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Conserved domains on  [gi|110625710|ref|NP_081189|]
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MIT domain-containing protein 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 97-245 1.01e-83

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


:

Pssm-ID: 239148  Cd Length: 148  Bit Score: 246.38  E-value: 1.01e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625710  97 NATGFSYESLFREYLHETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGYEGLGNtQQSSGLEEIKQS 176
Cdd:cd02685    1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQIRNFLRFCELVVKPPCELKYIHLVTGEDEDNGK-QQIEALEEIKQS 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110625710 177 LGSHGVVLEINYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQGRFSLGYYDLDLRPCHETTVDIFHNKH 245
Cdd:cd02685   80 LASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 6.33e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


:

Pssm-ID: 239146  Cd Length: 77  Bit Score: 137.56  E-value: 6.33e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110625710  10 SDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683    1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
 
Name Accession Description Interval E-value
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 97-245 1.01e-83

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 246.38  E-value: 1.01e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625710  97 NATGFSYESLFREYLHETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGYEGLGNtQQSSGLEEIKQS 176
Cdd:cd02685    1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQIRNFLRFCELVVKPPCELKYIHLVTGEDEDNGK-QQIEALEEIKQS 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110625710 177 LGSHGVVLEINYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQGRFSLGYYDLDLRPCHETTVDIFHNKH 245
Cdd:cd02685   80 LASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 100-237 2.63e-83

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 244.74  E-value: 2.63e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625710  100 GFSYESLFREYLHETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTsGYEGLGNTQQSSGLEEIKQSLGS 179
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRNLVRFCELLVKKCGNLKKIHLLT-GEDEENLDQQLDNLEELKDSLAS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 110625710  180 HGVVLEINYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQGRFSLGYYDLDLRPCHETT 237
Cdd:pfam16565  80 RGVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKFSLGYCDQDLRKCKETT 137
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 6.33e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 137.56  E-value: 6.33e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110625710  10 SDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683    1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 14-77 5.15e-16

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 70.26  E-value: 5.15e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625710   14 AAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKK 77
Cdd:pfam04212   3 KALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
8-81 7.05e-16

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 70.03  E-value: 7.05e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625710     8 QDSDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKKYLDQ 81
Cdd:smart00745   1 TRDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLLE 74
 
Name Accession Description Interval E-value
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 97-245 1.01e-83

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 246.38  E-value: 1.01e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625710  97 NATGFSYESLFREYLHETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTSGYEGLGNtQQSSGLEEIKQS 176
Cdd:cd02685    1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQIRNFLRFCELVVKPPCELKYIHLVTGEDEDNGK-QQIEALEEIKQS 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110625710 177 LGSHGVVLEINYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQGRFSLGYYDLDLRPCHETTVDIFHNKH 245
Cdd:cd02685   80 LASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 100-237 2.63e-83

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 244.74  E-value: 2.63e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625710  100 GFSYESLFREYLHETVTEVWIEDPYIRQTHQLYNFLRFCEMLIKKPCKVRTIHLLTsGYEGLGNTQQSSGLEEIKQSLGS 179
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRNLVRFCELLVKKCGNLKKIHLLT-GEDEENLDQQLDNLEELKDSLAS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 110625710  180 HGVVLEINYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQGRFSLGYYDLDLRPCHETT 237
Cdd:pfam16565  80 RGVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKFSLGYCDQDLRKCKETT 137
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 6.33e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 137.56  E-value: 6.33e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110625710  10 SDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683    1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
MIT cd02656
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 10-83 2.06e-22

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


Pssm-ID: 239121  Cd Length: 75  Bit Score: 87.36  E-value: 2.06e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625710  10 SDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKKYLDQEK 83
Cdd:cd02656    1 ELLQQAKELIKQAVKEDEDGNYEEALELYKEALDYLLQALKAEKEPKLRKLLRKKVKEYLDRAEFLKELLKKQK 74
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 14-77 5.15e-16

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 70.26  E-value: 5.15e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625710   14 AAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKK 77
Cdd:pfam04212   3 KALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
8-81 7.05e-16

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 70.03  E-value: 7.05e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625710     8 QDSDSTAAVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKKYLDQ 81
Cdd:smart00745   1 TRDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLLE 74
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 15-83 6.15e-12

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


Pssm-ID: 239141  Cd Length: 75  Bit Score: 59.59  E-value: 6.15e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110625710  15 AVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKKYLDQEK 83
Cdd:cd02678    6 AIELVKKAIEEDNAGNYEEALRLYQHALEYFMHALKYEKNPKSKESIRAKCTEYLDRAEKLKEYLAKKE 74
MIT_SNX15 cd02677
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT ...
 15-75 1.27e-05

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.


Pssm-ID: 239140  Cd Length: 75  Bit Score: 42.33  E-value: 1.27e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110625710  15 AVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENI 75
Cdd:cd02677    6 AAELIRLALEKEEEGDYEAAFEFYRAGVDLLLKGVQGDSSPERREAVKRKIAEYLKRAEEI 66
MIT_2 cd02684
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 15-79 5.21e-05

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239147  Cd Length: 75  Bit Score: 40.57  E-value: 5.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110625710  15 AVAVLKRAVELDAESRYQQALVCYQEGIDMLLQVLKGTKESSKRCVLRTKISGYMDRAENIKKYL 79
Cdd:cd02684    6 AIALVVQAVKKDQRGDAAAALSLYCSALQYFVPALHYETDAQRKEALRQKVLQYVSRAEELKALI 70
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 11-67 6.30e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 37.22  E-value: 6.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625710  11 DSTAAVAVLKRAVELDAESRY------------QQALVCYQEGIDMLLQVLKGTKESSKRC-----VLRTKISG 67
Cdd:cd24142   49 DVEEAREVLLRAIELDPDGGYekylylgqlsggEEALQYYEKGIEILEEELQALQAASAEAeeeaeELKRKLSS 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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