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Conserved domains on  [gi|21312318|ref|NP_081389|]
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WD repeat-containing protein 5B [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-325 4.12e-106

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 315.70  E-value: 4.12e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWD 109
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 110 MRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLC 189
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLfaSFSVTGRkWVV 269
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21312318 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-325 4.12e-106

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 315.70  E-value: 4.12e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWD 109
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 110 MRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLC 189
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLfaSFSVTGRkWVV 269
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21312318 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-325 4.52e-103

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 303.87  E-value: 4.52e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  31 LRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDM 110
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 111 RSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCR 190
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 191 IWDAASGQCLRTLADEgNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNekYCLFASFSVTGRkWVVS 270
Cdd:cd00200 161 LWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFSPDGY-LLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21312318 271 GSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAALenDKTIKVWS 325
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 35-328 3.09e-16

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 79.36  E-value: 3.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   35 LAGHSAAISSVKFSPNGEWLASSAADALIIIWgaydgNCKKT-------------LYGHSlEISDVAWSSD-SSRLVSAS 100
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIF-----ECESIikdgrdihypvveLASRS-KLSGICWNSYiKSQVASSN 552

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  101 DDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPS-NLIVSGSFDESVKIWEVKTGKCLKTLSAHSDpISAVNFNCN-GS 178
Cdd:PLN00181 553 FEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGR 631

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  179 LIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATlDNTLKLWDYSRGRC------LKTYTGHKNE 252
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNV 710

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21312318  253 KYclFASFSVTGrKWVVSGSEDNMVYIWnlqtkeivqrlqgHTDVVISAACHPTKNIIASAALENDKTIKVWSSDC 328
Cdd:PLN00181 711 KN--FVGLSVSD-GYIATGSETNEVFVY-------------HKAFPMPVLSYKFKTIDPVSGLEVDDASQFISSVC 770
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 154-193 6.39e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 6.39e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21312318    154 TGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
155-193 2.69e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 2.69e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21312318   155 GKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWD 193
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-325 4.12e-106

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 315.70  E-value: 4.12e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWD 109
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 110 MRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLC 189
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLfaSFSVTGRkWVV 269
Cdd:COG2319 271 RLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-TLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21312318 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-325 4.52e-103

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 303.87  E-value: 4.52e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  31 LRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDM 110
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 111 RSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCR 190
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 191 IWDAASGQCLRTLADEgNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNekYCLFASFSVTGRkWVVS 270
Cdd:cd00200 161 LWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFSPDGY-LLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21312318 271 GSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAALenDKTIKVWS 325
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
30-325 1.94e-98

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 296.05  E-value: 1.94e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWD 109
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 110 MRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLC 189
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLfaSFSVTGRkWVV 269
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPDGK-LLA 304

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21312318 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS--DDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
31-284 2.31e-87

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 267.93  E-value: 2.31e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  31 LRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDM 110
Cdd:COG2319 154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 111 RSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCR 190
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 191 IWDAASGQCLRTLADEGNPPVSfVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLfaSFSVTGRkWVVS 270
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRS-VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV--AFSPDGR-TLAS 389

                       250
                ....*....|....
gi 21312318 271 GSEDNMVYIWNLQT 284
Cdd:COG2319 390 GSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
30-325 4.24e-85

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 262.15  E-value: 4.24e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWD 109
Cdd:COG2319  27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 110 MRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLC 189
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 190 RIWDAASGQCLRTLADEGNpPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLfaSFSVTGRkWVV 269
Cdd:COG2319 187 RLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AFSPDGR-LLA 262

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21312318 270 SGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS--DDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
47-325 7.42e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.86  E-value: 7.42e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  47 FSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFV 126
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 127 FCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLADE 206
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 207 GNPPVSfVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLfaSFSVTGRkWVVSGSEDNMVYIWNLQTKE 286
Cdd:COG2319 162 SGAVTS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGK-LLASGSADGTVRLWDLATGK 237

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 21312318 287 IVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGS--ADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-327 1.79e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 189.85  E-value: 1.79e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 115 CLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDA 194
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 195 ASGQCLRTLADEgNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLfaSFSVTGrKWVVSGSED 274
Cdd:cd00200  81 ETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV--AFSPDG-TFVASSSQD 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 21312318 275 NMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWSSD 327
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS--SDGTIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 27-193 5.20e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 173.29  E-value: 5.20e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  27 PNYALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLK 106
Cdd:cd00200 123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 107 VWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYD 186
Cdd:cd00200 203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 21312318 187 GLCRIWD 193
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
88-325 2.53e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.32  E-value: 2.53e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  88 AWSSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDP 167
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 168 ISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSfVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 247
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21312318 248 GHKNEKYCLfaSFSVTGrKWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:COG2319 160 GHSGAVTSV--AFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS--ADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
30-112 4.68e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 4.68e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWD 109
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                ...
gi 21312318 110 MRS 112
Cdd:COG2319 401 LAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 35-328 3.09e-16

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 79.36  E-value: 3.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   35 LAGHSAAISSVKFSPNGEWLASSAADALIIIWgaydgNCKKT-------------LYGHSlEISDVAWSSD-SSRLVSAS 100
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIF-----ECESIikdgrdihypvveLASRS-KLSGICWNSYiKSQVASSN 552

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  101 DDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPS-NLIVSGSFDESVKIWEVKTGKCLKTLSAHSDpISAVNFNCN-GS 178
Cdd:PLN00181 553 FEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGR 631

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  179 LIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATlDNTLKLWDYSRGRC------LKTYTGHKNE 252
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNV 710

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21312318  253 KYclFASFSVTGrKWVVSGSEDNMVYIWnlqtkeivqrlqgHTDVVISAACHPTKNIIASAALENDKTIKVWSSDC 328
Cdd:PLN00181 711 KN--FVGLSVSD-GYIATGSETNEVFVY-------------HKAFPMPVLSYKFKTIDPVSGLEVDDASQFISSVC 770
PTZ00421 PTZ00421
coronin; Provisional
 77-197 6.71e-13

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 69.15  E-value: 6.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   77 LYGHSLEISDVAWSS-DSSRLVSASDDKTLKVWDM-------RSGKCLKTLKGHSDFVFCCDFNPPS-NLIVSGSFDESV 147
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 21312318  148 KIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASG 197
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 154-193 6.39e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 6.39e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21312318    154 TGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 8.34e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 8.34e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21312318    112 SGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWE 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 70-109 1.30e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.30e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21312318     70 DGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWD 109
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
155-193 2.69e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 2.69e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21312318   155 GKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWD 193
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
113-151 4.99e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 4.99e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21312318   113 GKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWE 151
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
71-109 5.14e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 5.14e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21312318    71 GNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWD 109
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 35-153 7.05e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.82  E-value: 7.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   35 LAGHSAAISSVKFSPNGE-WLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDMRSG 113
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 21312318  114 KCLKTLKGH-SDFVFCCDFNPPSNLIVSGSFDES----VKIWEVK 153
Cdd:PTZ00421 201 TIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSKSqqrqIMLWDTR 245
PTZ00421 PTZ00421
coronin; Provisional
 35-164 5.16e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.13  E-value: 5.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   35 LAGHSAAISSVKFSP-NGEWLASSAADALIIIWG-AYDG---NCKKT---LYGHSLEISDVAW-SSDSSRLVSASDDKTL 105
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGltqNISDPivhLQGHTKKVGIVSFhPSAMNVLASAGADMVV 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 21312318  106 KVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAH 164
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 102-325 6.89e-08

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 53.15  E-value: 6.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   102 DKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLK---------------------- 159
Cdd:pfam20426 103 ENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpf 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   160 -TLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTAtlDNTLKLWDYS 238
Cdd:pfam20426 183 hILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYA--DDDLSLHLYS 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   239 rgrclktytghKNEKYclFASFSVTGR----------KWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKN 308
Cdd:pfam20426 261 -----------INGKH--IASSESNGRlncielsscgEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEEC 327

                         250
                  ....*....|....*..
gi 21312318   309 IIASAaleNDKTIKVWS 325
Cdd:pfam20426 328 FLAGT---KDGSLLVYS 341
WD40 pfam00400
WD domain, G-beta repeat;
34-66 4.56e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 4.56e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 21312318    34 TLAGHSAAISSVKFSPNGEWLASSAADALIIIW 66
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 34-66 7.93e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.93e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 21312318     34 TLAGHSAAISSVKFSPNGEWLASSAADALIIIW 66
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 110-193 8.31e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 8.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  110 MRSGKCLKtLKGHSDFVFCCDFNPP-SNLIVSGSFDESVKIW----------EVKTGKCLktLSAHSDPISAVNFN-CNG 177
Cdd:PTZ00420  62 MRKPPVIK-LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWeiphndesvkEIKDPQCI--LKGHKKKISIIDWNpMNY 138

                         90
                 ....*....|....*.
gi 21312318  178 SLIVSGSYDGLCRIWD 193
Cdd:PTZ00420 139 YIMCSSGFDSFVNIWD 154
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
30-240 1.40e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 1.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318  30 ALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNC--KKTLYGHSLEISDVAWSSDSSRL-VSASDDKTLK 106
Cdd:COG3391  14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLagLGLGAAAVADADGADAGADGRRLyVANSGSGRVS 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 107 VWDMRSGKCLKTLKGHSD---FVFCCDFNppsNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPIS-AVNFNcNGSLIVS 182
Cdd:COG3391  94 VIDLATGKVVATIPVGGGprgLAVDPDGG---RLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGiAVDPD-GKRLYVA 169

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21312318 183 GSYDGlcRIW------DAASGQCLRTLaDEGNPPVsFVKFSPNGKYILTA--------TLDNTLKLWDYSRG 240
Cdd:COG3391 170 NSGSN--TVSvivsviDTATGKVVATI-PVGGGPV-GVAVSPDGRRLYVAnrgsntsnGGSNTVSVIDLATL 237
PTZ00420 PTZ00420
coronin; Provisional
 77-156 1.50e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   77 LYGHSLEISDVAWSSDSSR-LVSASDDKTLKVWDMR----SGKCLK----TLKGHSDFVFCCDFNPPSNLIV-SGSFDES 146
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEiLASGSEDLTIRVWEIPhndeSVKEIKdpqcILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149

                         90
                 ....*....|
gi 21312318  147 VKIWEVKTGK 156
Cdd:PTZ00420 150 VNIWDIENEK 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-236 2.41e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.41e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21312318    196 SGQCLRTLADEGNPpVSFVKFSPNGKYILTATLDNTLKLWD 236
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 112-274 4.22e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 44.68  E-value: 4.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   112 SGKCLKTLKGHSDfvfccdfnppSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRI 191
Cdd:pfam20426  81 GAQCFATLQTPSE----------NFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   192 WDAasgqcLRTLADEGNPPVSFVKFsPNGKYILTATLDNTLklwdysrgrClktytGHKNEKYCLFASFSVtgrKWVVSG 271
Cdd:pfam20426 151 WEV-----LRGRSSEKRSRNTQTEF-PRKDHVIAETPFHIL---------C-----GHDDIITCLYVSVEL---DIVISG 207


                  ...
gi 21312318   272 SED 274
Cdd:pfam20426 208 SKD 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 284-325 5.39e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.39e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 21312318    284 TKEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
137-284 8.29e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 8.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 137 LIVSGSFDESVKIWEVKTGKCLKTLSAHSDPIS-AVNFNcNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPpvSFVK 215
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGlAVDPD-GGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP--HGIA 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318 216 FSPNGKYILTA-TLDNT----LKLWDYSRGRCLKTYTGHKNekyCLFASFSVTGRK-WVV------SGSEDNMVYIWNLQ 283
Cdd:COG3391 159 VDPDGKRLYVAnSGSNTvsviVSVIDTATGKVVATIPVGGG---PVGVAVSPDGRRlYVAnrgsntSNGGSNTVSVIDLA 235


                .
gi 21312318 284 T 284
Cdd:COG3391 236 T 236
WD40 pfam00400
WD domain, G-beta repeat;
197-236 1.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21312318   197 GQCLRTLADEGNPpVSFVKFSPNGKYILTATLDNTLKLWD 236
Cdd:pfam00400   1 GKLLKTLEGHTGS-VTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
240-281 1.49e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21312318   240 GRCLKTYTGHKNEKYCLfaSFSVTGrKWVVSGSEDNMVYIWN 281
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSL--AFSPDG-KLLASGSDDGTVKVWD 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
211-275 2.29e-04

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 42.71  E-value: 2.29e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21312318 211 VSFVKFSPNGKYILTATLdNTLKLWDYSRGR-CLKTYTGHKN---------EKYCLFASFSVT---GRKWVVSGSEDN 275
Cdd:COG5170 283 ISDFKFSDNGRYILSRDY-LTVKIWDVNMAKnPIKTIPMHCDlmdelndvyENDAIFDKFEISfsgDDKHVLSGSYSN 359
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 137-254 4.17e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.72  E-value: 4.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318   137 LIVSGSFDESVKIWEVKtgkCLKTLSAHSDPISAVNFNCNGSLIVS---GSYDGLCRIWDAASGQCLRTlADEGNppVSF 213
Cdd:pfam08662  75 AVIYGYMPAKVSFFDLK---GNVIHSFGEQPRNTIFWSPFGRLVLLagfGNLAGDIEFWDVVNKKKIAT-AEASN--ATL 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 21312318   214 VKFSPNGKYILTATL------DNTLKLWDYSrGRCLktYTGHKNEKY 254
Cdd:pfam08662 149 CEWSPDGRYFLTATTaprlrvDNGFKIWHYN-GALV--YKYDFDELY 192
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 79-185 5.76e-04

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 41.29  E-value: 5.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312318    79 GHSlEISDVAWSSDSSRLVSASDDKTLKVW-----DMRSGKCLKTLKGH-----SDFVFCCDFNPPSN------LIVSGS 142
Cdd:pfam16529 185 EHS-LLVDAAFSPDGTALATASLDGEVKFFqiylfDNRNPRCLHEWKPHdgkplSSLFFLDNHKKPPEvqfwrfAITGAD 263

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 21312318   143 FDESVKIWEVKTGKCLKTLSAHSDPISAVNFNC-NGSLIVSGSY 185
Cdd:pfam16529 264 NNSELKLWSCESWTCLQTIRFVPDPPSSLQPPNlKAGLDLSANY 307
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 240-281 1.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 21312318    240 GRCLKTYTGHKNEKYCLfaSFSVTGrKWVVSGSEDNMVYIWN 281
Cdd:smart00320   2 GELLKTLKGHTGPVTSV--AFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
285-325 1.26e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21312318   285 KEIVQRLQGHTDVVISAACHPTKNIIASAAleNDKTIKVWS 325
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 131-176 7.18e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 7.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21312318   131 FNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCN 176
Cdd:pfam12894  46 WRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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