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Conserved domains on  [gi|47059504|ref|NP_082371|]
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EEF1A lysine methyltransferase 2 isoform 1 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11423066)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 57-191 1.07e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


:

Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 70.33  E-value: 1.07e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  57 EIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLSNINLKVED 136
Cdd:COG0500   4 SYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAD 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504 137 FLNPSTklsgfhvcVDKGTYDAISLNpdNAI-----EKRKQYVMSLSRVLEVKGFFLITS 191
Cdd:COG0500  84 LAELDP--------LPAESFDLVVAF--GVLhhlppEEREALLRELARALKPGGVLLLSA 133
 
Name Accession Description Interval E-value
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 57-191 1.07e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 70.33  E-value: 1.07e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  57 EIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLSNINLKVED 136
Cdd:COG0500   4 SYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAD 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504 137 FLNPSTklsgfhvcVDKGTYDAISLNpdNAI-----EKRKQYVMSLSRVLEVKGFFLITS 191
Cdd:COG0500  84 LAELDP--------LPAESFDLVVAF--GVLhhlppEEREALLRELARALKPGGVLLLSA 133
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 80-214 5.61e-14

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 67.06  E-value: 5.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504    80 DASVLDIGTGNGVFLVELVKHGFSN--ITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPSTKLS--GFHVCVDKGT 155
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCV 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 47059504   156 YDAISlNPDNAIEKrkqyvmsLSRVLEVKGFFLITSCNWtKAELLDAFSEGFELFEELP 214
Cdd:pfam13847  84 LNHIP-DPDKVLQE-------ILRVLKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCV 133
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 83-190 2.61e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.90  E-value: 2.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  83 VLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPSTKLSG-FHVCVDKGTYDAISL 161
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADEsFDVIISDPPLHHLVE 81

                        90       100
                ....*....|....*....|....*....
gi 47059504 162 NPDNAIEKrkqyvmsLSRVLEVKGFFLIT 190
Cdd:cd02440  82 DLARFLEE-------ARRLLKPGGVLVLT 103
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 65-152 3.00e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 49.84  E-value: 3.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504   65 MNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGFsNITGIDYSPSAIKLSASILEKEGLS-NINLKVEDfLNPstk 143
Cdd:PRK07580  49 RDTVLSWLPADGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDISPQMVEEARERAPEAGLAgNITFEVGD-LES--- 123

                         90
                 ....*....|..
gi 47059504  144 LSG-FH--VCVD 152
Cdd:PRK07580 124 LLGrFDtvVCLD 135
 
Name Accession Description Interval E-value
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 57-191 1.07e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 70.33  E-value: 1.07e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  57 EIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLSNINLKVED 136
Cdd:COG0500   4 SYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAD 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504 137 FLNPSTklsgfhvcVDKGTYDAISLNpdNAI-----EKRKQYVMSLSRVLEVKGFFLITS 191
Cdd:COG0500  84 LAELDP--------LPAESFDLVVAF--GVLhhlppEEREALLRELARALKPGGVLLLSA 133
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 80-214 5.61e-14

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 67.06  E-value: 5.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504    80 DASVLDIGTGNGVFLVELVKHGFSN--ITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPSTKLS--GFHVCVDKGT 155
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCV 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 47059504   156 YDAISlNPDNAIEKrkqyvmsLSRVLEVKGFFLITSCNWtKAELLDAFSEGFELFEELP 214
Cdd:pfam13847  84 LNHIP-DPDKVLQE-------ILRVLKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCV 133
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 83-159 4.89e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 57.57  E-value: 4.89e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47059504    83 VLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLsNINLKVEDFLNPStklsgfhvcVDKGTYDAI 159
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLP---------FPDGSFDLV 67
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 67-193 8.90e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 57.72  E-value: 8.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  67 RLIRWMQKHkIPLDASVLDIGTGNGVFLVELVKHGFsNITGIDYSPSAIKLSASILEKEglsNINLKVEDFLNPStklsg 146
Cdd:COG2227  13 RLAALLARL-LPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLP----- 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47059504 147 fhvcVDKGTYDAISLNpdNAIE---KRKQYVMSLSRVLEVKGFFLITSCN 193
Cdd:COG2227  83 ----LEDGSFDLVICS--EVLEhlpDPAALLRELARLLKPGGLLLLSTPN 126
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 83-190 2.61e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.90  E-value: 2.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  83 VLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPSTKLSG-FHVCVDKGTYDAISL 161
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADEsFDVIISDPPLHHLVE 81

                        90       100
                ....*....|....*....|....*....
gi 47059504 162 NPDNAIEKrkqyvmsLSRVLEVKGFFLIT 190
Cdd:cd02440  82 DLARFLEE-------ARRLLKPGGVLVLT 103
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 52-191 1.55e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 54.94  E-value: 1.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  52 YGDTGEIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLSN-I 130
Cdd:COG2230  24 YFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADrV 103

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47059504 131 NLKVEDFLNPSTklsgfhvcvdKGTYDAISLNpdNAIE-----KRKQYVMSLSRVLEVKGFFLITS 191
Cdd:COG2230 104 EVRLADYRDLPA----------DGQFDAIVSI--GMFEhvgpeNYPAYFAKVARLLKPGGRLLLHT 157
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 67-208 2.14e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 54.23  E-value: 2.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  67 RLIRWMQKHKiplDASVLDIGTGNGVFLVELVKHGFSnITGIDYSPSAIKLSASILEKEGLsNINLKVEDFLNPStklsg 146
Cdd:COG2226  13 ALLAALGLRP---GARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLP----- 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47059504 147 fhvcVDKGTYDAI-SLNPDNAIEKRKQYVMSLSRVLEVKGFFLITSCNW-TKAELLDAFSE-GFE 208
Cdd:COG2226  83 ----FPDGSFDLViSSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPpDLAELEELLAEaGFE 143
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 65-152 3.00e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 49.84  E-value: 3.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504   65 MNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGFsNITGIDYSPSAIKLSASILEKEGLS-NINLKVEDfLNPstk 143
Cdd:PRK07580  49 RDTVLSWLPADGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDISPQMVEEARERAPEAGLAgNITFEVGD-LES--- 123

                         90
                 ....*....|..
gi 47059504  144 LSG-FH--VCVD 152
Cdd:PRK07580 124 LLGrFDtvVCLD 135
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 76-162 3.65e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 45.88  E-value: 3.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504    76 KIPLDASVLDIGTGNGVFLVELVKHGFSnITGIDYSPSAIKLSASILEKEGLSNINLKVEDflnpstklsgfhvcvdkGT 155
Cdd:pfam13489  19 KLPSPGRVLDFGCGTGIFLRLLRAQGFS-VTGVDPSPIAIERALLNVRFDQFDEQEAAVPA-----------------GK 80


                  ....*..
gi 47059504   156 YDAISLN 162
Cdd:pfam13489  81 FDVIVAR 87
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
36-190 4.43e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 45.76  E-value: 4.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  36 EHWDAVYERELRTFQEYgdtgeiwfgEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGFSnITGIDYSPSAI 115
Cdd:COG4976  12 DQYADSYDAALVEDLGY---------EAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR-LTGVDLSEEML 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47059504 116 KLSAsilEKEGlsNINLKVEDFLNPStklsgfhvcVDKGTYDAI----SLNPDNAIEkrkQYVMSLSRVLEVKGFFLIT 190
Cdd:COG4976  82 AKAR---EKGV--YDRLLVADLADLA---------EPDGRFDLIvaadVLTYLGDLA---AVFAGVARALKPGGLFIFS 143
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-181 1.60e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 42.35  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504    84 LDIGTGNGVFLVELVKH-GFSNITGIDYSPSAIKLSASILEKEGL---SNINLKVEDFLNPstklsgfhvcvDKGTYDAI 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlPGLEYTGLDISPAALEAARERLAALGLlnaVRVELFQLDLGEL-----------DPGSFDVV 69

                          90       100
                  ....*....|....*....|....*
gi 47059504   160 SLNpdNAIE---KRKQYVMSLSRVL 181
Cdd:pfam08242  70 VAS--NVLHhlaDPRAVLRNIRRLL 92
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-136 7.66e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 40.34  E-value: 7.66e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 47059504    84 LDIGTGNGVFLVELVKHGfSNITGIDYSPSAIKLSASILEKEGLSNINLKVED 136
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG-ARVTGVDISPEMLELAREKAPREGLTFVVGDAED 52
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 83-159 1.85e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 41.23  E-value: 1.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  83 VLDIGTGNG----VfLVELVKHgfsnITGIDYSPSAIKLSASILEKEGLSNINLKVEDflnpstklsGFHVCVDKGTYDA 158
Cdd:COG2518  70 VLEIGTGSGyqaaV-LARLAGR----VYSVERDPELAERARERLAALGYDNVTVRVGD---------GALGWPEHAPFDR 135


                .
gi 47059504 159 I 159
Cdd:COG2518 136 I 136
PRK11207 PRK11207
tellurite resistance methyltransferase TehB;
81-139 2.06e-04

tellurite resistance methyltransferase TehB;


Pssm-ID: 183040  Cd Length: 197  Bit Score: 41.26  E-value: 2.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 47059504   81 ASVLDIGTGNGVFLVELVKHGFsNITGIDYSPSAIKLSASILEKEGLSNINLKVEDfLN 139
Cdd:PRK11207  32 GKTLDLGCGNGRNSLYLAANGF-DVTAWDKNPMSIANLERIKAAENLDNLHTAVVD-LN 88
PRK14968 PRK14968
putative methyltransferase; Provisional
 82-163 5.45e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 39.88  E-value: 5.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504   82 SVLDIGTGNGVFLVELVKHGfSNITGIDYSPSAIKLSASILEKEGLSNINLKVedflnpstKLSGFHVCVDKGTYDAISL 161
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAAKNG-KKVVGVDINPYAVECAKCNAKLNNIRNNGVEV--------IRSDLFEPFRGDKFDVILF 96


                 ..
gi 47059504  162 NP 163
Cdd:PRK14968  97 NP 98
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
80-163 6.74e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 39.50  E-value: 6.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  80 DASVLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGlSNINLKVEDFLNPStklsgfhvcvDKGTYDAI 159
Cdd:COG2263  46 GKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENAERLG-VRVDFIRADVTRIP----------LGGSVDTV 114


                ....
gi 47059504 160 SLNP 163
Cdd:COG2263 115 VMNP 118
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
80-162 7.67e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 37.88  E-value: 7.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  80 DASVLDIGTGNGVFLVELVKHG-FSNITGIDYSPSAIKLSasileKEGLSNINLKVEDFLNPSTklsgfhvcvdKGTYDA 158
Cdd:COG4106   2 PRRVLDLGCGTGRLTALLAERFpGARVTGVDLSPEMLARA-----RARLPNVRFVVADLRDLDP----------PEPFDL 66


                ....
gi 47059504 159 ISLN 162
Cdd:COG4106  67 VVSN 70
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
74-129 1.30e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 38.86  E-value: 1.30e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47059504  74 KHKIPLDASVLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLSN 129
Cdd:COG4076  30 ERVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSD 85
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 81-163 1.78e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 38.60  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504   81 ASVLDIGTGNGVFLVELVKH-GFSNITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPstklsgfhvcVDKGTYDAI 159
Cdd:PRK09328 110 LRVLDLGTGSGAIALALAKErPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEP----------LPGGRFDLI 179


                 ....
gi 47059504  160 SLNP 163
Cdd:PRK09328 180 VSNP 183
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
81-136 2.76e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 37.73  E-value: 2.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 47059504    81 ASVLDIGTGNG---VFLVELVKHGFSnITGIDYSPSAIKLSASILEKEGLSNINLKVED 136
Cdd:pfam01135  75 MRVLEIGSGSGyltACFARMVGEVGR-VVSIEHIPELVEIARRNLEKLGLENVIVVVGD 132
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 77-163 4.29e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 37.09  E-value: 4.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504  77 IPLDASVLDIGTGNGVFLVELVKHGF-SNITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPstklsgfhvcVDKGT 155
Cdd:COG2813  47 EPLGGRVLDLGCGYGVIGLALAKRNPeARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSG----------VPDGS 116


                ....*...
gi 47059504 156 YDAISLNP 163
Cdd:COG2813 117 FDLILSNP 124
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 83-215 6.55e-03

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 36.50  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504    83 VLDIGTGNGVFLVELVKHGFS-NITGID-YSPSAIKLSASIlEKEGLSNINLKvedFLNPSTKLSGFhvcVDKGTYDAIS 160
Cdd:pfam02390   5 FLEIGCGMGGFLVAMAKANPDkNFIGIEiRVPGVAKALKKI-DALGLQNLRIL---CGNALDVLPNY---FPPGSLQKIF 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47059504   161 LN-PDNAIEKRKQ--------YVMSLSRVLEVKGFFLitscnwTKAELLDAFSEGFELFEELPT 215
Cdd:pfam02390  78 INfPDPWPKKRHHkrrllqpeFLKEYARVLKPGGVLH------LATDVEEYAEEMLKHLAEHPL 135
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 78-163 9.41e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.03  E-value: 9.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059504    78 PLDASVLDIGTGNGVFLVELVKHGFSN-ITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPstklsgfhvcVDKGTY 156
Cdd:pfam05175  30 DLSGKVLDLGCGAGVLGAALAKESPDAeLTMVDINARALESARENLAANGLENGEVVASDVYSG----------VEDGKF 99


                  ....*..
gi 47059504   157 DAISLNP 163
Cdd:pfam05175 100 DLIISNP 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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