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Conserved domains on  [gi|110625792|ref|NP_081917|]
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sperm flagellar protein 1 [Mus musculus]

Protein Classification

calponin homology domain-containing protein( domain architecture ID 10533622)

calponin homology (CH) domain-containing protein may bind actin filament (F-actin) or serve a regulatory function

CATH:  1.10.418.10
Gene Ontology:  GO:0008017
PubMed:  12186940|11911887

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_2 pfam06294
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
 13-104 2.42e-45

CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.


:

Pssm-ID: 461871  Cd Length: 91  Bit Score: 146.42  E-value: 2.42e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625792   13 LYLWVDNIPLSRPKRNLSRDFSDGVLVAELIKFYFPKMVEMHNYVPANSLQQKLSNWGHLnRKVLNKLNFSVPDDVMRKI 92
Cdd:pfam06294   1 LLKWLQSLDLSRPVRNIARDFSDGFLVAEILSRYYPKLVDLHNYSPGSSVAAKLNNWETL-EKVLKKLGIKLSKEDIEDL 79

                          90
                  ....*....|..
gi 110625792   93 AQCSPGVVELVL 104
Cdd:pfam06294  80 ANGKPGAAERLL 91
 
Name Accession Description Interval E-value
CH_2 pfam06294
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
 13-104 2.42e-45

CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.


Pssm-ID: 461871  Cd Length: 91  Bit Score: 146.42  E-value: 2.42e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625792   13 LYLWVDNIPLSRPKRNLSRDFSDGVLVAELIKFYFPKMVEMHNYVPANSLQQKLSNWGHLnRKVLNKLNFSVPDDVMRKI 92
Cdd:pfam06294   1 LLKWLQSLDLSRPVRNIARDFSDGFLVAEILSRYYPKLVDLHNYSPGSSVAAKLNNWETL-EKVLKKLGIKLSKEDIEDL 79

                          90
                  ....*....|..
gi 110625792   93 AQCSPGVVELVL 104
Cdd:pfam06294  80 ANGKPGAAERLL 91
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 28-68 3.74e-03

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 35.75  E-value: 3.74e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 110625792    28 NLSRDFSDGVLVAELIKFYFPKMVEMHNYVPANSLQQKLSN 68
Cdd:smart00033  21 NFSSDLKDGVALCALLNSLSPGLVDKKKVAASLSRFKKIEN 61
 
Name Accession Description Interval E-value
CH_2 pfam06294
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
 13-104 2.42e-45

CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.


Pssm-ID: 461871  Cd Length: 91  Bit Score: 146.42  E-value: 2.42e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625792   13 LYLWVDNIPLSRPKRNLSRDFSDGVLVAELIKFYFPKMVEMHNYVPANSLQQKLSNWGHLnRKVLNKLNFSVPDDVMRKI 92
Cdd:pfam06294   1 LLKWLQSLDLSRPVRNIARDFSDGFLVAEILSRYYPKLVDLHNYSPGSSVAAKLNNWETL-EKVLKKLGIKLSKEDIEDL 79

                          90
                  ....*....|..
gi 110625792   93 AQCSPGVVELVL 104
Cdd:pfam06294  80 ANGKPGAAERLL 91
CAMSAP_CH pfam11971
CAMSAP CH domain; This domain is the N-terminal CH domain from the CAMSAP proteins.
 14-85 9.15e-14

CAMSAP CH domain; This domain is the N-terminal CH domain from the CAMSAP proteins.


Pssm-ID: 432229  Cd Length: 85  Bit Score: 64.63  E-value: 9.15e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625792   14 YLWVDNIPLSRPKRNLSRDFSDGVLVAELIKFYFPKMVEMHNYVPANSLQQKLS--NWGHLNRKVLNKLNFSVP 85
Cdd:pfam11971   1 PLSQRSLPLSPPVEDLLRDLSDGCALAALIHFYCPQLIDLEDICLKESMSLADSlyNIQLLQEFCQRHLGNRCC 74
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 28-68 3.74e-03

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 35.75  E-value: 3.74e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 110625792    28 NLSRDFSDGVLVAELIKFYFPKMVEMHNYVPANSLQQKLSN 68
Cdd:smart00033  21 NFSSDLKDGVALCALLNSLSPGLVDKKKVAASLSRFKKIEN 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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