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Conserved domains on  [gi|17105326|ref|NP_081129|]
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ankyrin repeat and SOCS box protein 11 isoform 2 [Mus musculus]

Protein Classification

ankyrin repeat and SOCS box protein( domain architecture ID 1562964)

ankyrin repeat and SOCS box protein (ASB) may be a substrate-recognition component of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Gene Ontology:  GO:0016567|GO:0005515
PubMed:  17176038|18948053|12076535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-251 1.74e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.30  E-value: 1.74e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  35 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGS 114
Cdd:COG0666  53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326 115 AACVNVLLEFGAKA-QLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:COG0666 133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17105326 194 DH-GQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLL 251
Cdd:COG0666 213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 253-294 3.61e-16

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 70.59  E-value: 3.61e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17105326 253 EGPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03728   1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-251 1.74e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.30  E-value: 1.74e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  35 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGS 114
Cdd:COG0666  53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326 115 AACVNVLLEFGAKA-QLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:COG0666 133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17105326 194 DH-GQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLL 251
Cdd:COG0666 213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-240 8.18e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 85.87  E-value: 8.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   33 CWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNAQTVHGATPLF 107
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  108 NA--CCSGSAACVNVLLEFGAKAQLEIYLA-SPIHEAVKRGHR--ECMEILLTKDVNIEqevpqlgtplyvACTyqRVDC 182
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGANVNIKNSDGeNLLHLYLESNKIdlKILKLLIDKGVDIN------------AKN--RVNY 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17105326  183 vkkLLELGASVD----HGqwlDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAV 240
Cdd:PHA03100 178 ---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI 233
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 253-294 3.61e-16

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 70.59  E-value: 3.61e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17105326 253 EGPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03728   1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-160 3.21e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 3.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326    73 LHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEIYLASPIHEAVKRGHRECMEI 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....*...
gi 17105326   153 LLTKDVNI 160
Cdd:pfam12796  80 LLEKGADI 87
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 254-292 9.11e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.94  E-value: 9.11e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17105326   254 GPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLL 292
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 256-294 1.10e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 38.54  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17105326    256 PALSQLCRLCVRKCLGrtchhAIYALGLPESLEKFLLYQ 294
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 169-194 8.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 8.02e-03
                           10        20
                   ....*....|....*....|....*.
gi 17105326    169 TPLYVACTYQRVDCVKKLLELGASVD 194
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-251 1.74e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.30  E-value: 1.74e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  35 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGS 114
Cdd:COG0666  53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326 115 AACVNVLLEFGAKA-QLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:COG0666 133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17105326 194 DH-GQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLL 251
Cdd:COG0666 213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-236 7.61e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.37  E-value: 7.61e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  36 DRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSA 115
Cdd:COG0666  87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326 116 ACVNVLLEFGAKAQLE-IYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASVD 194
Cdd:COG0666 167 EIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 17105326 195 H-GQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSAL 236
Cdd:COG0666 247 AkDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-253 1.55e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 1.55e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  35 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGS 114
Cdd:COG0666  20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326 115 AACVNVLLEFGAK-AQLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:COG0666 100 LEIVKLLLEAGADvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17105326 194 DH-GQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLLHE 253
Cdd:COG0666 180 NArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
49-240 7.71e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 92.71  E-value: 7.71e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  49 LLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAKA 128
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326 129 QLE-IYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAA 206
Cdd:COG0666  81 NAKdDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAqDNDGNTPLHLA 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 17105326 207 VRQSSVEVINLLTVYGANLNLRNAQGKSALDLAV 240
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAA 194
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-240 8.18e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 85.87  E-value: 8.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   33 CWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNAQTVHGATPLF 107
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  108 NA--CCSGSAACVNVLLEFGAKAQLEIYLA-SPIHEAVKRGHR--ECMEILLTKDVNIEqevpqlgtplyvACTyqRVDC 182
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGANVNIKNSDGeNLLHLYLESNKIdlKILKLLIDKGVDIN------------AKN--RVNY 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17105326  183 vkkLLELGASVD----HGqwlDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAV 240
Cdd:PHA03100 178 ---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI 233
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-171 1.97e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 1.97e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  34 WADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSG 113
Cdd:COG0666 151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17105326 114 SAACVNVLLEFGAKAQLEI-YLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPL 171
Cdd:COG0666 231 NLEIVKLLLEAGADLNAKDkDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 52-250 3.43e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 83.86  E-value: 3.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   52 LKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAKAQL- 130
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVk 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  131 EIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRvdCVKKLLELGASVDHgQWLD--TPLHAAVR 208
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASIND-QDIDgsTPLHHAIN 263

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 17105326  209 -QSSVEVINLLTVYGANLNLRNAQGKSALDLA---VPKSSVRQALL 250
Cdd:PHA02874 264 pPCDIDIIDILLYHKADISIKDNKGENPIDTAfkyINKDPVIKDII 309
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 253-294 3.61e-16

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 70.59  E-value: 3.61e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17105326 253 EGPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03728   1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-160 3.21e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 3.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326    73 LHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEIYLASPIHEAVKRGHRECMEI 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....*...
gi 17105326   153 LLTKDVNI 160
Cdd:pfam12796  80 LLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-127 8.29e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.60  E-value: 8.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326    40 LHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENgAHVNAQTvHGATPLFNACCSGSAACVN 119
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....*...
gi 17105326   120 VLLEFGAK 127
Cdd:pfam12796  79 LLLEKGAD 86
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 253-294 2.09e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.98  E-value: 2.09e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17105326 253 EGPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 37-246 2.58e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 73.17  E-value: 2.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   37 RSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLEN------------------------- 91
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNrsninkndlsllkairnedletsll 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   92 ----GAHVNAQTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-IYLASPIHEAVKRGH-RECMEILLTKDVNIEQEV 164
Cdd:PHA02876 259 lydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGYdTENIRTLIMLGADVNAAD 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  165 PQLGTPLYVACTYQRV-DCVKKLLELGASVDHGQWLD-TPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAV-- 240
Cdd:PHA02876 339 RLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALcg 418


                 ....*...
gi 17105326  241 --PKSSVR 246
Cdd:PHA02876 419 tnPYMSVK 426
Ank_2 pfam12796
Ankyrin repeats (3 copies);
138-229 4.06e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 4.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   138 IHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLElGASVDHGQWLDTPLHAAVRQSSVEVINL 217
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 17105326   218 LTVYGANLNLRN 229
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-254 5.12e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 72.02  E-value: 5.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   38 SPLHEAAAQGRLLAL-KTLIAQGINVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNAQTVHGATPLFNACC-SGS 114
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  115 AACVNVLLEFGAKAQLEIYL-ASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVA-CTYQRVDCVKKLLELGAS 192
Cdd:PHA02876 355 KDIVITLLELGANVNARDYCdKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17105326  193 VD-HGQWLDTPLHAAVRQS-SVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQaLLLHEG 254
Cdd:PHA02876 435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVN-ILLHYG 497
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 86-244 1.35e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 70.68  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   86 KALLENGAHVNAQTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEIYLASPIHEAVKRGHRECMEILLTKDVNIEQE 163
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  164 VPQLGTPLYVACTY-QRVDCVKKLLELGASVDHGQWLD--TPLHAAVRqsSVEVINLLTVYGANLNLRNAQGKSALDLAV 240
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 17105326  241 PKSS 244
Cdd:PHA02878 309 KQYL 312
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 255-294 6.35e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.02  E-value: 6.35e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17105326 255 PPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03587   2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 72-245 8.04e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 65.01  E-value: 8.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   72 SLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEIY-LASPIHEAVKRGHRECM 150
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPdIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  151 EILLTKDVNIEQEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQwLD--TPLHAAVRQSSVEVINLLTVYGANLNL 227
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170
                 ....*....|....*...
gi 17105326  228 RNAQGKSALDLAVPKSSV 245
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDI 181
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 254-292 9.11e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.94  E-value: 9.11e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17105326   254 GPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLL 292
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-240 1.65e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.05  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   47 GRLLALKTLIAQGIN-VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFG 125
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  126 AKAQLeiyLASPIHEavkrghRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASV----DHGQWldt 201
Cdd:PHA02874  92 VDTSI---LPIPCIE------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVniedDNGCY--- 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 17105326  202 PLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAV 240
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 43-195 2.22e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.96  E-value: 2.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   43 AAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLL 122
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  123 EFGAkaqleiylASPIH-------EAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH 195
Cdd:PLN03192 612 HFAS--------ISDPHaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 36-218 5.46e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 5.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   36 DRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNAccsgSA 115
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS----VG 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  116 ACVN-----VLLEFGAkaqleiylaspiheavkrghrecmeilltkDVNIEQEVPQLgTPLYVACTYQRVdcVKKLLELG 190
Cdd:PHA02878 244 YCKDydilkLLLEHGV------------------------------DVNAKSYILGL-TALHSSIKSERK--LKLLLEYG 290

                        170       180       190
                 ....*....|....*....|....*....|
gi 17105326  191 ASVDHGQWL-DTPLHAAVRQ-SSVEVINLL 218
Cdd:PHA02878 291 ADINSLNSYkLTPLSSAVKQyLCINIGRIL 320
PHA03095 PHA03095
ankyrin-like protein; Provisional
 42-237 7.21e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.19  E-value: 7.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   42 EAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAK---ALLENGAHVNAQTVHGATPLFNACCSGS-AAC 117
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAPERCGFTPLHLYLYNATtLDV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  118 VNVLLEFGAkaqleiylaspiheavkrghrecmeilltkDVNIEQEVPQlgTPLYVACTYQRVD--CVKKLLELGASV-- 193
Cdd:PHA03095 100 IKLLIKAGA------------------------------DVNAKDKVGR--TPLHVYLSGFNINpkVIRLLLRKGADVna 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 17105326  194 --DHGQwldTPLHAAVRQS--SVEVINLLTVYGANLNLRNAQGKSALD 237
Cdd:PHA03095 148 ldLYGM---TPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRFRSLLH 192
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 38-227 2.41e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.61  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   38 SPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVH-GATPLFNACCSGSAA 116
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  117 CVNVLLEFGAKAQL-EIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH 195
Cdd:PHA02875 117 IMKLLIARGADPDIpNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196

                        170       180       190
                 ....*....|....*....|....*....|....
gi 17105326  196 -GQWLD-TPLHAAVRQSSVEVINLLTVYGANLNL 227
Cdd:PHA02875 197 fGKNGCvAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 106-251 2.84e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.23  E-value: 2.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  106 LFNACCSGSAACVNVLLEFGAKAQLEIYLA-SPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVK 184
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17105326  185 KLLELGASVDHGQWLD--TPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLL 251
Cdd:PHA02875  86 ELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 38-161 5.14e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 5.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   38 SPLHEAAAQ--GRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHV--ACAKALLENGAHVNAQT-------------- 99
Cdd:PHA03100 108 TPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNrvnyllsygvpini 187

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17105326  100 --VHGATPLFNACCSGSAACVNVLLEFGAKAQL-EIYLASPIHEAVKRGHRECMEILLTKDVNIE 161
Cdd:PHA03100 188 kdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLvNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 255-294 5.88e-08

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 48.07  E-value: 5.88e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17105326 255 PPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 52-257 1.18e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   52 LKTLIAQGINVNLVTINRVSSLHeACLGG---HVACAKALLENGAHVNAQTVHGATPLfnACCSGSAAC----VNVLLEF 124
Cdd:PHA03095 100 IKLLIKAGADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDA 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  125 GAKAQ---------LEIYLASPiheavkRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQ--RVDCVKKLLELGASV 193
Cdd:PHA03095 177 GADVYavddrfrslLHHHLQSF------KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISI 250

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17105326  194 D----HGQwldTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQ-ALLLHEGPPA 257
Cdd:PHA03095 251 NarnrYGQ---TPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAvRAALAKNPSA 316
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 36-236 1.19e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 52.30  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   36 DRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSA 115
Cdd:PHA02875   2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  116 ACVNVLLEFGAKAQLEIYLA--SPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:PHA02875  82 KAVEELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 17105326  194 D-HGQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSAL 236
Cdd:PHA02875 162 DiEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
Ank_4 pfam13637
Ankyrin repeats (many copies);
37-89 2.77e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 2.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 17105326    37 RSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALL 89
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
37-98 3.71e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 3.71e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17105326    37 RSPLHEAAAQGRLLALKTLIAQgINVNLVTINRvSSLHEACLGGHVACAKALLENGAHVNAQ 98
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADINVK 90
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 55-238 4.75e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 4.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   55 LIAQGINVNLVTINRVS-------SLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAK 127
Cdd:PHA02876 124 ILKEAISGNDIHYDKINesieymkLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGAD 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  128 AQLeIYL--ASPIHEAVKRGHRECMEILLTKDVNIEQEvpqlGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLH 204
Cdd:PHA02876 204 VNI-IALddLSVLECAVDSKNIDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLH 278

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 17105326  205 AAVRQSSV-EVINLLTVYGANLNLRNAQGKSALDL 238
Cdd:PHA02876 279 HASQAPSLsRLVPKLLERGADVNAKNIKGETPLYL 313
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 255-294 5.16e-07

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 45.64  E-value: 5.16e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17105326 255 PPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03724   3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 39-240 5.65e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.65  E-value: 5.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   39 PLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLengAHVNAQTVhgatplFNACCSGSAACV 118
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI---RSINKCSV------FYTLVAIKDAFN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  119 N--------VLLEFGAKAQleiylASPIHEAVKRGHRECMEILLTK-------DVNIEQEvPQLGTPLYVACTYQRVDCV 183
Cdd:PHA02878 111 NrnveifkiILTNRYKNIQ-----TIDLVYIDKKSKDDIIEAEITKlllsygaDINMKDR-HKGNTALHYATENKDQRLT 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 17105326  184 KKLLELGASVDHGQWLD-TPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAV 240
Cdd:PHA02878 185 ELLLSYGANVNIPDKTNnSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 85-154 6.97e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.28  E-value: 6.97e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17105326   85 AKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEIYLASPIHEAVKRGHRECMEILL 154
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 37-191 2.93e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   37 RSPLHEAAAQGRLLALKTLIAQGINVNLVTINR-VSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSA 115
Cdd:PHA02875  69 ESELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17105326  116 ACVNVLLEFGAKAQLE-IYLASPIHEAVKRGHRECMEILLTKDVNIEQeVPQLG--TPLYVACTYQRVDCVKKLLELGA 191
Cdd:PHA02875 149 KGIELLIDHKACLDIEdCCGCTPLIIAMAKGDIAICKMLLDSGANIDY-FGKNGcvAALCYAIENNKIDIVRLFIKRGA 226
Ank_4 pfam13637
Ankyrin repeats (many copies);
69-122 5.93e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 5.93e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17105326    69 RVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLL 122
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 255-292 1.12e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 42.04  E-value: 1.12e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 17105326 255 PPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLL 292
Cdd:cd03723   3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 39-185 1.13e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.50  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   39 PLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAAcV 118
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA-I 238

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17105326  119 NVLLEFGAKAQLEIYLASPIHEAVKRG-HRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKK 185
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIK 306
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 255-294 2.46e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 40.71  E-value: 2.46e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17105326 255 PPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03743   3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 73-243 3.20e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   73 LHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEiYLASPIHEAVKRGHRECMEI 152
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVF-YTLVAIKDAFNNRNVEIFKI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  153 LLTKDVNIEQ--EVPQLGTPLYVACTYQRVdcVKKLLELGASVD--HGQWLDTPLHAAVRQSSVEVINLLTVYGANLNLR 228
Cdd:PHA02878 120 ILTNRYKNIQtiDLVYIDKKSKDDIIEAEI--TKLLLSYGADINmkDRHKGNTALHYATENKDQRLTELLLSYGANVNIP 197

                        170
                 ....*....|....*
gi 17105326  229 NAQGKSALDLAVPKS 243
Cdd:PHA02878 198 DKTNNSPLHHAVKHY 212
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 40-128 5.73e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 5.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   40 LHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVN 119
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*.
gi 17105326  120 VLL-------EFGAKA 128
Cdd:PTZ00322 166 LLSrhsqchfELGANA 181
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 253-294 6.04e-05

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 39.62  E-value: 6.04e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17105326 253 EGPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03719   1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 38-109 6.52e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 6.52e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17105326   38 SPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLggHVACAKALLENGAHVNAQTVHGATPLFNA 109
Cdd:PHA02874 192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHA 261
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 255-294 1.02e-04

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 39.19  E-value: 1.02e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17105326 255 PPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03744   3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 256-294 1.10e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 38.54  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17105326    256 PALSQLCRLCVRKCLGrtchhAIYALGLPESLEKFLLYQ 294
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-126 1.19e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   34 WADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNAQTVHGATPLFNACCS 112
Cdd:PHA02876 373 YCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNpYMSVKTLIDRGANVNSKNKDLSTPLHYACKK 452

                         90
                 ....*....|....*
gi 17105326  113 G-SAACVNVLLEFGA 126
Cdd:PHA02876 453 NcKLDVIEMLLDNGA 467
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-106 1.19e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 1.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 17105326    55 LIAQG-INVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPL 106
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 255-294 1.31e-04

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 38.56  E-value: 1.31e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17105326 255 PPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03720   3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_5 pfam13857
Ankyrin repeats (many copies);
197-239 1.42e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 1.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17105326   197 QWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLA 239
Cdd:pfam13857  14 GEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
169-218 2.95e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 2.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 17105326   169 TPLYVACTYQRVDCVKKLLELGASVDH--GQWlDTPLHAAVRQSSVEVINLL 218
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvdGNG-ETALHFAASNGNVEVLKLL 53
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 255-293 3.15e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 37.84  E-value: 3.15e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 17105326 255 PPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLY 293
Cdd:cd03729   3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 253-294 4.52e-04

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 37.15  E-value: 4.52e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17105326 253 EGPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03721   1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 127-239 7.47e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.35  E-value: 7.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  127 KAQLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQ----LGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLD- 200
Cdd:PHA02884  26 KKKNKICIANILYSSIKFHYTDIIDAILKLGADPEAPFPLsensKTNPLIYAIDCDNDDAAKLLIRYGADVNrYAEEAKi 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 17105326  201 TPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLA 239
Cdd:PHA02884 106 TPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA 144
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 253-294 7.49e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 37.13  E-value: 7.49e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 17105326 253 EGPPALSQLCRLCVRKCLGR---TCHHAIYALGLPESLEKFLLYQ 294
Cdd:cd03730   1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 169-263 1.26e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  169 TPLYVACTYQRVDCVKKLLELGASVdhgQWLD----TPLHAAVRQSSVEVINLLtvyganlnLRNAQGKSALDL-AVPKS 243
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADP---TLLDkdgkTPLELAEENGFREVVQLL--------SRHSQCHFELGAnAKPDS 185

                         90       100
                 ....*....|....*....|....*
gi 17105326  244 SVRQALLLHEGP-----PALSQLCR 263
Cdd:PTZ00322 186 FTGKPPSLEDSPisshhPDFSAVPQ 210
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 38-97 2.16e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.26  E-value: 2.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   38 SPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNA 97
Cdd:PHA03100 194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 183-287 3.94e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.73  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326  183 VKKLLELGASVD----HGQwldTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKS--SVRQALLLHEgpp 256
Cdd:PTZ00322  98 ARILLTGGADPNcrdyDGR---TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGfrEVVQLLSRHS--- 171

                         90       100       110
                 ....*....|....*....|....*....|.
gi 17105326  257 alsqlcrlcvrkclgrTCHHAIYALGLPESL 287
Cdd:PTZ00322 172 ----------------QCHFELGANAKPDSF 186
Ank_4 pfam13637
Ankyrin repeats (many copies);
201-252 5.46e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 5.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 17105326   201 TPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLLH 252
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 40-101 5.52e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 38.31  E-value: 5.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17105326   40 LHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVH 101
Cdd:PLN03192 626 LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
PHA03095 PHA03095
ankyrin-like protein; Provisional
 36-123 5.93e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.08  E-value: 5.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17105326   36 DRSPLHEAAAQGRLLALKT--LIAQGINVNLVTINRVSSLHEA-CLGGHVACAKaLLENGAHVNAQTVHGATPLFNACCS 112
Cdd:PHA03095 222 GNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAaVFNNPRACRR-LIALGADINAVSSDGNTPLSLMVRN 300

                         90
                 ....*....|.
gi 17105326  113 GSAACVNVLLE 123
Cdd:PHA03095 301 NNGRAVRAALA 311
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 169-194 8.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 8.02e-03
                           10        20
                   ....*....|....*....|....*.
gi 17105326    169 TPLYVACTYQRVDCVKKLLELGASVD 194
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 253-294 9.92e-03

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 33.34  E-value: 9.92e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17105326 253 EGPPALSQLCRLCVRKCLGRtchHAIYALGLPESLEKFLLYQ 294
Cdd:cd03717   1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLKEY 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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