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Conserved domains on  [gi|31980620|ref|NP_081555|]
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histidine protein methyltransferase 1 homolog [Mus musculus]

Protein Classification

AdoMet_MTases superfamily-containing protein( domain architecture ID 1938676)

AdoMet_MTases superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnt1 super family cl43977
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 176-312 1.57e-10

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3897:

Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 60.28  E-value: 1.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980620 176 FAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDEVTLpNVVAN-VPLqddsngknepdgkrqrksevgreicKC 254
Cdd:COG3897  69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRL-NAALNgVAI-------------------------TT 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31980620 255 RLfsGEWAEFcklvlreKLFVKYDLILTSETIYNPDYYSTLHETFLRLLSRSGRVLLA 312
Cdd:COG3897 123 RL--GDWRDP-------PAAGGFDLILGGDVLYERDLAEPLLPFLDRLAAPGGEVLIG 171
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-201 9.53e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member PRK14968:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 188  Bit Score: 36.80  E-value: 9.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 31980620  149 PGVYEGGlkiwECTFDLLTYftkAKVKfAGQKVLDLGCGSGLLGITASKGGAR 201
Cdd:PRK14968   3 DEVYEPA----EDSFLLAEN---AVDK-KGDRVLEVGTGSGIVAIVAAKNGKK 47
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 176-312 1.57e-10

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 60.28  E-value: 1.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980620 176 FAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDEVTLpNVVAN-VPLqddsngknepdgkrqrksevgreicKC 254
Cdd:COG3897  69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRL-NAALNgVAI-------------------------TT 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31980620 255 RLfsGEWAEFcklvlreKLFVKYDLILTSETIYNPDYYSTLHETFLRLLSRSGRVLLA 312
Cdd:COG3897 123 RL--GDWRDP-------PAAGGFDLILGGDVLYERDLAEPLLPFLDRLAAPGGEVLIG 171
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 155-314 2.21e-08

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 53.10  E-value: 2.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980620   155 GLKIWECTFDLLTYFTKA------KVKFAGQKVLDLGCGSGLLGIT-ASKGGAREVHFQDYnglvidEVTLPNVVANVPL 227
Cdd:pfam10294  18 GGHVWDAAVVLSKYLEMKifkelgANNLSGLNVLELGSGTGLVGIAvALLLPGASVTITDL------EEALELLKKNIEL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980620   228 qddsngkNEPDGKRQRKSevgreickcrLFsgeWAEfcklVLREKLFVK--YDLILTSETIYNPDYYSTLHETFLRLLSR 305
Cdd:pfam10294  92 -------NALSSKVVVKV----------LD---WGE----NLPPDLFDGhpVDLILAADCVYNEDSFPLLEKTLKDLLGK 147


                  ....*....
gi 31980620   306 SGRVLLASK 314
Cdd:pfam10294 148 ESVILVAYK 156
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
172-225 7.30e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 49.77  E-value: 7.30e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 31980620  172 AKVKFAGQKVLDLGCGSGLLGITASKGGAREVHfqdynGLVIDEVTLPNVVANV 225
Cdd:PRK00517 114 EKLVLPGKTVLDVGCGSGILAIAAAKLGAKKVL-----AVDIDPQAVEAARENA 162
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 178-237 4.24e-05

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 44.82  E-value: 4.24e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31980620   178 GQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIdEVTLPNVVAN-VP--LQDDSNGKNEP 237
Cdd:TIGR00406 160 DKNVIDVGCGSGILSIAALKLGAAKVVGIDIDPLAV-ESARKNAELNqVSdrLQVKLIYLEQP 221
PRK14968 PRK14968
putative methyltransferase; Provisional
 149-201 9.53e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.80  E-value: 9.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 31980620  149 PGVYEGGlkiwECTFDLLTYftkAKVKfAGQKVLDLGCGSGLLGITASKGGAR 201
Cdd:PRK14968   3 DEVYEPA----EDSFLLAEN---AVDK-KGDRVLEVGTGSGIVAIVAAKNGKK 47
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 176-312 1.57e-10

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 60.28  E-value: 1.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980620 176 FAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDEVTLpNVVAN-VPLqddsngknepdgkrqrksevgreicKC 254
Cdd:COG3897  69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRL-NAALNgVAI-------------------------TT 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31980620 255 RLfsGEWAEFcklvlreKLFVKYDLILTSETIYNPDYYSTLHETFLRLLSRSGRVLLA 312
Cdd:COG3897 123 RL--GDWRDP-------PAAGGFDLILGGDVLYERDLAEPLLPFLDRLAAPGGEVLIG 171
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 155-314 2.21e-08

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 53.10  E-value: 2.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980620   155 GLKIWECTFDLLTYFTKA------KVKFAGQKVLDLGCGSGLLGIT-ASKGGAREVHFQDYnglvidEVTLPNVVANVPL 227
Cdd:pfam10294  18 GGHVWDAAVVLSKYLEMKifkelgANNLSGLNVLELGSGTGLVGIAvALLLPGASVTITDL------EEALELLKKNIEL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980620   228 qddsngkNEPDGKRQRKSevgreickcrLFsgeWAEfcklVLREKLFVK--YDLILTSETIYNPDYYSTLHETFLRLLSR 305
Cdd:pfam10294  92 -------NALSSKVVVKV----------LD---WGE----NLPPDLFDGhpVDLILAADCVYNEDSFPLLEKTLKDLLGK 147


                  ....*....
gi 31980620   306 SGRVLLASK 314
Cdd:pfam10294 148 ESVILVAYK 156
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
172-225 1.46e-07

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 52.10  E-value: 1.46e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 31980620 172 AKVKFAGQKVLDLGCGSGLLGITASKGGAREVHFQDynglvIDEVTLPNVVANV 225
Cdd:COG2264 143 EKLLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVD-----IDPVAVEAARENA 191
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
172-225 7.30e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 49.77  E-value: 7.30e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 31980620  172 AKVKFAGQKVLDLGCGSGLLGITASKGGAREVHfqdynGLVIDEVTLPNVVANV 225
Cdd:PRK00517 114 EKLVLPGKTVLDVGCGSGILAIAAAKLGAKKVL-----AVDIDPQAVEAARENA 162
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 177-218 1.93e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 45.72  E-value: 1.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 31980620   177 AGQKVLDLGCGSGLLGITASKGGAREVHfqdynGLVIDEVTL 218
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVV-----GVDIDPVAV 197
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 178-237 4.24e-05

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 44.82  E-value: 4.24e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31980620   178 GQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIdEVTLPNVVAN-VP--LQDDSNGKNEP 237
Cdd:TIGR00406 160 DKNVIDVGCGSGILSIAALKLGAAKVVGIDIDPLAV-ESARKNAELNqVSdrLQVKLIYLEQP 221
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
171-215 6.98e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 43.49  E-value: 6.98e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 31980620 171 KAKVKfAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDE 215
Cdd:COG4076  30 ERVVK-PGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAV 73
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
176-218 5.00e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 40.66  E-value: 5.00e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 31980620 176 FAGQKVLDLGCGSGLLGITASKGGAREVHFQDynglvIDEVTL 218
Cdd:COG2263  44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVD-----IDPEAL 81
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 177-207 4.88e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 37.86  E-value: 4.88e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 31980620 177 AGQKVLDLGCGSGLLGIT-ASKGGAREVHFQD 207
Cdd:COG2813  49 LGGRVLDLGCGYGVIGLAlAKRNPEARVTLVD 80
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 165-193 6.25e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 37.82  E-value: 6.25e-03
                        10        20
                ....*....|....*....|....*....
gi 31980620 165 LLTYFTKAKvkfAGQKVLDLGCGSGLLGI 193
Cdd:COG4123  28 LLAAFAPVK---KGGRVLDLGTGTGVIAL 53
PRK14968 PRK14968
putative methyltransferase; Provisional
 149-201 9.53e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.80  E-value: 9.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 31980620  149 PGVYEGGlkiwECTFDLLTYftkAKVKfAGQKVLDLGCGSGLLGITASKGGAR 201
Cdd:PRK14968   3 DEVYEPA----EDSFLLAEN---AVDK-KGDRVLEVGTGSGIVAIVAAKNGKK 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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