NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|226342960|ref|NP_081455|]
View 

very-long-chain enoyl-CoA reductase isoform 2 [Mus musculus]

Protein Classification

Ubl1_cv_Nsp3_N-like and PLN02560 superfamily-containing protein( domain architecture ID 1012136)

Ubl1_cv_Nsp3_N-like and PLN02560 superfamily-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02560 super family cl28409
enoyl-CoA reductase
 38-290 3.36e-79

enoyl-CoA reductase


The actual alignment was detected with superfamily member PLN02560:

Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 242.32  E-value: 3.36e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960  38 KTQGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFrVPFIYGR-KYDFTSSRHTVVHLAC 116
Cdd:PLN02560  55 KTRPTVLDDSKSLKDYGLGDGGTVVFKDLGPQVSYRTLFFFEYLGPLLIYPLFYF-FPQVYKYfGYPARRVIHPVQTYAM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960 117 MCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPtyGVQQVKLALAVFVICQLGNFSI 196
Cdd:PLN02560 134 YYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWTFGAYIAYFVNHPLYTPV--SETQMKVGFGFGLVCQLANFYC 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960 197 HMALRDLR-PAGSKTRKIPYptknpfTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYL 275
Cdd:PLN02560 212 HIILRNLRkPDGKGGYQIPR------GFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLK 285

                        250       260
                 ....*....|....*....|
gi 226342960 276 KEF-----RDYPPLRMPIIP 290
Cdd:PLN02560 286 KLFdgkdgRPKYPRRWVILP 305
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 3-66 2.58e-34

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17124:

Pssm-ID: 475130 [Multi-domain]  Cd Length: 79  Bit Score: 119.67  E-value: 2.58e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342960   3 HYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKT---------------QGKSLKDEDVLQKLPVGTTATLYFRDL 66
Cdd:cd17124    1 FFEVEILDAKTKEKLCFLDKVEPNATIGEIKNLFHKShpqwyparqslrldpKGKSLKDEDILQNLPVGTTATFYFRDL 79
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 38-290 3.36e-79

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 242.32  E-value: 3.36e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960  38 KTQGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFrVPFIYGR-KYDFTSSRHTVVHLAC 116
Cdd:PLN02560  55 KTRPTVLDDSKSLKDYGLGDGGTVVFKDLGPQVSYRTLFFFEYLGPLLIYPLFYF-FPQVYKYfGYPARRVIHPVQTYAM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960 117 MCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPtyGVQQVKLALAVFVICQLGNFSI 196
Cdd:PLN02560 134 YYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWTFGAYIAYFVNHPLYTPV--SETQMKVGFGFGLVCQLANFYC 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960 197 HMALRDLR-PAGSKTRKIPYptknpfTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYL 275
Cdd:PLN02560 212 HIILRNLRkPDGKGGYQIPR------GFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLK 285

                        250       260
                 ....*....|....*....|
gi 226342960 276 KEF-----RDYPPLRMPIIP 290
Cdd:PLN02560 286 KLFdgkdgRPKYPRRWVILP 305
Ubl_TECR cd17124
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed ...
 3-66 2.58e-34

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR homolog (TSC13p) is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340644 [Multi-domain]  Cd Length: 79  Bit Score: 119.67  E-value: 2.58e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342960   3 HYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKT---------------QGKSLKDEDVLQKLPVGTTATLYFRDL 66
Cdd:cd17124    1 FFEVEILDAKTKEKLCFLDKVEPNATIGEIKNLFHKShpqwyparqslrldpKGKSLKDEDILQNLPVGTTATFYFRDL 79
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 140-293 4.61e-28

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 105.56  E-value: 4.61e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960  140 TMPLRNIFKNCTY--YWGF--AAWMAYYinhPLYTPPTYGVQQVKLALAVFVICQLGNFSIHMALRDLRPAGSKTRKIPy 215
Cdd:pfam02544   2 TMPLTIVAKAFAFctLNGLiqGRYNSYY---QPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIP- 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342960  216 ptknpFTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL 293
Cdd:pfam02544  78 -----RGGLFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 38-290 3.36e-79

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 242.32  E-value: 3.36e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960  38 KTQGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFrVPFIYGR-KYDFTSSRHTVVHLAC 116
Cdd:PLN02560  55 KTRPTVLDDSKSLKDYGLGDGGTVVFKDLGPQVSYRTLFFFEYLGPLLIYPLFYF-FPQVYKYfGYPARRVIHPVQTYAM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960 117 MCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPtyGVQQVKLALAVFVICQLGNFSI 196
Cdd:PLN02560 134 YYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWTFGAYIAYFVNHPLYTPV--SETQMKVGFGFGLVCQLANFYC 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960 197 HMALRDLR-PAGSKTRKIPYptknpfTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYL 275
Cdd:PLN02560 212 HIILRNLRkPDGKGGYQIPR------GFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLK 285

                        250       260
                 ....*....|....*....|
gi 226342960 276 KEF-----RDYPPLRMPIIP 290
Cdd:PLN02560 286 KLFdgkdgRPKYPRRWVILP 305
Ubl_TECR cd17124
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed ...
 3-66 2.58e-34

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR homolog (TSC13p) is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340644 [Multi-domain]  Cd Length: 79  Bit Score: 119.67  E-value: 2.58e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342960   3 HYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKT---------------QGKSLKDEDVLQKLPVGTTATLYFRDL 66
Cdd:cd17124    1 FFEVEILDAKTKEKLCFLDKVEPNATIGEIKNLFHKShpqwyparqslrldpKGKSLKDEDILQNLPVGTTATFYFRDL 79
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 140-293 4.61e-28

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 105.56  E-value: 4.61e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960  140 TMPLRNIFKNCTY--YWGF--AAWMAYYinhPLYTPPTYGVQQVKLALAVFVICQLGNFSIHMALRDLRPAGSKTRKIPy 215
Cdd:pfam02544   2 TMPLTIVAKAFAFctLNGLiqGRYNSYY---QPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIP- 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342960  216 ptknpFTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL 293
Cdd:pfam02544  78 -----RGGLFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
Ubl_TECR_like cd01801
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; ...
 5-66 2.98e-10

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; This family includes TECR and many TECR-like proteins, such as TECRL. TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR (TSC13) homolog is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain. TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life-threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both TECR and TECRL contain an N-terminal Ubl domain with a beta-grasp Ubl fold, and a C-terminal catalytic domain.


Pssm-ID: 340499 [Multi-domain]  Cd Length: 77  Bit Score: 55.37  E-value: 2.98e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342960   5 EVEIRDAKTReKLCFLDKVEPQATISEIKTLFTKT----------------QGKSLKDEDVLQKLPVGTTATLYFRDL 66
Cdd:cd01801    1 KIEVVSRKGG-KQIITLEVSSSATVADLKKAIHKKkkklyperqrlrlevpKGKVLKDDKTLSSYGVKDGSTLYFKDL 77
Ubl_TECRL cd17125
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase-like (TECRL); TECRL, also ...
 4-66 8.98e-10

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase-like (TECRL); TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life?threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). TECRL contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340645  Cd Length: 78  Bit Score: 54.10  E-value: 8.98e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342960   4 YEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKT---------------QGKSLKDEDVLQKLPVGTTATLYFRDL 66
Cdd:cd17125    1 FEVEILDAQTRKQICVVDKVHPSSTILDVKIKFHKTcpqwypsrvglqlerNGPFLKDSCEIQSIAVSSIVTLYFTDL 78
PLN02392 PLN02392
probable steroid reductase DET2
 218-292 1.10e-06

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 49.04  E-value: 1.10e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342960 218 KNPFTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEF-RDYPPLRMPIIPFL 292
Cdd:PLN02392 184 KVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLEKFgEDYPKGRKAVIPFL 259
PLN03164 PLN03164
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional
 181-292 3.62e-04

3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional


Pssm-ID: 215610 [Multi-domain]  Cd Length: 323  Bit Score: 41.34  E-value: 3.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342960 181 LALAVFVICQLGNFSIHMALRDLRPAGSKTRK--IPYPTknpftWlFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLV 258
Cdd:PLN03164 213 IGAAIFLWGWIHQYRCHAILGSLREHKKQADEyvIPYGD-----W-FEMVSCPHYLAEIVIYAGLLIASGGTDLTIWLLF 286

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 226342960 259 GF--TQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFL 292
Cdd:PLN03164 287 GFvvANLTFAAAETHRWYLQKFENYPRNRYAIIPFV 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH