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Conserved domains on  [gi|27229143|ref|NP_082299|]
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cell division cycle-associated protein 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SERTA pfam06031
SERTA motif; This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and ...
 33-68 3.90e-15

SERTA motif; This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif.


:

Pssm-ID: 461806  Cd Length: 36  Bit Score: 66.80  E-value: 3.90e-15
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 27229143    33 LLDMSLVKLQLCHMLVEPNLCRSVLIANTVRQIQEE 68
Cdd:pfam06031   1 VLNLSLDKLQRSRDLVEPSLRRSVLINNTLRRIQDE 36
GET2 super family cl07347
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 103-216 6.74e-03

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


The actual alignment was detected with superfamily member pfam08690:

Pssm-ID: 400847  Cd Length: 308  Bit Score: 37.00  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229143   103 GAEEEHPAPELEDAPlqnSVSELPIVGSAPGQRNPQSSLWEMDSPQenrgsfqksLDQIFETLENKNSSSVEELFSDVDS 182
Cdd:pfam08690  63 PSADEHDDPEIVDIS---EIASQPKKTASVPKKPPSSEESDPENPQ---------LDQMFKQLLGQQQQGGGENGQPAGS 130

                          90       100       110
                  ....*....|....*....|....*....|....
gi 27229143   183 SYYDLDTVLTGMMSGTKSSLCNGLEGFAAATPPP 216
Cdd:pfam08690 131 STPDLFSQMMKMMMQGGGGGPDGAPGTSSNPAEP 164
 
Name Accession Description Interval E-value
SERTA pfam06031
SERTA motif; This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and ...
 33-68 3.90e-15

SERTA motif; This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif.


Pssm-ID: 461806  Cd Length: 36  Bit Score: 66.80  E-value: 3.90e-15
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 27229143    33 LLDMSLVKLQLCHMLVEPNLCRSVLIANTVRQIQEE 68
Cdd:pfam06031   1 VLNLSLDKLQRSRDLVEPSLRRSVLINNTLRRIQDE 36
GET2 pfam08690
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 103-216 6.74e-03

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


Pssm-ID: 400847  Cd Length: 308  Bit Score: 37.00  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229143   103 GAEEEHPAPELEDAPlqnSVSELPIVGSAPGQRNPQSSLWEMDSPQenrgsfqksLDQIFETLENKNSSSVEELFSDVDS 182
Cdd:pfam08690  63 PSADEHDDPEIVDIS---EIASQPKKTASVPKKPPSSEESDPENPQ---------LDQMFKQLLGQQQQGGGENGQPAGS 130

                          90       100       110
                  ....*....|....*....|....*....|....
gi 27229143   183 SYYDLDTVLTGMMSGTKSSLCNGLEGFAAATPPP 216
Cdd:pfam08690 131 STPDLFSQMMKMMMQGGGGGPDGAPGTSSNPAEP 164
 
Name Accession Description Interval E-value
SERTA pfam06031
SERTA motif; This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and ...
 33-68 3.90e-15

SERTA motif; This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif.


Pssm-ID: 461806  Cd Length: 36  Bit Score: 66.80  E-value: 3.90e-15
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 27229143    33 LLDMSLVKLQLCHMLVEPNLCRSVLIANTVRQIQEE 68
Cdd:pfam06031   1 VLNLSLDKLQRSRDLVEPSLRRSVLINNTLRRIQDE 36
GET2 pfam08690
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 103-216 6.74e-03

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


Pssm-ID: 400847  Cd Length: 308  Bit Score: 37.00  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229143   103 GAEEEHPAPELEDAPlqnSVSELPIVGSAPGQRNPQSSLWEMDSPQenrgsfqksLDQIFETLENKNSSSVEELFSDVDS 182
Cdd:pfam08690  63 PSADEHDDPEIVDIS---EIASQPKKTASVPKKPPSSEESDPENPQ---------LDQMFKQLLGQQQQGGGENGQPAGS 130

                          90       100       110
                  ....*....|....*....|....*....|....
gi 27229143   183 SYYDLDTVLTGMMSGTKSSLCNGLEGFAAATPPP 216
Cdd:pfam08690 131 STPDLFSQMMKMMMQGGGGGPDGAPGTSSNPAEP 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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