd:COG0738 382 LA 383
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
303-480 7.12e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 7.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 303 VFSALFIAILLFDIGGFPPSLLmedvARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKwINTLYLYVATLIITGL 382
Cdd:cd17474 204 LVSAFLYFFLYFAFLTYLPFLL----ELLYGISPIIIGL-LFAGWSVLLALGSLFVGRLLKKR-FGARRILVIGLLLYAL 277
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 383 ALCAIPFAKSYVTLAILSGILGFLTGNwsIFPYVTT---KTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYd 459
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLGL--NLPLLTTlvtELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS- 354
                       170       180
                ....*....|....*....|.
gi 27229004 460 iAFYFSGFCVLLGGFILLLAI 480
Cdd:cd17474 355 -APFLVGAAIALAAAVLLALL 374
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
11-189 1.92e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.92e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  11 WGWVIVVVSFFTQFLSYGSPLAVG---VLYVEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGF 87
Cdd:COG0738 207 LKNPRLLLGGLAIFLYVGAEGAIGdwlPLYLK--DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL 284
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  88 LVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGL 167
Cdd:COG0738 285 LAAVGLLLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGL 363
                       170       180
                ....*....|....*....|..
gi 27229004 168 DGCLLIVGALALNILACGSLMR 189
Cdd:COG0738 364 RAAFLVPLVCYLLILLLALALK 385
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
343-479 2.55e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.49  E-value: 2.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILAdfKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFltGNWSIFPYVTTKTVG 422
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLK--RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGL--GFGLLLPTLNSWAMS 313
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27229004 423 IDKLAH-----AYGILMFFagLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17473 314 LVPPELrgramGIVTSAFF--LGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
343-475 3.32e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.09  E-value: 3.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFAKSY-VTLAILSGILGFLTGnwSIFPY---VTT 418
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLAD--RFDRRRVLLGCALLGALAALLLPLVPGLpLALLVLLFLWGGAAG--PLYTLalaLAG 303
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27229004 419 KTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFI 475
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
11-179 5.71e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 5.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  11 WGWVIVVVSFFTQFLSYGSPLAVGVLYveWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVA 90
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLF--LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLM 280
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  91 GGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRMLI-EFYGLD 168
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEiRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLT 360
                       170
                ....*....|.
gi 27229004 169 GCLLIVGALAL 179
Cdd:cd06174 361 GAFLVLAVLLL 371
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-157 5.72e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 5.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGSPLAVGVLYVEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFL-VAG 91
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFK--YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLaALG 307
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYT---ATVTITCQY-----FDSRRGLALGLISTGSSVGLFIYAAL 157
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAGIGLGAILVlpwAMLADVVDYdewktGRRREGLYFGIFTFAIKLGQALAGAL 381
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
56-183 1.31e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.20  E-value: 1.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  56 SLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-S 134
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA-AVLYGLGFGLLFPALQALAVDLVPpH 312
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 27229004 135 RRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILA 183
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
53-191 1.36e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.19  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  53 WVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYGIVvGLGCGLLYTATVTITCQYF 132
Cdd:cd17330  38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD-GLTGGNVSVAQAYIADITD 116
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 133 DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALAL-NILACGSLMRPL 191
Cdd:cd17330 117 EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALlNLVLVLFFLPPL 176
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
13-179 1.94e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 46.83  E-value: 1.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGSPLAVGVLYVEWLdafGEGKGKTAWVGSLASGVGLLASPVC-SLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17490 197 LFFSLLAILQQMITFSTTFGFTPLIAKQL---GASSFQLGLLSIIYLLPNALASLLSgTLFYKKLGERNTIIIGFLLLGA 273
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGC 170
Cdd:cd17490 274 YCFLIPFAPNLTLLYLLQ-ALNGFGTGILFPLLMSLSIEGVPAEqRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTG 352

                ....*....
gi 27229004 171 LLIVGALAL 179
Cdd:cd17490 353 FFVIGVIAL 361
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
343-481 5.44e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.26  E-value: 5.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLgILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGnwSIFPYVTT---K 419
Cdd:cd17330 215 LLALVGIAGILAQLLL-IPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTG--IVFPALSAllsK 291
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27229004 420 TVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYdwtqtydiAFYFSGFCVLLGGFILLLAIL 481
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY--------SFLGPGVPFLLAAGLLLIALF 345
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
13-189 2.58e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.41  E-value: 2.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGsplaVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGG 92
Cdd:cd17355 213 WLLALAFFLCGFAVVG----LIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALG 288
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  93 LMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRR-GLALGLISTGSSVGLFIYAALQRMLIEFYGlDGCL 171
Cdd:cd17355 289 LALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSyGTLFGLVFAPHQLGSALGPWLGGLLYDRTG-SYTA 367
                       170
                ....*....|....*...
gi 27229004 172 LIVGALALNILACGSLMR 189
Cdd:cd17355 368 AWALAVALGLIAALLVLP 385
MFS_1 pfam07690
Major Facilitator Superfamily;
13-153 2.66e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.18  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004    13 WVIVVVSFFTQFLSYGSPLAVGVLYVEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARP---VTIFSGFLV 89
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQE---VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILA 278
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27229004    90 AGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFI 153
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLAL-LLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGAL 342
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
9-188 3.02e-04

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 43.02  E-value: 3.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   9 GGWGWVIVVVSFFTqFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVG-SLASGVGLLASpvcSLFVSSFGARPVTIFSGF 87
Cdd:cd17393 198 NRLLLLLGLLALAA-ALAEGAAADWSALYLRDVLGASAALAALGYAVfSLAMTVGRLFG---DRLVDRFGDVAVLRAGAL 273
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  88 LVAGGLMLSSLAPNIYFLFFSYGIvVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGL 167
Cdd:cd17393 274 LAALGLLLALLAPSVWVALAGFAL-MGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGL 352
                       170       180
                ....*....|....*....|.
gi 27229004 168 DGCLLIVGALALNILACGSLM 188
Cdd:cd17393 353 RTAFLVVALLALLVALLARAV 373
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
328-478 3.16e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 43.13  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   328 VARSYHVREEDLTMP----LISIFGIMTAVGKLLLGILADFKwiNTLYLYVATLIITGLALCAIPFAKSYVTLAILSGIL 403
Cdd:TIGR00881  16 LAMPYLVEEIGLSKTdlglLLSSFSIAYGISKFVMGSVSDRS--NPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004   404 GFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVG----WFYDWTQTydiaFYFSGFCVLLGGFILLL 478
Cdd:TIGR00881  94 GIFQGmGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfgiaELYSWHWV----FIVPGIIAIIVSLICFL 169
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
343-504 3.26e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.97  E-value: 3.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILAD---FKWIntlylYVATLIITGLALCAIPFAKSYVTLAILSGILGFltgNWSIFPYVT-- 417
Cdd:cd17489  36 VVGLFTLAALLARPFAGRLLDrfgRKRL-----LLIGLLIFALATLLYLLATSVALLLVLRLIHGI---GWGAFTTAAat 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 418 --TKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLGgfILLLAILPCwdmCNKKLPKPA 495
Cdd:cd17489 108 lvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLA--LLLVFLVKD---PPPVAAEEA 181

                ....*....
gi 27229004 496 VPTTFFYKV 504
Cdd:cd17489 182 EAGTRAFRR 190
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
54-207 3.36e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.93  E-value: 3.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  54 VGSLASGVGLLAS---PVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQ 130
Cdd:cd17478  33 AGLLVSVFSITSSllqPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAAFHPEGARLASQ 111
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27229004 131 YFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGcLLIVGALALniLACGSLMRPLQTSDCPFPEKTAPENV 207
Cdd:cd17478 112 AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLG-LLILLIIPG--LAVALLLLRLRPLKKPEAKKAAAKSS 185
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
343-453 3.90e-04

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 42.62  E-value: 3.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILADF-----KWINTLYLyVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGN-WSIFPYV 416
Cdd:cd17354 235 LVSLFSIFSFLGRLLSGLLSDLfvrkfRLPRPSRM-VLLLLILSLGHLLQAFGLPSGALYVASALIGFGYGGlFSIAPTI 313
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 27229004 417 TTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYD 453
Cdd:cd17354 314 VSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYY 350
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
12-157 4.00e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.55  E-value: 4.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  12 GWVIVVVSFFTQFLSYGSPLAVGVLYvewldaFGEGKGKTAWVGSLA----SGVGLLASPVCSLFVSSFGARPVTIFSGF 87
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLLPLY------LQGVLGYSPLQAGLAllplALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27229004  88 LVAGGLMLSSL--APNIYFLFFSYGIVVGLGCGLLYTA-TVTITCQYFDSRRGLALGLIST----GSSVGLFIYAAL 157
Cdd:cd17321 243 LTAVGLLLLALlgADSSVWLLLPGLVLLGLGLGLFATPlTNAALSSVPKEKAGAASGILNTarqlGGALGVALLGAL 319
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
303-478 5.33e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 42.26  E-value: 5.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 303 VFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFkwINTLYLYVATLIITGL 382
Cdd:cd17312   4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGI-IGSAFLIAYAVGKFISGFLSDR--SNIRRFMSAGLLLSAL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 383 ALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIA 461
Cdd:cd17312  81 ANIFMGFSTSLWFFAVLWGLNGLFQSmGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG-WRAA 159
                       170
                ....*....|....*..
gi 27229004 462 FYFSGFCVLLGGFILLL 478
Cdd:cd17312 160 FLVPGIVGLVVAIILFF 176
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
345-479 5.42e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.20  E-value: 5.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 345 SIFGIMTAVGKLLLGILADFKwiNTLYLYVATLIITGLALCAIPFAKSyVTLAILSGILgFLTGNWSIFPYVTTKTVGI- 423
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRK--GPKTVIIPGLLLLALGLLLLSFAGS-PWMLLLAAVL-YGLGFGLLFPALQALAVDLv 309
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 424 --DKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17489 310 ppHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFL 366
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
13-189 6.82e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.79  E-value: 6.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGSPLAVGVLyvewldaFGEGKGKTAWVGSLASG--------VGLLASPVCSLFVSSFGARPVTIF 84
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQL-------LQLPTPTGFGLGITEAGllllpgalVMLIAGPLAGRLIARVGPRRVLLI 252
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  85 SGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLIST----GSSVGLFIYAALQR 159
Cdd:cd17504 253 GLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPpDRTGIATGMNTVlrtiGSAIGPAIAGAILT 332
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 27229004 160 MLIEFYGLDGC---------LLIVGALALNILACGSLMR 189
Cdd:cd17504 333 TYTVSITSGGVptegayvlaFLIGAALALAALLLSLLIP 371
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
57-179 7.76e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 7.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  57 LASGVGLLASPVCSLFVSSFGARPVTIF---SGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCqyfD 133
Cdd:cd17370 242 LFNLVYALAAYPAGRLSDRIGRKKLLILgylSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP---A 318
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 27229004 134 SRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALAL 179
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLAL 364
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
301-479 9.30e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.45  E-value: 9.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 301 NKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKwiNTLYLYVATLIIT 380
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGL-LLAAFGVGALLGALLLGRLSKRR--RRGRLLLIGALLL 284
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 381 GLALCAIPFAKSYVTLAILSGILGFLTGNWSIfPYVTT--KTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTY 458
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNV-PLNTLlqLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-GL 362
                       170       180
                ....*....|....*....|.
gi 27229004 459 DIAFYFSGFCVLLGGFILLLA 479
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLLL 383
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
11-188 1.11e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 41.41  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  11 WGWVIVVVSFFTQFLSYGSplAVGVLYVEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFS-GFLV 89
Cdd:cd17320 204 LGYALALGLSFAGLFAYLA--AAPFIYIE---QLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGlLLLL 278
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  90 AGGLML---SSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:cd17320 279 AAALVLllaALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTA 358
                       170       180
                ....*....|....*....|..
gi 27229004 167 LdgcLLIVGALALNILACGSLM 188
Cdd:cd17320 359 L---PMGLLILVLGLLALLLLI 377
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
295-477 1.29e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.15  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 295 TASLFKNKVFSALFIAILLFD-----IGGFPPSLLMEdvarSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINT 369
Cdd:cd17333 192 ASRLLRNPSIILGALALFLYVgaetaFSSWVPSYLVE----KKHVSDGLAGY-LLSGFWVGITIGRLLGGPISRRIKPHT 266
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 370 LYlyVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNwsIFPYVTTKTVGIDKLAH--AYGILMFFAGLGNSLGPPI 447
Cdd:cd17333 267 LL--VLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAA--LFPTILSLGISNLPYAKgkGTSVLLAAGSIGGAIIPFI 342
                       170       180       190
                ....*....|....*....|....*....|
gi 27229004 448 VGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17333 343 MGFIAEAVGIQTAMLLITILYAIIFVLALL 372
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
343-477 1.32e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.05  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFA---KSYVTLAILSGILGFLTGNWSIFPYVTTK 419
Cdd:cd17316 218 YLLLISLGALVGALIAGLLSD--RIGRKKTLVIGLILSGILALPLFYLlsgSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27229004 420 TVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17316 296 LFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
352-477 1.43e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.07  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 352 AVGKLLLGILADFKWI-NTLYLYVATLIITGLALCAIPFAKS---YVTLAILSGILGFLTGNW-SIFPYVTTKTVGIDKL 426
Cdd:cd17475 248 ALGRIGLGRVSDRVFGgRRRPVLVITAAIAAAALLVLSLLSPgtpLWLLVLLLILLGLFAIGWnGLYLTLVAESAGPEQA 327
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 27229004 427 AHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17475 328 GTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
343-480 1.72e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 40.63  E-value: 1.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGnwSIFP---YVTTK 419
Cdd:cd17319  43 IASAFFLGYALFQVPGGWLLD--RFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA--GFFPgaiKALAE 118
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27229004 420 TVGIDKLAHAYGILMFFAGLGNSLGPPIVGW---FYDWTQtydiAFYFSGFCVLLGGFILLLAI 480
Cdd:cd17319 119 WFPARERGRATGLFNSGAPLGAAIGPPLSGWlllLFGWRW----AFIIEGLLGLLLAVLWWFYL 178
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
15-189 1.77e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 1.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  15 IVVVSFFtQFLSYGSPLAVGVLYVEwldafgEGKGKTAWVG---SLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17489   1 ILLANFF-FFLSFYLLLPVLPLYAH------DLGGSEAVAGlvvGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFAL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  92 GLMLSSLAPNIyFLFFSYGIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGC 170
Cdd:cd17489  74 ATLLYLLATSV-ALLLVLRLIHGIGWGAFTTAAATLVADIIPpSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVL 152
                       170
                ....*....|....*....
gi 27229004 171 LLIVGALALNILACGSLMR 189
Cdd:cd17489 153 FIVAAVLALLALLLVFLVK 171
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
300-478 1.92e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.18  E-value: 1.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 300 KNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLII 379
Cdd:COG0477  12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGW-IVSAYLLGRAIGLLLFGRLGD--RYGRKRVLLIGLLL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 380 TGLALCAIPFAKSYVTLAILSGILGF-LTGNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTY 458
Cdd:COG0477  89 FGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL-GW 167
                       170       180
                ....*....|....*....|
gi 27229004 459 DIAFYFSGFCVLLGGFILLL 478
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLR 187
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
343-495 1.97e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.62  E-value: 1.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILADFKwiNTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFltGNwSIF----PYVTT 418
Cdd:cd17478  36 LVSVFSITSSLLQPLFGYLADRK--PRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI--GS-AAFhpegARLAS 110
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27229004 419 KTVGIDKlAHAYGILMFFAGLGNSLGPPIVGWFydwtqtYDIAFYFSGFCVLLGGFILLLAILPCWDMCNKKLPKPA 495
Cdd:cd17478 111 QAAGGRR-GLAMSIFSVGGNLGFALGPLIAAAL------VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKA 180
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
297-478 3.18e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.90  E-value: 3.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 297 SLFKNK---VFSalFIAILLFDIG-----GFPPSLLMEDVARSYHvreedLTMpLISIFGIMTAVGKLLLGILAdFKWIN 368
Cdd:cd17490 189 SVLKDKkllFFS--LLAILQQMITfsttfGFTPLIAKQLGASSFQ-----LGL-LSIIYLLPNALASLLSGTLF-YKKLG 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 369 TLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGnwSIFPYVTT---KTVGIDKLAHAYGILMFFAGLGNSLGP 445
Cdd:cd17490 260 ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTG--ILFPLLMSlsiEGVPAEQRSTAMGFFQAIYALGMFLGP 337
                       170       180       190
                ....*....|....*....|....*....|...
gi 27229004 446 PIVGWFYDWTqTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17490 338 VLVGIISEAF-GLQTGFFVIGVIALLAAILSLA 369
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
281-477 3.40e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 39.91  E-value: 3.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 281 AKRKWQLYRNYCGETASLFKNKVF--SALFIAILLFDIGG---FPPSLLMedvaRSYHVREEDLTmPLISIFGIMTAV-- 353
Cdd:cd17328 186 GVMAKSTATSFLADLKALAKNPSFilSTLGFTAVSFVTGAlafWAPTFFL----RAFGVGDLSSA-DVGLIFGAITCIag 260
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 354 --GKLLLGILADF--KWINTLYLYV---ATLIITGLALCAIPFAKS--YVTLAILSGILGFLTGNWSIFPYVTTKTVGID 424
Cdd:cd17328 261 vlGVLLGGILADRlrRKTPRADPLVcavGLLAAAPFLFLALVLALSnlLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPT 340
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27229004 425 KLAHAYGILMFFAG-LGNSLGPPIVGWFYDWTQTYDI-----------AFYFSGFCVLLGGFILL 477
Cdd:cd17328 341 RRSTASAIQILLSHlLGDAGSPYLIGLISDLLRQNKDsplaeaaslqyALLLCSFVLVLGGFFFL 405
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
41-188 4.41e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.49  E-value: 4.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  41 LDAFGEGKGKTAWVGSLASgVGLLASPVCSLFVSS-FGARPVTIFSGFLVAGGLMLSSLAPNIY-FLFFSYGIVVGLGcG 118
Cdd:cd17365  26 AQDWGLSPAQLGPVGSAAL-FGMAIGALLAGPLADrFGRKRVLLVSVALFGLFTLLTAFAQSVLqLALLRFLTGLGLG-A 103
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27229004 119 LLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLI--VGALALNILACGSLM 188
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLggVPPLILLPLLRGTLL 175
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
19-179 4.58e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.53  E-value: 4.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  19 SFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVtIFSGFLVAGGLMLSSL 98
Cdd:cd17475   1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRV-LAVGLLLMGAAALLMA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  99 APNIYFLFFSYGIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGAL 177
Cdd:cd17475  80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFpPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159

                ..
gi 27229004 178 AL 179
Cdd:cd17475 160 SI 161
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
76-188 5.44e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.08  E-value: 5.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  76 FGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIY 154
Cdd:cd17321  58 FGRKRVFLIGLALFGLASLLCALAPSLAFLIAAR-ALQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVGIGAALG 136
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 27229004 155 AALQRMLIEFYG---------------LDGCLLIVGALALNILACGSLM 188
Cdd:cd17321 137 PLLGGLLLELFGwrwiflinvpiglvaLLLARTFSGAVLAAFLLGAALG 185
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
13-122 6.08e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.13  E-value: 6.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  13 WVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAfgeGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPV-TIFSGFLVAG 91
Cdd:cd17332 223 FLILLLAYLLYFLAFNIVNTVLVYYFKYVLG---GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAfFIGLLLAILG 299
                        90       100       110
                ....*....|....*....|....*....|.
gi 27229004  92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYT 122
Cdd:cd17332 300 LLLLFFLPPGNLVLILVLAVLAGIGYGGANL 330
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
40-183 6.32e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.69  E-value: 6.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  40 WLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGL 119
Cdd:cd17477  22 RLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR-FVMGIGLAG 100
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27229004 120 LYTATVT-ITCQYFDSRRGLALGLISTGSSVGLfiyaALQRMLIEFYGLDGCLLIVGALALNILA 183
Cdd:cd17477 101 LFVVSESwLNALATNENRGRVLGLYSTVLGLGF----ALGPLLLALVGTAGALPFLIAAVLLLLA 161
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
51-162 8.57e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.44  E-value: 8.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004  51 TAWVGSLASgVGLLASPVCSLF----VSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFsYGIVVGLGCGLLYTATVT 126
Cdd:cd17371  33 EAEAGLLGT-VTLAGGAIGGILggilADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI-LRALAGLGFGGEWAAGAA 110
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 27229004 127 ITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRMLI 162
Cdd:cd17371 111 LMAEYVPARhRGKALGYVQSGWAVGWLLATLLAALLF 147
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
343-477 8.67e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.31  E-value: 8.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229004 343 LISIFGIMTAVGKLLLGILADFkwINTLYLYVATLIITGLALCAIPFAKSYVTLaILSGILGFLTGnwSIFPY--VTTKT 420
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDR--FGRRRVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLF--ASFPVtvVLAQE 309
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27229004 421 VGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17478 310 LLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAF-GLESVLLILALLPLLGALLAF 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH