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Conserved domains on  [gi|47498088|ref|NP_081696|]
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arpin [Mus musculus]

Protein Classification

arpin( domain architecture ID 10566018)

arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UPF0552 pfam10574
Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting ...
1-224 1.67e-152

Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting proteins (Arpin). Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex. It induces cell turning by pausing cell migration.


:

Pssm-ID: 463152  Cd Length: 224  Bit Score: 422.20  E-value: 1.67e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47498088     1 MSRIYQDSALRNKAVQSARLPGTWDPATHQGGNGILLEGELVDVSRHSILDAHGRKERYYVLYIQPSCIHRRKFDPKGNE 80
Cdd:pfam10574   1 MSRIYDNTALQNKPVHNEKLPGVWDPSAYQSGSGVILEGRLVDRSRHSITDASGRKERYYVLYLRPSRAHRRKFDSKGKE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47498088    81 IEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTLEALKSLVNKPQLLELTESLTPDQAVAFWMPESEMEVMELELGTGVRL 160
Cdd:pfam10574  81 IEPNFSDTKKVNTGYLMSSYKVEAKGQSDRLSEDQLKALVNKTELLKVTEKHTPSGTLAFWLPEAEMEKTELELGDEVRL 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47498088   161 KTRGDGPFIDSLAKLELGTVTKCNFAGDGKTGASWTDNIMAQKSSERNTAEIREQGDGAEDEEW 224
Cdd:pfam10574 161 KTRGDGPFIFSLAKLDAGTVTKCNFAGDDKVGASWTDKIMANKSDQESASEPRGQGDGAEDDEW 224
 
Name Accession Description Interval E-value
UPF0552 pfam10574
Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting ...
1-224 1.67e-152

Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting proteins (Arpin). Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex. It induces cell turning by pausing cell migration.


Pssm-ID: 463152  Cd Length: 224  Bit Score: 422.20  E-value: 1.67e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47498088     1 MSRIYQDSALRNKAVQSARLPGTWDPATHQGGNGILLEGELVDVSRHSILDAHGRKERYYVLYIQPSCIHRRKFDPKGNE 80
Cdd:pfam10574   1 MSRIYDNTALQNKPVHNEKLPGVWDPSAYQSGSGVILEGRLVDRSRHSITDASGRKERYYVLYLRPSRAHRRKFDSKGKE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47498088    81 IEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTLEALKSLVNKPQLLELTESLTPDQAVAFWMPESEMEVMELELGTGVRL 160
Cdd:pfam10574  81 IEPNFSDTKKVNTGYLMSSYKVEAKGQSDRLSEDQLKALVNKTELLKVTEKHTPSGTLAFWLPEAEMEKTELELGDEVRL 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47498088   161 KTRGDGPFIDSLAKLELGTVTKCNFAGDGKTGASWTDNIMAQKSSERNTAEIREQGDGAEDEEW 224
Cdd:pfam10574 161 KTRGDGPFIFSLAKLDAGTVTKCNFAGDDKVGASWTDKIMANKSDQESASEPRGQGDGAEDDEW 224
 
Name Accession Description Interval E-value
UPF0552 pfam10574
Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting ...
1-224 1.67e-152

Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting proteins (Arpin). Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex. It induces cell turning by pausing cell migration.


Pssm-ID: 463152  Cd Length: 224  Bit Score: 422.20  E-value: 1.67e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47498088     1 MSRIYQDSALRNKAVQSARLPGTWDPATHQGGNGILLEGELVDVSRHSILDAHGRKERYYVLYIQPSCIHRRKFDPKGNE 80
Cdd:pfam10574   1 MSRIYDNTALQNKPVHNEKLPGVWDPSAYQSGSGVILEGRLVDRSRHSITDASGRKERYYVLYLRPSRAHRRKFDSKGKE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47498088    81 IEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTLEALKSLVNKPQLLELTESLTPDQAVAFWMPESEMEVMELELGTGVRL 160
Cdd:pfam10574  81 IEPNFSDTKKVNTGYLMSSYKVEAKGQSDRLSEDQLKALVNKTELLKVTEKHTPSGTLAFWLPEAEMEKTELELGDEVRL 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47498088   161 KTRGDGPFIDSLAKLELGTVTKCNFAGDGKTGASWTDNIMAQKSSERNTAEIREQGDGAEDEEW 224
Cdd:pfam10574 161 KTRGDGPFIFSLAKLDAGTVTKCNFAGDDKVGASWTDKIMANKSDQESASEPRGQGDGAEDDEW 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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