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Conserved domains on  [gi|58037173|ref|NP_081462|]
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RPA-interacting protein isoform 1 [Mus musculus]

Protein Classification

RPA_interact_N and RPA_interact_C domain-containing protein( domain architecture ID 10632122)

protein containing domains RPA_interact_N, RPA_interact_M, and RPA_interact_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPA_interact_C pfam14768
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-217 5.40e-27

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


:

Pssm-ID: 464305  Cd Length: 80  Bit Score: 98.52  E-value: 5.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037173   136 ICPVCIKYNLRIMNSVVTCPCGLHIPVHStDLTEQKLRACLEENVNEHSVHCPHTPVFSVTGGTEEKpSLLMNCLTCDTW 215
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLNTGD-SITLEHLRALLEEAVTEHSEGCSSTPQFSVEPGFGLS-SLYLSCESCDFL 78


                  ..
gi 58037173   216 AV 217
Cdd:pfam14768  79 EV 80
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 1.11e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


:

Pssm-ID: 464304  Cd Length: 39  Bit Score: 67.93  E-value: 1.11e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 58037173     8 PHRLLYKQVgSPHWKETFRQGCLERMRNSRHRLLNKYRQA 47
Cdd:pfam14766   1 PRRASYKSR-SPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M super family cl20690
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 59-127 5.18e-09

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


The actual alignment was detected with superfamily member pfam14767:

Pssm-ID: 434193  Cd Length: 82  Bit Score: 51.65  E-value: 5.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037173    59 LLVQEVMEEEWASLQSVENCPEALLQLELPLDL-------------AVLQDIEQELCNEEKSIISEYEEDLEFDESCLRR 125
Cdd:pfam14767   1 SAVQEVMSDELEKLKQSSTSLPSLKIPTADNDDmgesedillemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAA 80


                  ..
gi 58037173   126 ML 127
Cdd:pfam14767  81 AV 82
 
Name Accession Description Interval E-value
RPA_interact_C pfam14768
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-217 5.40e-27

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


Pssm-ID: 464305  Cd Length: 80  Bit Score: 98.52  E-value: 5.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037173   136 ICPVCIKYNLRIMNSVVTCPCGLHIPVHStDLTEQKLRACLEENVNEHSVHCPHTPVFSVTGGTEEKpSLLMNCLTCDTW 215
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLNTGD-SITLEHLRALLEEAVTEHSEGCSSTPQFSVEPGFGLS-SLYLSCESCDFL 78


                  ..
gi 58037173   216 AV 217
Cdd:pfam14768  79 EV 80
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 1.11e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


Pssm-ID: 464304  Cd Length: 39  Bit Score: 67.93  E-value: 1.11e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 58037173     8 PHRLLYKQVgSPHWKETFRQGCLERMRNSRHRLLNKYRQA 47
Cdd:pfam14766   1 PRRASYKSR-SPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 59-127 5.18e-09

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


Pssm-ID: 434193  Cd Length: 82  Bit Score: 51.65  E-value: 5.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037173    59 LLVQEVMEEEWASLQSVENCPEALLQLELPLDL-------------AVLQDIEQELCNEEKSIISEYEEDLEFDESCLRR 125
Cdd:pfam14767   1 SAVQEVMSDELEKLKQSSTSLPSLKIPTADNDDmgesedillemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAA 80


                  ..
gi 58037173   126 ML 127
Cdd:pfam14767  81 AV 82
 
Name Accession Description Interval E-value
RPA_interact_C pfam14768
Replication protein A interacting C-terminal; This family of proteins represents the ...
 136-217 5.40e-27

Replication protein A interacting C-terminal; This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger.


Pssm-ID: 464305  Cd Length: 80  Bit Score: 98.52  E-value: 5.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037173   136 ICPVCIKYNLRIMNSVVTCPCGLHIPVHStDLTEQKLRACLEENVNEHSVHCPHTPVFSVTGGTEEKpSLLMNCLTCDTW 215
Cdd:pfam14768   1 ICPVCQKGNLRENSNFISCSCGLRLNTGD-SITLEHLRALLEEAVTEHSEGCSSTPQFSVEPGFGLS-SLYLSCESCDFL 78


                  ..
gi 58037173   216 AV 217
Cdd:pfam14768  79 EV 80
RPA_interact_N pfam14766
Replication protein A interacting N-terminal; This family of proteins represents the ...
 8-47 1.11e-15

Replication protein A interacting N-terminal; This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta.


Pssm-ID: 464304  Cd Length: 39  Bit Score: 67.93  E-value: 1.11e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 58037173     8 PHRLLYKQVgSPHWKETFRQGCLERMRNSRHRLLNKYRQA 47
Cdd:pfam14766   1 PRRASYKSR-SPPWKETLRERCLERLRESRQQLLWKFRSG 39
RPA_interact_M pfam14767
Replication protein A interacting middle; This family of proteins represents the middle domain ...
 59-127 5.18e-09

Replication protein A interacting middle; This family of proteins represents the middle domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA.


Pssm-ID: 434193  Cd Length: 82  Bit Score: 51.65  E-value: 5.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037173    59 LLVQEVMEEEWASLQSVENCPEALLQLELPLDL-------------AVLQDIEQELCNEEKSIISEYEEDLEFDESCLRR 125
Cdd:pfam14767   1 SAVQEVMSDELEKLKQSSTSLPSLKIPTADNDDmgesedillemelALYEDIQQELMSQELSILEEYEESLQEEEEYLAA 80


                  ..
gi 58037173   126 ML 127
Cdd:pfam14767  81 AV 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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